LOCUS       NM_001407402            7650 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus signal-induced proliferation-associated 1 like 1
            (Sipa1l1), transcript variant 3, mRNA.
ACCESSION   NM_001407402 XM_011244068
VERSION     NM_001407402.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7650)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7650)
  AUTHORS   Patel,S.D., Anand,D., Motohashi,H., Katsuoka,F., Yamamoto,M. and
            Lachke,S.A.
  TITLE     Deficiency of the bZIP transcription factors Mafg and Mafk causes
            misexpression of genes in distinct pathways and results in lens
            embryonic developmental defects
  JOURNAL   Front Cell Dev Biol 10, 981893 (2022)
   PUBMED   36092713
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7650)
  AUTHORS   Matsuura,K., Kobayashi,S., Konno,K., Yamasaki,M., Horiuchi,T.,
            Senda,T., Hayashi,T., Satoh,K., Arima-Yoshida,F., Iwasaki,K.,
            Negishi,L., Yasui-Shimizu,N., Kohu,K., Kawahara,S., Kirino,Y.,
            Nakamura,T., Watanabe,M., Yamamoto,T., Manabe,T. and Akiyama,T.
  TITLE     SIPA1L1/SPAR1 Interacts with the Neurabin Family of Proteins and is
            Involved in GPCR Signaling
  JOURNAL   J Neurosci 42 (12), 2448-2473 (2022)
   PUBMED   35121636
  REMARK    GeneRIF: SIPA1L1/SPAR1 Interacts with the Neurabin Family of
            Proteins and is Involved in GPCR Signaling.
REFERENCE   4  (bases 1 to 7650)
  AUTHORS   Wang,P.J., Lin,S.T., Liu,S.H., Kuo,K.T., Hsu,C.H., Knepper,M.A. and
            Yu,M.J.
  TITLE     Vasopressin-induced serine 269 phosphorylation reduces Sipa1l1
            (signal-induced proliferation-associated 1 like 1)-mediated
            aquaporin-2 endocytosis
  JOURNAL   J Biol Chem 292 (19), 7984-7993 (2017)
   PUBMED   28336531
  REMARK    GeneRIF: PDZ domain-containing protein Sipa1l1 (signal-induced
            proliferation-associated 1 like 1) binds to the cytoplasmic
            PDZ-ligand motif of aquaporin-2 and accelerates its endocytosis in
            the absence of vasopressin
REFERENCE   5  (bases 1 to 7650)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 7650)
  AUTHORS   Thuret,S., Bhatt,L., O'Leary,D.D. and Simon,H.H.
  TITLE     Identification and developmental analysis of genes expressed by
            dopaminergic neurons of the substantia nigra pars compacta
  JOURNAL   Mol Cell Neurosci 25 (3), 394-405 (2004)
   PUBMED   15033168
REFERENCE   7  (bases 1 to 7650)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   8  (bases 1 to 7650)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 7650)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 7650)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130222.4, AC122227.4 and AC156643.2.
