LOCUS       NP_033214               1098 aa            linear   ROD 10-FEB-2025
DEFINITION  paired amphipathic helix protein Sin3b isoform 1 [Mus musculus].
ACCESSION   NP_033214
VERSION     NP_033214.2
DBSOURCE    REFSEQ: accession NM_009188.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1098)
  AUTHORS   Calderon,A., Mestvirishvili,T., Boccalatte,F., Ruggles,K.V. and
            David,G.
  TITLE     Chromatin accessibility and cell cycle progression are controlled
            by the HDAC-associated Sin3B protein in murine hematopoietic stem
            cells
  JOURNAL   Epigenetics Chromatin 17 (1), 2 (2024)
   PUBMED   38254205
  REMARK    GeneRIF: Chromatin accessibility and cell cycle progression are
            controlled by the HDAC-associated Sin3B protein in murine
            hematopoietic stem cells.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1098)
  AUTHORS   Yang,X., Graff,S.M., Heiser,C.N., Ho,K.H., Chen,B., Simmons,A.J.,
            Southard-Smith,A.N., David,G., Jacobson,D.A., Kaverina,I.,
            Wright,C.V.E., Lau,K.S. and Gu,G.
  TITLE     Coregulator Sin3a Promotes Postnatal Murine beta-Cell Fitness by
            Regulating Genes in Ca2+ Homeostasis, Cell Survival, Vesicle
            Biosynthesis, Glucose Metabolism, and Stress Response
  JOURNAL   Diabetes 69 (6), 1219-1231 (2020)
   PUBMED   32245798
  REMARK    GeneRIF: Coregulator Sin3a Promotes Postnatal Murine beta-Cell
            Fitness by Regulating Genes in Ca(2+) Homeostasis, Cell Survival,
            Vesicle Biosynthesis, Glucose Metabolism, and Stress Response.
REFERENCE   3  (residues 1 to 1098)
  AUTHORS   Langlet,F., Tarbier,M., Haeusler,R.A., Camastra,S., Ferrannini,E.,
            Friedlander,M.R. and Accili,D.
  TITLE     microRNA-205-5p is a modulator of insulin sensitivity that inhibits
            FOXO function
  JOURNAL   Mol Metab 17, 49-60 (2018)
   PUBMED   30174230
REFERENCE   4  (residues 1 to 1098)
  AUTHORS   Kurita,J.I., Hirao,Y., Nakano,H., Fukunishi,Y. and Nishimura,Y.
  TITLE     Sertraline, chlorprothixene, and chlorpromazine characteristically
            interact with the REST-binding site of the corepressor mSin3,
            showing medulloblastoma cell growth inhibitory activities
  JOURNAL   Sci Rep 8 (1), 13763 (2018)
   PUBMED   30213984
  REMARK    GeneRIF: Active compounds showed a new chemo-type for inhibitors of
            the REST/NRSF-mSin3 interaction, raising the possibility of new
            therapies for neuropathies caused by dysregulation of REST/NRSF.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1098)
  AUTHORS   Langlet,F., Haeusler,R.A., Linden,D., Ericson,E., Norris,T.,
            Johansson,A., Cook,J.R., Aizawa,K., Wang,L., Buettner,C. and
            Accili,D.
  TITLE     Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates
            Hepatic Glucose Handling
  JOURNAL   Cell 171 (4), 824-835 (2017)
   PUBMED   29056338
REFERENCE   6  (residues 1 to 1098)
  AUTHORS   Heinzel,T., Lavinsky,R.M., Mullen,T.M., Soderstrom,M.,
            Laherty,C.D., Torchia,J., Yang,W.M., Brard,G., Ngo,S.D.,
            Davie,J.R., Seto,E., Eisenman,R.N., Rose,D.W., Glass,C.K. and
            Rosenfeld,M.G.
  TITLE     A complex containing N-CoR, mSin3 and histone deacetylase mediates
            transcriptional repression
  JOURNAL   Nature 387 (6628), 43-48 (1997)
   PUBMED   9139820
REFERENCE   7  (residues 1 to 1098)
  AUTHORS   Hurlin,P.J., Queva,C., Koskinen,P.J., Steingrimsson,E., Ayer,D.E.,
            Copeland,N.G., Jenkins,N.A. and Eisenman,R.N.
  TITLE     Mad3 and Mad4: novel Max-interacting transcriptional repressors
            that suppress c-myc dependent transformation and are expressed
            during neural and epidermal differentiation
  JOURNAL   EMBO J 15 (8), 2030 (1996)
   PUBMED   8617250
  REMARK    Correction to:[EMBO J. 1995 Nov 15;14(22):5646-59. doi:
            10.1002/j.1460-2075.1995.tb00252.x.. PMID: 8521822]
REFERENCE   8  (residues 1 to 1098)
  AUTHORS   Rao,G., Alland,L., Guida,P., Schreiber-Agus,N., Chen,K., Chin,L.,
            Rochelle,J.M., Seldin,M.F., Skoultchi,A.I. and DePinho,R.A.
  TITLE     Mouse Sin3A interacts with and can functionally substitute for the
            amino-terminal repression of the Myc antagonist Mxi1
  JOURNAL   Oncogene 12 (5), 1165-1172 (1996)
   PUBMED   8649810
REFERENCE   9  (residues 1 to 1098)
  AUTHORS   Hurlin,P.J., Queva,C., Koskinen,P.J., Steingrimsson,E., Ayer,D.E.,
            Copeland,N.G., Jenkins,N.A. and Eisenman,R.N.
