LOCUS       NM_027498               6296 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus SIK family kinase 3 (Sik3), mRNA.
ACCESSION   NM_027498 XM_194455
VERSION     NM_027498.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6296)
  AUTHORS   Kamei,K., Yahara,Y., Kim,J.D., Tsuji,M., Iwasaki,M., Takemori,H.,
            Seki,S., Makino,H., Futakawa,H., Hirokawa,T., Nguyen,T.C.T.,
            Nakagawa,T. and Kawaguchi,Y.
  TITLE     Impact of the SIK3 pathway inhibition on osteoclast differentiation
            via oxidative phosphorylation
  JOURNAL   J Bone Miner Res 39 (9), 1340-1355 (2024)
   PUBMED   39030684
  REMARK    GeneRIF: Impact of the SIK3 pathway inhibition on osteoclast
            differentiation via oxidative phosphorylation.
REFERENCE   2  (bases 1 to 6296)
  AUTHORS   Hayes,E.T., Hassan,M., Lakomy,O., Filzen,R., Armouti,M., Foretz,M.,
            Tsumaki,N., Takemori,H. and Stocco,C.
  TITLE     SIK2 and SIK3 Differentially Regulate Mouse Granulosa Cell Response
            to Exogenous Gonadotropins In Vivo
  JOURNAL   Endocrinology 165 (10) (2024)
   PUBMED   39158086
REFERENCE   3  (bases 1 to 6296)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 6296)
  AUTHORS   Jiang,Z.F., Xuan,L.N., Sun,X.W., Liu,S.B. and Yin,J.
  TITLE     Knockdown of SIK3 in the CA1 Region can Reduce Seizure
            Susceptibility in Mice by Inhibiting Decreases in GABAAR alpha1
            Expression
  JOURNAL   Mol Neurobiol 61 (3), 1404-1416 (2024)
   PUBMED   37715891
  REMARK    GeneRIF: Knockdown of SIK3 in the CA1 Region can Reduce Seizure
            Susceptibility in Mice by Inhibiting Decreases in GABAAR alpha1
            Expression.
REFERENCE   5  (bases 1 to 6296)
  AUTHORS   Li,Y., Li,C., Liu,Y., Yu,J., Yang,J., Cui,Y., Wang,T.V., Li,C.,
            Jiang,L., Song,M. and Rao,Y.
  TITLE     Sleep need, the key regulator of sleep homeostasis, is indicated
            and controlled by phosphorylation of threonine 221 in
            salt-inducible kinase 3
  JOURNAL   Genetics 225 (1) (2023)
   PUBMED   37477881
  REMARK    GeneRIF: Sleep need, the key regulator of sleep homeostasis, is
            indicated and controlled by phosphorylation of threonine 221 in
            salt-inducible kinase 3.
REFERENCE   6  (bases 1 to 6296)
  AUTHORS   Clark,K., MacKenzie,K.F., Petkevicius,K., Kristariyanto,Y.,
            Zhang,J., Choi,H.G., Peggie,M., Plater,L., Pedrioli,P.G.,
            McIver,E., Gray,N.S., Arthur,J.S. and Cohen,P.
  TITLE     Phosphorylation of CRTC3 by the salt-inducible kinases controls the
            interconversion of classically activated and regulatory macrophages
  JOURNAL   Proc Natl Acad Sci U S A 109 (42), 16986-16991 (2012)
   PUBMED   23033494
REFERENCE   7  (bases 1 to 6296)
  AUTHORS   Sasagawa,S., Takemori,H., Uebi,T., Ikegami,D., Hiramatsu,K.,
            Ikegawa,S., Yoshikawa,H. and Tsumaki,N.
  TITLE     SIK3 is essential for chondrocyte hypertrophy during skeletal
            development in mice
  JOURNAL   Development 139 (6), 1153-1163 (2012)
   PUBMED   22318228
  REMARK    GeneRIF: results demonstrate an essential role for SIK3 in
            facilitating chondrocyte hypertrophy during skeletogenesis and
            growth plate maintenance
REFERENCE   8  (bases 1 to 6296)
  AUTHORS   Uebi,T., Itoh,Y., Hatano,O., Kumagai,A., Sanosaka,M., Sasaki,T.,
            Sasagawa,S., Doi,J., Tatsumi,K., Mitamura,K., Morii,E., Aozasa,K.,
            Kawamura,T., Okumura,M., Nakae,J., Takikawa,H., Fukusato,T.,
            Koura,M., Nish,M., Hamsten,A., Silveira,A., Bertorello,A.M.,
            Kitagawa,K., Nagaoka,Y., Kawahara,H., Tomonaga,T., Naka,T.,
            Ikegawa,S., Tsumaki,N., Matsuda,J. and Takemori,H.
