LOCUS       NM_001291019            4043 bp    mRNA    linear   ROD 24-MAR-2023
DEFINITION  Mus musculus signal-regulatory protein alpha (Sirpa), transcript
            variant 4, mRNA.
ACCESSION   NM_001291019 XM_006498985
VERSION     NM_001291019.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4043)
  AUTHORS   Jiang D, Burger CA, Akhanov V, Liang JH, Mackin RD, Albrecht NE,
            Andrade P, Schafer DP and Samuel MA.
  TITLE     Neuronal signal-regulatory protein alpha drives microglial
            phagocytosis by limiting microglial interaction with CD47 in the
            retina
  JOURNAL   Immunity 55 (12), 2318-2335 (2022)
   PUBMED   36379210
  REMARK    GeneRIF: Neuronal signal-regulatory protein alpha drives microglial
            phagocytosis by limiting microglial interaction with CD47 in the
            retina.
REFERENCE   2  (bases 1 to 4043)
  AUTHORS   Wang D, Lin Y, Xu F, Zhang H, Zhu X, Liu Z, Hu Y, Dong G, Sun B, Yu
            Y, Ma G, Tang Z, Legarda D, Ting A, Liu Y, Hou J, Dong L and Xiong
            H.
  TITLE     SIRPalpha maintains macrophage homeostasis by interacting with
            PTK2B kinase in Mycobacterium tuberculosis infection and through
            autophagy and necroptosis
  JOURNAL   EBioMedicine 85, 104278 (2022)
   PUBMED   36202053
  REMARK    GeneRIF: SIRPalpha maintains macrophage homeostasis by interacting
            with PTK2B kinase in Mycobacterium tuberculosis infection and
            through autophagy and necroptosis.
REFERENCE   3  (bases 1 to 4043)
  AUTHORS   Thomas SS, Wu J, Davogustto G, Holliday MW, Eckel-Mahan K, Verzola
            D, Garibotto G, Hu Z, Mitch WE and Taegtmeyer H.
  TITLE     SIRPalpha Mediates IGF1 Receptor in Cardiomyopathy Induced by
            Chronic Kidney Disease
  JOURNAL   Circ Res 131 (3), 207-221 (2022)
   PUBMED   35722884
  REMARK    GeneRIF: SIRPalpha Mediates IGF1 Receptor in Cardiomyopathy Induced
            by Chronic Kidney Disease.
REFERENCE   4  (bases 1 to 4043)
  AUTHORS   Shen Q, Zhao L, Pan L, Li D, Chen G, Chen Z and Jiang Z.
  TITLE     Soluble SIRP-Alpha Promotes Murine Acute Lung Injury Through
            Suppressing Macrophage Phagocytosis
  JOURNAL   Front Immunol 13, 865579 (2022)
   PUBMED   35634325
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4043)
  AUTHORS   Ren B, Xia H, Liao Y, Zhou H, Wang Z, Shi Y and Zhu M.
  TITLE     Endothelial SIRPalpha signaling controls VE-cadherin endocytosis
            for thymic homing of progenitor cells
  JOURNAL   Elife 11, e69219 (2022)
   PUBMED   35511221
  REMARK    GeneRIF: Endothelial SIRPalpha signaling controls VE-cadherin
            endocytosis for thymic homing of progenitor cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4043)
  AUTHORS   Ohnishi H, Kubota M and Sano S.
  TITLE     BIT (Bit) maps to mouse chromosome 2
  JOURNAL   Genomics 40 (3), 504-506 (1997)
   PUBMED   9073522
REFERENCE   7  (bases 1 to 4043)
  AUTHORS   Yamao T, Matozaki T, Amano K, Matsuda Y, Takahashi N, Ochi F,
            Fujioka Y and Kasuga M.
  TITLE     Mouse and human SHPS-1: molecular cloning of cDNAs and chromosomal
            localization of genes
  JOURNAL   Biochem Biophys Res Commun 231 (1), 61-67 (1997)
   PUBMED   9070220
REFERENCE   8  (bases 1 to 4043)
  AUTHORS   Fujioka Y, Matozaki T, Noguchi T, Iwamatsu A, Yamao T, Takahashi N,
            Tsuda M, Takada T and Kasuga M.
  TITLE     A novel membrane glycoprotein, SHPS-1, that binds the
            SH2-domain-containing protein tyrosine phosphatase SHP-2 in
            response to mitogens and cell adhesion
  JOURNAL   Mol Cell Biol 16 (12), 6887-6899 (1996)
   PUBMED   8943344
REFERENCE   9  (bases 1 to 4043)
  AUTHORS   Ohnishi H, Kubota M, Ohtake A, Sato K and Sano Si.