  TITLE     Mad3 and Mad4: novel Max-interacting transcriptional repressors
            that suppress c-myc dependent transformation and are expressed
            during neural and epidermal differentiation
  JOURNAL   EMBO J 14 (22), 5646-5659 (1995)
   PUBMED   8521822
  REMARK    Erratum:[EMBO J. 1996 Apr 15;15(8):2030.. PMID: 8617250]
REFERENCE   10 (residues 1 to 1098)
  AUTHORS   Ayer,D.E., Lawrence,Q.A. and Eisenman,R.N.
  TITLE     Mad-Max transcriptional repression is mediated by ternary complex
            formation with mammalian homologs of yeast repressor Sin3
  JOURNAL   Cell 80 (5), 767-776 (1995)
   PUBMED   7889570
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC171917.14 and AK169433.1.
            
            On Jan 3, 2008 this sequence version replaced NP_033214.1.
            
            Transcript Variant: This variant (1) represents the longer variant
            and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159076.1, ERR3363658.3034776.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1098
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 35.08 cM"
     Protein         1..1098
                     /product="paired amphipathic helix protein Sin3b isoform
                     1"
                     /note="SIN3 homolog B, transcription regulator; paired
                     amphipathic helix protein Sin3b; transcriptional
                     corepressor Sin3b; histone deacetylase complex subunit
                     Sin3b; transcriptional regulator, SIN3 yeast homolog B"
                     /calculated_mol_wt=126275
     Region          1..299
                     /region_name="Interaction with CRY1.
                     /evidence=ECO:0000269|PubMed:15226430"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62141.2)"
     Region          1..26
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62141.2)"
     Region          31..1009
                     /region_name="Sin3"
                     /note="Histone deacetylase complex, regulatory component
                     SIN3 [Chromatin structure and dynamics]; COG5602"
                     /db_xref="CDD:227889"
     Region          52..98
                     /region_name="Interaction with REST.
                     /evidence=ECO:0000269|PubMed:16288918"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62141.2)"
     Region          238..274
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62141.2)"
     Region          275..499
                     /region_name="Interaction with NCOR1.
                     /evidence=ECO:0000269|PubMed:9139820"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62141.2)"
     Region          383..550
                     /region_name="Interaction with SUDS3 and HDAC1.
                     /evidence=ECO:0000269|PubMed:11909966"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62141.2)"
     Region          661..702
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62141.2)"
     Site            667
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q62141.2)"
     Site            670
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q62141.2)"
     CDS             1..1098
                     /gene="Sin3b"
                     /gene_synonym="2810430C10Rik"
                     /coded_by="NM_009188.4:41..3337"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS52599.1"
                     /db_xref="GeneID:20467"
                     /db_xref="MGI:MGI:107158"
ORIGIN      
        1 mahagsggsa grgfggsrwg rsgsgghekl pvhvedalty ldqvkirfgs dpatyngfle
       61 imkefksqsi dtpgvirrvs qlfhehpdli vgfnaflplg yridipkngk lniqsplssq
      121 dnshshgdcg edfkqmsyke drgqvplesd svefnnaisy vnkiktrfld hpeiyrsfle
      181 ilhtyqkeql htkgrpfrgm seeevfteva nlfrgqedll sefgqflpea krslftgngs
      241 cemnsgqkne ekslehnkkr srpsllrpvs apakkkmklr gtkdlsiaav gkygtlqefs
      301 ffdkvrrvlk sqevyenflr cialfnqelv sgsellqlvs pflgkfpelf aqfksflgvk
      361 elsfappmsd rsgdgisrei dyasckrigs syralpktyq qpkcsgrtai ckevlndtwv
      421 sfpswsedst fvsskktpye eqlhrceder feldvvletn latirvlesv qkklsrmape
      481 dqeklrlddc lggtseviqr raihriygdk apevieslkr npatavpvvl krlkakeeew
      541 reaqqgfnki wreqyekayl ksldhqavnf kqndtkalrs ksllneiesv ydehqeqhse
      601 grsapsseph lifvyedrqi ledaaalisy yvkrqpaiqk edqgtirqll hrflpslffs
      661 qqcpgtsdds aderdrdrds aeperrrptd ekppadaspe ppkvlddvys lffannnwyf
      721 flrlhqtlca rllkiyrqaq kqllehrreq ereqllcegr rekaadpame lrlkqpseve
      781 leeyypafld mvrsllegsi dptqyedtlr emftihayig ftmdklvqni arqlhhlvsd
      841 dvclkvvely lneqqrgaag gnlssrcvra aretsyqwka ercmadencf kvmflqrrgq
      901 vimtielldt eeaqtedpve vqhlaryveq yvgsegasss stegfllkpv flqrnlkkfr
      961 rwqceqvram rgeaksswkr lmgvesacdv dcrfrlgthk mvfivnsedy myrrgtlcra
     1021 kqvqplvllr hhrhfeewhg rwlednvtva aaglvqdwlm geeeedmvpc ktlcetahvh
     1081 glpvtryrvq ysrrpasp
//
