LOCUS       NM_022432               1843 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus sirtuin 2 (Sirt2), transcript variant 1, mRNA.
ACCESSION   NM_022432
VERSION     NM_022432.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1843)
  AUTHORS   Nevoral,J., Drutovic,D., Vaskovicova,M., Benc,M., Liska,F.,
            Valentova,I., Stachovicova,S., Kubovciak,J., Havrankova,J.,
            Shavit,M., Monsef,L., Iniesta-Cuerda,M., Zalmanova,T., Hosek,P.,
            Strejcek,F., Kralickova,M. and Petr,J.
  TITLE     Dynamics and necessity of SIRT1 for maternal-zygotic transition
  JOURNAL   Sci Rep 14 (1), 21598 (2024)
   PUBMED   39285243
  REMARK    GeneRIF: Dynamics and necessity of SIRT1 for maternal-zygotic
            transition.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1843)
  AUTHORS   Zhang,Q., Guo,J., Shi,C., Zhang,D., Wang,Y., Wang,L. and Gong,Z.
  TITLE     The SIRT2-AMPK axis regulates autophagy induced by acute liver
            failure
  JOURNAL   Sci Rep 14 (1), 16278 (2024)
   PUBMED   39009648
  REMARK    GeneRIF: The SIRT2-AMPK axis regulates autophagy induced by acute
            liver failure.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1843)
  AUTHORS   Guo,J., Nie,J., Li,D., Zhang,H., Zhao,T., Zhang,S., Ma,L., Lu,J.,
            Ji,H., Li,S., Tao,S. and Xu,B.
  TITLE     The role of NAD-dependent deacetylase sirtuin-2 in liver metabolic
            stress through regulating pyruvate kinase M2 ubiquitination
  JOURNAL   J Transl Med 22 (1), 656 (2024)
   PUBMED   39004743
  REMARK    GeneRIF: The role of NAD-dependent deacetylase sirtuin-2 in liver
            metabolic stress through regulating pyruvate kinase M2
            ubiquitination.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1843)
  AUTHORS   Zhang,Z., Yang,Q., Dong,Y., Wang,L., Niu,R., Xia,J., Bi,Y. and
            Liu,G.
  TITLE     Sirtuin 2 regulates neutrophil functions through NAD+ synthesis
            pathway in virus infection
  JOURNAL   iScience 27 (7), 110184 (2024)
   PUBMED   38974970
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1843)
  AUTHORS   Hou,D., Yu,T., Lu,X., Hong,J.Y., Yang,M., Zi,Y., Ho,T.T. and Lin,H.
  TITLE     Sirt2 inhibition improves gut epithelial barrier integrity and
            protects mice from colitis
  JOURNAL   Proc Natl Acad Sci U S A 121 (18), e2319833121 (2024)
   PUBMED   38648480
  REMARK    GeneRIF: Sirt2 inhibition improves gut epithelial barrier integrity
            and protects mice from colitis.
REFERENCE   6  (bases 1 to 1843)
  AUTHORS   Wang,F., Nguyen,M., Qin,F.X. and Tong,Q.
  TITLE     SIRT2 deacetylates FOXO3a in response to oxidative stress and
            caloric restriction
  JOURNAL   Aging Cell 6 (4), 505-514 (2007)
   PUBMED   17521387
  REMARK    GeneRIF: SIRT2 responds to caloric restriction and oxidative stress
            to deacetylate FOXO transcription factors
REFERENCE   7  (bases 1 to 1843)
  AUTHORS   Southwood,C.M., Peppi,M., Dryden,S., Tainsky,M.A. and Gow,A.
  TITLE     Microtubule deacetylases, SirT2 and HDAC6, in the nervous system
  JOURNAL   Neurochem Res 32 (2), 187-195 (2007)
   PUBMED   16933150
  REMARK    GeneRIF: In oligodendrocytes, targeting of SirT2 to paranodes
            coincides with presence of the microtubule-destabilizing protein
            stathmin-1 during early myelinogenesis & suggests the existence of
            a microtubule regulatory network that modulates cytoskeletal
            dynamics.
REFERENCE   8  (bases 1 to 1843)
  AUTHORS   Vaquero,A., Scher,M.B., Lee,D.H., Sutton,A., Cheng,H.L., Alt,F.W.,
            Serrano,L., Sternglanz,R. and Reinberg,D.
  TITLE     SirT2 is a histone deacetylase with preference for histone H4 Lys
            16 during mitosis
  JOURNAL   Genes Dev 20 (10), 1256-1261 (2006)
   PUBMED   16648462
REFERENCE   9  (bases 1 to 1843)
  AUTHORS   Bouras,T., Fu,M., Sauve,A.A., Wang,F., Quong,A.A., Perkins,N.D.,
            Hay,R.T., Gu,W. and Pestell,R.G.