            
            On Jun 2, 2022 this sequence version replaced XM_011244068.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.58848.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC130222.4         72826-72853         c
            29-89               AC130222.4         72253-72313         c
            90-155              AC130222.4         7801-7866           c
            156-216             AC122227.4         78320-78380         c
            217-2054            AC122227.4         47230-49067         c
            2055-2185           AC122227.4         32366-32496         c
            2186-2374           AC122227.4         26598-26786         c
            2375-2549           AC122227.4         17187-17361         c
            2550-2653           AC122227.4         4975-5078           c
            2654-2811           AC122227.4         2017-2174           c
            2812-3385           AC156643.2         186870-187443       c
            3386-3660           AC156643.2         186016-186290       c
            3661-3930           AC156643.2         180457-180726       c
            3931-4077           AC156643.2         166586-166732       c
            4078-4202           AC156643.2         162974-163098       c
            4203-4321           AC156643.2         161143-161261       c
            4322-4764           AC156643.2         158181-158623       c
            4765-5004           AC156643.2         150644-150883       c
            5005-5170           AC156643.2         149782-149947       c
            5171-5417           AC156643.2         145702-145948       c
            5418-5564           AC156643.2         142675-142821       c
            5565-5679           AC156643.2         136705-136819       c
            5680-5764           AC156643.2         134245-134329       c
            5765-7650           AC156643.2         131850-133735       c
FEATURES             Location/Qualifiers
     source          1..7650
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 38.14 cM"
     gene            1..7650
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /note="signal-induced proliferation-associated 1 like 1"
                     /db_xref="GeneID:217692"
                     /db_xref="MGI:MGI:2443679"
     exon            1..28
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            29..89
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            90..155
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            156..216
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            217..2054
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /inference="alignment:Splign:2.1.0"
     CDS             557..5908
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /note="isoform 3 is encoded by transcript variant 3;
                     signal-induced proliferation-associated 1-like protein 1;
                     SIPA1-like protein 1"
                     /codon_start=1
                     /product="signal-induced proliferation-associated 1-like
                     protein 1 isoform 3"
                     /protein_id="NP_001394331.1"
                     /db_xref="GeneID:217692"
                     /db_xref="MGI:MGI:2443679"
                     /translation="MTSLKRSQTERPVTADRASVVSTDGAPKVHTDDFYMRRFRSQNG
                     SLGSSVMAAVGPPRSEGPHHITSTPGVPKMGVRARIADWPPRKENVKESSRSSQEIET
                     SSCLESLSSKGSPVSQGSSVSLNSNDSAMLKSIQNTLKNKTGPAESMDSRFLMPEAYP
