LOCUS       NM_011377               3670 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus single-minded family bHLH transcription factor 2
            (Sim2), mRNA.
ACCESSION   NM_011377 XM_193849 XM_207055
VERSION     NM_011377.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3670)
  AUTHORS   Yan,F., Suzuki,A., Iwaya,C., Pei,G., Chen,X., Yoshioka,H., Yu,M.,
            Simon,L.M., Iwata,J. and Zhao,Z.
  TITLE     Single-cell multiomics decodes regulatory programs for mouse
            secondary palate development
  JOURNAL   Nat Commun 15 (1), 821 (2024)
   PUBMED   38280850
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3670)
  AUTHORS   Sanchez,L., Epps,J., Wall,S., McQueen,C., Pearson,S.J.,
            Scribner,K., Wellberg,E.A., Giles,E.D., Rijnkels,M. and Porter,W.W.
  TITLE     SIM2s directed Parkin-mediated mitophagy promotes mammary
            epithelial cell differentiation
  JOURNAL   Cell Death Differ 30 (6), 1472-1487 (2023)
   PUBMED   36966227
REFERENCE   3  (bases 1 to 3670)
  AUTHORS   Xu,P., He,H., Gao,Q., Zhou,Y., Wu,Z., Zhang,X., Sun,L., Hu,G.,
            Guan,Q., You,Z., Zhang,X., Zheng,W., Xiong,M. and Chen,Y.
  TITLE     Human midbrain dopaminergic neuronal differentiation markers
            predict cell therapy outcomes in a Parkinson's disease model
  JOURNAL   J Clin Invest 132 (14) (2022)
   PUBMED   35700056
REFERENCE   4  (bases 1 to 3670)
  AUTHORS   Xu,J., Liu,H., Lan,Y., Park,J.S. and Jiang,R.
  TITLE     Genome-wide Identification of Foxf2 Target Genes in Palate
            Development
  JOURNAL   J Dent Res 99 (4), 463-471 (2020)
   PUBMED   32040930
REFERENCE   5  (bases 1 to 3670)
  AUTHORS   Vanyai,H.K., Garnham,A., May,R.E., McRae,H.M., Collin,C.,
            Wilcox,S., Smyth,G.K., Thomas,T. and Voss,A.K.
  TITLE     MOZ directs the distal-less homeobox gene expression program during
            craniofacial development
  JOURNAL   Development 146 (14) (2019)
   PUBMED   31340933
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3670)
  AUTHORS   Moffett,P., Dayo,M., Reece,M., McCormick,M.K. and Pelletier,J.
  TITLE     Characterization of msim, a murine homologue of the Drosophila sim
            transcription factor
  JOURNAL   Genomics 35 (1), 144-155 (1996)
   PUBMED   8661115
REFERENCE   7  (bases 1 to 3670)
  AUTHORS   Yamaki,A., Noda,S., Kudoh,J., Shindoh,N., Maeda,H., Minoshima,S.,
            Kawasaki,K., Shimizu,Y. and Shimizu,N.
  TITLE     The mammalian single-minded (SIM) gene: mouse cDNA structure and
            diencephalic expression indicate a candidate gene for Down syndrome
  JOURNAL   Genomics 35 (1), 136-143 (1996)
   PUBMED   8661114
REFERENCE   8  (bases 1 to 3670)
  AUTHORS   Ema,M., Suzuki,M., Morita,M., Hirose,K., Sogawa,K., Matsuda,Y.,
            Gotoh,O., Saijoh,Y., Fujii,H., Hamada,H. and Fujii-Kuriyama,Y.
  TITLE     cDNA cloning of a murine homologue of Drosophila single-minded, its
            mRNA expression in mouse development, and chromosome localization
  JOURNAL   Biochem Biophys Res Commun 218 (2), 588-594 (1996)
   PUBMED   8561800
REFERENCE   9  (bases 1 to 3670)
  AUTHORS   Fan,C.M., Kuwana,E., Bulfone,A., Fletcher,C.F., Copeland,N.G.,
            Jenkins,N.A., Crews,S., Martinez,S., Puelles,L., Rubenstein,J.L.
            and Tessier-Lavigne,M.
