LOCUS       NM_019812               3910 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus sirtuin 1 (Sirt1), transcript variant 1, mRNA.
ACCESSION   NM_019812 XM_905809
VERSION     NM_019812.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3910)
  AUTHORS   Tang,Y., Sun,L., Li,S., Luo,L., Liu,H., Chen,Z. and Li,G.
  TITLE     miR-9-5p regulates Sirt1 involved in testicular development and
            spermatogenesis in mouse
  JOURNAL   Theriogenology 230, 61-71 (2024)
   PUBMED   39270444
  REMARK    GeneRIF: miR-9-5p regulates Sirt1 involved in testicular
            development and spermatogenesis in mouse.
REFERENCE   2  (bases 1 to 3910)
  AUTHORS   Zhao,Y., Wang,Y., Zheng,H., Xu,Q., Zhou,K., Liu,H., Xia,Y.,
            Wei,D.H., Jiang,M., Tang,Z.H., Liu,L.S., Zheng,H. and Jiang,Z.
  TITLE     Hydrogen sulfide upregulates SIRT1 to inhibit ox-HDL-induced
            endothelial cell damage and mitochondrial dysfunction
  JOURNAL   Nitric Oxide 152, 78-89 (2024)
   PUBMED   39305980
  REMARK    GeneRIF: Hydrogen sulfide upregulates SIRT1 to inhibit
            ox-HDL-induced endothelial cell damage and mitochondrial
            dysfunction.
REFERENCE   3  (bases 1 to 3910)
  AUTHORS   Xu,G., Qiu,F., Zhang,W., Li,S., Chen,J., Wang,G., Wang,Y., Pan,J.
            and Pan,X.
  TITLE     Fibroblast growth factor 21 alleviates acetaminophen induced acute
            liver injury by activating Sirt1 mediated autophagy
  JOURNAL   Cell Signal 123, 111379 (2024)
   PUBMED   39233207
  REMARK    GeneRIF: Fibroblast growth factor 21 alleviates acetaminophen
            induced acute liver injury by activating Sirt1 mediated autophagy.
REFERENCE   4  (bases 1 to 3910)
  AUTHORS   Nevoral,J., Drutovic,D., Vaskovicova,M., Benc,M., Liska,F.,
            Valentova,I., Stachovicova,S., Kubovciak,J., Havrankova,J.,
            Shavit,M., Monsef,L., Iniesta-Cuerda,M., Zalmanova,T., Hosek,P.,
            Strejcek,F., Kralickova,M. and Petr,J.
  TITLE     Dynamics and necessity of SIRT1 for maternal-zygotic transition
  JOURNAL   Sci Rep 14 (1), 21598 (2024)
   PUBMED   39285243
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3910)
  AUTHORS   Wu,L., Zhang,S., Zhang,M., Ou,Y. and Chen,J.
  TITLE     Occlusal disharmony promotes anxiety-like behaviours by suppressing
            Sirt1
  JOURNAL   Clin Oral Investig 28 (10), 526 (2024)
   PUBMED   39276172
  REMARK    GeneRIF: Occlusal disharmony promotes anxiety-like behaviours by
            suppressing Sirt1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3910)
  AUTHORS   Giblin,W., Skinner,M.E. and Lombard,D.B.
  TITLE     Sirtuins: guardians of mammalian healthspan
  JOURNAL   Trends Genet 30 (7), 271-286 (2014)
   PUBMED   24877878
  REMARK    Review article
REFERENCE   7  (bases 1 to 3910)
  AUTHORS   Luo,J., Nikolaev,A.Y., Imai,S., Chen,D., Su,F., Shiloh,A.,
            Guarente,L. and Gu,W.
  TITLE     Negative control of p53 by Sir2alpha promotes cell survival under
            stress
  JOURNAL   Cell 107 (2), 137-148 (2001)
   PUBMED   11672522
  REMARK    GeneRIF: Sirt1(Sir2alpha) deacetylates p53 and promotes survival
REFERENCE   8  (bases 1 to 3910)
  AUTHORS   Hwang,S.Y., Oh,B., Knowles,B.B., Solter,D. and Lee,J.S.
  TITLE     Expression of genes involved in mammalian meiosis during the
            transition from egg to embryo
  JOURNAL   Mol Reprod Dev 59 (2), 144-158 (2001)
   PUBMED   11389549
REFERENCE   9  (bases 1 to 3910)
  AUTHORS   Muth,V., Nadaud,S., Grummt,I. and Voit,R.
