LOCUS       NM_009188               4135 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus transcriptional regulator, SIN3B (yeast) (Sin3b),
            transcript variant 1, mRNA.
ACCESSION   NM_009188
VERSION     NM_009188.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4135)
  AUTHORS   Calderon,A., Mestvirishvili,T., Boccalatte,F., Ruggles,K.V. and
            David,G.
  TITLE     Chromatin accessibility and cell cycle progression are controlled
            by the HDAC-associated Sin3B protein in murine hematopoietic stem
            cells
  JOURNAL   Epigenetics Chromatin 17 (1), 2 (2024)
   PUBMED   38254205
  REMARK    GeneRIF: Chromatin accessibility and cell cycle progression are
            controlled by the HDAC-associated Sin3B protein in murine
            hematopoietic stem cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4135)
  AUTHORS   Yang,X., Graff,S.M., Heiser,C.N., Ho,K.H., Chen,B., Simmons,A.J.,
            Southard-Smith,A.N., David,G., Jacobson,D.A., Kaverina,I.,
            Wright,C.V.E., Lau,K.S. and Gu,G.
  TITLE     Coregulator Sin3a Promotes Postnatal Murine beta-Cell Fitness by
            Regulating Genes in Ca2+ Homeostasis, Cell Survival, Vesicle
            Biosynthesis, Glucose Metabolism, and Stress Response
  JOURNAL   Diabetes 69 (6), 1219-1231 (2020)
   PUBMED   32245798
  REMARK    GeneRIF: Coregulator Sin3a Promotes Postnatal Murine beta-Cell
            Fitness by Regulating Genes in Ca(2+) Homeostasis, Cell Survival,
            Vesicle Biosynthesis, Glucose Metabolism, and Stress Response.
REFERENCE   3  (bases 1 to 4135)
  AUTHORS   Langlet,F., Tarbier,M., Haeusler,R.A., Camastra,S., Ferrannini,E.,
            Friedlander,M.R. and Accili,D.
  TITLE     microRNA-205-5p is a modulator of insulin sensitivity that inhibits
            FOXO function
  JOURNAL   Mol Metab 17, 49-60 (2018)
   PUBMED   30174230
REFERENCE   4  (bases 1 to 4135)
  AUTHORS   Kurita,J.I., Hirao,Y., Nakano,H., Fukunishi,Y. and Nishimura,Y.
  TITLE     Sertraline, chlorprothixene, and chlorpromazine characteristically
            interact with the REST-binding site of the corepressor mSin3,
            showing medulloblastoma cell growth inhibitory activities
  JOURNAL   Sci Rep 8 (1), 13763 (2018)
   PUBMED   30213984
  REMARK    GeneRIF: Active compounds showed a new chemo-type for inhibitors of
            the REST/NRSF-mSin3 interaction, raising the possibility of new
            therapies for neuropathies caused by dysregulation of REST/NRSF.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4135)
  AUTHORS   Langlet,F., Haeusler,R.A., Linden,D., Ericson,E., Norris,T.,
            Johansson,A., Cook,J.R., Aizawa,K., Wang,L., Buettner,C. and
            Accili,D.
  TITLE     Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates
            Hepatic Glucose Handling
  JOURNAL   Cell 171 (4), 824-835 (2017)
   PUBMED   29056338
REFERENCE   6  (bases 1 to 4135)
  AUTHORS   Heinzel,T., Lavinsky,R.M., Mullen,T.M., Soderstrom,M.,
            Laherty,C.D., Torchia,J., Yang,W.M., Brard,G., Ngo,S.D.,
            Davie,J.R., Seto,E., Eisenman,R.N., Rose,D.W., Glass,C.K. and
            Rosenfeld,M.G.
  TITLE     A complex containing N-CoR, mSin3 and histone deacetylase mediates
            transcriptional repression
  JOURNAL   Nature 387 (6628), 43-48 (1997)
   PUBMED   9139820
REFERENCE   7  (bases 1 to 4135)
  AUTHORS   Hurlin,P.J., Queva,C., Koskinen,P.J., Steingrimsson,E., Ayer,D.E.,
            Copeland,N.G., Jenkins,N.A. and Eisenman,R.N.
