LOCUS       NM_010831               4523 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus salt inducible kinase 1 (Sik1), mRNA.
ACCESSION   NM_010831
VERSION     NM_010831.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4523)
  AUTHORS   Wang,Y., Liu,L., Gu,J.H., Wang,C.N., Guan,W., Liu,Y., Tang,W.Q.,
            Ji,C.H., Chen,Y.M., Huang,J., Li,W.Y., Shi,T.S., Chen,W.J.,
            Zhu,B.L. and Jiang,B.
  TITLE     Salt-inducible kinase 1-CREB-regulated transcription coactivator 1
            signalling in the paraventricular nucleus of the hypothalamus plays
            a role in depression by regulating the
            hypothalamic-pituitary-adrenal axis
  JOURNAL   Mol Psychiatry 29 (6), 1660-1670 (2024)
   PUBMED   36434056
  REMARK    GeneRIF: Salt-inducible kinase 1-CREB-regulated transcription
            coactivator 1 signalling in the paraventricular nucleus of the
            hypothalamus plays a role in depression by regulating the
            hypothalamic-pituitary-adrenal axis.
REFERENCE   2  (bases 1 to 4523)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4523)
  AUTHORS   Yoon,S.H., Meyer,M.B., Arevalo,C., Tekguc,M., Zhang,C., Wang,J.S.,
            Castro Andrade,C.D., Strauss,K., Sato,T., Benkusky,N.A., Lee,S.M.,
            Berdeaux,R., Foretz,M., Sundberg,T.B., Xavier,R.J., Adelmann,C.H.,
            Brooks,D.J., Anselmo,A., Sadreyev,R.I., Rosales,I.A., Fisher,D.E.,
            Gupta,N., Morizane,R., Greka,A., Pike,J.W., Mannstadt,M. and
            Wein,M.N.
  TITLE     A parathyroid hormone/salt-inducible kinase signaling axis controls
            renal vitamin D activation and organismal calcium homeostasis
  JOURNAL   J Clin Invest 133 (9), e163627 (2023)
   PUBMED   36862513
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4523)
  AUTHORS   Pang,B., Mori,T., Badawi,M., Zhou,M., Guo,Q., Suzuki-Kouyama,E.,
            Yanagawa,T., Shirai,Y. and Tabuchi,K.
  TITLE     An Epilepsy-Associated Mutation of Salt-Inducible Kinase 1
            Increases the Susceptibility to Epileptic Seizures and Interferes
            with Adrenocorticotropic Hormone Therapy for Infantile Spasms in
            Mice
  JOURNAL   Int J Mol Sci 23 (14), 7927 (2022)
   PUBMED   35887274
  REMARK    GeneRIF: An Epilepsy-Associated Mutation of Salt-Inducible Kinase 1
            Increases the Susceptibility to Epileptic Seizures and Interferes
            with Adrenocorticotropic Hormone Therapy for Infantile Spasms in
            Mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4523)
  AUTHORS   Nefla,M., Darling,N.J., van Gijsel Bonnello,M., Cohen,P. and
            Arthur,J.S.C.
  TITLE     Salt inducible kinases 2 and 3 are required for thymic T cell
            development
  JOURNAL   Sci Rep 11 (1), 21550 (2021)
   PUBMED   34732767
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4523)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   7  (bases 1 to 4523)
  AUTHORS   Takemori,H., Katoh,Y., Horike,N., Doi,J. and Okamoto,M.
  TITLE     ACTH-induced nucleocytoplasmic translocation of salt-inducible
            kinase. Implication in the protein kinase A-activated gene
            transcription in mouse adrenocortical tumor cells
  JOURNAL   J Biol Chem 277 (44), 42334-42343 (2002)
   PUBMED   12200423
REFERENCE   8  (bases 1 to 4523)
  AUTHORS   Feldman,J.D., Vician,L., Crispino,M., Hoe,W., Baudry,M. and
            Herschman,H.R.
  TITLE     The salt-inducible kinase, SIK, is induced by depolarization in
            brain
  JOURNAL   J Neurochem 74 (6), 2227-2238 (2000)
   PUBMED   10820182
REFERENCE   9  (bases 1 to 4523)
  AUTHORS   Burmeister,M. and Meyer,G.E.
