LOCUS       NM_025679               2798 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus suppressor of IKBKE 1 (Sike1), mRNA.
ACCESSION   NM_025679 NM_028311
VERSION     NM_025679.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2798)
  AUTHORS   Dias,A.P., Rehmani,T., Applin,B.D., Salih,M. and Tuana,B.
  TITLE     SLMAP3 is crucial for organogenesis through mechanisms involving
            primary cilia formation
  JOURNAL   Open Biol 14 (10), rsob240206 (2024)
   PUBMED   39417621
REFERENCE   2  (bases 1 to 2798)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2798)
  AUTHORS   Bai,L., Qu,W., Cheng,X., Yang,H., Huang,Y.P., Wang,Z., Han,C.,
            Tian,R.F., Hu,F., Yang,L., Tian,S., Tian,H., Cai,Z., Wan,J.,
            Jiang,J., Fu,J., Zhou,J., Hu,Y., Ma,T., Zhang,X., Ji,Y.X., Cai,J.,
            She,Z.G., Wang,Y., Zhang,P., Huang,L., Li,H. and Zhang,X.J.
  TITLE     Multispecies transcriptomics identifies SIKE as a MAPK repressor
            that prevents NASH progression
  JOURNAL   Sci Transl Med 16 (734), eade7347 (2024)
   PUBMED   38354227
  REMARK    GeneRIF: Multispecies transcriptomics identifies SIKE as a MAPK
            repressor that prevents NASH progression.
REFERENCE   4  (bases 1 to 2798)
  AUTHORS   Deng,K.Q., Wang,A., Ji,Y.X., Zhang,X.J., Fang,J., Zhang,Y.,
            Zhang,P., Jiang,X., Gao,L., Zhu,X.Y., Zhao,Y., Gao,L., Yang,Q.,
            Zhu,X.H., Wei,X., Pu,J. and Li,H.
  TITLE     Suppressor of IKKvarepsilon is an essential negative regulator of
            pathological cardiac hypertrophy
  JOURNAL   Nat Commun 7, 11432 (2016)
   PUBMED   27249321
  REMARK    GeneRIF: Sike-deficient mice develop cardiac hypertrophy and heart
            failure, whereas Sike-overexpressing transgenic (Sike-TG) mice are
            protected from hypertrophic stimuli.
            Erratum:[Nat Commun. 2023 May 25;14(1):3018. doi:
            10.1038/s41467-023-38331-w.. PMID: 37230962]
            Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK033553.1.
            
            On Apr 5, 2007 this sequence version replaced NM_025679.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033553.1, AK035590.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2798              AK033553.1         5-2802
FEATURES             Location/Qualifiers
     source          1..2798
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.25 cM"
     gene            1..2798
                     /gene="Sike1"
                     /gene_synonym="2810005O12Rik; 5730470L24Rik; Sike; Sikeb"
                     /note="suppressor of IKBKE 1"
                     /db_xref="GeneID:66641"
                     /db_xref="MGI:MGI:1913891"
     exon            1..228
                     /gene="Sike1"
                     /gene_synonym="2810005O12Rik; 5730470L24Rik; Sike; Sikeb"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..693
                     /gene="Sike1"
                     /gene_synonym="2810005O12Rik; 5730470L24Rik; Sike; Sikeb"
                     /note="suppressor of IKK epsilon"
                     /codon_start=1
                     /product="suppressor of IKBKE 1"
                     /protein_id="NP_079955.1"
                     /db_xref="CCDS:CCDS17690.1"
                     /db_xref="GeneID:66641"
                     /db_xref="MGI:MGI:1913891"
                     /translation="MSCTIEKILTDAKTLLERLREHDAAAESLVDQSAALHRRVAAMR
                     EAGAVLPEQYQEDASDVKDMSKYKPHILLSQENTQIRDLQQENRELWVSLEEHQDALE
                     LIMSKYRKQMLQLMVAKKAVDAEPVLKAHQSHSAEIESQIDRICEMGAVMRRAVQVDD
                     NQFCKVQERLAQLELENKELRELLSISSESLQVGKESSVAPASQTIK"
     exon            229..334
                     /gene="Sike1"
                     /gene_synonym="2810005O12Rik; 5730470L24Rik; Sike; Sikeb"
                     /inference="alignment:Splign:2.1.0"
     exon            335..477
                     /gene="Sike1"
                     /gene_synonym="2810005O12Rik; 5730470L24Rik; Sike; Sikeb"
                     /inference="alignment:Splign:2.1.0"
     exon            478..591
                     /gene="Sike1"
                     /gene_synonym="2810005O12Rik; 5730470L24Rik; Sike; Sikeb"
                     /inference="alignment:Splign:2.1.0"
     exon            592..2798
                     /gene="Sike1"
