LOCUS       NM_001127351            1439 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus sirtuin 3 (Sirt3), transcript variant 2, mRNA.
ACCESSION   NM_001127351
VERSION     NM_001127351.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1439)
  AUTHORS   Hu,Y., Zheng,Y., Liu,C., You,Y., Wu,Y., Wang,P., Wu,Y., Ba,H.,
            Lu,J., Yuan,Y., Liu,P. and Mao,Y.
  TITLE     Mitochondrial MOF regulates energy metabolism in heart failure via
            ATP5B hyperacetylation
  JOURNAL   Cell Rep 43 (10), 114839 (2024)
   PUBMED   39392752
REFERENCE   2  (bases 1 to 1439)
  AUTHORS   Chen,J.X., Zhang,J., Chen,Y. and Zeng,H.
  TITLE     Knockout of Sirtuin 3 in endothelial cells impairs
            endothelial-dependent relaxation and myogenic response in mice
  JOURNAL   Physiol Rep 12 (20), e70060 (2024)
   PUBMED   39425510
  REMARK    GeneRIF: Knockout of Sirtuin 3 in endothelial cells impairs
            endothelial-dependent relaxation and myogenic response in mice.
REFERENCE   3  (bases 1 to 1439)
  AUTHORS   Richardson,K.K., Adam,G.O., Ling,W., Warren,A.,
            Marques-Carvalho,A., Thostenson,J.D., Krager,K., Aykin-Burns,N.,
            Byrum,S.D., Almeida,M. and Kim,H.N.
  TITLE     Mitochondrial protein deacetylation by SIRT3 in osteoclasts
            promotes bone resorption with aging in female mice
  JOURNAL   Mol Metab 88, 102012 (2024)
   PUBMED   39154858
  REMARK    GeneRIF: Mitochondrial protein deacetylation by SIRT3 in
            osteoclasts promotes bone resorption with aging in female mice.
REFERENCE   4  (bases 1 to 1439)
  AUTHORS   Li,Y., Kong,E., Ding,R., Chu,R., Lu,J., Deng,M., Hua,T., Yang,M.,
            Wang,H., Chen,D., Song,H., Wei,H., Zhang,P., Han,C. and Yuan,H.
  TITLE     Hyperglycemia-induced Sirt3 downregulation increases microglial
            aerobic glycolysis and inflammation in diabetic neuropathic pain
            pathogenesis
  JOURNAL   CNS Neurosci Ther 30 (8), e14913 (2024)
   PUBMED   39123294
  REMARK    GeneRIF: Hyperglycemia-induced Sirt3 downregulation increases
            microglial aerobic glycolysis and inflammation in diabetic
            neuropathic pain pathogenesis.
REFERENCE   5  (bases 1 to 1439)
  AUTHORS   Ge,Y., Wu,X., Cai,Y., Hu,Q., Wang,J., Zhang,S., Zhao,B., Cui,W.,
            Wu,Y., Wang,Q., Feng,T., Liu,H., Qu,Y. and Ge,S.
  TITLE     FNDC5 prevents oxidative stress and neuronal apoptosis after
            traumatic brain injury through SIRT3-dependent regulation of
            mitochondrial quality control
  JOURNAL   Cell Death Dis 15 (5), 364 (2024)
   PUBMED   38802337
  REMARK    GeneRIF: FNDC5 prevents oxidative stress and neuronal apoptosis
            after traumatic brain injury through SIRT3-dependent regulation of
            mitochondrial quality control.
            Erratum:[Cell Death Dis. 2024 Jul 24;15(7):527. doi:
            10.1038/s41419-024-06901-5. PMID: 39048543]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1439)
  AUTHORS   Lombard,D.B., Alt,F.W., Cheng,H.L., Bunkenborg,J., Streeper,R.S.,
            Mostoslavsky,R., Kim,J., Yancopoulos,G., Valenzuela,D., Murphy,A.,
            Yang,Y., Chen,Y., Hirschey,M.D., Bronson,R.T., Haigis,M.,
            Guarente,L.P., Farese,R.V. Jr., Weissman,S., Verdin,E. and
            Schwer,B.
  TITLE     Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine
            acetylation
  JOURNAL   Mol Cell Biol 27 (24), 8807-8814 (2007)
   PUBMED   17923681
  REMARK    GeneRIF: These results extend the recent finding of lysine
            acetylation of mitochondrial proteins and demonstrate that SIRT3
            has evolved to control reversible lysine acetylation in this
            organelle.
REFERENCE   7  (bases 1 to 1439)
  AUTHORS   Hallows,W.C., Lee,S. and Denu,J.M.
  TITLE     Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
  JOURNAL   Proc Natl Acad Sci U S A 103 (27), 10230-10235 (2006)
   PUBMED   16790548
REFERENCE   8  (bases 1 to 1439)
  AUTHORS   Shi,T., Wang,F., Stieren,E. and Tong,Q.
  TITLE     SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial
            function and thermogenesis in brown adipocytes
  JOURNAL   J Biol Chem 280 (14), 13560-13567 (2005)
   PUBMED   15653680
  REMARK    GeneRIF: Results demonstrate that SIRT3 activates mitochondria and
            plays an important role in adaptive thermogenesis in brown adipose
            tissue.
            GeneRIF: Caloric restriction and cold exposure elevate SIRT3
            expression in brown adipose to regulate thermogenesis through
            PGC-1alpha and UCP1.
REFERENCE   9  (bases 1 to 1439)
  AUTHORS   Yang,Y.H., Chen,Y.H., Zhang,C.Y., Nimmakayalu,M.A., Ward,D.C. and
            Weissman,S.
