LOCUS       NM_181586               1660 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus sirtuin 6 (Sirt6), transcript variant 1, mRNA.
ACCESSION   NM_181586
VERSION     NM_181586.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1660)
  AUTHORS   Zhang,Z., Huang,H., Tao,Y., Liu,H. and Fan,Y.
  TITLE     Sirt6 ameliorates high glucose-induced podocyte cytoskeleton
            remodeling via the PI3K/AKT signaling pathway
  JOURNAL   Ren Fail 46 (2), 2410396 (2024)
   PUBMED   39378103
  REMARK    GeneRIF: Sirt6 ameliorates high glucose-induced podocyte
            cytoskeleton remodeling via the PI3K/AKT signaling pathway.
REFERENCE   2  (bases 1 to 1660)
  AUTHORS   Zaretsky,A., Venzor,A.G., Eremenko,E., Stein,D., Smirnov,D.,
            Rabuah,Y., Dryer,R., Kriukov,D., Kaluski-Kopatch,S., Einav,M.,
            Khrameeva,E. and Toiber,D.
  TITLE     SIRT6-dependent functional switch via K494 modifications of RE-1
            silencing transcription factor
  JOURNAL   Cell Death Dis 15 (11), 798 (2024)
   PUBMED   39511137
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1660)
  AUTHORS   Zou,D., Liao,J., Xiao,M., Liu,L., Dai,D. and Xu,M.
  TITLE     Impaired SUMOylation of FoxA1 promotes nonalcoholic fatty liver
            disease through down-regulation of Sirt6
  JOURNAL   Cell Death Dis 15 (9), 674 (2024)
   PUBMED   39277582
  REMARK    GeneRIF: Impaired SUMOylation of FoxA1 promotes nonalcoholic fatty
            liver disease through down-regulation of Sirt6.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1660)
  AUTHORS   Su,X., Zhao,L., Zhang,H., Wang,D., Sun,J. and Shen,L.
  TITLE     Sirtuin 6 inhibits group 3 innate lymphoid cell function and gut
            immunity by suppressing IL-22 production
  JOURNAL   Front Immunol 15, 1402834 (2024)
   PUBMED   39253083
  REMARK    GeneRIF: Sirtuin 6 inhibits group 3 innate lymphoid cell function
            and gut immunity by suppressing IL-22 production.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1660)
  AUTHORS   Du,Y., He,J., Xu,Y., Wu,X., Cheng,H., Yu,J., Wang,X., An,Y., Wu,Y.
            and Guo,W.
  TITLE     SIRT6 prevent chronic cerebral hypoperfusion induced cognitive
            impairment by remodeling mitochondrial dynamics in a
            STAT5-PGAM5-Drp1 dependent manner
  JOURNAL   J Transl Med 22 (1), 788 (2024)
   PUBMED   39183280
  REMARK    GeneRIF: SIRT6 prevent chronic cerebral hypoperfusion induced
            cognitive impairment by remodeling mitochondrial dynamics in a
            STAT5-PGAM5-Drp1 dependent manner.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1660)
  AUTHORS   Witt,O., Deubzer,H.E., Milde,T. and Oehme,I.
  TITLE     HDAC family: What are the cancer relevant targets?
  JOURNAL   Cancer Lett 277 (1), 8-21 (2009)
   PUBMED   18824292
  REMARK    Review article
REFERENCE   7  (bases 1 to 1660)
  AUTHORS   Lall,S.
  TITLE     No SIRT6
  JOURNAL   Nat Struct Mol Biol 15 (4), 336 (2008)
   PUBMED   18388907
  REMARK    GeneRIF: suggests similarities in the molecular mechanisms by which
            SIRT6 and WRN may prevent premature aging-like phenotypes
REFERENCE   8  (bases 1 to 1660)
  AUTHORS   Kanfi,Y., Shalman,R., Peshti,V., Pilosof,S.N., Gozlan,Y.M.,
            Pearson,K.J., Lerrer,B., Moazed,D., Marine,J.C., de Cabo,R. and
            Cohen,H.Y.
  TITLE     Regulation of SIRT6 protein levels by nutrient availability
  JOURNAL   FEBS Lett 582 (5), 543-548 (2008)
   PUBMED   18242175
  REMARK    GeneRIF: Levels of the mammalian sirtuin, SIRT6, increased upon
            nutrient deprivation in cultured cells, in mice after fasting, and
            in rats fed a calorie-restricted diet.
REFERENCE   9  (bases 1 to 1660)
  AUTHORS   Mostoslavsky,R., Chua,K.F., Lombard,D.B., Pang,W.W., Fischer,M.R.,
            Gellon,L., Liu,P., Mostoslavsky,G., Franco,S., Murphy,M.M.,
            Mills,K.D., Patel,P., Hsu,J.T., Hong,A.L., Ford,E., Cheng,H.L.,
            Kennedy,C., Nunez,N., Bronson,R., Frendewey,D., Auerbach,W.,
            Valenzuela,D., Karow,M., Hottiger,M.O., Hursting,S., Barrett,J.C.,
            Guarente,L., Mulligan,R., Demple,B., Yancopoulos,G.D. and Alt,F.W.
  TITLE     Genomic instability and aging-like phenotype in the absence of
            mammalian SIRT6
  JOURNAL   Cell 124 (2), 315-329 (2006)
   PUBMED   16439206
REFERENCE   10 (bases 1 to 1660)
  AUTHORS   Liszt,G., Ford,E., Kurtev,M. and Guarente,L.
  TITLE     Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase
  JOURNAL   J Biol Chem 280 (22), 21313-21320 (2005)
   PUBMED   15795229
  REMARK    GeneRIF: SIRT6 is a nuclear ADP-ribosyltransferase
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153919.8.