  TITLE     Mad3 and Mad4: novel Max-interacting transcriptional repressors
            that suppress c-myc dependent transformation and are expressed
            during neural and epidermal differentiation
  JOURNAL   EMBO J 15 (8), 2030 (1996)
   PUBMED   8617250
  REMARK    Correction to:[EMBO J. 1995 Nov 15;14(22):5646-59. doi:
            10.1002/j.1460-2075.1995.tb00252.x.. PMID: 8521822]
REFERENCE   8  (bases 1 to 4135)
  AUTHORS   Rao,G., Alland,L., Guida,P., Schreiber-Agus,N., Chen,K., Chin,L.,
            Rochelle,J.M., Seldin,M.F., Skoultchi,A.I. and DePinho,R.A.
  TITLE     Mouse Sin3A interacts with and can functionally substitute for the
            amino-terminal repression of the Myc antagonist Mxi1
  JOURNAL   Oncogene 12 (5), 1165-1172 (1996)
   PUBMED   8649810
REFERENCE   9  (bases 1 to 4135)
  AUTHORS   Hurlin,P.J., Queva,C., Koskinen,P.J., Steingrimsson,E., Ayer,D.E.,
            Copeland,N.G., Jenkins,N.A. and Eisenman,R.N.
  TITLE     Mad3 and Mad4: novel Max-interacting transcriptional repressors
            that suppress c-myc dependent transformation and are expressed
            during neural and epidermal differentiation
  JOURNAL   EMBO J 14 (22), 5646-5659 (1995)
   PUBMED   8521822
  REMARK    Erratum:[EMBO J. 1996 Apr 15;15(8):2030.. PMID: 8617250]
REFERENCE   10 (bases 1 to 4135)
  AUTHORS   Ayer,D.E., Lawrence,Q.A. and Eisenman,R.N.
  TITLE     Mad-Max transcriptional repression is mediated by ternary complex
            formation with mammalian homologs of yeast repressor Sin3
  JOURNAL   Cell 80 (5), 767-776 (1995)
   PUBMED   7889570
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC171917.14 and AK169433.1.
            
            On Oct 31, 2013 this sequence version replaced NM_009188.3.
            
            Transcript Variant: This variant (1) represents the longer variant
            and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159076.1, ERR3363658.3034776.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC171917.14        78221-78238
            19-862              AK169433.1         4-847
            863-952             AC171917.14        96425-96514
            953-1071            AC171917.14        96761-96879
            1072-1279           AC171917.14        99409-99616
            1280-1396           AC171917.14        99845-99961
            1397-1635           AC171917.14        101361-101599
            1636-1819           AC171917.14        102636-102819
            1820-2369           AC171917.14        104670-105219
            2370-2539           AC171917.14        105387-105556
            2540-2713           AC171917.14        108118-108291
            2714-2806           AC171917.14        108496-108588
            2807-2901           AC171917.14        111424-111518
            2902-3106           AC171917.14        111799-112003
            3107-4135           AC171917.14        112126-113154
FEATURES             Location/Qualifiers
     source          1..4135
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 35.08 cM"
     gene            1..4135
                     /gene="Sin3b"
                     /gene_synonym="2810430C10Rik"
                     /note="transcriptional regulator, SIN3B (yeast)"
                     /db_xref="GeneID:20467"
                     /db_xref="MGI:MGI:107158"
     exon            1..139
                     /gene="Sin3b"
                     /gene_synonym="2810430C10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..3337