  TITLE     Expression patterns of two murine homologs of Drosophila
            single-minded suggest possible roles in embryonic patterning and in
            the pathogenesis of Down syndrome
  JOURNAL   Mol Cell Neurosci 7 (1), 1-16 (1996)
   PUBMED   8812055
  REMARK    Erratum:[Mol Cell Neurosci 1996 Jun;7(6):519]
REFERENCE   10 (bases 1 to 3670)
  AUTHORS   Muenke,M., Bone,L.J., Mitchell,H.F., Hart,I., Walton,K.,
            Hall-Johnson,K., Ippel,E.F., Dietz-Band,J., Kvaloy,K., Fan,C.M. et
            al.
  TITLE     Physical mapping of the holoprosencephaly critical region in
            21q22.3, exclusion of SIM2 as a candidate gene for
            holoprosencephaly, and mapping of SIM2 to a region of chromosome 21
            important for Down syndrome
  JOURNAL   Am J Hum Genet 57 (5), 1074-1079 (1995)
   PUBMED   7485157
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D63383.1, U42554.1 and CU207273.8.
            
            On Dec 9, 2006 this sequence version replaced NM_011377.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D64135.1, U42554.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1343              D63383.1           7-1349
            1344-2070           U42554.1           1016-1742
            2071-2467           D63383.1           2077-2473
            2468-3670           CU207273.8         26177-27379
FEATURES             Location/Qualifiers
     source          1..3670
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 55.05 cM"
     gene            1..3670
                     /gene="Sim2"
                     /gene_synonym="bHLHe15"
                     /note="single-minded family bHLH transcription factor 2"
                     /db_xref="GeneID:20465"
                     /db_xref="MGI:MGI:98307"
     exon            1..731
                     /gene="Sim2"
                     /gene_synonym="bHLHe15"
                     /inference="alignment:Splign:2.1.0"
     CDS             557..2530
                     /gene="Sim2"
                     /gene_synonym="bHLHe15"
                     /note="single-minded 2; mSIM; SIM transcription factor"
                     /codon_start=1
                     /product="single-minded homolog 2"
                     /protein_id="NP_035507.2"
                     /db_xref="CCDS:CCDS37406.1"
                     /db_xref="GeneID:20465"
                     /db_xref="MGI:MGI:98307"
                     /translation="MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIR
                     LTTSYLKMRAVFPEGLGDAWGQPSRTGPLDSVAKELGSHLLQTLDGFVFVVASDGKIM
                     YISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHPPLHHHLLQEYEIERSF
                     FLRMKCVLAKRNAGLTCSGYKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLP
                     PSAITEIKLHSNMFMFRASLDLKLIFLDSRVTELTGYEPQDLIEKTLYHHVHGCDTFH
                     LRYAHHLLLVKGQVTTKYYRLLSKLGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTD
                     VEYKELQLSLDQVSTSKSQESWRTTLSTSQETRKSAKPKNTKMKTKLRTNPYPPQQYS
                     SFQMDKLECSQVGNWRTSPPTNAVAPPEQQLHSEASDLLYGPPYSLPFSYHYGHFPLD
                     SHVFSSKKPGLPAKFGQPQGSPCEVARFFLSTLPASSECQWHCANSLVPSSSSPAKNL
                     SEPSPVNAARHGLVPNYEAPSAAARRFCEDPAPPSFPSCGHYREEPALGPAKAPRQAS