  TITLE     Activation of protein-tyrosine phosphatase SH-PTP2 by a
            tyrosine-based activation motif of a novel brain molecule
  JOURNAL   J Biol Chem 271 (41), 25569-25574 (1996)
   PUBMED   8810330
REFERENCE   10 (bases 1 to 4043)
  AUTHORS   Chuang W and Lagenaur CF.
  TITLE     Central nervous system antigen P84 can serve as a substrate for
            neurite outgrowth
  JOURNAL   Dev Biol 137 (2), 219-232 (1990)
   PUBMED   2303162
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD578948.1, AK159617.1, AB018194.1 and BM899883.1.
            
            [WARNING] On May 5, 2023 this sequence was replaced by
            NM_001291019.2.
            
            On Mar 21, 2014 this sequence version replaced XM_006498985.1.
            
            Transcript Variant: This variant (4) represents the longest
            transcript and encodes the longest isoform (3). Both variants 4 and
            5 encode isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y10349.1, D87968.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-435               CD578948.1         1-435
            436-668             AK159617.1         239-471
            669-1614            AB018194.1         235-1180
            1615-4022           AK159617.1         1424-3831
            4023-4043           BM899883.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..4043
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.19 cM"
     gene            1..4043
                     /gene="Sirpa"
                     /gene_synonym="Bit; CD172a; Idd13.2; P84; Ptpns1; SHP-1;
                     SHPS-1; SIRP"
                     /note="signal-regulatory protein alpha"
                     /db_xref="GeneID:19261"
                     /db_xref="MGI:MGI:108563"
     exon            1..526
                     /gene="Sirpa"
                     /gene_synonym="Bit; CD172a; Idd13.2; P84; Ptpns1; SHP-1;
                     SHPS-1; SIRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             445..1986
                     /gene="Sirpa"
                     /gene_synonym="Bit; CD172a; Idd13.2; P84; Ptpns1; SHP-1;
                     SHPS-1; SIRP"
                     /EC_number="3.1.3.48"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 4; tyrosine-protein phosphatase non-receptor type
                     substrate 1; mSIRP-alpha1; sirp-alpha-1; myD-1 antigen;
                     SHP substrate 1; inhibitory receptor SHPS-1;
                     signal-regulatory protein alpha-1; CD172 antigen-like
                     family member A; brain Ig-like molecule with
                     tyrosine-based activation motifs; brain immunological-like
                     with tyrosine-based motifs; protein tyrosine phosphatase,
                     non-receptor type substrate 1"
                     /codon_start=1
                     /product="tyrosine-protein phosphatase non-receptor type
                     substrate 1 isoform 3 precursor"
                     /protein_id="NP_001277948.1"
                     /db_xref="CCDS:CCDS71142.1"
                     /db_xref="GeneID:19261"
                     /db_xref="MGI:MGI:108563"
                     /translation="MEPAGPAPGRLGPLLLCLLLSASCFCTGATGKELKVTQPEKSVS
                     VAAGDSTVLNCTLTSLLPVGPIRWYRGVGPSRLLIYSFAGEYVPRIRNVSDTTKRNNM
                     DFSIRISNVTPADAGIYYCVKFQKGSSEPDTEIQSGGGTEVYVLAKPSPPEVSGPADR
                     GIPDQKVNFTCKSHGFSPRNITLKWFKDGQELHPLETTVNPSGKNVSYNISSTVRVVL