  TITLE     Involvement of SIK3 in glucose and lipid homeostasis in mice
  JOURNAL   PLoS One 7 (5), e37803 (2012)
   PUBMED   22662228
  REMARK    GeneRIF: SIK3 is a novel energy regulator that modulates
            cholesterol and bile acid metabolism by coupling with retinoid
            metabolism, and may alter the size of energy storage in mice.
REFERENCE   9  (bases 1 to 6296)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 6296)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ171970.1, BC080688.1, AK129257.1 and BG229919.1.
            
            On Nov 15, 2007 this sequence version replaced NM_027498.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063268.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                CJ171970.1         1-58
            59-2803             BC080688.1         1-2745
            2804-6276           AK129257.1         1817-5289
            6277-6296           BG229919.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..6296
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 25.36 cM"
     gene            1..6296
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /note="SIK family kinase 3"
                     /db_xref="GeneID:70661"
                     /db_xref="MGI:MGI:2446296"
     exon            1..311
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..4148
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /EC_number="2.7.11.1"
                     /note="salt-inducible kinase 3; serine/threonine-protein
                     kinase QSK"
                     /codon_start=1
                     /product="serine/threonine-protein kinase SIK3"
                     /protein_id="NP_081774.3"
                     /db_xref="CCDS:CCDS23140.2"
                     /db_xref="GeneID:70661"
                     /db_xref="MGI:MGI:2446296"
                     /translation="MAAAAASGAGGVAVAGAGGAGPAGRLLPPPAAGPPAAPAAVPPA
                     AVPARPTAPASRGSMAARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKSQL
                     DEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRM
                     AEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQL
                     LKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVL
                     SGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICRHKWMKLGDADPNFDRLIAECQ
                     QLKEERQSDPLNDDVLLAMEDMGLDKERTLQSLRSDAYDHYSAIYSLLCDRHKKHKTL
                     RPGALPSMPQAMTFQAPVNLQAEQTGTAMNLSVPQVQLINPENQIIEPDGAVNLDSDE
                     GEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQGPFLQVAPNMNF
                     THNLLPMQSLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLK
                     RPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEAVQRYLANRSKRHTLAMTSPTAEIP
                     PDLQRQLGQQSFRSRVWPPHLVPDQHRSTYKDSNTLHLPTERFSPVRRFSDGAASIQA
                     FKAHLEKMGNSSSIKQLQQECEQLQKMYGGQVDERTLEKTQQQHMLYQQEQHHQILQQ
                     QIQDSICPPQPSPPLQVACENQPALLTHQLQRLRIQPSSPPPNHPSNHLFRQPSNSPP
                     PVSSAMITSHGATSPSQFQGLPSHGAIFQQQPENCSPPPSVALTCLGLQQASQSQPVT
                     IQLQEPVDMLSNMAGTAAGSAGRSIPISPSASQIQIQHRASLMAPFSYGHRPLSKQLS
                     ADSAEAHSLNMNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFPPTQALKVPP
                     LDQFPTFPPSAQQQPPHYTTSALQQALLSPTPPDYPRHQQVPHILQGLLSPRHSLTGH
                     SDIRLPPAEFAQLIKRQQQHRQQQQQQQQQQEYHELFRHMNQGDAVSLAPSLGGQNMT