  TITLE     Cloning and characterization of two mouse genes with homology to
            the yeast Sir2 gene
  JOURNAL   Genomics 69 (3), 355-369 (2000)
   PUBMED   11056054
REFERENCE   10 (bases 1 to 1439)
  AUTHORS   Fukasawa,K.M., Li,W.H., Yagi,K., Luo,C.C. and Li,S.S.
  TITLE     Molecular evolution of mammalian lactate dehydrogenase-A genes and
            pseudogenes: association of a mouse processed pseudogene with a B1
            repetitive sequence
  JOURNAL   Mol Biol Evol 3 (4), 330-342 (1986)
   PUBMED   3444409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF299339.1, AF299338.1, CT010402.1 and BF681854.1.
            
            Transcript Variant: This variant (2) has an additional segment,
            resulting in a downstream AUG start codon, as compared to variant
            3. The resulting isoform (1) is shorter at the N-terminus, as
            compared to isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF299339.1, BC025878.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               AF299339.1         1-107
            108-663             AF299338.1         153-708
            664-1022            CT010402.1         415-773
            1023-1416           AF299338.1         1068-1461
            1417-1439           BF681854.1         642-664
FEATURES             Location/Qualifiers
     source          1..1439
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 86.07 cM"
     gene            1..1439
                     /gene="Sirt3"
                     /gene_synonym="2310003L23Rik; Sir2l3"
                     /note="sirtuin 3"
                     /db_xref="GeneID:64384"
                     /db_xref="MGI:MGI:1927665"
     exon            1..107
                     /gene="Sirt3"
                     /gene_synonym="2310003L23Rik; Sir2l3"
                     /inference="alignment:Splign:2.1.0"
     exon            108..296
                     /gene="Sirt3"
                     /gene_synonym="2310003L23Rik; Sir2l3"
                     /inference="alignment:Splign:2.1.0"
     exon            297..529
                     /gene="Sirt3"
                     /gene_synonym="2310003L23Rik; Sir2l3"
                     /inference="alignment:Splign:2.1.0"
     exon            530..630
                     /gene="Sirt3"
                     /gene_synonym="2310003L23Rik; Sir2l3"
                     /inference="alignment:Splign:2.1.0"
     exon            631..792
                     /gene="Sirt3"
                     /gene_synonym="2310003L23Rik; Sir2l3"
                     /inference="alignment:Splign:2.1.0"
     exon            793..1002
                     /gene="Sirt3"
                     /gene_synonym="2310003L23Rik; Sir2l3"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1423
                     /gene="Sirt3"
                     /gene_synonym="2310003L23Rik; Sir2l3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1398..1403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sirt3"
                     /gene_synonym="2310003L23Rik; Sir2l3"
                     /note="hexamer: AATAAA"
     polyA_site      1416
                     /gene="Sirt3"
                     /gene_synonym="2310003L23Rik; Sir2l3"
                     /note="major polyA site"
ORIGIN      
        1 ggggattcgg atggcgcttg accctctagg cgccgtcgtc ctgcagagca tcatggcgct
       61 aagcggtcga ctggcattgg ccgcgctcag actgtggggt ccgggagtgt tacaggtggg
      121 agaaggccca tatccctctg tgtgggagcc tcaggcggct ttggaggtgg aggaagcagt
      181 gagaagaagt tttctctgca ggatgtagct gagctgcttc ggaccagagc ctgcagtagg
      241 gtggtggtca tggtgggggc cggcatcagc acacccagtg gcatcccgga cttcagatcc
      301 ccagggagcg gcctctacag caaccttcag cagtatgaca tcccgtaccc tgaagccatc
      361 tttgaacttg gctttttctt tcacaacccc aagccctttt tcatgttggc caaggagctg
      421 taccctgggc actacaggcc caatgtcact cactacttcc tgaggctcct ccacgacaag
      481 gagctgcttc tgcggctcta tacacagaac atcgacgggc ttgagagagc atctgggatc
      541 cctgcctcaa agctggttga agcccacggg acctttgtaa cagctacatg cacggtctgt
      601 cgaaggtcct tcccagggga agacatatgg gctgatgtga tggcggacag ggtgccccgc
      661 tgccctgtct gtactggcgt tgtgaaaccc gacattgtgt tctttgggga gcagctgcct
      721 gcaaggttcc tactccatat ggctgacttc gctttggcag atctgctact cattcttggg
      781 acctccctgg aggtggagcc ttttgccagc ttgtctgaag cagtacagaa atcagtgccc
      841 cgactgctca tcaatcgaga cttggtgggg ccgttcgttc tgagtcctcg aaggaaagat
      901 gtggtccagc taggggatgt agttcatggt gtggaaaggc tggtggacct cctggggtgg
      961 acacaagaac tgctggatct tatgcagcgg gaacgtggca agctggatgg acaggacaga
     1021 taagactatg gcttcttcac ctggggaagt cacacagcag atcatcctat gtccagcaag
     1081 acttcatgcc tgaagacagc tccaacacgt ttacaaacat gaaccagacc acaacatgtg
     1141 gcctggacag tggtcctccg aggctgcctt tggaaaggct gaccagggat gtctaccctt
     1201 ggggcccctc catgtgtgcg ccctgtccac ctcatcactg ctgaaggtgt agtgcaggtg
     1261 ctgctttctg cagcggccct taagttatca cgagggcagc acagcacgcc cgtcgccagg
     1321 caggcgatgc actagggcaa tctagcatgt tgatcggtaa agtggcatct ttaactacaa
     1381 catcatttct tgcatgaaat aaacttagta taaaaacttg gcaaaaaaaa aaaaaaaaa
//