  TITLE     The trefoil gene maps to mouse chromosome 17
  JOURNAL   Mamm Genome 8 (3), 223-224 (1997)
   PUBMED   9072957
REFERENCE   10 (bases 1 to 4523)
  AUTHORS   Ruiz,J.C., Conlon,F.L. and Robertson,E.J.
  TITLE     Identification of novel protein kinases expressed in the myocardium
            of the developing mouse heart
  JOURNAL   Mech Dev 48 (3), 153-164 (1994)
   PUBMED   7893599
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166654.1 and AK141817.1.
            
            On Jan 24, 2017 this sequence version replaced NM_010831.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141817.1, U11494.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC166654.1         10359-10370
            13-4521             AK141817.1         2-4510
            4522-4523           AC166654.1         21914-21915
FEATURES             Location/Qualifiers
     source          1..4523
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.25 cM"
     gene            1..4523
                     /gene="Sik1"
                     /gene_synonym="Hrt-20; Msk; Sik; Sik-1; Snf1lk"
                     /note="salt inducible kinase 1"
                     /db_xref="GeneID:17691"
                     /db_xref="MGI:MGI:104754"
     exon            1..133
                     /gene="Sik1"
                     /gene_synonym="Hrt-20; Msk; Sik; Sik-1; Snf1lk"
                     /inference="alignment:Splign:2.1.0"
     exon            134..304
                     /gene="Sik1"
                     /gene_synonym="Hrt-20; Msk; Sik; Sik-1; Snf1lk"
                     /inference="alignment:Splign:2.1.0"
     exon            305..421
                     /gene="Sik1"
                     /gene_synonym="Hrt-20; Msk; Sik; Sik-1; Snf1lk"
                     /inference="alignment:Splign:2.1.0"
     exon            422..485
                     /gene="Sik1"
                     /gene_synonym="Hrt-20; Msk; Sik; Sik-1; Snf1lk"
                     /inference="alignment:Splign:2.1.0"
     exon            486..647
                     /gene="Sik1"
                     /gene_synonym="Hrt-20; Msk; Sik; Sik-1; Snf1lk"
                     /inference="alignment:Splign:2.1.0"
     exon            648..772
                     /gene="Sik1"
                     /gene_synonym="Hrt-20; Msk; Sik; Sik-1; Snf1lk"
                     /inference="alignment:Splign:2.1.0"
     exon            773..896
                     /gene="Sik1"
                     /gene_synonym="Hrt-20; Msk; Sik; Sik-1; Snf1lk"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1120
                     /gene="Sik1"
                     /gene_synonym="Hrt-20; Msk; Sik; Sik-1; Snf1lk"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1276
                     /gene="Sik1"
                     /gene_synonym="Hrt-20; Msk; Sik; Sik-1; Snf1lk"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1399
                     /gene="Sik1"
                     /gene_synonym="Hrt-20; Msk; Sik; Sik-1; Snf1lk"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1616
                     /gene="Sik1"
                     /gene_synonym="Hrt-20; Msk; Sik; Sik-1; Snf1lk"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1898
                     /gene="Sik1"
                     /gene_synonym="Hrt-20; Msk; Sik; Sik-1; Snf1lk"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2127
                     /gene="Sik1"