                     EQQALSYQNADSYHRHHTSPQHILQIRAQDCISQGPSPTPTHGYAHQPPLMHSESMEE
                     DCLCEGLKEGFPDKSSSTLTKGCHNSPLLLCTSGPGDPEPLLGTVSQARELGIHPYGH
                     QPTATTFSRNKVPSRESVLGNCLERSSPGQAMELPDHNGLGYPVRPLVSEHLRSRTLQ
                     RHHTIQNSDDAYVQLDTLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDEEDEEC
                     GVSLGHEHPGLGDGSQHLNSSRYPATCVTDIMLSHKHPEVSFSMEQAGV"
     exon            312..428
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            429..492
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            493..654
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            655..779
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            780..903
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1022
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1133
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1277
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1355
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1465
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1619
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1775
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1846
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1990
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2141
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2267
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2353
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2463
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2803
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..3696
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3697..3860
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3861..3993
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            3994..4161
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     exon            4162..6287
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6258..6263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /note="hexamer: AATAAA"
     polyA_site      6281
                     /gene="Sik3"
                     /gene_synonym="5730525O22Rik; 9030204A07Rik; mKIAA0999;
                     Qsk; SIK-3"
                     /note="major polyA site"
ORIGIN      
        1 ggctccccgc ggccccggag gtttcactgc acaacaagat ggcggcggcg gcggcgagcg
       61 gagctggcgg ggttgccgtg gccggagcag ggggagccgg gccggccggc cgcctgctgc
      121 ctccgcccgc cgcggggccc ccggcagccc ccgccgcagt gcccccggcc gccgtcccgg
      181 cgcgtcccac agccccggcc tcccgcgggt cgatggccgc tcgcatcggc tactacgaga
      241 tcgaccgcac catcggcaag ggcaacttcg ctgtggtcaa gcgggccacg cacctcgtca
      301 ccaaggccaa ggttgctatt aaaatcatag ataagagcca gctggatgaa gaaaacttga
      361 agaagatttt ccgggaggtt cagataatga agatgctttg ccatccacac atcatcagac
      421 tctaccaggt catggagaca gagcgcatga tttacctggt gacagaatac gctagcggag
      481 gggagatatt tgaccacttg gtagcccatg gaagaatggc agagaaggaa gctcgacgga
      541 agttcaaaca gatcgtcaca gcggtgtatt tttgtcactg tcggaatatc gttcatcgtg
      601 atttaaaagc cgaaaactta cttctggacg ccaatctgaa tatcaaaata gcagactttg
      661 gcttcagcaa cctcttcact ccagggcagc tgctgaagac gtggtgtggc agccctccct
      721 atgccgcccc agagctcttc gaagggaagg aatatgatgg gcccaaagtg gacatatgga
      781 gccttggagt tgtcctctat gtgctggtgt gtggcgccct gccgtttgat gggagcacac
      841 tgcagaatct gcgggcccgc gtgctgagtg gcaagttccg catcccgttc tttatgtcca