  TITLE     Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA
            polymerase I transcription
  JOURNAL   EMBO J 20 (6), 1353-1362 (2001)
   PUBMED   11250901
REFERENCE   10 (bases 1 to 3910)
  AUTHORS   Imai,S., Armstrong,C.M., Kaeberlein,M. and Guarente,L.
  TITLE     Transcriptional silencing and longevity protein Sir2 is an
            NAD-dependent histone deacetylase
  JOURNAL   Nature 403 (6771), 795-800 (2000)
   PUBMED   10693811
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC153516.8, AK140330.1,
            BE989110.1, BX523319.1, AK139946.1 and AK141245.1.
            
            On Sep 29, 2015 this sequence version replaced NM_019812.2.
            
            Summary: This gene encodes a member of the sirtuin family of
            proteins, characterized by their deacetylase activity and proposed
            role in longevity. The encoded protein regulates gene expression in
            a wide range of cell and tissue types through its NAD+-dependent
            deacetylation of histones, transcription factors and
            transcriptional coactivators. Brain-specific overexpression of this
            gene has been shown to result in increased median lifespan.
            Viability of homozygous knockout mice for this gene varies with
            strain background. Homozygous knockout mice of strains that do not
            exhibit embryonic lethality are sterile and have a reduced
            lifespan. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY377984.1, AF214646.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AC153516.8         65565-65620
            57-741              AK140330.1         2-686
            742-1023            BE989110.1         168-449
            1024-1102           AC153516.8         78454-78532
            1103-1593           BX523319.1         8-498               c
            1594-2186           AK139946.1         86-678
            2187-2241           AC153516.8         83872-83926
            2242-3856           AK141245.1         17-1631
            3857-3910           AC153516.8         85542-85595
FEATURES             Location/Qualifiers
     source          1..3910
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.57 cM"
     gene            1..3910
                     /gene="Sirt1"
                     /gene_synonym="Sir2; Sir2a; Sir2alpha; SIR2L1"
                     /note="sirtuin 1"
                     /db_xref="GeneID:93759"
                     /db_xref="MGI:MGI:2135607"
     exon            1..471
                     /gene="Sirt1"
                     /gene_synonym="Sir2; Sir2a; Sir2alpha; SIR2L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..2279
                     /gene="Sirt1"
                     /gene_synonym="Sir2; Sir2a; Sir2alpha; SIR2L1"
                     /EC_number="2.3.1.286"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SIR2-like protein 1; sirtuin 1 ((silent mating type
                     information regulation 2, homolog) 1; regulatory protein
                     SIR2 homolog 1; NAD-dependent protein deacetylase
                     sirtuin-1; NAD-dependent protein deacylase sirtuin-1"
                     /codon_start=1
                     /product="NAD-dependent protein deacetylase sirtuin-1
                     isoform 1"
                     /protein_id="NP_062786.1"
                     /db_xref="CCDS:CCDS23898.1"
                     /db_xref="GeneID:93759"
                     /db_xref="MGI:MGI:2135607"
                     /translation="MADEVALALQAAGSPSAAAAMEAASQPADEPLRKRPRRDGPGLG
                     RSPGEPSAAVAPAAAGCEAASAAAPAALWREAAGAAASAEREAPATAVAGDGDNGSGL
                     RREPRAADDFDDDEGEEEDEAAAAAAAAAIGYRDNLLLTDGLLTNGFHSCESDDDDRT
                     SHASSSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVIN
                     ILSEPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLA
                     VDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRN
                     YTQNIDTLEQVAGIQRILQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPA
                     DEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHE
                     VPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPR
                     PQKELVHLSELPPTPLHISEDSSSPERTVPQDSSVIATLVDQATNNNVNDLEVSESSC
                     VEEKPQEVQTSRNVENINVENPDFKAVGSSTADKNERTSVAETVRKCWPNRLAKEQIS
                     KRLEGNQYLFVPPNRYIFHGAEVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPLEDE
                     SEIEEFYNGLEDDTERPECAGGSGFGADGGDQEVVNEAIATRQELTDVNYPSDKS"
     exon            472..588
                     /gene="Sirt1"
                     /gene_synonym="Sir2; Sir2a; Sir2alpha; SIR2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            589..830
                     /gene="Sirt1"
                     /gene_synonym="Sir2; Sir2a; Sir2alpha; SIR2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            831..983
                     /gene="Sirt1"
                     /gene_synonym="Sir2; Sir2a; Sir2alpha; SIR2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1131
                     /gene="Sirt1"
                     /gene_synonym="Sir2; Sir2a; Sir2alpha; SIR2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1211
                     /gene="Sirt1"
                     /gene_synonym="Sir2; Sir2a; Sir2alpha; SIR2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1398
                     /gene="Sirt1"
                     /gene_synonym="Sir2; Sir2a; Sir2alpha; SIR2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1950
                     /gene="Sirt1"
                     /gene_synonym="Sir2; Sir2a; Sir2alpha; SIR2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..3910
                     /gene="Sirt1"
                     /gene_synonym="Sir2; Sir2a; Sir2alpha; SIR2L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3831..3836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sirt1"
                     /gene_synonym="Sir2; Sir2a; Sir2alpha; SIR2L1"
                     /note="hexamer: AATACA"
     polyA_site      3858
                     /gene="Sirt1"
                     /gene_synonym="Sir2; Sir2a; Sir2alpha; SIR2L1"
                     /note="major polyA site"
     regulatory      3878..3883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sirt1"
                     /gene_synonym="Sir2; Sir2a; Sir2alpha; SIR2L1"
                     /note="hexamer: ATTAAA"
     polyA_site      3910
                     /gene="Sirt1"
                     /gene_synonym="Sir2; Sir2a; Sir2alpha; SIR2L1"
                     /note="major polyA site"
ORIGIN      
        1 gccagtgccg cgcgtcgagc ggagcagagg aggcgagggc ggagggccag agaggcagtt
       61 ggaagatggc ggacgaggtg gcgctcgccc ttcaggccgc cggctcccct tccgcggcgg
      121 ccgccatgga ggccgcgtcg cagccggcgg acgagccgct ccgcaagagg ccccgccgag
      181 acgggcctgg cctcgggcgc agcccgggcg agccgagcgc agcagtggcg ccggcggccg
      241 cggggtgtga ggcggcgagc gccgcggccc cggcggcgct gtggcgggag gcggcagggg
      301 cggcggcgag cgcggagcgg gaggccccgg cgacggccgt ggccggggac ggagacaatg
      361 ggtccggcct gcggcgggag ccgagggcgg ctgacgactt cgacgacgac gagggcgagg
      421 aggaggacga ggcggcggcg gcagcggcgg cggcagcgat cggctaccga gacaacctcc
      481 tgttgaccga tggactcctc actaatggct ttcattcctg tgaaagtgat gacgatgaca
      541 gaacgtcaca cgccagctct agtgactgga ctccgcggcc gcggataggt ccatatactt
      601 ttgttcagca acatctcatg attggcaccg atcctcgaac aattcttaaa gatttattac
      661 cagaaacaat tcctccacct gagctggatg atatgacgct gtggcagatt gttattaata
      721 tcctttcaga accaccaaag cggaaaaaaa gaaaagatat caatacaatt gaagatgctg
      781 tgaagttact gcaggagtgt aaaaagataa tagttctgac tggagctggg gtttctgtct
