LOCUS       NM_178710               3536 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus salt inducible kinase 2 (Sik2), transcript variant 1,
            mRNA.
ACCESSION   NM_178710
VERSION     NM_178710.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3536)
  AUTHORS   Hayes,E.T., Hassan,M., Lakomy,O., Filzen,R., Armouti,M., Foretz,M.,
            Tsumaki,N., Takemori,H. and Stocco,C.
  TITLE     SIK2 and SIK3 Differentially Regulate Mouse Granulosa Cell Response
            to Exogenous Gonadotropins In Vivo
  JOURNAL   Endocrinology 165 (10) (2024)
   PUBMED   39158086
REFERENCE   2  (bases 1 to 3536)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3536)
  AUTHORS   Yoon,S.H., Meyer,M.B., Arevalo,C., Tekguc,M., Zhang,C., Wang,J.S.,
            Castro Andrade,C.D., Strauss,K., Sato,T., Benkusky,N.A., Lee,S.M.,
            Berdeaux,R., Foretz,M., Sundberg,T.B., Xavier,R.J., Adelmann,C.H.,
            Brooks,D.J., Anselmo,A., Sadreyev,R.I., Rosales,I.A., Fisher,D.E.,
            Gupta,N., Morizane,R., Greka,A., Pike,J.W., Mannstadt,M. and
            Wein,M.N.
  TITLE     A parathyroid hormone/salt-inducible kinase signaling axis controls
            renal vitamin D activation and organismal calcium homeostasis
  JOURNAL   J Clin Invest 133 (9), e163627 (2023)
   PUBMED   36862513
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3536)
  AUTHORS   Liu,B., Zhang,L., Yang,H., Chen,X., Zheng,H. and Liao,X.
  TITLE     SIK2 protects against renal tubular injury and the progression of
            diabetic kidney disease
  JOURNAL   Transl Res 253, 16-30 (2023)
   PUBMED   36075517
  REMARK    GeneRIF: SIK2 protects against renal tubular injury and the
            progression of diabetic kidney disease.
REFERENCE   5  (bases 1 to 3536)
  AUTHORS   van Gijsel-Bonnello,M., Darling,N.J., Tanaka,T., Di Carmine,S.,
            Marchesi,F., Thomson,S., Clark,K., Kurowska-Stolarska,M.,
            McSorley,H.J., Cohen,P. and Arthur,J.S.C.
  TITLE     Salt-inducible kinase 2 regulates fibrosis during bleomycin-induced
            lung injury
  JOURNAL   J Biol Chem 298 (12), 102644 (2022)
   PUBMED   36309093
  REMARK    GeneRIF: Salt-inducible kinase 2 regulates fibrosis during
            bleomycin-induced lung injury.
REFERENCE   6  (bases 1 to 3536)
  AUTHORS   Horike,N., Kumagai,A., Shimono,Y., Onishi,T., Itoh,Y., Sasaki,T.,
            Kitagawa,K., Hatano,O., Takagi,H., Susumu,T., Teraoka,H.,
            Kusano,K., Nagaoka,Y., Kawahara,H. and Takemori,H.
  TITLE     Downregulation of SIK2 expression promotes the melanogenic program
            in mice
  JOURNAL   Pigment Cell Melanoma Res 23 (6), 809-819 (2010)
   PUBMED   20819186
  REMARK    GeneRIF: SIK2 represses eumelanogenesis in mice.
REFERENCE   7  (bases 1 to 3536)
  AUTHORS   Muraoka,M., Fukushima,A., Viengchareun,S., Lombes,M., Kishi,F.,
            Miyauchi,A., Kanematsu,M., Doi,J., Kajimura,J., Nakai,R., Uebi,T.,
            Okamoto,M. and Takemori,H.
  TITLE     Involvement of SIK2/TORC2 signaling cascade in the regulation of
            insulin-induced PGC-1alpha and UCP-1 gene expression in brown
            adipocytes
  JOURNAL   Am J Physiol Endocrinol Metab 296 (6), E1430-E1439 (2009)
   PUBMED   19351809
  REMARK    GeneRIF: SIK2-TORC2 cascade may be important for the regulation of
            PGC-1alpha and UCP-1 gene expression in insulin signaling in brown
            adipose tissue
REFERENCE   8  (bases 1 to 3536)
  AUTHORS   Du,J., Chen,Q., Takemori,H. and Xu,H.
