LOCUS       NM_001002898            1232 bp    mRNA    linear   ROD 17-FEB-2022
DEFINITION  Mus musculus signal-regulatory protein beta 1A (Sirpb1a), mRNA.
ACCESSION   NM_001002898 NM_198405 XM_142434
VERSION     NM_001002898.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1232)
  AUTHORS   Rousseaux MW, Marcogliese PC, Qu D, Hewitt SJ, Seang S, Kim RH,
            Slack RS, Schlossmacher MG, Lagace DC, Mak TW and Park DS.
  TITLE     Progressive dopaminergic cell loss with unilateral-to-bilateral
            progression in a genetic model of Parkinson disease
  JOURNAL   Proc Natl Acad Sci U S A 109 (39), 15918-15923 (2012)
   PUBMED   23019375
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11212]
REFERENCE   2  (bases 1 to 1232)
  AUTHORS   Lahoud MH, Proietto AI, Gartlan KH, Kitsoulis S, Curtis J,
            Wettenhall J, Sofi M, Daunt C, O'keeffe M, Caminschi I, Satterley
            K, Rizzitelli A, Schnorrer P, Hinohara A, Yamaguchi Y, Wu L, Smyth
            G, Handman E, Shortman K and Wright MD.
  TITLE     Signal regulatory protein molecules are differentially expressed by
            CD8- dendritic cells
  JOURNAL   J Immunol 177 (1), 372-382 (2006)
   PUBMED   16785533
  REMARK    GeneRIF: Sirp beta genes encode cell surface molecules containing
            extracellular Ig domains and short intracytoplasmic domains that
            have a charged amino acid in the transmembrane region which
            potentially interacts with ITAM-bearing molecules to mediate
            signaling.
REFERENCE   3  (bases 1 to 1232)
  AUTHORS   Hayashi A, Ohnishi H, Okazawa H, Nakazawa S, Ikeda H, Motegi S,
            Aoki N, Kimura S, Mikuni M and Matozaki T.
  TITLE     Positive regulation of phagocytosis by SIRPbeta and its signaling
            mechanism in macrophages
  JOURNAL   J Biol Chem 279 (28), 29450-29460 (2004)
   PUBMED   15123631
  REMARK    GeneRIF: Results suggest that engagement of SIRPbeta promotes
            phagocytosis in macrophages by inducing the tyrosine
            phosphorylation of DAP12, Syk, and SLP-76 and the subsequent
            activation of a MEK-MAPK-myosin light chain kinase cascade.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB112022.1.
            
            On or before Sep 7, 2007 this sequence version replaced
            NM_198405.1, XM_142434.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB112022.1, ERR2680379.13005.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1232
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3"
     gene            1..1232
                     /gene="Sirpb1a"
                     /gene_synonym="9930027N05Rik; SIRP-beta; Sirpb; Sirpb1"
                     /note="signal-regulatory protein beta 1A"
                     /db_xref="GeneID:320832"
                     /db_xref="MGI:MGI:2444824"
     exon            1..95
                     /gene="Sirpb1a"
                     /gene_synonym="9930027N05Rik; SIRP-beta; Sirpb; Sirpb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1198
                     /gene="Sirpb1a"
                     /gene_synonym="9930027N05Rik; SIRP-beta; Sirpb; Sirpb1"
                     /note="SIRP beta 1 cell surface protein"
                     /codon_start=1
                     /product="signal-regulatory protein beta 1"
                     /protein_id="NP_001002898.1"
                     /db_xref="CCDS:CCDS17252.1"
                     /db_xref="GeneID:320832"
                     /db_xref="MGI:MGI:2444824"
                     /translation="MLLLDAWTHIPHSVLLLILLLGFKGAAVRELKVIQPVKSFFVGA
                     GGSATLNCTVTSLLPVGPIRWYRGVGQSRLLIYPFTGEHSPRITNVSDVTKRNNMDFS
                     IRISNVTPADSGTYYCVKFQRGSSEPDIEIQSGGGTELLVLAKPSSPMVSGPAARAVP
                     QQTVTFTCRSHGFFPRNLTLKWFKNGDEISHLETSVEPEETSVSYRVSSTVQVVLEPR
                     DVRSQIICEVDHVTLDRAPLRGIAHISEFIQVPPTLEIRQQPTMVWNVINVTCQIQKF
                     YPPSFQLTWLENGNISRREVPFTLIVNKDGTYNWISCLLVNISALEENMVVTCKVEHD
                     EQAEVIETHTVLVTEHQRVKELKTAGIAKIPVAVLLGSKILLLIAATVIYMHKKQNA"
     exon            96..452
                     /gene="Sirpb1a"
                     /gene_synonym="9930027N05Rik; SIRP-beta; Sirpb; Sirpb1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..770
                     /gene="Sirpb1a"
                     /gene_synonym="9930027N05Rik; SIRP-beta; Sirpb; Sirpb1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..1085
                     /gene="Sirpb1a"
                     /gene_synonym="9930027N05Rik; SIRP-beta; Sirpb; Sirpb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1200
                     /gene="Sirpb1a"
                     /gene_synonym="9930027N05Rik; SIRP-beta; Sirpb; Sirpb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1232
                     /gene="Sirpb1a"
                     /gene_synonym="9930027N05Rik; SIRP-beta; Sirpb; Sirpb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacagggttc ttaacaccaa ccatgcttct cctagatgcc tggacccaca ttcctcacag
       61 tgtcctgctg ttgatcctgc ttctgggatt taaaggagca gctgtgagag agctgaaagt
      121 gatccaacct gttaaatcat tttttgttgg tgctggaggg tcagccactc taaactgcac
      181 agtgacatcc ctcctccctg tggggcccat aaggtggtat aggggtgtag gacaaagtcg
      241 actcttgata tacccgttca caggagaaca ttccccccga ataacaaatg tttcagatgt
      301 tacaaagaga aacaacatgg acttttccat ccgtatcagt aatgtcactc ctgctgattc
      361 gggtacctac tactgtgtga agttccagag aggatcatca gagcctgaca ttgagattca
      421 gtctggaggt ggcactgagt tgttagtcct tgctaaacca tcttcaccta tggtctccgg
      481 tcctgcagcc agagctgtcc ctcagcagac agtgaccttt acatgcagat cccatggatt
      541 ctttccgcgg aacctcacgc tgaagtggtt caagaatgga gatgagatct ctcacttgga
      601 aacttctgtg gaaccggaag aaacaagtgt ctcctataga gtttccagca cagtccaggt
      661 ggtgttggaa cctagggatg tccgctctca gatcatctgt gaagtggatc atgtcacttt
      721 agatcgagcc cctctcagag ggattgctca catctctgag ttcattcaag ttccacccac
      781 cctggagatc cgccagcagc caacaatggt ttggaatgtg ataaatgtca cctgccaaat
      841 acagaagttc tatcctccaa gttttcagtt gacctggtta gagaatggaa atatatcccg
      901 gagagaagta ccttttacac ttatagtaaa caaggatgga acttacaact ggatcagctg
      961 tctcttggtg aacatatctg cccttgagga gaacatggta gtgacatgca aggttgagca
     1021 tgatgaacaa gcagaagtca ttgaaaccca tactgtgctg gtcactgaac atcagagagt
     1081 gaaagaactg aagacggcag gtattgctaa aatacctgta gctgtgctcc ttggatccaa
     1141 aatactgctg ttaattgctg ccactgtcat ttacatgcat aagaagcaaa atgcctgaat
     1201 aggctccgaa tggaaataag tgctaatgag ca
//