                     /gene_synonym="Hrt-20; Msk; Sik; Sik-1; Snf1lk"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..4523
                     /gene="Sik1"
                     /gene_synonym="Hrt-20; Msk; Sik; Sik-1; Snf1lk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2632..2637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sik1"
                     /gene_synonym="Hrt-20; Msk; Sik; Sik-1; Snf1lk"
                     /note="hexamer: AACAAG"
     polyA_site      2653
                     /gene="Sik1"
                     /gene_synonym="Hrt-20; Msk; Sik; Sik-1; Snf1lk"
                     /note="major polyA site"
     regulatory      3426..3431
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sik1"
                     /gene_synonym="Hrt-20; Msk; Sik; Sik-1; Snf1lk"
                     /note="hexamer: TATAAA"
     polyA_site      3447
                     /gene="Sik1"
                     /gene_synonym="Hrt-20; Msk; Sik; Sik-1; Snf1lk"
                     /note="major polyA site"
ORIGIN      
        1 ggggcgctga catgcggcga ggcccgggcg gtggcggcag cgttggcggc ggcggcgcga
       61 acggcgggca ccggagcaga gctagcagcc gagcgggtgg catcccgggt cgggctcacg
      121 gagggcggcg gaggtgcggc ccgaagccat ggtgatcatg tcggagttca gtgcggtccc
      181 ctcaggcact ggccagggcc agcagaagcc cctccgggtg ggcttttacg acgtggaacg
      241 gaccctgggc aaaggcaatt ttgcagtggt taagctggcg cggcaccgag tcaccaaaac
      301 gcaggttgca ataaaaataa ttgacaagac acggttagat tctagcaatc tggagaagat
      361 ctaccgggag gtccagctca tgaaactttt gaaccaccca aatatcatca agctttatca
      421 ggttatggag acaaaggata tgctctacat tgtcacagaa tttgcaaaaa atggagaaat
      481 gtttgattat ctgacttcca acgggcactt gagtgaaaac gaggctaggc agaagttctg
      541 gcagattctg tcagccgtgg agtactgcca caaccaccac attgtccacc gggacctcaa
      601 gacggagaac ctgctcctgg acagcaacat ggatatcaag ctagcagatt ttggatttgg
      661 gaatttctac aagccaggcg agcctctgtc cacgtggtgt gggagccccc cgtatgcagc
      721 ccctgaagtc ttcgagggga aggagtacga gggtccccag ctggacgtct ggagcctcgg
      781 tgtggtgctg tacgtcctgg tctgtggctc cctccccttc gacgggccca acctgcctac
      841 gctgagacag cgggtactgg agggccgctt ccgcatcccc ttcttcatgt ctcaagactg
      901 tgagacgctg atcagacgca tgctggtcgt ggaccccgct aagcgcatca ccatagccca
      961 gatccgccag caccggtgga tgcaggccga ccccactctc ctgcagcagg atgaccctgc
     1021 cttcgacatg caaggctaca cctccaacct gggcgactac aacgaacagg tgctagggat
     1081 catgcaggcc ctcggcatcg accggcagcg gactatagag tctctgcaga acagcagcta
     1141 caaccacttt gccgccattt actacctcct actcgagcgc ctcaaggagc atcgaagcgc
     1201 ccagccctca tcccggccca cccctgcacc caccagacag ccccagctcc gaagctcaga
     1261 cctcagcagt ctggaggttc ctcaagaaat tctcccgtgt gaccctttcc ggccctctct
     1321 gctgtgccca cagccccagg ccttggctca gtctgtcctg caggctgaga tagactgtga
     1381 tctccacagc tcacttcagc ccttattatt ccccctggat accaactgca gtggagtgtt
     1441 ccggcaccga tccatctccc ccagcagtct gctggacaca gctatcagcg aggaggccag
     1501 gcagggtccc agcctagagg aggaacagga ggtccaggaa cccctgcccg gaagcacagg
     1561 ccggaggcac acattggctg aagtctccac ccatttctcc ccgctcaacc ctccttgcat
     1621 aattgtctcc tcctctgcca cggcgagtcc ctcggaaggg accagctccg acagctgcct
     1681 ccccttctct gcaagtgaag gtcctgcagg gcttggcagt ggcctggcca ccccagggct
     1741 gctgggcacc agctctccag tcagattggc ctcgcccttc ctgggatcac agtcagccac
     1801 ccctgtgctc cagactcagg caggtctggg cacagccgtc ttacctcccg tcagcttcca