  TITLE     SIK2 can be activated by deprivation of nutrition and it inhibits
            expression of lipogenic genes in adipocytes
  JOURNAL   Obesity (Silver Spring) 16 (3), 531-538 (2008)
   PUBMED   18239551
  REMARK    GeneRIF: Results support a role for SIK2 in adipocyte energy
            metabolism. SIK2 may function similarly to AMPK for turning off
            lipogenesis in low-energy state.
REFERENCE   9  (bases 1 to 3536)
  AUTHORS   Katoh,Y., Takemori,H., Lin,X.Z., Tamura,M., Muraoka,M., Satoh,T.,
            Tsuchiya,Y., Min,L., Doi,J., Miyauchi,A., Witters,L.A., Nakamura,H.
            and Okamoto,M.
  TITLE     Silencing the constitutive active transcription factor CREB by the
            LKB1-SIK signaling cascade
  JOURNAL   FEBS J 273 (12), 2730-2748 (2006)
   PUBMED   16817901
REFERENCE   10 (bases 1 to 3536)
  AUTHORS   Horike,N., Takemori,H., Katoh,Y., Doi,J., Min,L., Asano,T.,
            Sun,X.J., Yamamoto,H., Kasayama,S., Muraoka,M., Nonaka,Y. and
            Okamoto,M.
  TITLE     Adipose-specific expression, phosphorylation of Ser794 in insulin
            receptor substrate-1, and activation in diabetic animals of
            salt-inducible kinase-2
  JOURNAL   J Biol Chem 278 (20), 18440-18447 (2003)
   PUBMED   12624099
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC103406.7.
            
            On Apr 19, 2022 this sequence version replaced NM_178710.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB067780.1, SRR13422600.1015209.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-317               AC103406.7         13199-13515
            318-434             AC103406.7         23640-23756
            435-498             AC103406.7         26585-26648
            499-660             AC103406.7         86679-86840
            661-785             AC103406.7         104604-104728
            786-909             AC103406.7         105119-105242
            910-1130            AC103406.7         106594-106814
            1131-1283           AC103406.7         108720-108872
            1284-1448           AC103406.7         114685-114849
            1449-1677           AC103406.7         122708-122936
            1678-1962           AC103406.7         123490-123774
            1963-2126           AC103406.7         123905-124068
            2127-2237           AC103406.7         124773-124883
            2238-2329           AC103406.7         125521-125612
            2330-2947           AC103406.7         126295-126912
            2948-3536           AC103406.7         128867-129455
FEATURES             Location/Qualifiers
     source          1..3536
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 27.75 cM"
     gene            1..3536
                     /gene="Sik2"
                     /gene_synonym="G630080D20Rik; Snf1lk2"
                     /note="salt inducible kinase 2"
                     /db_xref="GeneID:235344"
                     /db_xref="MGI:MGI:2445031"
     exon            1..317
                     /gene="Sik2"
                     /gene_synonym="G630080D20Rik; Snf1lk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..2978
                     /gene="Sik2"
                     /gene_synonym="G630080D20Rik; Snf1lk2"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SNF1-like kinase 2; salt induceable kinase 2;
                     serine/threonine-protein kinase SIK2; SIK-2;
                     salt-inducible protein kinase 2; serine/threonine-protein
                     kinase SNF1-like kinase 2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase SIK2 isoform 1"
                     /protein_id="NP_848825.2"
                     /db_xref="CCDS:CCDS40627.1"
                     /db_xref="GeneID:235344"
                     /db_xref="MGI:MGI:2445031"
                     /translation="MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKT
                     EVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNG
                     EIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKVVHRDLKAENLLLDNNMNIKIAD