                     RDAARLALARAPPECCAPPAPEPQAPAQLPFVLLNYHRVLARRGPLGSAAPGAPEAAG
                     SLRPRHPGPVAASAPGAPRPHYLGASVIITNGR"
     exon            732..814
                     /gene="Sim2"
                     /gene_synonym="bHLHe15"
                     /inference="alignment:Splign:2.1.0"
     exon            815..904
                     /gene="Sim2"
                     /gene_synonym="bHLHe15"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1013
                     /gene="Sim2"
                     /gene_synonym="bHLHe15"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1099
                     /gene="Sim2"
                     /gene_synonym="bHLHe15"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1299
                     /gene="Sim2"
                     /gene_synonym="bHLHe15"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1406
                     /gene="Sim2"
                     /gene_synonym="bHLHe15"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1554
                     /gene="Sim2"
                     /gene_synonym="bHLHe15"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1723
                     /gene="Sim2"
                     /gene_synonym="bHLHe15"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..2135
                     /gene="Sim2"
                     /gene_synonym="bHLHe15"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..3670
                     /gene="Sim2"
                     /gene_synonym="bHLHe15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3643..3648
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sim2"
                     /gene_synonym="bHLHe15"
                     /note="hexamer: AATAAA"
     polyA_site      3670
                     /gene="Sim2"
                     /gene_synonym="bHLHe15"
                     /note="major polyA site"
ORIGIN      
        1 gccaccgatc gcgggctccg gacgaccgga ctaaggaagc cggaaccgcc ggggagggca
       61 ggaaagcgca ccgagctcag gcttggcact ggccactgcc acctcgctcc gctcccgccc
      121 catggctccg cggcggccgc cgccgctgcc gcccttgcct tccgagggcc ctcgcggcag
      181 cgggtacaag ccctccttta aggactaaac agggtcggcg cctgctcgcc cgccaaccac
      241 agccccagga aggtcgaggc gggagatact ggagaccaga aggaagagcg agctgggatc
      301 aggtccacac gggacggtcc agcctccagc ctcagacaga gaggggggct gcgcagctgg
      361 tttgcgacgg actcagggct ggcgccttgc agaagacgtt gggtgctcca ggccggtctc
      421 ccgcacctgc ccgagcccgg caccccgact cacctgaccc ctggcgtccc tgtccccatt
      481 ccggctgccg cagcccaagc gggactccgc gggcctggag cgcagcgagg tctaatatgc
      541 ccagagccga ggcgcgatga aggagaagtc caaaaatgcg gccaaaacca ggagggagaa
      601 ggaaaatggc gagttttacg agctggccaa gctgctcccg ctgccttcgg ccatcacctc
      661 gcagctggac aaagcgtcca tcatccgact caccaccagc tacctgaaga tgcgcgcggt
      721 cttcccggaa ggtctaggag acgcgtgggg acagccgagc aggacagggc ctctggacag
      781 cgtggcaaaa gagctgggat cccatttgct gcagactcta gatggatttg tgttcgtggt
      841 ggcctctgat ggcaaaatca tgtatatatc tgagaccgct tctgtccatt taggcttgtc
      901 ccaggtggag ctcacaggca acagtattta tgaatacata catccttctg accacgacga
      961 gatgacagcc gtacttacag cccacccacc gctccaccat cacctgctcc aagagtacga
     1021 gatagagcgg tctttctttc ttcgaatgaa gtgcgtcttg gcaaaacgaa acgcaggcct