                     /gene="Sin3b"
                     /gene_synonym="2810430C10Rik"
                     /note="isoform 1 is encoded by transcript variant 1; SIN3
                     homolog B, transcription regulator; paired amphipathic
                     helix protein Sin3b; transcriptional corepressor Sin3b;
                     histone deacetylase complex subunit Sin3b; transcriptional
                     regulator, SIN3 yeast homolog B"
                     /codon_start=1
                     /product="paired amphipathic helix protein Sin3b isoform
                     1"
                     /protein_id="NP_033214.2"
                     /db_xref="CCDS:CCDS52599.1"
                     /db_xref="GeneID:20467"
                     /db_xref="MGI:MGI:107158"
                     /translation="MAHAGSGGSAGRGFGGSRWGRSGSGGHEKLPVHVEDALTYLDQV
                     KIRFGSDPATYNGFLEIMKEFKSQSIDTPGVIRRVSQLFHEHPDLIVGFNAFLPLGYR
                     IDIPKNGKLNIQSPLSSQDNSHSHGDCGEDFKQMSYKEDRGQVPLESDSVEFNNAISY
                     VNKIKTRFLDHPEIYRSFLEILHTYQKEQLHTKGRPFRGMSEEEVFTEVANLFRGQED
                     LLSEFGQFLPEAKRSLFTGNGSCEMNSGQKNEEKSLEHNKKRSRPSLLRPVSAPAKKK
                     MKLRGTKDLSIAAVGKYGTLQEFSFFDKVRRVLKSQEVYENFLRCIALFNQELVSGSE
                     LLQLVSPFLGKFPELFAQFKSFLGVKELSFAPPMSDRSGDGISREIDYASCKRIGSSY
                     RALPKTYQQPKCSGRTAICKEVLNDTWVSFPSWSEDSTFVSSKKTPYEEQLHRCEDER
                     FELDVVLETNLATIRVLESVQKKLSRMAPEDQEKLRLDDCLGGTSEVIQRRAIHRIYG
                     DKAPEVIESLKRNPATAVPVVLKRLKAKEEEWREAQQGFNKIWREQYEKAYLKSLDHQ
                     AVNFKQNDTKALRSKSLLNEIESVYDEHQEQHSEGRSAPSSEPHLIFVYEDRQILEDA
                     AALISYYVKRQPAIQKEDQGTIRQLLHRFLPSLFFSQQCPGTSDDSADERDRDRDSAE
                     PERRRPTDEKPPADASPEPPKVLDDVYSLFFANNNWYFFLRLHQTLCARLLKIYRQAQ
                     KQLLEHRREQEREQLLCEGRREKAADPAMELRLKQPSEVELEEYYPAFLDMVRSLLEG
                     SIDPTQYEDTLREMFTIHAYIGFTMDKLVQNIARQLHHLVSDDVCLKVVELYLNEQQR
                     GAAGGNLSSRCVRAARETSYQWKAERCMADENCFKVMFLQRRGQVIMTIELLDTEEAQ
                     TEDPVEVQHLARYVEQYVGSEGASSSSTEGFLLKPVFLQRNLKKFRRWQCEQVRAMRG
                     EAKSSWKRLMGVESACDVDCRFRLGTHKMVFIVNSEDYMYRRGTLCRAKQVQPLVLLR
                     HHRHFEEWHGRWLEDNVTVAAAGLVQDWLMGEEEEDMVPCKTLCETAHVHGLPVTRYR
                     VQYSRRPASP"
     exon            140..246
                     /gene="Sin3b"
                     /gene_synonym="2810430C10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            247..400
                     /gene="Sin3b"
                     /gene_synonym="2810430C10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            401..598
                     /gene="Sin3b"
                     /gene_synonym="2810430C10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            599..742
                     /gene="Sin3b"
                     /gene_synonym="2810430C10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            743..862
                     /gene="Sin3b"
                     /gene_synonym="2810430C10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            863..952
                     /gene="Sin3b"
                     /gene_synonym="2810430C10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1071
                     /gene="Sin3b"
                     /gene_synonym="2810430C10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1279
                     /gene="Sin3b"
                     /gene_synonym="2810430C10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1396