                     SSPRKALRRIRQRSNSDITISELDVDSFDECISPTYKSGPSLHREYGSTSSIDKQGTS
                     GDSFFDLLKGYKDDRSDRGPTPTKLSDFLITGGGKGSGFSLDVIDGPISQRENLRLFK
                     EREKPLKRRSKSETGDSSIFRKLRNAKGEELGKSSDLEDNRSEDSVRPWTCPKCFAHY
                     DVQSILFDLNEAIMNRHNVIKRRNTTTGASAAAVASLVSGPLSHSASFSSPMGSTEDL
                     NSKGSLGMDQGDDKSNELVMSCPYFRNEIGGEGERKISLSKSNSGSFSGCESTSFESA
                     LSSHCTNAGVAVLEVPKESLMLHLDRVKRYTVEHVDLGAYYYRKFFYQKEHWNYFGAD
                     ENLGPVAVSIRREKPEDMKENGSPYNYRIIFRTSELMTLRGSVLEDAIPSTAKHSTAR
                     GLPLKEVLEHVIPELNVQCLRLAFNTPKVTEQLMKLDEQGLNYQQKVGIMYCKAGQST
                     EEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQLDTKTDSTGTHSLYTTYKDYEI
                     MFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVIVR
                     AHNPCTESVCYSVAVTRSRDVPSFGPPIPKGVTFPKSNVFRDFLLAKVINAENAAHKS
                     EKFRAMATRTRQEYLKDLAEKNVTNTPIDPSGKFPFISLASKKKEKSKPYPGAELSSM
                     GAIVWAVRAKDYNKAMEFDCLLGISSEFIVLIEQETKSVAFNCSCRDVIGWTSSDTSL
                     KIFYERGECVSVESFISGEDIKEIVRRLQFVSKGCESVEMTLRRNGLGQLGFHVNYEG
                     IVADVEPYGYAWQAGLRQGSRLVEICKVAVATLSHEQMIDLLRTSVTVKVVIIPPHDD
                     CTPRRSCSETYRMPVMEYQMNEGISYEFKFPFRNNNKWQRNASKGAHSPQVPSQLQSP
                     MTSRLNAGKGDGKMPPPERAANIPRSISSDGRPLERRLSPGSDIYVTVSSMALARSQC
                     RNSPSNLSSSSETGSGGGTYRQKSMPEGFGVSRRSPASIDRQNTQSDISGSGKSTPSW
                     QRSEDSLADQMEPTCHLPAVSKVLPAFRESPSGRLMRQDPVVHLSPNKQGHSDSHYSS
                     HSSSNTLSSNASSAHSDEKWYDGDRTESDLNSYNYLQGTSADSGIDTASYGPSHGSTA
                     SLGASTSSPRSGPGKEKVAPLWHSSSEVLSLADRTLETEGHGMDRKAESSLSLDIHSK
                     SQGGSSPLSRENSTFSINDAASHTSTMSSRHSASPVVFSSARSSPKEELHPTASSQLA
                     PSFSSSSSSSSGPRTFYPRQGATSKYLIGWKKPEGTINSVGFMDTRKRHQSDGNEIAH
                     TRLRASTRDLQASPKPTSKSTIEEDLKKLIDLESPTPESQKNFKFHALSSPQSPFPTT
                     PTSRRALHRTLSDESIYSSQREHFFTSRASLLDQALPNDVLFSSTYPSLPKSLPLRRP
                     SYTLGMKSLHGEFSASDSSLTDIQETRRQPIPDPGLMPLPDAASDLDWSNLVDAAKAY
                     EVQRASFFAASDENHRPLSAASNSDQLEEQALVQMKSYSSSKDPSPTLASKVDQLEGM
                     LKMLREDLKKEKEDKAQLQAEVEHLREDNLRLQEESQNASDKLKKFTEWVFNTIDMS"
     exon            2055..2185
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2374
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2549
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2653
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2811
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            2812..3385
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            3386..3660
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            3661..3930
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            3931..4077
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            4078..4202
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            4203..4321
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            4322..4764
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            4765..5004
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            5005..5170
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            5171..5417
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            5418..5564
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            5565..5679
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            5680..5764