                     /gene_synonym="2810005O12Rik; 5730470L24Rik; Sike; Sikeb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1077..1082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sike1"
                     /gene_synonym="2810005O12Rik; 5730470L24Rik; Sike; Sikeb"
                     /note="hexamer: AATACA"
     polyA_site      1099
                     /gene="Sike1"
                     /gene_synonym="2810005O12Rik; 5730470L24Rik; Sike; Sikeb"
                     /note="major polyA site"
     regulatory      2346..2351
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sike1"
                     /gene_synonym="2810005O12Rik; 5730470L24Rik; Sike; Sikeb"
                     /note="hexamer: AATAAA"
     polyA_site      2365
                     /gene="Sike1"
                     /gene_synonym="2810005O12Rik; 5730470L24Rik; Sike; Sikeb"
                     /note="major polyA site"
ORIGIN      
        1 gagccagggc cgggtaaggt ctgagcgaag cgcctaggct agcgggcccg gcgcgcctcc
       61 tcggccacta tgagctgcac gatcgagaag atcttgacgg acgccaagac gctgctggag
      121 cggctgcgcg agcacgatgc ggcggccgag tcgctggtgg accagtcggc tgcgctgcac
      181 cggcgggtgg cggcgatgcg ggaggcgggc gccgtgttac ccgagcagta tcaagaggat
      241 gcatccgacg tgaaggacat gtctaaatat aaacctcaca ttctgctgtc tcaagagaat
      301 acccagatta gagacttaca gcaggaaaac agagaactgt gggtttcctt ggaggagcac
      361 caggatgcgt tggaactgat catgagcaag taccggaaac agatgttaca gttaatggtc
      421 gctaagaaag ccgtggatgc cgaaccagtt ctgaaagctc accagtctca ctctgcagag
      481 attgaaagtc agatcgatag aatctgtgaa atgggagcag tgatgcggag agctgttcag
      541 gtggacgata accaattctg taaggttcag gagagactag ctcagctgga gcttgaaaat
      601 aaggaacttc gagagttact gtccatcagc agtgaatctc tgcaggttgg aaaagaaagc
      661 tctgtggctc ctgcctctca gaccatcaag taactggact tccgaaggct ggctacagct
      721 tgcccgtcag agcgagaagc cgtgccctcc tctcctgccg tgtccaagag tcctgccgca
      781 gacttgactt agtgttgggt agaggtatgg ggtggcagtt tagaattgcc acttggtatt
      841 cattgtccac taactagttt ggggtgtact agtgaaacta gacaagtccc ccattgctgg
      901 gacagagatg acatttgtca ctctagtccg gaatctctat aaactgttac ctgcagttca
      961 atgttgtttt tcacagcttg gaaacactga acacttttat tataagccag gattttattt
     1021 tatataggat tataaaaatt ccttctaaga gtttttcaaa gatttaactt tttaaaaata
     1081 catatttggt gtaaacctag attttttttt tcttccactt gtaaaagtag catgacttca
     1141 aagaagcaga ttggcagagt ctctgagtga cgtcgctcat ccatggggtt tgatcctctc
     1201 cggtgctagg agttggcact ttgtggtcag gtgtctttgc tcttaatttg agagaatcta
     1261 ttagtcccca ggaaatacgc ttgaaaacaa gtaagccggg ttcgcgttgc tcctcctcct
     1321 cctcaaggat ccacagtcat tcagagagtg ctgaggaact tgggcctgcc ccatcatgca
     1381 cagggagcta ttagatgtac atgactgtac atgtacattg gacttaaatg ccaaaaatag
     1441 cttttattta tttgaccaag tagttttcca ttctgtctgc ctaaggagtc ttcggcttag
     1501 gtagttgcct tgtatgagac atacacatac acacacacac acacacacac acacacacac
     1561 acacacatac ctcactcaca ggttcctagc tcctaggcac tttcatggac acacagctgt
     1621 gctgtgctgt gctgtgcaga gcagcaccac tgggatggtt tagaccggca tcagtacttt
     1681 gctgtctttc catctgctgg gttttctcat ggaagcattt tattactcac agaaagttac
     1741 cacattcctg atgccatgca ttcaggcaat caagaacaac ctgagattct aatagctccc
     1801 tgtcagttcc ttctcatctt ggtttgctca tatgtcaggt ttataaataa ttccttttgc
     1861 actgtttgcc cagatggact ttggtttttg ttcccatgtt aactttcact ccagctgctc
     1921 cccttgatgt ttcccctaag ggccccaagt gtgtactcca caaacccatt caggggtggg
     1981 ttcctttacc acttgtcagc tgtcacagca ggtcccatca cagtgagagc attatcagtc
     2041 agtctatttc agcagtgagc atggtgtccc tttctttatc tgccttctgt tcccgtagca
     2101 ctcactacaa aggtctttgc atctagcttt cagaggaatc tctccattgc agtcctgagg
     2161 gtagagcaag ctttcggtgc cctgtgtcgt ataaattctg cctggtgtta gtgctgtgaa
     2221 ggcattgcag agctagcaca ttgaatggag aaagaatgtt tcacacttgt gtgaagatgc
     2281 taatatctct tgcaatgggt ggaagtattt agtgtataaa attttagtat gaaattatat
     2341 taactaataa aaaccttttt gagaagattt gctcatttta ctgagaaatg agtctaagaa
     2401 gttgagctgg aaaaaaaaag gaagtttagc tgagcagtgg cgatgtacac ctgcaatccc
     2461 agcacttgga aggcagaggc acatctcttg aattcgagga catgcaggtt tacctagtga
     2521 gtcccaggag actacacagg gagaccctgt cttgaaaaaa gcaaaaagaa gtataggaga
     2581 tttttttcac atattcacat acatagcaac catggcaagt gttcatgaca tagatgtcat
     2641 aagcagcttg caattattca atatattcag cagtataaac ctttgaaaag cacattaaca
     2701 acctattcat tgcagaagtc ctgaatgtat aatttaccac tgaagtctat ttccatgttt
     2761 cttaaaatgc acctaatgaa atagaaattt atggatgg
//
