LOCUS       NM_153056               1728 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus sirtuin 7 (Sirt7), transcript variant 1, mRNA.
ACCESSION   NM_153056
VERSION     NM_153056.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1728)
  AUTHORS   Li,F., Zhang,X., Xu,J., Zhang,Y., Li,G., Yang,X., Deng,G., Dai,Y.,
            Liu,B., Kosan,C., Chen,X. and Cai,Y.
  TITLE     SIRT7 remodels the cytoskeleton via RAC1 to enhance host resistance
            to Mycobacterium tuberculosis
  JOURNAL   mBio 15 (10), e0075624 (2024)
   PUBMED   39287444
  REMARK    GeneRIF: SIRT7 remodels the cytoskeleton via RAC1 to enhance host
            resistance to Mycobacterium tuberculosis.
REFERENCE   2  (bases 1 to 1728)
  AUTHORS   Yu,H., Xie,Y., Lan,L., Ma,S., Mok,S.W.F., Wong,I.N., Wang,Y.,
            Zhong,G., Yuan,L., Zhao,H., Hu,X., Macrae,V.E., He,S., Chen,G. and
            Zhu,D.
  TITLE     Sirt7 protects against vascular calcification via modulation of
            reactive oxygen species and senescence of vascular smooth muscle
            cells
  JOURNAL   Free Radic Biol Med 223, 30-41 (2024)
   PUBMED   39053861
  REMARK    GeneRIF: Sirt7 protects against vascular calcification via
            modulation of reactive oxygen species and senescence of vascular
            smooth muscle cells.
REFERENCE   3  (bases 1 to 1728)
  AUTHORS   Zhang,J., Xu,C., Tang,X., Sun,S., Liu,S., Yang,L., Chen,Y.,
            Yang,Q., Wei,T.W., Wu,X., Wang,J., Wang,C., Yan,X., Yang,L.,
            Niu,Y., Gou,D., Shyy,J.Y.J. and Liu,B.
  TITLE     Endothelium-specific SIRT7 targeting ameliorates pulmonary
            hypertension through Krupple-like factor 4 deacetylation
  JOURNAL   Cardiovasc Res 120 (4), 403-416 (2024)
   PUBMED   38198357
  REMARK    GeneRIF: Endothelium-specific SIRT7 targeting ameliorates pulmonary
            hypertension through Krupple-like factor 4 deacetylation.
REFERENCE   4  (bases 1 to 1728)
  AUTHORS   Wei,Y., Wang,X., Ma,Z., Xiang,P., Liu,G., Yin,B., Hou,L., Shu,P.,
            Liu,W. and Peng,X.
  TITLE     Sirt6 regulates the proliferation of neural precursor cells and
            cortical neurogenesis in mice
  JOURNAL   iScience 27 (2), 108706 (2023)
   PUBMED   38288355
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1728)
  AUTHORS   Wang,C.L., Ohkubo,R., Mu,W.C., Chen,W., Fan,J.L., Song,Z.,
            Maruichi,A., Sudmant,P.H., Pisco,A.O., Dubal,D.B., Ji,N. and
            Chen,D.
  TITLE     The mitochondrial unfolded protein response regulates hippocampal
            neural stem cell aging
  JOURNAL   Cell Metab 35 (6), 996-1008 (2023)
   PUBMED   37146607
REFERENCE   6  (bases 1 to 1728)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 1728)
  AUTHORS   Witt,O., Deubzer,H.E., Milde,T. and Oehme,I.
  TITLE     HDAC family: What are the cancer relevant targets?
  JOURNAL   Cancer Lett 277 (1), 8-21 (2009)
   PUBMED   18824292
  REMARK    Review article
REFERENCE   8  (bases 1 to 1728)
  AUTHORS   Vakhrusheva,O., Braeuer,D., Liu,Z., Braun,T. and Bober,E.