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /inference="alignment:Splign:2.1.0"
     exon            5765..7650
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6117..6122
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /note="hexamer: AATAAA"
     polyA_site      6138
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /note="major polyA site"
     regulatory      6767..6772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /note="hexamer: AATAAA"
     polyA_site      6786
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
     regulatory      7620..7625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /note="hexamer: AATAAA"
     polyA_site      7650
                     /gene="Sipa1l1"
                     /gene_synonym="4931426N11Rik; mKIAA0440; Spar"
                     /note="major polyA site"
ORIGIN      
        1 agtacgtgcg tgagcgagtg agcggaaagg agagcgcgcg gacgacgcgc ccgggacgcg
       61 cggctgcacc gggaagccca ggccaagcgg ttttgagaga ttgctacaat ttggactcac
      121 aagcaagatt tactgcaaac tttgagatgg agtaggtcat atgtcattag tgtggacgct
      181 gctgtcttaa gtctgtggcc atggcaccag aacacaggga agcgtgggat tctggtgacc
      241 acagagcccc agtgatgcaa gctctactca gtcttaggga ctgaaggaag cctgctgtta
      301 gagtgaggca cagggactga aggaagcctg ctgttagagt gaggcacagg gactgttgtg
      361 gattacaatg tttggaagat ctgggttctc tgtcgtctgc aaacaaggca tcatttaacc
      421 ttttaaatga aaaggcttaa gatctcaaca ccactgctgt attttctgga agccattctc
      481 taaagcagaa gtgcatattt aaaacgcaaa catggtgatc ctttctgcag ggatttaagt
      541 gatcgctttt tacatcatga ccagtttgaa gcggtcgcag accgaaagac ctgtcaccgc
      601 tgacagagcc tctgttgtca gcacagatgg cgcccccaaa gtccacaccg atgacttcta
      661 catgcgtcgc ttccgctctc agaatggcag cctaggatca tcagtcatgg ctgcagtggg
      721 gccccctcga agtgaaggcc ctcaccatat cacctcaacc cccggggtcc ccaagatggg
      781 ggttagggca agaatagcag attggcctcc gagaaaggaa aatgtaaaag aatccagccg
      841 ttcaagccag gaaatagaaa cctcaagttg ccttgagagc ctgtcctcca aaggcagtcc
      901 tgtgagtcag gggagttctg ttagcctcaa ttccaatgac tcagccatgc tgaagagcat
      961 acagaacacc ctgaagaaca agacagggcc agcggagagc atggactcca gattcctcat
     1021 gcctgaagcc taccccagtt cccccaggaa agcccttcgc agaattcggc agcgcagcaa
     1081 cagtgatatc accataagtg agcttgatgt ggatagcttc gatgaatgta tctccccaac
     1141 ctacaagtcg gggccatcat tgcacaggga atatggcagc acatcttcaa tcgacaagca
     1201 gggaacatcc ggagacagct tcttcgattt gttaaagggc tataaagatg acagatctga
     1261 ccgaggtcca actccaacca aactcagtga cttcctcatc actggtgggg gcaagggttc
     1321 tggtttctcc ttggatgtga tcgatggccc catctcacag agagagaacc tcaggctttt
     1381 caaggaaagg gaaaaaccac tcaagcgacg ctctaagtct gagactggag actcgtccat
     1441 ttttcgtaaa ttgcgcaatg ccaaaggtga agaactcggg aaatcatcag accttgaaga
     1501 caacagatca gaagattctg tgaggccctg gacatgtcca aagtgctttg cccactatga
     1561 tgtccagagc atattgtttg acttgaatga agccattatg aacagacata atgtgattaa
     1621 gaggagaaac accacaacag gagcttcggc ggctgcggtg gcatccttgg tctccggacc
     1681 tctgtctcac tcagccagct tcagctctcc catgggcagc acagaggacc tcaactccaa
     1741 aggaagcctt ggcatggacc agggagatga caagagcaat gaactcgtca tgagctgtcc
     1801 gtattttcgg aatgagattg ggggagaagg tgagaggaag atcagcctgt ccaagtcgaa
     1861 ttctggctca tttagtgggt gtgagagcac atcctttgag tctgccctca gctctcactg
     1921 caccaacgcg ggcgtggcag ttctcgaagt gcccaaggaa agcttgatgc tgcatctgga
     1981 cagggtgaaa aggtacaccg tggaacacgt ggatcttggc gcatactatt acaggaagtt
     2041 cttctaccag aaggaacact ggaactattt tggggctgat gagaacctcg gtccagtggc