                     /gene="Sin3b"
                     /gene_synonym="2810430C10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1635
                     /gene="Sin3b"
                     /gene_synonym="2810430C10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1819
                     /gene="Sin3b"
                     /gene_synonym="2810430C10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..2369
                     /gene="Sin3b"
                     /gene_synonym="2810430C10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2539
                     /gene="Sin3b"
                     /gene_synonym="2810430C10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..2713
                     /gene="Sin3b"
                     /gene_synonym="2810430C10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2714..2806
                     /gene="Sin3b"
                     /gene_synonym="2810430C10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2807..2901
                     /gene="Sin3b"
                     /gene_synonym="2810430C10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..3106
                     /gene="Sin3b"
                     /gene_synonym="2810430C10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3107..4135
                     /gene="Sin3b"
                     /gene_synonym="2810430C10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4112..4117
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sin3b"
                     /gene_synonym="2810430C10Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      4135
                     /gene="Sin3b"
                     /gene_synonym="2810430C10Rik"
                     /note="major polyA site"
ORIGIN      
        1 ctcaggcgga ggcggggcag aagcggctct gacttccaac atggcgcatg caggcagcgg
       61 aggctccgcg ggccggggat tcggtggctc ccgctggggt cgttcgggct ccggagggca
      121 cgagaagctg ccggtgcacg tggaggacgc tctcacctac ctcgaccagg tgaagatccg
      181 ctttggcagt gaccctgcca cctacaacgg cttcctggag atcatgaagg agttcaaaag
      241 ccagagcatc gacactcctg gtgtgatcag gcgtgtgtcc cagctcttcc atgagcaccc
      301 tgacctcatc gtggggttta atgctttcct tccgcttgga taccgtatag acattcccaa
      361 gaacggcaag ctgaacatcc agtcgccgct gagcagccag gacaactccc atagccatgg
      421 tgactgtggg gaggacttca agcagatgtc ctacaaggag gacagaggcc aggtgcccct
      481 ggagtctgac tctgtggagt tcaacaatgc tatcagctat gtgaacaaga tcaagacccg
      541 ctttctggac caccctgaga tctacaggtc cttcctggag atcctacaca cctaccagaa
      601 ggaacagctg cacactaagg gccgtccatt ccgtggcatg tctgaggagg aggttttcac
      661 agaggtggcc aatcttttcc gtggtcagga ggacctgctg tcagagttcg gacagttcct
      721 gcctgaggca aagcggtccc tgtttacagg caatgggtcg tgcgagatga acagtgggca
      781 gaagaatgag gagaagagtc tggaacacaa caagaaacgc tctcggcctt cactcctgcg
      841 ccctgtgtct gcgccagcca agaagaagat gaagctccga ggcaccaaag acctgtccat
      901 tgctgccgtg gggaaatacg gcacactgca ggaattctcc ttctttgaca aggtgcgcag
      961 ggtgctgaag agccaggagg tatatgagaa ctttctgcgc tgcattgcgc tcttcaatca
     1021 ggagctggtg tccgggtctg agttgctgca gcttgtcagt ccattcctgg ggaaatttcc
     1081 agaactcttt gcacagttca agtccttcct aggagtgaaa gagctgtcct ttgcaccacc
     1141 tatgagtgac cggtctggag atgggataag cagagaaatt gactatgcgt cttgtaagcg
     1201 aataggatcc agctatcggg cacttcccaa gacctaccag cagcccaagt gcagcggaag
     1261 gactgccatt tgcaaggagg tcctgaatga tacatgggtc tcctttccat cctggtctga
     1321 agactccacc tttgttagct ccaagaagac gccctacgag gagcaactgc atcgctgtga