  TITLE     SIRT1 deacetylation and repression of p300 involves lysine residues
            1020/1024 within the cell cycle regulatory domain 1
  JOURNAL   J Biol Chem 280 (11), 10264-10276 (2005)
   PUBMED   15632193
REFERENCE   10 (bases 1 to 1843)
  AUTHORS   Yang,Y.H., Chen,Y.H., Zhang,C.Y., Nimmakayalu,M.A., Ward,D.C. and
            Weissman,S.
  TITLE     Cloning and characterization of two mouse genes with homology to
            the yeast Sir2 gene
  JOURNAL   Genomics 69 (3), 355-369 (2000)
   PUBMED   11056054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC171210.1.
            
            On Nov 28, 2022 this sequence version replaced NM_022432.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144431.1, SRR17784643.598633.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AC171210.1         123686-123786       c
            102-148             AC171210.1         122875-122921       c
            149-197             AC171210.1         118694-118742       c
            198-311             AC171210.1         118345-118458       c
            312-353             AC171210.1         113654-113695       c
            354-460             AC171210.1         113451-113557       c
            461-517             AC171210.1         113306-113362       c
            518-586             AC171210.1         111563-111631       c
            587-716             AC171210.1         107655-107784       c
            717-776             AC171210.1         105114-105173       c
            777-832             AC171210.1         104834-104889       c
            833-909             AC171210.1         104671-104747       c
            910-961             AC171210.1         104537-104588       c
            962-1032            AC171210.1         102900-102970       c
            1033-1099           AC171210.1         102725-102791       c
            1100-1843           AC171210.1         101893-102636       c
FEATURES             Location/Qualifiers
     source          1..1843
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.92 cM"
     gene            1..1843
                     /gene="Sirt2"
                     /gene_synonym="5730427M03Rik; Sir2l; SIR2L2"
                     /note="sirtuin 2"
                     /db_xref="GeneID:64383"
                     /db_xref="MGI:MGI:1927664"
     exon            1..101
                     /gene="Sirt2"
                     /gene_synonym="5730427M03Rik; Sir2l; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1255
                     /gene="Sirt2"
                     /gene_synonym="5730427M03Rik; Sir2l; SIR2L2"
                     /EC_number="2.3.1.286"
                     /note="isoform 1 is encoded by transcript variant 1;
                     NAD-dependent deacetylase sirtuin-2; mSIR2L2; SIR2-like
                     protein 2; silent mating type information regulation 2,
                     (S.cerevisiae, homolog)-like; sirtuin 2; regulatory
                     protein SIR2 homolog 2; NAD-dependent protein deacetylase
                     sirtuin-2; NAD-dependent protein defatty-acylase
                     sirtuin-2"
                     /codon_start=1
                     /product="NAD-dependent protein deacetylase sirtuin-2
                     isoform 1"
                     /protein_id="NP_071877.3"
                     /db_xref="CCDS:CCDS21055.1"
                     /db_xref="GeneID:64383"
                     /db_xref="MGI:MGI:1927664"
                     /translation="MAEPDPSDPLETQAGKVQEAQDSDSDTEGGATGGEAEMDFLRNL
                     FTQTLGLGSQKERLLDELTLEGVTRYMQSERCRKVICLVGAGISTSAGIPDFRSPSTG
                     LYANLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFIRLLKEKGL
                     LLRCYTQNIDTLERVAGLEPQDLVEAHGTFYTSHCVNTSCRKEYTMGWMKEKIFSEAT
                     PRCEQCQSVVKPDIVFFGENLPSRFFSCMQSDFSKVDLLIIMGTSLQVQPFASLISKA
                     PLATPRLLINKEKTGQTDPFLGMMMGLGGGMDFDSKKAYRDVAWLGDCDQGCLALADL
                     LGWKKELEDLVRREHANIDAQSGSQAPNPSTTISPGKSPPPAKEAARTKEKEEQQ"
     exon            102..148
                     /gene="Sirt2"
                     /gene_synonym="5730427M03Rik; Sir2l; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            149..197
                     /gene="Sirt2"
                     /gene_synonym="5730427M03Rik; Sir2l; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            198..311
                     /gene="Sirt2"
                     /gene_synonym="5730427M03Rik; Sir2l; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            312..353
                     /gene="Sirt2"
