LOCUS       NP_001103820            1277 aa            linear   ROD 14-FEB-2025
DEFINITION  paired amphipathic helix protein Sin3a isoform 2 [Mus musculus].
ACCESSION   NP_001103820
VERSION     NP_001103820.1
DBSOURCE    REFSEQ: accession NM_001110350.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1277)
  AUTHORS   Stokes,G., Li,Z., Talaba,N., Genthe,W., Brix,M.B., Pham,B.,
            Wienhold,M.D., Sandok,G., Hernan,R., Wynn,J., Tang,H., Tabima,D.M.,
            Rodgers,A., Hacker,T.A., Chesler,N.C., Zhang,P., Murad,R.,
            Yuan,J.X., Shen,Y., Chung,W.K. and McCulley,D.J.
  TITLE     Rescuing lung development through embryonic inhibition of histone
            acetylation
  JOURNAL   Sci Transl Med 16 (732), eadc8930 (2024)
   PUBMED   38295182
REFERENCE   2  (residues 1 to 1277)
  AUTHORS   Perucho,L., Icardi,L., Di Simone,E., Basso,V., Agresti,A., Vilas
            Zornoza,A., Lozano,T., Prosper,F., Lasarte,J.J. and Mondino,A.
  TITLE     The transcriptional regulator Sin3A balances IL-17A and Foxp3
            expression in primary CD4 T cells
  JOURNAL   EMBO Rep 24 (5), e55326 (2023)
   PUBMED   36929576
  REMARK    GeneRIF: The transcriptional regulator Sin3A balances IL-17A and
            Foxp3 expression in primary CD4 T cells.
REFERENCE   3  (residues 1 to 1277)
  AUTHORS   Zhang,X., Zhang,C., Zhou,D., Zhang,T., Chen,X., Ren,J., He,C.,
            Meng,F., Zhou,Q., Yang,Q., Dai,C., Lin,G., Zeng,S. and Leng,L.
  TITLE     Telomeres cooperate in zygotic genome activation by affecting
            DUX4/Dux transcription
  JOURNAL   iScience 26 (3), 106158 (2023)
   PUBMED   36843839
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1277)
  AUTHORS   Bartolome,A., Ravussin,Y., Yu,J., Ferrante,A.W. and Pajvani,U.B.
  TITLE     An Overfeeding-Induced Obesity Mouse Model Reveals Necessity for
            Sin3a in Postnatal Peak beta-Cell Mass Acquisition
  JOURNAL   Diabetes 71 (11), 2395-2401 (2022)
   PUBMED   35944274
  REMARK    GeneRIF: An Overfeeding-Induced Obesity Mouse Model Reveals
            Necessity for Sin3a in Postnatal Peak beta-Cell Mass Acquisition.
REFERENCE   5  (residues 1 to 1277)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1277)
  AUTHORS   Hurlin,P.J., Queva,C., Koskinen,P.J., Steingrimsson,E., Ayer,D.E.,
            Copeland,N.G., Jenkins,N.A. and Eisenman,R.N.
  TITLE     Mad3 and Mad4: novel Max-interacting transcriptional repressors
            that suppress c-myc dependent transformation and are expressed
            during neural and epidermal differentiation
  JOURNAL   EMBO J 15 (8), 2030 (1996)
   PUBMED   8617250
  REMARK    Correction to:[EMBO J. 1995 Nov 15;14(22):5646-59. doi:
            10.1002/j.1460-2075.1995.tb00252.x.. PMID: 8521822]
REFERENCE   7  (residues 1 to 1277)
  AUTHORS   Hurlin,P.J., Queva,C., Koskinen,P.J., Steingrimsson,E., Ayer,D.E.,
            Copeland,N.G., Jenkins,N.A. and Eisenman,R.N.
  TITLE     Mad3 and Mad4: novel Max-interacting transcriptional repressors
            that suppress c-myc dependent transformation and are expressed
            during neural and epidermal differentiation
  JOURNAL   EMBO J 14 (22), 5646-5659 (1995)
   PUBMED   8521822
  REMARK    Erratum:[EMBO J. 1996 Apr 15;15(8):2030.. PMID: 8617250]
REFERENCE   8  (residues 1 to 1277)
  AUTHORS   Halleck,M.S., Pownall,S., Harder,K.W., Duncan,A.M., Jirik,F.R. and
            Schlegel,R.A.
  TITLE     A widely distributed putative mammalian transcriptional regulator
            containing multiple paired amphipathic helices, with similarity to
            yeast SIN3
  JOURNAL   Genomics 26 (2), 403-406 (1995)
   PUBMED   7601471
REFERENCE   9  (residues 1 to 1277)
  AUTHORS   Schreiber-Agus,N., Chin,L., Chen,K., Torres,R., Rao,G., Guida,P.,
            Skoultchi,A.I. and DePinho,R.A.
  TITLE     An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic
            activity and interacts with a homolog of the yeast transcriptional
            repressor SIN3
  JOURNAL   Cell 80 (5), 777-786 (1995)
   PUBMED   7889571
REFERENCE   10 (residues 1 to 1277)
  AUTHORS   Ayer,D.E., Lawrence,Q.A. and Eisenman,R.N.