     1861 ggagggacgg agagcgtctg atacctctct cactcagggg ctgaaggcct tccggcagca
     1921 gctgaggaaa aatgcgagga ccaaggggtt cctgggactg aacaagatca aagggttggc
     1981 tcgccaggtg tgccagtcct ccgtccgaac tccccgggga gggatgagta ccttccacac
     2041 cccagcccca agctccggcc tgcaaggctg cacgaccagc aatcgggagg gcaggagcct
     2101 acttgaagag gtcctgcacc agcagaggct gctccagtta cagcaccact cttctaccgc
     2161 cgccgcctca tctggctgcc agcagggccc ccagctgtcc ccggtcccct atgtgcttgc
     2221 tccctgtgac agcctcctcg tgtctggaat tccactgctg ccaacacccc ttctccaggc
     2281 tggcatgtcc cctgtggcgt ctgctgcgca tctcctggat acccacttgc acatcagtgc
     2341 tggcccagtg gccctcccca ctgggcccct gccacagtgc ctcaccaggc tgtccccagg
     2401 ctgtgatcca gctgggctgc cacaggggga ctgtgagatg gaggacctga cctctggcca
     2461 gcgggggaca ttcgtcctgg tacagtgagg gtggctctgg cccacatccc cccaacctcg
     2521 ccaccttcac cacccccccc caaccgtggc cgattgactc ttccaagcaa taatttcgga
     2581 gtatgtgaag atggtttccg gactcaaaag ccaagaactt tctagacgtg aaacaagcaa
     2641 tacgtttggt gtatgggctt tttaggattt ttgttgttgt tgttttttgt tttgttttct
     2701 ccttgcactg agtgacctca atgataagta gggaaacttt ctgaagaaaa ataataattg
     2761 agagtatgtc acgtgggcgg gcggacggga gggaagggca gtggggggag agcggcctcc
     2821 gaggcgtgat gagctggggc atccctgaag tgggggcagc tcgtactgtt gctcatgcct
     2881 gtgtagtggt tggcgttgtt tcaggcttgg gttcacagct ctccacttct gaaacgcgca
     2941 tgctttagac agaaactgtg aactcgctgc tttctgtgtg ggtttcagag tagccaaggc
     3001 tcagcccagg ggaagacaaa cggcatgcat tctcggggtc tcccgtcagc cagaagaccg
     3061 ccttgtcgtg gttcagcttg ggggtttttg tagctgctca agtcagtgcg ccaggcttat
     3121 tcagaggcct ggaagggagg aagttccttc cggccttgta cctcgactct gctgctaatt
     3181 atcagatttt tatgcatttc attatcaggg tcccgctaga acacctgact tgggggaatt
     3241 gtgcaatacc aaggggctgt cggcatcttg gttatgacta ccttgccctt ggcctgggac
     3301 ctttcctggt aaaagcctgg cccccccccc aaggcctggg ctctgtctgg cttgctttcc
     3361 aggaggatca taagtatagg tcagtgtttg taaagtttct ttttaaagca aatactgtat
     3421 gtgtatataa ataggaaaca gacactactt atttttttct attttgtata catttttgtg
     3481 tttctggctt aaaaaaacct cccttggtca cattaggaag ttgtccccat gtttgtggtg
     3541 aaaggcctgt aggctaccca cctcctgtac agagtagagg tgtcagggaa gaagtggccc
     3601 cacctgacag gtctacctgg gcagggaagg cccaggcaac agccgtgcca tccaaacacc
     3661 tctggaagga accagggatg tcaacccttc tgactcgcgt ctgtctctct gcctcccggg
     3721 cgacttccac caccaaatct caccgcagca gtattaacct gaggtcatta agggagagga
     3781 aaggagacac ttcaaaagcc aaagattgac cgagttacct gaggccagga agaggcagcg
     3841 ccgaaacctg atgtcccagc gtggtcctcc gtgggccccg tggcccatcc tataccgctt
     3901 actctccaga caggcgaagg accgaccagt cttctgggtt ggaactggtg ccctccacag
     3961 aacaaaccaa aaagtgtccc tcctgccgac tcacctgatg tgtgcatcag ggaagcaagc
     4021 actcagtatc ctaaggcagc cagccctcat ctcccatagt tcctgtctgg ataccacaga
     4081 tcaaaggcct gtgcactgct gtgtgtcaga atcgacaagc actttacttt ctggcagttt
     4141 ttgtgtcttc tagttgctat caaccctctg ggggacagta acatcatggt ttttagttct
     4201 tgggttttgg ggttttgttt tttgggtttt gttttttttt tttttttttt ttttttggtg
     4261 tgtgtgctat gtttttgtag atcctcacgg ccctggactg gactgtaatg gaatcgccta
     4321 tttaaagaca ctacgtgatc tcagatgtat ataatggttt tgttttgttt tcgttttttt
     4381 tttttttttt tttactatga tggaatcgtt tcatttctca tgttaatgtg agagacgtat
     4441 gccaaatgat tagttgatgt atttttttta atttaatatt taaataaaat atttgggggg
     4501 aaatcttgac ttacccttgg ttc
//