     2101 tgtgagcatt cgaagggaaa aaccagaaga catgaaggaa aacggatctc catacaacta
     2161 ccgaataata ttcaggacta gtgagctcat gacgctgagg gggtctgtcc tggaggatgc
     2221 cattccctcc acggccaagc actcgacagc caggggattg cctctgaaag aggtgctgga
     2281 acacgtgatc ccagagctca acgtgcagtg cctgcgcttg gccttcaaca cacccaaagt
     2341 cacagagcag ctcatgaaac tggacgagca agggctgaac tatcagcaga aagtaggcat
     2401 catgtactgc aaagcaggcc agagcacgga ggaggagatg tacaacaacg agtctgcagg
     2461 cccagccttt gaggagttcc ttcagctgct gggggaacga gtccggctaa aaggattcga
     2521 gaagtatcgt gcgcagcttg acaccaaaac tgactccact ggaacccact ctctgtacac
     2581 aacctacaaa gactatgaga taatgttcca cgtctccacc atgctgccct acacacctaa
     2641 caacaagcaa cagctcctga ggaagcggca cattgggaat gacattgtga caatagtttt
     2701 ccaagagcct ggagcacaac cattcagccc gaaaaacatc cggtctcact ttcagcatgt
     2761 ttttgtcatt gtccgggctc acaacccttg cactgagagt gtctgttaca gtgtggcagt
     2821 caccaggtcc agagatgtac cttcttttgg acctcccatc cctaaagggg tcaccttccc
     2881 caagtcaaat gtgttcaggg acttcctttt ggccaaagtg ataaatgcag aaaatgctgc
     2941 tcataaatca gagaagttcc gggccatggc gacaaggacc cgccaggaat acctgaaaga
     3001 tctggcagaa aagaatgtca ccaacacacc tattgaccct tctggcaagt ttccatttat
     3061 ttctctggcc tccaagaaga aggaaaagtc taagccttat ccaggagctg agctcagtag
     3121 catgggggcc attgtgtggg ctgtccgggc caaagactac aacaaggcca tggagttcga
     3181 ctgcctcctt gggatctcca gcgagttcat cgtcctcatt gagcaggaga caaagagtgt
     3241 ggctttcaat tgctcctgca gagatgtcat agggtggact tccagcgaca ccagcctcaa
     3301 aatcttctat gagcggggag aatgtgtgtc ggtggagagc ttcattagcg gtgaagatat
     3361 caaagaaatt gtcagaaggc tgcagtttgt ttcaaaaggt tgtgaatctg tggaaatgac
     3421 tctgcgaaga aatgggctgg ggcagcttgg cttccatgtc aactatgagg gcattgtggc
     3481 ggatgtagaa ccctacggct acgcatggca agcagggctg aggcagggca gccgcctggt
     3541 ggagatctgc aaggtagcag tggccaccct gagccatgaa cagatgatcg atctcttgag
     3601 aacatcagtc acagtgaagg ttgtcattat ccctccccat gacgactgca ccccacggag
     3661 gagttgctca gaaacctacc gcatgccagt gatggagtac cagatgaatg aaggcatttc
     3721 ctacgagttc aagtttccct tccggaataa taacaaatgg cagcggaatg ccagcaaggg
     3781 tgctcattcg ccccaggttc catctcagct gcagagtccc atgacctcac gactgaatgc
     3841 tgggaaggga gatgggaaaa tgccccctcc agaaagagct gccaacatcc ctcgaagcat
     3901 ctccagtgac gggcgcccac tggaaaggag gctgtctcct ggttcggaca tctatgtgac
     3961 agtctcatcc atggctttgg cgagatccca gtgccgtaac tctcccagca acttgtcttc
     4021 gtccagtgag actggctctg gaggtggtac ctacagacaa aaatccatgc ccgaagggtt
     4081 tggggtgagc cgaagatccc cagcttccat cgacaggcag aacacccagt cggatataag
     4141 tggcagtgga aaatccactc ccagctggca gagaagtgag gacagccttg ccgaccagat
     4201 ggagccgacg tgccatctcc cagcagtatc gaaggtactg cctgctttcc gagagagccc
     4261 cagtgggaga ttgatgcggc aggatccagt ggttcacttg tctccaaaca aacaaggcca
     4321 ttctgacagc cactactcca gccactccag cagcaacacg ctctccagca acgcctcgag
     4381 tgcacacagt gacgagaagt ggtacgatgg ggaccgcacg gagtccgacc tcaacagcta
     4441 caactaccta cagggcacgt ctgccgacag cgggattgac accgcctcct acggccccag
     4501 ccatggcagc acggcctccc tgggggcctc cacatcctca cctcgttcag ggccaggcaa
     4561 agaaaaggtg gctcccctgt ggcacagctc cagtgaagtg ctctccctgg cagatcggac
     4621 cttagagact gagggccacg gcatggacag gaaagcagag tcctccctga gcctggacat
     4681 ccacagcaag agccagggcg ggtcaagccc gctgagcagg gagaacagca ccttcagcat
     4741 aaatgatgct gcgtcccaca ccagtaccat gagctcccga cactctgcca gcccagtggt
     4801 attctccagt gccagaagtt cccccaaaga ggagcttcac cccaccgcat cctcccagct