                     NSMDVNSKVICEVAHITLDRSPLRGIANLSNFIRVSPTVKVTQQSPTSMNQVNLTCRA
                     ERFYPEDLQLIWLENGNVSRNDTPKNLTKNTDGTYNYTSLFLVNSSAHREDVVFTCQV
                     KHDQQPAITRNHTVLGFAHSSDQGSMQTFPDNNATHNWNVFIGVGVACALLVVLLMAA
                     LYLLRIKQKKAKGSTSSTRLHEPEKNAREITQVQSLIQDTNDINDITYADLNLPKEKK
                     PAPRAPEPNNHTEYASIETGKVPRPEDTLTYADLDMVHLSRAQPAPKPEPSFSEYASV
                     QVQRK"
     exon            527..883
                     /gene="Sirpa"
                     /gene_synonym="Bit; CD172a; Idd13.2; P84; Ptpns1; SHP-1;
                     SHPS-1; SIRP"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1201
                     /gene="Sirpa"
                     /gene_synonym="Bit; CD172a; Idd13.2; P84; Ptpns1; SHP-1;
                     SHPS-1; SIRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1537
                     /gene="Sirpa"
                     /gene_synonym="Bit; CD172a; Idd13.2; P84; Ptpns1; SHP-1;
                     SHPS-1; SIRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1651
                     /gene="Sirpa"
                     /gene_synonym="Bit; CD172a; Idd13.2; P84; Ptpns1; SHP-1;
                     SHPS-1; SIRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1676
                     /gene="Sirpa"
                     /gene_synonym="Bit; CD172a; Idd13.2; P84; Ptpns1; SHP-1;
                     SHPS-1; SIRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1728
                     /gene="Sirpa"
                     /gene_synonym="Bit; CD172a; Idd13.2; P84; Ptpns1; SHP-1;
                     SHPS-1; SIRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..4030
                     /gene="Sirpa"
                     /gene_synonym="Bit; CD172a; Idd13.2; P84; Ptpns1; SHP-1;
                     SHPS-1; SIRP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggaaggtg cgggcgcgag gagggggcgc tcggccgggc cgccctcgcg ctggcctcgc
       61 gacggctccg cacagcccgc actcgctctg cgagctgtcc ccgctcgcgc ttgctctccg
      121 atctccgtcc ccgctccctc tccctcttcc tctccccctc tttccttctc cctcgctatc
      181 cgctcccccg cccccgtgcc tctggctctg cgcctggctc cctcgggtcc gctccccttt
      241 cccgccggcc tggcccggcg tcacgctccc ggagtctccc cgctcggcgg cgtctcattg
      301 tgggaggggg tcagatcacc ccgccgggcg gtggcgctgg ggggcagcgg agggggaggg
      361 gccttagtcg ttcgcccgcg ccgcccgccc gcctgccgag cgcgctcacc gccgctctcc
      421 ctccttgctc tgcagccgcg gcccatggag cccgccggcc cggcccctgg ccgcctaggg
      481 ccgctgctgc tctgcctgct gctctccgcg tcctgtttct gtacaggagc cacggggaag
      541 gaactgaagg tgactcagcc tgagaaatca gtgtctgttg ctgctgggga ttcgaccgtt
      601 ctgaactgca ctttgacctc cttgttgccg gtgggaccca ttaggtggta cagaggagta
      661 gggccaagcc ggctgttgat ctacagtttc gcaggagaat acgttcctcg aattagaaat
      721 gtttcagata ctactaagag aaacaatatg gacttttcca tccgtatcag taatgtcacc
      781 ccagcagatg ctggcatcta ctactgtgtg aagttccaga aaggatcatc agagcctgac
      841 acagaaatac aatctggagg gggaacagag gtctatgtac tcgccaaacc ttctccaccg
      901 gaggtatccg gcccagcaga caggggcata cctgaccaga aagtgaactt cacctgcaag
      961 tctcatggct tctctccccg gaatatcacc ctgaagtggt tcaaagatgg gcaagaactc
     1021 caccccttgg agaccaccgt gaaccctagt ggaaagaatg tctcctacaa catctccagc
     1081 acagtcaggg tggtactaaa ctccatggat gttaattcta aggtcatctg cgaggtagcc
     1141 cacatcacct tggatagaag ccctcttcgt gggattgcta acctgtctaa cttcatccga
     1201 gtttcaccca ccgtgaaggt cacccaacag tccccgacgt caatgaacca ggtgaacctc