  TITLE     Sirt7-dependent inhibition of cell growth and proliferation might
            be instrumental to mediate tissue integrity during aging
  JOURNAL   J Physiol Pharmacol 59 Suppl 9, 201-212 (2008)
   PUBMED   19261981
  REMARK    GeneRIF: Using Sirt7 knockout and overexpressing cells we
            demonstrate an anti-proliferative role of Sirt7. We also show that
            Sirt7 expression inversely correlates with the tumorigenic
            potential of several murine cell lines
REFERENCE   9  (bases 1 to 1728)
  AUTHORS   Vakhrusheva,O., Smolka,C., Gajawada,P., Kostin,S., Boettger,T.,
            Kubin,T., Braun,T. and Bober,E.
  TITLE     Sirt7 increases stress resistance of cardiomyocytes and prevents
            apoptosis and inflammatory cardiomyopathy in mice
  JOURNAL   Circ Res 102 (6), 703-710 (2008)
   PUBMED   18239138
  REMARK    GeneRIF: Suggest a critical role of Sirt7 in the regulation of
            stress responses and cell death in the heart. Enhanced p53
            activation by lack of Sirt7-mediated deacetylation contributes to
            the heart phenotype of Sirt7 mutant mice.
REFERENCE   10 (bases 1 to 1728)
  AUTHORS   Ford,E., Voit,R., Liszt,G., Magin,C., Grummt,I. and Guarente,L.
  TITLE     Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I
            transcription
  JOURNAL   Genes Dev 20 (9), 1075-1080 (2006)
   PUBMED   16618798
  REMARK    GeneRIF: SIRT7 is a positive regulator of Pol I transcription and
            is required for cell viability in mammals.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL663030.12, BY125424.1, AY251540.1, AK135484.1 and AV001692.1.
            
            On May 18, 2018 this sequence version replaced NM_153056.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040759.1, AY251540.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AL663030.12        80817-80828         c
            13-36               BY125424.1         13-36
            37-324              AY251540.1         1-288
            325-624             AK135484.1         310-609
            625-1001            AY251540.1         589-965
            1002-1725           AK135484.1         1202-1925
            1726-1727           AV001692.1         206-207
            1728-1728           AL663030.12        74185-74185         c
FEATURES             Location/Qualifiers
     source          1..1728
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 84.34 cM"
     gene            1..1728
                     /gene="Sirt7"
                     /note="sirtuin 7"
                     /db_xref="GeneID:209011"
                     /db_xref="MGI:MGI:2385849"
     exon            1..138
                     /gene="Sirt7"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1251
                     /gene="Sirt7"
                     /EC_number="2.3.1.286"
                     /note="isoform 1 is encoded by transcript variant 1;
                     NAD-dependent deacetylase sirtuin-7; SIR2-like protein 7;
                     regulatory protein SIR2 homolog 7; NAD-dependent protein
                     deacetylase sirtuin-7; NAD-dependent protein deacylase
                     sirtuin-7"
                     /codon_start=1
                     /product="NAD-dependent protein deacetylase sirtuin-7
                     isoform 1"
                     /protein_id="NP_694696.2"
                     /db_xref="CCDS:CCDS49006.1"
                     /db_xref="GeneID:209011"
                     /db_xref="MGI:MGI:2385849"
                     /translation="MAAGGGLSRSERKAAERVRRLREEQQRERLRQVSRILRKAAAER
                     SAEEGRLLAESEDLVTELQGRSRRREGLKRRQEEVCDDPEELRRKVRELAGAVRSARH
                     LVVYTGAGISTAASIPDYRGPNGVWTLLQKGRPVSAADLSEAEPTLTHMSITRLHEQK