     4861 cgcaccgtcc ttttcctctt cttcctcatc ctcctctgga cctaggactt tctaccctcg
     4921 ccagggcgcc actagcaaat atctgattgg atggaaaaag ccagaaggaa ccattaactc
     4981 cgtgggattt atggacacac gaaagcgaca tcagagtgat ggcaatgaga tagcccacac
     5041 taggcttcga gcctcaacca gggacctgca ggcatcccca aagccgacct ccaagtctac
     5101 cattgaggaa gatctaaaga aactcatcga ccttgagagc ccaactcccg aatcccagaa
     5161 gaatttcaag ttccatgcac tgtcctcccc gcagtccccg ttccccacta cccctacctc
     5221 ccggcgggcc ctgcacagga ctctgtcaga tgagagcatt tacagcagcc agagggagca
     5281 tttcttcacc tccagggctt cgcttctaga ccaagccctg cccaacgatg tcctcttcag
     5341 cagtacctac ccatctctcc ccaagtcact tccactgagg aggccatctt acacgttggg
     5401 aatgaagtca ttgcatggag agttctctgc ctcggacagc tccctcaccg acatccagga
     5461 gacccgaagg cagcctatcc ctgaccctgg cctgatgccc ctgcctgatg cagcttcaga
     5521 tttggactgg tccaacctag tagatgccgc caaagcctat gaggtccaga gagcctcatt
     5581 ttttgctgct agtgatgaaa accatcgccc cctgagcgcg gcctccaaca gtgaccagct
     5641 ggaggagcag gccctggtcc agatgaagtc ctacagcagc agtaaggacc cctctcccac
     5701 tctggcttct aaggtggacc agctggaagg tatgctgaaa atgcttcgag aagatttgaa
     5761 gaaggaaaaa gaagacaagg cccagctgca ggcggaagtt gagcacctgc gggaggacaa
     5821 cctgaggctg caggaggagt cccagaacgc ctcggacaag ctgaagaagt tcacagagtg
     5881 ggtcttcaac accatagaca tgagctaggg ccagccgagg ggaaacgaga aagggacagg
     5941 ctgccctatg tgggccccta aagcacccat tcacgccttg gaaagtattc tcagagtccc
     6001 cagcgtccca gcctgttcat atcggacagt gcacagcaca attgcagatc aacaatcatt
     6061 atctgccttt tttagaaaag aaaaacaaaa aattaaataa aaattttaaa aagtaaaata
     6121 aaaatttaac tgctcaaatg tgaatgtctt tattttttgc acaatatctt tctctgttat
     6181 gtatttacaa agaagctggg cccagaccca agtgcccctg gccctcagtc tctgcttcca
     6241 tcagctgacc tggttcaggt accccaagct ccctgtcccc tgacagatgt ctgtgttcct
     6301 aggaaggaag tttttctttt ttaactgttt gggggtgggg aggggccttt ccttgcctca
     6361 gtccctaaaa tgcctgtgag agggacttta agggaaggcc ccacccctaa gtggtctggg
     6421 tggggcttct gccctctgca tcctgtctgc tggggaccag cagggccaca ccactcaccc
     6481 ttcagatctt gcatcttgtc ccttctttct ccagaagaac tgtccccagt accttcctaa
     6541 tactttgttt ggcttaagtg aaccctacta aatcagaaat caacctattc caccttcctg
     6601 gctcctaaca ttaattggca tctgaatttt ctcaaatgaa aaccttacct gtttgcattg
     6661 taaacacatt ttggtcaaaa gtctctctct ctatatatat atatatagtt tctgtttgag
     6721 atttttaaag atgtagcaaa ctttttaaag cttgttcaaa atgactaata aatctttctc
     6781 accaaagcaa gacttcaacc agtgtttgta attaggaaaa gctaacagca gcaaatgtta
     6841 aaccgcgagt ttaatccctg cctgtttgga gcaatgccta aaacaaaatg ggcttttgga
     6901 acctgcatgt cgcagtgtgg agtttatgca cagcattttc tgcatccttt tgatgccatc
     6961 caaaggactc tgctgcagaa attacccctg cactgttcct cctgtccagt gatgcaggct
     7021 gttctgggcc cctaaccctt gctgctgtac agacatgggg ctggccagtg ttaactggcg
     7081 ttgtgctaaa agttccctgc tgtaaactag aaaaccactt gccctggttt ctatccctaa
     7141 agcaatatgt atcccccttc ctcctccctc ttcctcctct ctctccctct ctgtctccct
     7201 ctgtctttct cttctctctt ctcctctctc tctctctctc tctcctctct ctctctctct
     7261 cacacacaca cacacctctt tatgctgtag tttcacaaat gattgtgagt tcccccacca
     7321 ccaggttttt tctttcccct gttaacattt ctaccgtgaa gtaggaggat ttgggaatgc
     7381 tttgtaaaga tgatagtcga ctctctaatg tccatgaagg aggttgtaca ttgcctgatg
     7441 tctttctgta aatgagaaat attgctaaca tccgagcatt ctgaagtctt gcttatcttc
     7501 ccgagtttcc tttcatttgg ttttcctgtt tctttgggga cttggggcaa gctatttatt
     7561 agagttttgc aaccgagttc ttgtttgaag tctctgaaga ctacttgtaa aattcaaaca
     7621 ataaaattca ttttaaatgc tcttttaaaa
//