     1261 acctgccggg ctgagaggtt ctaccccgag gatctccagc tgatctggct ggagaatgga
     1321 aacgtatcac ggaatgacac gcccaagaat ctcacaaaga acacggatgg gacctataat
     1381 tacacaagct tgttcctggt gaactcatct gctcatagag aggacgtggt gttcacgtgc
     1441 caggtgaagc acgaccaaca gccagcgatc acccgaaacc ataccgtgct gggatttgcc
     1501 cactcgagtg atcaagggag catgcaaacc ttccctgata ataatgctac ccacaactgg
     1561 aatgtcttca tcggtgtggg cgtggcgtgt gctttgctcg tagtcctgct gatggctgct
     1621 ctctacctcc tccggatcaa acagaagaaa gccaaggggt caacatcttc cacacggttg
     1681 cacgagcccg agaagaacgc cagggaaata acccaggtac agtctttgat ccaggacaca
     1741 aatgacatca acgacatcac atacgcagac ctgaatctgc ccaaagagaa gaagcccgca
     1801 ccccgggccc ctgagcctaa caaccacaca gaatatgcaa gcattgagac aggcaaagtg
     1861 cctaggccag aggataccct cacctatgct gacctggaca tggtccacct cagccgggca
     1921 cagccagccc ccaagcctga gccatctttc tcagagtatg ctagtgtcca ggtccagagg
     1981 aagtgaatgg ggctgtggtc tgtactaggc cccatcccca caagttttct tgtcctacat
     2041 ggagtggcca tgacgaggac atccagccag ccaatcctgt ccccagaagg ccaggtggca
     2101 cgggtcctag gaccaggggt aagggtggcc tttgtcttcc ctccgtggct cttcaacacc
     2161 tcttgggcac ccacgtcccc ttcttccgga ggctgggtgt tgcagaacca gagggcgaac
     2221 tggagaaagc tgcctggaat ccaagaagtg ttgtgcctcg gcccatcact cgtgggtctg
     2281 gatcctggtc ttggcaaccc caggttgcgt ccttgatgtt ccagagcttg gtcttctgtg
     2341 tggagaagag ctcaccatct ctacccaact tgagctttgg gaccagactc cctttagatc
     2401 aaaccgcccc atctgtggaa gaactacacc agaagtcagc aagttttcag ccaacagtgc
     2461 tggcctcccc acctcccagg ctgactagcc ctggggagaa ggaaccctct cctcctagac
     2521 cagcagagac tccctgggca tgttcagtgt ggccccacct cccttccagt cccagcttgc
     2581 ttcctccagc tagcactaac tcagcagcat cgctctgtgg acgcctgtaa attattgaga
     2641 aatgtgaact gtgcagtctt aaagctaagg tgttagaaaa tttgatttat gctgtttagt
     2701 tgttgttggg tttcttttct ttttaatttc tttttctttt ttgatttttt ttctttccct
     2761 taaaacaaca gcagcagcat cttggctctt tgtcatgtgt tgaatggttg ggtcttgtga
     2821 agtctgaggt ctaacagttt attgtcctgg aaggattttc ttacagcaga aacagatttt
     2881 tttcaaattc ccagaatcct gaggaccaag aaggatccct cagctgctac ttccagcacc
     2941 cagcgtcact gggacgaacc aggccctgtt cttacaaggc cacatggctg gccctttgcc
     3001 tccatggcta ctgtggtaag tgcagccttg tctgacccaa tgctgaccta atgttggcca
     3061 ttccacattg aggggacaag gtcagtgatg ccccccttca ctcacaagca cttcagaggc
     3121 atgcagagag aagggacact cggccagctc tctgaggtaa tcagtgcaag gaggagtccg
     3181 ttttttgcca gcaaacctca gcaggatcac actggaacag aacctggtca tacctgtgac
     3241 aacacagctg tgagccaggg caaaccaccc actgtcactg gctcgagagt ctgggcagag
     3301 gctctgaccc tccacccttt aaactggatg ccggggcctg gctgggccca atgccaagtg
     3361 gttatggcaa ccctgactat ctggtcttaa catgtagctc aggaagtgga ggcgctaatg
     3421 tccccaatcc ctggggattc ctgattccag ctattcatgt aagcagagcc aacctgccta
     3481 tttctgtagg tgcgactggg atgttaggag cacagcaagg acccagctct gtagggctgg
     3541 tgacctgata cttctcataa tggcatctag aagttaggct gagttggcct cactggccca
     3601 gcaaaccaga acttgtcttt gtccgggcca tgttcttggg ctgtcttcta attccaaagg
     3661 gttggttggt aaagctccac ccccttctcc tctgcctaaa gacatcacat gtgtatacac
     3721 acacgggtgt atagatgagt taaaagaatg tcctcgctgg catcctaatt ttgtcttaag
     3781 tttttttgga gggagaaagg aacaaggcaa gggaagatgt gtagctttgg ctttaaccag
     3841 gcagcctggg ggctcccaag cctatggaac cctggtacaa agaagagaac agaagcgccc
     3901 tgtgaggagt gggatttgtt tttctgtaga ccagatgaga aggaaacagg ccctgttttg
     3961 tacatagttg caacttaaaa tttttggctt gcaaaatatt tttgtaataa agatttctgg
     4021 gtaacaataa aaaaaaaaaa aaa
//