            
            On Mar 17, 2020 this sequence version replaced NM_181586.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1 and 3 both encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052763.1, AK013316.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AC153919.8         29162-29256
            96-223              AC153919.8         30111-30238
            224-406             AC153919.8         30830-31012
            407-466             AC153919.8         31612-31671
            467-562             AC153919.8         32486-32581
            563-643             AC153919.8         32656-32736
            644-767             AC153919.8         33856-33979
            768-1660            AC153919.8         34049-34941
FEATURES             Location/Qualifiers
     source          1..1660
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..1660
                     /gene="Sirt6"
                     /gene_synonym="2810449N18Rik; mSIRT6; Sir2l6"
                     /note="sirtuin 6"
                     /db_xref="GeneID:50721"
                     /db_xref="MGI:MGI:1354161"
     exon            1..95
                     /gene="Sirt6"
                     /gene_synonym="2810449N18Rik; mSIRT6; Sir2l6"
                     /inference="alignment:Splign:2.1.0"
     exon            96..223
                     /gene="Sirt6"
                     /gene_synonym="2810449N18Rik; mSIRT6; Sir2l6"
                     /inference="alignment:Splign:2.1.0"
     exon            224..406
                     /gene="Sirt6"
                     /gene_synonym="2810449N18Rik; mSIRT6; Sir2l6"
                     /inference="alignment:Splign:2.1.0"
     exon            407..466
                     /gene="Sirt6"
                     /gene_synonym="2810449N18Rik; mSIRT6; Sir2l6"
                     /inference="alignment:Splign:2.1.0"
     exon            467..562
                     /gene="Sirt6"
                     /gene_synonym="2810449N18Rik; mSIRT6; Sir2l6"
                     /inference="alignment:Splign:2.1.0"
     exon            563..643
                     /gene="Sirt6"
                     /gene_synonym="2810449N18Rik; mSIRT6; Sir2l6"
                     /inference="alignment:Splign:2.1.0"
     exon            644..767
                     /gene="Sirt6"
                     /gene_synonym="2810449N18Rik; mSIRT6; Sir2l6"
                     /inference="alignment:Splign:2.1.0"
     exon            768..1660
                     /gene="Sirt6"
                     /gene_synonym="2810449N18Rik; mSIRT6; Sir2l6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1631..1636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sirt6"
                     /gene_synonym="2810449N18Rik; mSIRT6; Sir2l6"
                     /note="hexamer: AATAAA"
     polyA_site      1660
                     /gene="Sirt6"
                     /gene_synonym="2810449N18Rik; mSIRT6; Sir2l6"
                     /note="major polyA site"
ORIGIN      
        1 attgttcccg tgcggcagcg ccggcgacga tgtcggtgaa ttatgcagca gggttgtcgc
       61 cttacgcgga taagggcaag tgcgggctgc ccgagatctt cgacccacca gaggagctgg
      121 aacgcaaggt gtgggagctg gcccggctaa tgtggcagtc ctccagcgtg gttttccaca
      181 cgggcgccgg catcagcacc gcctctggca tccccgactt cagaggcccc catggcgtgt
      241 ggaccatgga ggaacgcggc ctggccccca agtttgacac caccttcgag aatgctcggc
      301 cctcgaagac ccacatggcc ctggttcagc tagaacgcat gggcttcctc agcttcctgg
      361 tcagccagaa cgtagacggg ctgcacgtgc gctcgggctt ccccagggac aagctggcag
      421 agctgcacgg aaacatgttt gtagaggaat gtcccaagtg taagacgcag tacgtcagag
      481 acacggttgt gggcaccatg ggcctcaagg ccacaggccg gctctgcacc gtggccaaga
      541 ccaggggact tcgggcctgt agaggggagc tgagagacac cattctggac tgggaggact
      601 cgttgcctga ccgggacctg atgctcgctg atgaggccag caggaccgca gacctgtctg
      661 tcaccctggg tacctcgctg cagatccgcc ccagtgggaa cctgcccctt gccactaagc
      721 gccgaggagg ccgtctggtc attgtcaacc tgcaacccac aaaacatgac cgccaggctg
      781 acctgcgcat ccacggctac gtggatgagg tgatgtgcag actcatgaag catctggggc
      841 tggagattcc agcctgggat ggaccctgcg tgctagacaa agccctgcca cctctgcctc
      901 gcccagtagc actcaaggct gagccccccg tgcatctcaa tggtgcagtg catgtttcgt
      961 ataagtccaa gcccaacagc cctatactcc acaggccccc caaaagagtg aagaccgagg
     1021 ctgcccccag ctgacccggg tatgtggggc gggaggggaa cttgaaggaa ccacacatgt
     1081 tgaggttttt gtttgtttgt ttgtttgttt gttttttata ttctggggac tgagcccagg
     1141 tttgcatatc tcaccctggt gtcttttcag attttttttt tttttttttt ttttttgaga
     1201 ccaggactcc ctagatcgct caggctggtc tggaactcac tgctatagcc caggctggcc
     1261 tggaactagc ctgcctgcct cagcctctac tgtagtaggg acagcgggca ggtacaccat
     1321 gtccaacaca gctcctttct tcaaagtctc actgtgtccc ttgtccaggt ccttccaggg
     1381 aatctcaggg catggggaat cccacacatg tggaagaggc cgtgtcccag ggatccacgt
     1441 gcctctctac caatcacacc cgctcgtgac tcaggatgtg cccggagcag cagtctcaca
     1501 cactccacac accattgctg ccccctgcac gcatctcccc cccatcccct ggccctgaca
     1561 cagagccacc aagggcccac caggcaccca tctgtgctaa gggccccagg ctcccagaag
     1621 ctcccaatgc aataaataca aaatcccttc cattctttta
//