  TITLE     Mad-Max transcriptional repression is mediated by ternary complex
            formation with mammalian homologs of yeast repressor Sin3
  JOURNAL   Cell 80 (5), 767-776 (1995)
   PUBMED   7889570
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132406.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and uses
            an alternate in-frame splice junction compared to variant 1. The
            resulting isoform (2) has the same N- and C-termini but is longer
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220292.1, SRR17784645.1050424.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1277
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 30.89 cM"
     Protein         1..1277
                     /product="paired amphipathic helix protein Sin3a isoform
                     2"
                     /note="paired amphipathic helix protein Sin3a;
                     transcriptional corepressor Sin3a; histone deacetylase
                     complex subunit Sin3a; transcriptional regulator, SIN3
                     yeast homolog A"
                     /calculated_mol_wt=145344
     Region          1..26
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60520.3)"
     Region          8..1217
                     /region_name="Sin3"
                     /note="Histone deacetylase complex, regulatory component
                     SIN3 [Chromatin structure and dynamics]; COG5602"
                     /db_xref="CDD:227889"
     Site            10
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96ST3; propagated from
                     UniProtKB/Swiss-Prot (Q60520.3)"
     Region          85..110
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60520.3)"
     Region          119..196
                     /region_name="Interaction with HCFC1.
                     /evidence=ECO:0000250|UniProtKB:Q96ST3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60520.3)"
     Region          205..479
                     /region_name="Interaction with REST.
                     /evidence=ECO:0000269|PubMed:10734093"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60520.3)"
     Region          205..297
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60520.3)"
     Site            277
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q60520.3)"
     Site            284
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q60520.3)"
     Region          398..443
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60520.3)"
     Region          459..526
                     /region_name="Interaction with SAP30.
                     /evidence=ECO:0000269|PubMed:9702189"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60520.3)"
     Site            470
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q96ST3; propagated from
                     UniProtKB/Swiss-Prot (Q60520.3)"
     Region          524..851
                     /region_name="Interaction with NCOR1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60520.3)"
     Region          525..660
                     /region_name="Interactions with SUDS3 and SAP130.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60520.3)"
     Region          688..830
                     /region_name="Interactions with HDAC1 and ARID4B.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60520.3)"
     Site            833
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:15345747,
                     ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (Q60520.3)"
     Region          835..865
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60520.3)"
     Site            861
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96ST3; propagated from
                     UniProtKB/Swiss-Prot (Q60520.3)"
     Site            866
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q60520.3)"
     Site            876
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q60520.3)"
     Region          889..968
                     /region_name="Interaction with OGT. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60520.3)"
     Site            941
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96ST3; propagated from
                     UniProtKB/Swiss-Prot (Q60520.3)"
     Site            1090
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96ST3; propagated from
                     UniProtKB/Swiss-Prot (Q60520.3)"
     Site            1116
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q60520.3)"
     Region          1140..1160
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60520.3)"
     CDS             1..1277
                     /gene="Sin3a"
                     /gene_synonym="mKIAA4126; mSin3A; Sin3"
                     /coded_by="NM_001110350.2:292..4125"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS52805.1"
                     /db_xref="GeneID:20466"
                     /db_xref="MGI:MGI:107157"
ORIGIN      
        1 mkrrlddqes pvyaaqqrri pgsteafshq hrvlapappv yeavsetmqs atgiqysvap
       61 nyqvsavpqs sgshgpaiaa vhsshhhpta vqphggqvvq shahpappva pvqgqqqfqr
      121 lkvedalsyl dqvklqfgsq pqvyndfldi mkefksqsid tpgvisrvsq lfkghpdlim
      181 gfntflppgy kievqtndmv nvttpgqvhq ipthgiqpqp qpppqhpsqp ssqsaptpaq
      241 papqptaakv skpsqlqaht pasqqtpplp pyasprsppv qphtpvtisl gtapslqnnq
      301 pvefnhainy vnkiknrfqg qpdiykafle ilhtyqkeqr nakeaggnyt palteqevya
      361 qvarlfknqe dllsefgqfl pdanssvlls kttaekvdsv rndhggtvkk pqlnnkpqrp
      421 sqngcqirrh sgtgatppvk kkpklmslke ssmadaskhg vgteslffdk vrkalrsaea
      481 yenflrclvi fnqevisrae lvqlvspflg kfpelfnwfk nflgykesvh lesfpkerat
      541 egiameidya sckrlgssyr alpksyqqpk ctgrtplcke vlndtwvsfp swsedstfvs
      601 skktqyeehi yrcederfel dvvletnlat irvleaiqkk lsrlsaeeqa kfrldntlgg
      661 tsevihrkal qriyadkaad iidglrknps iavpivlkrl kmkeeewrea qrgfnkvwre
      721 qnekyylksl dhqginfkqn dtkvlrsksl lneiesiyde rqeqateena gvpvgphlsl
      781 ayedkqiled aaaliihhvk rqtgiqkedk ykikqimhhf ipdllfaqrg dlsdveeeee
      841 eemdvdeatg apkkhngvgg sppkskllfs ntaaqklrgm devynlfyvn nnwyifmrlh
      901 qilclrllri csqaerqiee enrerewere vlgikrdksd spaiqlrlke pmdvdvedyy
      961 pafldmvrsl ldgnidssqy edslremfti hayiaftmdk liqsivrqlq hivsdevcvq
     1021 vtdlylaenn ngatggqlns qtsrsllesa yqrkaeqlms dencfklmfi qsqgqvqltv
     1081 elldteeens ddpveaevwt rwsdyverym ssdttspelr ehlaqkpvfl prnlrrirkc
     1141 qrgreqqeke gkegnskktm envesldkle crfklnsykm vyviksedym yrrtallrah
     1201 qshervskrl hqrfqawvdk wtkehvprem aaetskwlmg egleglvpct ttcdtetlhf
     1261 vsinkyrvky gtvfkap
//