                     FGFGNFFKTGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFD
                     GPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLSIAQIKEHKWMLIEVP
                     VQRPILYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTVESLQNKSYNHFAAIYFLLV
                     ERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTLHPPNVRLMRSTLLPQ
                     ASNVEAFSFPTSSCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSSMMET
                     SIDEGLETEGEAEEDPSQAFEAFQATRSGQRRHTLSEVTNQLVVMPGAGKMFSMSDNP
                     SLESVDSEYDMGSAQRDLNFLEDSPSLKDIMLANQPSPRMTSPFISLRPANPAMQALS
                     SQKREAHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQM
                     GSNADPTLTSTAPQLQDLSSSCPQEEISQQQESVSSLSASMHPQLSPQQSLETQYLQH
                     RLQKPNLLPKAQSPCPVYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIA
                     ESSYPGPSQQLALPHQETPLTSQQPPSFSLTQALSPVLEPSSEQMQFSSFLSQYPEMQ
                     LQPLPSTPGPQAPPPLPSQLQQHQQPPPPPPPPPPQQPGAAPTSLQFSYQTCELPSTT
                     SSVPNYPASCHYPVDGAQQSNLTGADCPRSSGLQDTASSYDPLALSELPGLFDCEMVE
                     AVDPQHNGVVSCLARET"
     exon            318..434
                     /gene="Sik2"
                     /gene_synonym="G630080D20Rik; Snf1lk2"
                     /inference="alignment:Splign:2.1.0"
     exon            435..498
                     /gene="Sik2"
                     /gene_synonym="G630080D20Rik; Snf1lk2"
                     /inference="alignment:Splign:2.1.0"
     exon            499..660
                     /gene="Sik2"
                     /gene_synonym="G630080D20Rik; Snf1lk2"
                     /inference="alignment:Splign:2.1.0"
     exon            661..785
                     /gene="Sik2"
                     /gene_synonym="G630080D20Rik; Snf1lk2"
                     /inference="alignment:Splign:2.1.0"
     exon            786..909
                     /gene="Sik2"
                     /gene_synonym="G630080D20Rik; Snf1lk2"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1130
                     /gene="Sik2"
                     /gene_synonym="G630080D20Rik; Snf1lk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1283
                     /gene="Sik2"
                     /gene_synonym="G630080D20Rik; Snf1lk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1448
                     /gene="Sik2"
                     /gene_synonym="G630080D20Rik; Snf1lk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1677
                     /gene="Sik2"
                     /gene_synonym="G630080D20Rik; Snf1lk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1962
                     /gene="Sik2"
                     /gene_synonym="G630080D20Rik; Snf1lk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2126
                     /gene="Sik2"
                     /gene_synonym="G630080D20Rik; Snf1lk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2237
                     /gene="Sik2"
                     /gene_synonym="G630080D20Rik; Snf1lk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2329
                     /gene="Sik2"
                     /gene_synonym="G630080D20Rik; Snf1lk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2947
                     /gene="Sik2"
                     /gene_synonym="G630080D20Rik; Snf1lk2"
                     /inference="alignment:Splign:2.1.0"
     exon            2948..3536
                     /gene="Sik2"
                     /gene_synonym="G630080D20Rik; Snf1lk2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3536
                     /gene="Sik2"
                     /gene_synonym="G630080D20Rik; Snf1lk2"
                     /note="major polyA site"
ORIGIN      
        1 agcgccggcg cgcgcctggc tgggccctgt ggggcgggag ggaagcagcg ccggagcgag
       61 agccgcggcc gtcgcccaga gcccaggcgc gccgcccgac gccctcctgc ccgctccgtg
      121 ccgcttcttg ccggccagtt cgttcgcgtt cccgtcgccg tgtcctgcag cgggggccaa
      181 gcatggtcat ggcggatggc ccgaggcact tgcagcgcgg gccagtccgg gtggggttct
      241 acgacatcga gggcacgctg ggcaagggca actttgccgt ggtgaagctg gggcggcacc