     1381 ggatgagaga tttgaattgg atgttgtcct ggagaccaac ctggccacca tccgagtgct
     1441 ggagagtgtg cagaagaagt tgtcacggat ggctcctgag gaccaggaga agctccgcct
     1501 ggatgactgc ctgggtggca catcagaggt gattcaacgc cgtgccatac accgcatcta
     1561 tggagacaag gccccagagg tcattgagag cctgaaaagg aaccctgcca ccgctgtgcc
     1621 tgtcgttctg aaaaggctga aggccaagga ggaggagtgg cgggaggccc agcagggctt
     1681 caacaagatc tggcgtgagc agtacgagaa agcatacctc aagtccctgg accaccaggc
     1741 tgtgaacttc aagcagaatg acaccaaggc actgcgctct aagagcctgc tcaatgagat
     1801 cgaaagtgtc tatgatgagc accaggagca gcactcagag ggccgcagtg cgccttccag
     1861 cgagccgcac cttatcttcg tgtatgagga ccgacagatc ctagaggacg cagcagcact
     1921 catcagctac tatgttaagc ggcagccagc cattcagaaa gaggaccagg gcactatccg
     1981 ccagctgctt caccgtttcc tgcccagcct gttcttctcg cagcagtgcc ccggcacctc
     2041 cgatgactct gctgatgagc gcgaccggga ccgggacagc gctgagcctg agcgccgccg
     2101 gcccacagat gagaagcccc ctgcagatgc atctccagaa ccgcccaagg tcctggacga
     2161 tgtgtacagt ctgttttttg ccaacaacaa ctggtacttc ttcctgcggc tgcaccagac
     2221 gctgtgcgcc cgcctgctca agatctaccg gcaggcgcag aagcagctgc tggaacatcg
     2281 acgagagcag gagagggagc agctgctgtg cgagggccgc cgtgagaagg ctgcagaccc
     2341 tgccatggag ctgcgactca agcagcctag tgaagtggag ctggaggagt actacccggc
     2401 cttcctggac atggtgcgga gcctgctaga ggggagcatc gaccccacac agtatgagga
     2461 cactctccgt gagatgttca ccatccatgc ctacattggc ttcactatgg acaagctagt
     2521 gcagaacatt gcccgccagc tacaccatct ggtgagtgac gacgtatgtc tgaaggtggt
     2581 agagctgtac ctgaatgagc agcagcgagg ggcagcgggg ggaaacctgt cctccagatg
     2641 tgttcgtgca gcacgggaga ctagctatca gtggaaggcg gagcgctgca tggcagatga
     2701 gaactgcttc aaggtaatgt tcctgcagcg cagaggtcag gtgatcatga ccatagagct
     2761 cctggacaca gaagaggcac agactgagga ccctgtggag gtacagcacc tggctcgcta
     2821 tgtggagcag tatgtggggt ctgagggtgc atccagctca tctactgaag gcttcctgct
     2881 gaagccggtg ttcctgcaga ggaacctgaa gaagttccgg cgttggcagt gtgagcaggt
     2941 acgtgccatg cgcggtgagg ctaagagctc ctggaagcgg ctcatgggcg tggagagcgc
     3001 ttgtgatgtg gactgccggt tccgcttggg cacacacaag atggtgttca tcgtcaattc
     3061 cgaggactac atgtaccgcc gtgggacact atgccgtgcc aagcaggtgc agcccctggt
     3121 gttgttgcgc caccaccggc acttcgagga gtggcatggt cgctggctgg aggacaatgt
     3181 aactgtggcg gcggcagggc tggtgcagga ctggctgatg ggtgaggaag aggaggacat
     3241 ggtaccctgc aagacgcttt gcgagactgc gcatgttcac gggctgccgg tgactcgcta
     3301 ccgagtgcag tacagccgcc gccctgcttc accctgaaca tctggagggg cccccagcac
     3361 acgaacccca cacacaccac atattctgct cccaagaggg tttttgtcac tttgagcctg
     3421 gggtcgcacc ttgacctcaa gcaagcagga gctatagctc ttggcagtgt agactagacc
     3481 ccaggcaacc ccagggactg tccccagtag ggcagcccct tccggcagag ttcgagatga
     3541 cgtttgcaca tgtatttatt ccttcctgtg ctcatagtgg tcatgacttt tgaagcagca
     3601 gctccctggc ttcccacggg agagaccttc ctgtgggcct gtgaaccacc cgctgtccct
     3661 acagttgccc tctgcagggc catgtcgcca tgccaaaccc aaggtttcag agagcacttg
     3721 ttctcaaagt ttcctgagcc gttttttttt ttttttgttt gtttgttaat tggttttttt
     3781 tttgttgttg tttttttttt tgtatttttt ttttttactc cgggcctggg cactggggag
     3841 caggtgtgcc tgcccaggcc tggctgtgtg cctctcaaag gatccatggg catcttgggc
     3901 acatcctact ttcctgagac gggcattgca cgtggggacc ccaagccgcc tcagaccctc
     3961 tgggcctccc ttccccagag gggagcccgg gcacacttgc atgcttctgg ggatctgctc
     4021 cttaacgttt ttgagcaatt tctgttccag ctttgacctc catttgcagc tgttttgaat
     4081 gtagggtttt tttttttcta tttatttgca cattaaagtt aaatattgat gccaa
//