      901 cagagtgtga gcacttgatc cgccacatgc tggtgttaga tccaaataag cgcctctcaa
      961 tggaacagat ctgcaggcac aagtggatga agctcggaga tgcagacccc aactttgaca
     1021 ggttaatagc ggagtgccag caactgaagg aggaaaggca gtcggacccc ctcaacgatg
     1081 atgtcctctt ggctatggaa gacatggggc tggacaagga gcgcacactt cagtcattaa
     1141 ggtcagatgc ctatgaccac tatagtgcaa tctacagcct gctgtgcgat cgacacaaga
     1201 aacataaaac tctgcgtccc ggagcacttc ccagcatgcc ccaagccatg actttccagg
     1261 caccagtcaa tctccaggcg gagcagacag gcactgctat gaaccttagc gtccctcaag
     1321 ttcagctgat caacccagag aaccaaatta tagagcctga cggggctgtg aacttggaca
     1381 gtgatgaggg tgaagagcct tctccagaag ccttggttcg ctatttgtca atgaggaggc
     1441 acacggtggg agtggctgac ccacgcacgg aagttatgga agatctgcag aagctgctgc
     1501 ctggctttcc tggagtaaac ccacagggtc cattcctaca agtggcccct aacatgaact
     1561 tcacgcacaa cctgttgccc atgcagagtc tgcagccaac tgggcagctt gagtacaagg
     1621 aacagtctct gttacagccg cctacactac agctactgaa cggaatgggg ccccttggcc
     1681 ggagagcctc agatggaggc gccaacatcc aactgcatgc ccagcagctg ctcaagcgcc
     1741 cacggggacc gtccccactt gtcaccatga caccagcagt gccagcagtt acccctgtgg
     1801 atgaggagag ctcggatggg gagccagatc aggaagctgt gcagaggtac ttggcaaata
     1861 ggtccaaaag gcacacactg gccatgacca gcccgacagc tgagatccca ccggacctgc
     1921 aacggcagct aggacaacag tctttccgtt cccgggtctg gcctcctcac ctggtacctg
     1981 accagcatcg ctccacctac aaggactcca acaccctgca tctccctacg gagcgtttct
     2041 cccccgtgcg ccggttctca gacggggctg caagcatcca ggccttcaaa gctcacctgg
     2101 aaaaaatggg caacagcagc agcatcaagc agttgcagca ggagtgtgag cagctgcaga
     2161 agatgtacgg ggggcaggtg gatgagagga ccctggagaa gacccagcag cagcatatgt
     2221 tgtaccagca ggagcagcac catcagatcc tccagcagca aatccaagat tctatttgtc
     2281 ctcctcagcc ctccccacct cttcaggttg cctgtgaaaa ccaaccagcc ctcctcaccc
     2341 accagctcca gaggttaagg attcaacctt caagcccacc ccccaaccat cccagcaacc
     2401 atctcttcag acagccaagt aacagtcctc ccccggtcag cagtgccatg atcacgtctc
     2461 acggtgctac gtctccctcc cagtttcaag gcttaccctc ccatggtgca atcttccagc
     2521 agcaacccga gaactgttcc ccgcctccca gtgtagcact aacctgcctg ggcctacagc
     2581 aggctagcca gtcacagcca gtgactatcc agctacagga gccagttgac atgctcagca
     2641 acatggccgg aaccgcggca ggctctgcag ggcggagcat ccccatcagc cccagcgcca
     2701 gtcagattca gatacagcac cgagccagcc taatggctcc cttcagctat gggcaccggc
     2761 ccttgtccaa gcagctgagc gctgacagtg cagaggccca cagcttgaac atgaatcggt
     2821 tctcccctgc caactacgac caggcgcatt tacaccccca tctgttttcg gaccagtccc
     2881 gaggttcccc cagcagctac agcccttcaa caggagtggg gtttcctcca actcaagccc
     2941 tgaaagttcc tccgcttgac cagttcccca ctttccctcc cagtgcccag cagcagccac
     3001 cccactatac cacgtcagca ctacagcagg ccctgctatc tcctacaccg ccagactatc
     3061 cccgacacca gcaggttccc catatccttc aaggactgct ctctccccgg cattcactca
     3121 ccggccactc ggacattcgg ctgcctccgg cagagtttgc acagctcatc aaaaggcagc
     3181 aacagcatcg acagcagcag cagcagcagc agcagcaaca agaataccat gaattgttca
     3241 ggcacatgaa ccaaggggat gctgttagcc tagctcccag cctcggggga cagaatatga
     3301 cagagcaaca ggctttatct tatcaaaatg ctgactcgta ccaccgccac cacaccagcc
     3361 cccagcatat cttacagatc agggcgcaag attgtatctc acagggtccc tcgcccaccc
     3421 ccacccatgg ctatgcccat cagccaccac taatgcattc ggagagtatg gaggaagact
     3481 gcttgtgtga ggggctcaag gagggcttcc cagacaagag ctcaagcaca ctgaccaaag
     3541 gttgccacaa cagccctctg ctcttgtgta ccagtgggcc tggggaccct gagcctttgc