                     LVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVCTSCIPNREYVRVFDVTERTALH
                     RHLTGRTCHKCGTQLRDTIVHFGERGTLGQPLNWEAATEAASKADTILCLGSSLKVLK
                     KYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGKCDDVMQLLMNELGLEIPVY
                     NRWQDPIFSLATPLRAGEEGSHSRKSLCRSREEAPPGDQSDPLASAPPILGGWFGRGC
                     AKRAKRKKVA"
     exon            139..276
                     /gene="Sirt7"
                     /inference="alignment:Splign:2.1.0"
     exon            277..381
                     /gene="Sirt7"
                     /inference="alignment:Splign:2.1.0"
     exon            382..452
                     /gene="Sirt7"
                     /inference="alignment:Splign:2.1.0"
     exon            453..525
                     /gene="Sirt7"
                     /inference="alignment:Splign:2.1.0"
     exon            526..624
                     /gene="Sirt7"
                     /inference="alignment:Splign:2.1.0"
     exon            625..861
                     /gene="Sirt7"
                     /inference="alignment:Splign:2.1.0"
     exon            862..942
                     /gene="Sirt7"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1049
                     /gene="Sirt7"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1728
                     /gene="Sirt7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1708..1713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sirt7"
                     /note="hexamer: ATTAAA"
     polyA_site      1727
                     /gene="Sirt7"
                     /note="major polyA site"
ORIGIN      
        1 gatgaggcgg aagcggaagc cggaagcgca gtcaaaggag cgatggcagc cggtggcggt
       61 ctgagccgct cggagcgcaa agctgctgag cgggtccgga ggctgcggga ggagcagcag
      121 cgggagcgcc tccgccaggt gtcacgcatc ctgaggaagg cggctgcaga gcgcagcgcg
      181 gaggagggcc ggctcttggc cgagagcgag gatctggtga ccgagctgca gggtcgaagt
      241 cggcggcgtg agggcctcaa gcgccgccag gaggaggtgt gtgatgaccc ggaggagctg
      301 cggaggaagg tccgcgaact ggccggagct gtccgaagtg ccaggcactt ggttgtctac
      361 acgggcgctg gaatcagcac agcagcttct atcccagatt atcggggtcc taatggagta
      421 tggacactgc ttcagaaagg aaggcctgtg agtgctgccg acctaagcga agcggagcct
      481 accctcaccc acatgagcat cacccgtttg catgagcaaa agctggtgca acacgtggtg
      541 tctcagaact gtgatgggct ccacctgcgg agtgggttgc cccggaccgc catctcagag
      601 ctccatggga atatgtatat tgaagtctgc acctcctgca tccctaacag agagtatgta
      661 cgagtgtttg atgtgactga gcgtactgcc cttcaccgac acctgacagg ccggacctgc
      721 cacaagtgcg ggacccagct tcgggatacc attgtgcact ttggggagag ggggacatta
      781 gggcagcctc tgaactggga ggcagcgacc gaggctgcta gcaaagcaga cacaatcctg
      841 tgtttagggt ccagcttgaa ggtactaaag aaatatcccc gcctctggtg catgacgaag
      901 cctccaagcc gtcgacccaa actctacatc gtgaacctgc agtggacccc gaaggatgac
      961 tgggctgccc tgaaactcca tgggaagtgt gatgatgtca tgcaactcct catgaatgaa
     1021 ctgggcctgg agattcctgt ctacaaccgg tggcaggatc caatcttctc cttggcgacc
     1081 cccctccgtg ctggtgaaga aggcagccac agtaggaagt cactatgcag aagcagagaa
     1141 gaagccccac ctggggacca gagtgacccc cttgcctcag ctccccctat cctaggaggc
     1201 tggtttggca ggggttgtgc caagcgtgca aaaaggaaga aagtggcata gcccggagtt
     1261 gacaaagaac agttggcact ttgcagatgg cttgaccctt gttcaggggc tccgcccgtg
     1321 tcgccgtgaa ggcgagagtg ccccctccgg ctctagtggg tgccggcttc gcggtgacgg
     1381 tcgtctttag ccatttgtcc ttgtggaaag gctctcttgc actgctgtga ctgccccgct
     1441 atgggcttga tcttcaagga cacctccctc ctgttcaccc ctgtacaaag gtggcagcaa
     1501 ggcctctgtg agaagagctc cggcccttcc caggcctggc cagcaggaga gtccaccact
     1561 gccttacctc actctccagg ctagtctcag ggcctccctc tttctactcc ttatcacgta
     1621 caagtgttca ctttatagaa gcctttttct gtattgggta tgcggcacag ggagaatcta
     1681 actaagcctc cagtctgagc aagtcttatt aaacatctct caattgct
//