                     /gene_synonym="5730427M03Rik; Sir2l; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            354..460
                     /gene="Sirt2"
                     /gene_synonym="5730427M03Rik; Sir2l; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            461..517
                     /gene="Sirt2"
                     /gene_synonym="5730427M03Rik; Sir2l; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            518..586
                     /gene="Sirt2"
                     /gene_synonym="5730427M03Rik; Sir2l; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            587..716
                     /gene="Sirt2"
                     /gene_synonym="5730427M03Rik; Sir2l; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            717..776
                     /gene="Sirt2"
                     /gene_synonym="5730427M03Rik; Sir2l; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            777..832
                     /gene="Sirt2"
                     /gene_synonym="5730427M03Rik; Sir2l; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            833..909
                     /gene="Sirt2"
                     /gene_synonym="5730427M03Rik; Sir2l; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            910..961
                     /gene="Sirt2"
                     /gene_synonym="5730427M03Rik; Sir2l; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1032
                     /gene="Sirt2"
                     /gene_synonym="5730427M03Rik; Sir2l; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1099
                     /gene="Sirt2"
                     /gene_synonym="5730427M03Rik; Sir2l; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1843
                     /gene="Sirt2"
                     /gene_synonym="5730427M03Rik; Sir2l; SIR2L2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1830..1835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sirt2"
                     /gene_synonym="5730427M03Rik; Sir2l; SIR2L2"
                     /note="hexamer: AACAAA"
     polyA_site      1843
                     /gene="Sirt2"
                     /gene_synonym="5730427M03Rik; Sir2l; SIR2L2"
                     /note="major polyA site"
ORIGIN      
        1 atcctatctc ggcctcttct tgtttccgct gccgtcacgg gacagagcag tcggtgacag
       61 tcccgagggc ccccaccccg ttcccatggc cgagccggac ccctctgacc ctctggagac
      121 ccaggcaggg aaggtgcagg aggctcagga ttcagactcg gacactgagg gaggagccac
      181 tggtggagag gcagagatgg acttcctgag gaatttattc acccagaccc tgggcctggg
      241 ttcccaaaag gagcgtcttc tagacgagct gaccctcgaa ggagtgacac gctacatgca
      301 gagcgagcgc tgccgcaagg tcatctgttt ggtgggagcc ggaatctcca cgtccgcggg
      361 tatccctgac ttccgctccc cgtccactgg cctctatgca aacctggaga agtaccacct
      421 tccttaccca gaggccatct ttgagatcag ctacttcaag aaacatccgg aacccttctt
      481 tgcccttgcc aaggagctct atcccgggca gttcaagcca accatctgcc actacttcat
      541 ccgcctgctg aaggagaagg ggctgctgct gcgctgctac acgcagaaca tagacacgct
      601 ggaacgagtg gcggggctgg agccccagga cctggtggag gcccacggca ccttctacac
      661 atcacactgt gtcaacacct cctgcagaaa agaatacacg atgggctgga tgaaagagaa
      721 gatcttctca gaagcaactc ccaggtgtga gcagtgtcag agtgtggtaa agcctgatat
      781 cgtgtttttc ggtgagaacc ttccatcgcg cttcttctcc tgcatgcagt cagacttctc
      841 caaggtggac ctcctcatca tcatgggcac ctccctgcag gtgcagccct tcgcctccct
      901 catcagcaag gcaccactag ccaccccacg gctgctcatt aacaaggaaa agacaggcca
      961 gacggacccc ttcctgggca tgatgatggg cctgggaggt ggcatggatt ttgactccaa
     1021 gaaggcttac agggacgtgg cctggctggg tgactgtgat caaggctgcc tggctctcgc
     1081 tgacctcctc ggatggaaga aggaactgga agaccttgtc cggagggagc atgccaacat
     1141 agatgcccag tcagggtcac aggcccccaa ccccagcact accatctccc ctggaaagtc
     1201 cccaccgcct gccaaggagg cggccaggac caaagagaaa gaggaacagc agtaacagta
     1261 accatgacct cccgcaggac agcggagccc ggccagcact gggccctctt aacatgcagc
     1321 ttgtgtgagc tcaaagaccc ttcgttcttt aaccacgttc ttgaaatcag ggtccccaac
     1381 tcaatcccag aaaagcctaa tatacctagg ggctgaggcc tgtgcagtct gtagctgggg
     1441 cctctaacca ccatagcctc taaccaccat agcctctaac caccatagcc tctaaccacc
     1501 caggcaagaa gcagccttcc ctaacttcta attattccca gacaacaggc taccccaaaa
     1561 cccctaacag tgccagaata aggcatttct ctattgtttt cagggggcct atggctaaat
     1621 caaattaacc taccccgcat aggggctgga ctctacaaat agaacttcac ccaagggggt
     1681 ggggccttgt gggatctctg agcctgaagg cctgccaact ctctgcctcc aacaaagtgg
     1741 gtactaggct ccctttcctg gggacccact tgccagctgt tggtggatga gcaagagacc
     1801 ttgcttatta gaaacaaatt aaaaaacaaa acaaagcaac taa
//