      841 cctgtgggat tcctgacttc agatcaagag acggtatcta tgctcgcctt gcggtggact
      901 tcccagacct cccagaccct caagccatgt ttgatattga gtattttaga aaagacccaa
      961 gaccattctt caagtttgca aaggaaatat atcccggaca gttccagccg tctctgtgtc
     1021 acaaattcat agctttgtca gataaggaag gaaaactact tcgaaattat actcaaaata
     1081 tagatacctt ggagcaggtt gcaggaatcc aaaggatcct tcagtgtcat ggttcctttg
     1141 caacagcatc ttgcctgatt tgtaaataca aagttgattg tgaagctgtt cgtggagaca
     1201 tttttaatca ggtagttcct cggtgcccta ggtgcccagc tgatgagcca cttgccatca
     1261 tgaagccaga gattgtcttc tttggtgaaa acttaccaga acagtttcat agagccatga
     1321 agtatgacaa agatgaagtt gacctcctca ttgttattgg atcttctctg aaagtgagac
     1381 cagtagcact aattccaagt tctatacccc atgaagtgcc tcaaatatta ataaataggg
     1441 aacctttgcc tcatctacat tttgatgtag agctccttgg agactgcgat gttataatta
     1501 atgagttgtg tcataggcta ggtggtgaat atgccaaact ttgttgtaac cctgtaaagc
     1561 tttcagaaat tactgaaaaa cctccacgcc cacaaaagga attggttcat ttatcagagt
     1621 tgccaccaac acctcttcat atttcggaag actcaagttc acctgaaaga actgtaccac
     1681 aagactcttc tgtgattgct acacttgtag accaagcaac aaacaacaat gttaatgatt
     1741 tagaagtatc tgaatcaagt tgtgtggaag aaaaaccaca agaagtacag actagtagga
     1801 atgttgagaa cattaatgtg gaaaatccag attttaaggc tgttggttcc agtactgcag
     1861 acaaaaatga aagaacttca gttgcagaaa cagtgagaaa atgctggcct aatagacttg
     1921 caaaggagca gattagtaag cggcttgagg gtaatcaata cctgtttgta ccaccaaatc
     1981 gttacatatt ccacggtgct gaggtatact cagactctga agatgacgtc ttgtcctcta
     2041 gttcctgtgg cagtaacagt gacagtggca catgccagag tccaagttta gaagaaccct
     2101 tggaagatga aagtgaaatt gaagaattct acaatggctt ggaagatgat acggagaggc
     2161 ccgaatgtgc tggaggatct ggatttggag ctgatggagg ggatcaagag gttgttaatg
     2221 aagctatagc tacaagacag gaattgacag atgtaaacta tccatcagac aaatcataac
     2281 actattgaag ctgtccggat tcaggaattg ctccaccagc attgggaact ttagcatgtc
     2341 aaaaaatgaa tgtttacttg tgaacttgaa caaggaaatc tgaaagatgt attatttata
     2401 gactggaaaa tagattgtct tcttggataa tttctaaagt tccatcattt ctgtttgtac
     2461 ttgtacattc aacactgttg gttgacttca tcttcctttc aaggttcatt tgtatgatac
     2521 attcgtatgt atgtataatt ttgttttttg cctaatgagt ttcaaccttt taaagttttc
     2581 aaaagccatt ggaatgttaa tgtaaaggga acagcttatc tagaccaaag aatggtattt
     2641 cacacttttt tgtttgtaac attgaatagt ttaaagccct caatttctgt tctgctgaac
     2701 ttttattttt aggacagtta actttttaaa cactggcatt ttccaaaact tgtggcagct
     2761 aactttttaa aatcacagat gacttgtaat gtgaggagtc agcaccgtgt ctggagcact
     2821 caaaacttgg tgctcagtgt gtgaagcgta cttactgcat cgtttttgta cttgctgcag
     2881 acgtggtaat gtccaaacag gcccctgaga ctaatctgat aaatgatttg gaaatgtgtt
     2941 tcagttgttc tagaaacaat agtgcctgtc tatataggtc cccttagttt gaatatttgc
     3001 cattgtttaa ttaaatacct atcactgtgg tagagcctgc atagatcttc accacaaata
     3061 ctgccaagat gtgaatatgc aaagcctttc tgaatctaat aatggtactt ctactgggga
     3121 gagtgtaata ttttggactg ctgtttttcc attaatgagg aaagcaatag gcctcttaat
     3181 taaagtccca aagtcataag ataaattgta gctcaaccag aaagtacact gttgcctgtt
     3241 gaggatttgg tgtaatgtat cccaaggtgt tagccttgta ttatggagat gaatacagat
     3301 ccaatagtca aatgaaacta gttcttagtt atttaaaagc ttagcttgcc ttaaaactag
     3361 ggatcaattt tctcaactgc agaaactttt agcctttcaa acagttcaca cctcagaaag
     3421 tcagtattta ttttacagac ttctttggaa cattgccccc aaatttaaat attcatgtgg
     3481 gtttagtatt tattacaaaa aaatgatttg aaatatagct gttctttatg cataaaatac
     3541 ccagttagga ccattactgc cagaggagaa aagtattaag tagctcattt ccctacctaa
     3601 aagataactg aatttatttg gctacactaa agaatgcagt atatttagtt ttccatttgc
     3661 atgatgtgtt tgtgctatag acaatatttt aaattgaaaa atttgtttta aattattttt
     3721 acagtgaaga ctgttttcag ctctttttat attgtacata gacttttatg taatctggca
     3781 tatgttttgt agaccgttta atgactggat tatcttcctc caacttttga aatacaaaaa
     3841 cagtgtttta tacttgtatc ttgttttaaa gtcttatatt aaaattgtca tttgactttt
     3901 ttcccgttaa
//