     1081 gacatgcagt ggatacaagg tcattcactg cagcggctac ctaaagatca gacagtacat
     1141 gctggacatg tccctgtacg actcctgtta ccagatcgtg gggctggtgg ccgtgggcca
     1201 gtcgctaccg cccagcgcca tcacggagat caagctccac agcaacatgt tcatgttcag
     1261 ggccagcctt gacctgaagc tcatattcct ggactccagg gtgacagagc ttacgggcta
     1321 tgagccacaa gacctgatcg aaaagacact gtaccatcat gtgcatggct gtgacacctt
     1381 ccacctccga tatgcacacc acctcttgct ggtgaagggc caggtcacca ccaaatacta
     1441 ccggctgctg tccaagctgg gcggctgggt ctgggtgcag agctacgcca ccgtggtgca
     1501 caacagccgc tcctcccggc ctcactgcat cgtgagtgtc aattatgttc tcacggatgt
     1561 tgaatacaag gaacttcagc tgtctctgga ccaggtatcc acctctaagt cccaggagtc
     1621 ctggagaacc accttgtcta cctcacaaga aactaggaaa tcagctaaac ccaaaaacac
     1681 aaagatgaag acaaagctga gaaccaaccc atatccccca cagcaataca gctccttcca
     1741 aatggacaaa ctggagtgca gccaggtggg aaactggaga actagtcccc ccacaaatgc
     1801 tgtggctccc ccggaacagc agctccattc agaagccagc gaccttttat atgggccgcc
     1861 ctacagcctc cccttctcct accattatgg acacttccca ttggactctc acgtcttcag
     1921 cagcaagaag ccaggattgc ccgccaagtt cgggcagccc caaggatccc cgtgtgaggt
     1981 ggcacgcttc ttcctgagca cactgccagc cagcagcgaa tgccagtggc actgtgccaa
     2041 ctctctagtg cccagcagct catcgccagc taaaaacctt tctgagcctt ctcctgtgaa
     2101 tgctgcccgg catggtcttg tgccaaacta tgaagcgccc tccgcagccg cgcgcaggtt
     2161 ctgcgaggac cccgcgcccc caagcttccc gagctgcggc cactaccgcg aggagccggc
     2221 gctgggccct gccaaggcgc ctcgccaggc gtcccgggac gcagcccggc tggcgctggc
     2281 ccgagcgccc cccgagtgct gcgcgccgcc cgcccccgag ccgcaggcgc cggcgcagtt
     2341 gcccttcgtg ctgctcaact accaccgcgt gctggcgcgc cgcgggcctc tggggagcgc
     2401 tgcgcccgga gcccccgagg cggccggctc gctgaggccc cgacacccag gccccgtcgc
     2461 cgcctctgcg cccggcgcgc cccgaccgca ttacctgggc gcctcggtca tcatcaccaa
     2521 cggcaggtga cccgccaggg ccagtcccgc tcggcagggc ggccctcagg gagaagccat
     2581 aggccaggcc ttctctggtt cctctttcac ccccaaggtc cagcagatgg aggggcgaac
     2641 tgtatatgca cgatataaat taatttatac agagacaact attttaatag aactccgcag
     2701 ccgactttta gatttttacc gtagatgctg gtgtagaggg ttgggacgca gttgggaaat
     2761 ggggagaagg gactgcccat tcctgtccaa gggccggttt tcatggggct gagcatccag
     2821 gtgtcaatct gtgacctcaa actaccgtct ccagggatct tggtttcctc accatgaagc
     2881 caatcaagcc gaggtccaat aatgggaatt caagacattg catacagctt ggcagacaga
     2941 tgccacttta agaccctcac tccccccccc cccgagcccc cctctgtggt cctctgttcc
     3001 cgaggggtac agacagggtg gaaagtccct tcagagtcct tttggacact tgtaaacgca
     3061 gaatgttatc cttgtaagtc ccacgtgcag acaacagttt ctgctgtctt tgaactcatg
     3121 catctcattt ttaaatttaa tccttttaaa aatacaaaag ccaacaagga gaggctaagg
     3181 aggcagacgt gcaagcctat tgtgtgcatg cacacgggtg tgcttccgaa gcacactaac
     3241 aagctcgctc ataaccgagc ccttaggaac tctggttgac acaagttgca ccttcaaaat
     3301 atgaagtagg cattaaatgc aaaaacgata tatatagcca ggcatgttag agaatggccc
     3361 tgtcaagcac ctccctggca gcatccctcc agcccgcaca gatttgctag tcctacgctt
     3421 gtgtttgctt gcgattagga actcttaaag ctagttaaac tgcatgtgca atacggaaac
     3481 cagaacggac tgcaccttgt ggaagaaaaa catgcttaag ggatgtattg aaagcggtgt
     3541 atacatttaa gcgttttcta cgtagcaaga gcttcatacg aacatgttgt gtgtaacagg
     3601 tgaatggaga tcctttttat aaacttacca gcagtgttta aaaataaatt tccattactt
     3661 ttgtttcaca
//