     3601 tgggaactgt gagtcaggcc cgggagctgg ggatccatcc ctacggacac cagccaactg
     3661 ccaccacgtt cagtagaaat aaggtgccca gccgagagtc tgtcctaggg aactgcctgg
     3721 aaagaagttc tcctggacaa gcaatggagc tgccggatca caacggcctt gggtacccag
     3781 tacggccctt agtcagtgag cacctcaggt cccggacgct ccagagacac cacacgatcc
     3841 agaacagcga cgatgcctat gtacagctgg ataccttgcc aggaatgagc ctggtggcag
     3901 gcaaggcgct gagctctgcc cggatgtcag atgcagttct tagtcagtct tcactcatgg
     3961 gcagccaaca gtttcaggat gaggaagatg aagaatgtgg ggtgagcctg ggccacgagc
     4021 atccaggcct gggtgatggc agccagcatc tcaactcctc tcgctatcca gctacgtgtg
     4081 ttacagacat catgctcagc cacaagcacc cagaggtctc cttcagcatg gagcaagccg
     4141 gcgtgtagca agatatggaa agttcgagta cagctccagg aggaggctga gtctagacca
     4201 atagaccaac agtgtccaac agcgccgcac cgctcctccg tctgtgtctc caccacaaca
     4261 gtgcagctcc ttcccctaca ctaggcacca gtaggccggc gcttgggttg cgagggacat
     4321 ttgccatgtt tgcttgtatg accaaggcac caaggaaata aacaggaaat cagtgtcctc
     4381 catctttcat gagccagcat ctggtgtgct tgagttgagt tctgctgtta ggaggtttgc
     4441 ttgtgttttg ttttggaaat tttcctttgg agataactta ttctctttgc cttgcccacc
     4501 cctaccccct tgagcatatt cccccccccc tctcgttttc acctaccatt tctgaggtag
     4561 atgaaccaga ggttagtatt caggggctga acctcaggac cctcccttcc acagcctgtc
     4621 tcagaccaga ctctctccct ctgccccggt ctaccaggaa caaatgctag accggagctt
     4681 ggtggccaag aaaaggagag gagggggcag tggcccctgc ctttggagat tggaacagaa
     4741 gaaaaaactg agcctgggat ctggcagaat ctcctgctgg cctctactag aatcctatct
     4801 ggcccagcag aattccatca gatcccagca caggccggat ggcctggtgc tgaaggtttg
     4861 ccatccagaa tagctcagtg taggcccctc tggtgtgtgg tccagttccc ctccagtcac
     4921 caactggttc cccctcatga gtgaacaccc aggagtggtg cactgtgctg tttgtgtgat
     4981 ctccattctt attctctact gcgttgtaaa aagggccgtt ggtccatttg tgtgcacacg
     5041 tatgagtgtg tacatgccct tccctgcggc ctctttgtca cagacaagaa ttggaggctg
     5101 tactgggtct cttaaccttc tcctctcccc agcatcctcg gcccctatat tttaattctt
     5161 gatcatgtag gaattgtttt tgataaatgt tgatattatt gttattattg ttattattaa
     5221 taaagacaaa aaggattttg tttatttgtt taaaagagaa atgtttaacc agattctgtg
     5281 ctgttgaact gtggcttgca acttctgttt gaagtgtttt ccttggcttt ggcatcgtga
     5341 gccactctcc tgtgccagca gcggatgcag tggcctccct tccccagccg aagcagcaca
     5401 taggcagtgg ctactgtcct tgtcacttcc tttctctctg cagtcagaaa ccaaagtctg
     5461 gggccaaacg aggccggccc ggcttctctt ctggtcttca aaaccagaga gggatggtcc
     5521 ctgctctgac tcccagccct catttctgag agccaggggc caccaacctc tgagtatgca
     5581 cagaagaaag ccgctgcctg ccatggcatc tggacattac cagcagggtc cctagccatt
     5641 ttatccttcc gcaccaaccc tgaaagcttg cctctttgaa caaatccatt gtctcttgaa
     5701 tggatttgtt ttcaatgtga gagcttggct ggggacctgt ttcgtggtcc catgtcctcc
     5761 aatttcccct ccacttcagg tgtcactaat tactagccag aagatgtctg actcccaaga
     5821 aagcttgaca agccattgtc agcttccaag ctcagtccag ctctgatact ccagccccgc
     5881 cctgctgctc cccacgctca gcctgacctg tttacgtggt actggattga tggaagagca
     5941 ggcaccaccc tccagagcca cccagacgaa agccagtgag cctattaacc gtgccatctt
     6001 gcgaactatt ttcaagatca ccattgcttt atattgtagt aaccaatatg cgcagtatat
     6061 gttgaatgta tatgaatcta ctttgctatt tctgttcttt gaaaatgtaa gaagtatttt
     6121 tcctttctca tttctgttga tctaaaaatg ataataataa taataatctc cagattcaag
     6181 ttgctaagag cttttgtcct tgtttgtgtg ggacatctac aacttagtga cttggttgga
     6241 ctgtaggagg ttgtggaaat aaaaacctga ttatgtacta acgctgaaaa aaaaaa
//