      301 ggatcaccaa gacggaggtg gctataaaaa taatagacaa gtcacagctg gatgcagtaa
      361 accttgagaa aatctaccga gaagtacaga taatgaaaat gctcgaccat cctcacatca
      421 ttaaactgta tcaggtaatg gagaccaaaa gtatgttgta ccttgtgaca gaatatgcca
      481 aaaatggaga aatttttgat tatcttgcta atcatggccg attaaatgaa tctgaagcca
      541 ggagaaaatt ctggcaaatt ctgtctgctg ttgattattg ccatggccgg aaggtagtgc
      601 acagagacct gaaggctgaa aatctcctgc tggataacaa catgaatatc aaaatagcag
      661 atttcggctt tggaaatttc tttaaaactg gtgaactgct ggcaacatgg tgtggcagcc
      721 ccccttatgc agccccagaa gtctttgaag ggcagcagta tgaaggacca cagctggata
      781 tatggagcat gggagttgtt ctttatgtcc ttgtctgtgg agctctacct tttgatggac
      841 caactctccc tattttgagg cagagggttt tagaaggaag attccggatt ccttatttca
      901 tgtcagaaga ttgtgaacac ctcattagaa ggatgttggt cctagatcct tccaaacggc
      961 taagcatagc tcaaatcaag gagcacaagt ggatgctcat agaggttcct gtacagaggc
     1021 ctattctcta cccacaagaa caggaaaacg agccgtccat tggagaattt aatgagcagg
     1081 ttcttcgact gatgcacagc cttgggattg atcagcagaa gactgttgag tctttgcaaa
     1141 acaagagcta taatcacttt gctgccattt atttcttgtt ggtggaacgt ctaaaatcac
     1201 ataggagcag ttttcctgtg gagcagagac ttgatggccg ccagcgtcgg cctagcacca
     1261 ttgctgaaca aacagttgcc aaggcacaaa ctgtggggct gccagtgacc ttgcatccac
     1321 cgaacgtgag actgatgcga tctaccctcc tcccacaggc atccaatgtg gaggcctttt
     1381 catttccaac atccagctgt caagcagaag ctgcctttat ggaggaagag tgtgtcgaca
     1441 ctccaaaggt gaatggctgc ctgcttgacc ctgtgccccc tgtcctggtg aggaagggat
     1501 gccagtcact gcccagcagt atgatggaga cctccattga tgaaggcttg gagacagaag
     1561 gagaggctga ggaagacccc agtcaggcct ttgaagcttt ccaggccaca cgcagtgggc
     1621 agcgacggca cactctgtca gaagtgacta accaattggt tgtgatgccc ggggcaggga
     1681 aaatgttctc catgagtgat aacccctccc ttgagagtgt ggactctgag tatgatatgg
     1741 ggtctgccca gagggacctg aactttctgg aagacagccc ttccttgaag gacatcatgt
     1801 tagccaatca gccgtcaccc cgcatgacat ctcctttcat aagcctcaga cctgccaacc
     1861 cagccatgca ggctctgagc tcacagaagc gtgaggccca caaccggtcc cccgtgagct
     1921 tccgagaagg ccgcagagca tcagatacgt cccttacaca aggaattgta gcatttagac
     1981 aacatcttca gaatcttgct agaaccaaag gaattctgga gttgaacaaa gtacaattgc
     2041 tgtatgaaca aatgggatca aacgcagacc ctaccttaac atcaactgct cctcagctcc
     2101 aagacctttc gagcagttgc cctcaggagg aaatctccca gcagcaggaa agtgtctcca
     2161 gcctgtctgc cagcatgcac cctcagctct caccacagca aagcttggaa acccagtacc
     2221 tacagcatcg actccagaag cccaatcttc tgccaaaggc ccagagtcct tgtccagtgt
     2281 attgtaaaga gccacctcgg agcctggaac agcagctaca ggagcatagg ctccaacaga
     2341 agcgactctt cctccagaag cagtctcagc tgcaagcata ttttaatcag atgcagatag
     2401 cagagagctc ctaccctgga ccaagtcagc agctggctct tccccaccag gagactccac
     2461 tgacatccca gcagccccca tcattcagcc tgacccaggc cctgagtcct gtcctcgagc
     2521 cctcttctga gcagatgcaa tttagctctt tcctcagcca atacccagag atgcagttgc
     2581 agccactgcc ctctactccc ggcccccagg ctccacctcc cttaccctca caattgcagc
     2641 aacatcagca gccaccaccc ccaccaccac cccctccacc acagcagcca ggagctgctc
     2701 caacctcctt acagttctcc tatcagactt gtgagctgcc aagcaccact tcttctgtac
     2761 caaactatcc tgcttcctgt cactatcctg tggatggagc ccagcagagc aacctcacag
     2821 gggcggactg tcccaggagc tcaggacttc aggacaccgc atctagctat gacccactgg
     2881 ccctctctga gctccctgga ctctttgatt gtgaaatggt agaagctgtg gatccacaac
     2941 acaatggggt tgtgagctgc ttagcccggg agacctagca gctatggcag gacagttagg
     3001 caacagatga ggggctgcgg agaggctgtc agaagtttaa aggctgcaga gagaagctgg
     3061 gaacgctcat cagcggccaa gcctgttagg cactgacaca gagaggaggt gaggacagtc
     3121 gccttgtgaa gaccgagaac catcctgccg gaacctgtcg taagctccca tttcctcctt
     3181 ccttcctttc aagtagacat ccctagttcc acggctacct ttatgtcctg aggtggaagc
     3241 tggtgagagc aatgggccct ccactcatct gattgcttct gtgtctgccc ccacctagtg
     3301 actcatggaa gcttccaagc cttttctcct cacaagtact aaagtaacac taagaaggct
     3361 taggctctct cgtggagagg cagctttgta atactgacgt gtctgcctgt cggttcacat
     3421 cagcagtgtg tacactactg tatagtaacc cttagctttg ttactgtaaa ctagcctctc
     3481 caaagagact ggtgatccaa acatgaggta aaatttccat tcggcaaaaa gtgcaa
//
