LOCUS       NM_011014               1640 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Mus musculus sigma non-opioid intracellular receptor 1 (Sigmar1),
            transcript variant 1, mRNA.
ACCESSION   NM_011014
VERSION     NM_011014.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1640)
  AUTHORS   Tan,R., Sui,C., Diao,Y., Shi,G., Hu,X., Hao,Z., Li,C., Hao,M.,
            Xie,M. and Zhu,T.
  TITLE     Activation of the sigma-1 receptor ameliorates neuronal ferroptosis
            via IRE1alpha after spinal cord injury
  JOURNAL   Brain Res 1838, 149011 (2024)
   PUBMED   38763502
  REMARK    GeneRIF: Activation of the sigma-1 receptor ameliorates neuronal
            ferroptosis via IRE1alpha after spinal cord injury.
REFERENCE   2  (bases 1 to 1640)
  AUTHORS   Ruiz-Cantero,M.C., Entrena,J.M., Artacho-Cordon,A., Huerta,M.A.,
            Portillo-Salido,E., Nieto,F.R., Baeyens,J.M., Costigan,M.,
            Gonzalez-Cano,R. and Cobos,E.J.
  TITLE     Sigma-1 Receptors Control Neuropathic Pain and Peripheral
            Neuroinflammation After Nerve Injury in Female Mice: A
            Transcriptomic Study
  JOURNAL   J Neuroimmune Pharmacol 19 (1), 46 (2024)
   PUBMED   39162886
  REMARK    GeneRIF: Sigma-1 Receptors Control Neuropathic Pain and Peripheral
            Neuroinflammation After Nerve Injury in Female Mice: A
            Transcriptomic Study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1640)
  AUTHORS   Shioda,N., Ishikawa,K., Tagashira,H., Ishizuka,T., Yawo,H. and
            Fukunaga,K.
  TITLE     Expression of a truncated form of the endoplasmic reticulum
            chaperone protein, sigma1 receptor, promotes mitochondrial energy
            depletion and apoptosis
  JOURNAL   J Biol Chem 287 (28), 23318-23331 (2012)
   PUBMED   22619170
  REMARK    GeneRIF: Data indicate that sigma1-receptor short form sigma(1)SR
            isoform interferes with sigma(1)R function relevant to
            mitochondrial energy production under endoplasmic reticulum stress
            conditions, promoting cellular apoptosis.
REFERENCE   4  (bases 1 to 1640)
  AUTHORS   Pal,A., Fontanilla,D., Gopalakrishnan,A., Chae,Y.K., Markley,J.L.
            and Ruoho,A.E.
  TITLE     The sigma-1 receptor protects against cellular oxidative stress and
            activates antioxidant response elements
  JOURNAL   Eur J Pharmacol 682 (1-3), 12-20 (2012)
   PUBMED   22381068
  REMARK    GeneRIF: novel functions of the sigma-1 receptor
REFERENCE   5  (bases 1 to 1640)
  AUTHORS   Mavlyutov,T.A., Epstein,M.L., Andersen,K.A., Ziskind-Conhaim,L. and
            Ruoho,A.E.
  TITLE     The sigma-1 receptor is enriched in postsynaptic sites of
            C-terminals in mouse motoneurons. An anatomical and behavioral
            study
  JOURNAL   Neuroscience 167 (2), 247-255 (2010)
   PUBMED   20167253
  REMARK    GeneRIF: The sigma-1 receptor may play a role in the regulation of
            motor behavior.
REFERENCE   6  (bases 1 to 1640)
  AUTHORS   Mishina,M., Ishiwata,K., Ishii,K., Kitamura,S., Kimura,Y.,
            Kawamura,K., Oda,K., Sasaki,T., Sakayori,O., Hamamoto,M.,
            Kobayashi,S. and Katayama,Y.
  TITLE     Function of sigma1 receptors in Parkinson's disease
  JOURNAL   Acta Neurol Scand 112 (2), 103-107 (2005)
   PUBMED   16008536
REFERENCE   7  (bases 1 to 1640)
  AUTHORS   Hayashi,T. and Su,T.P.
  TITLE     Regulating ankyrin dynamics: Roles of sigma-1 receptors
  JOURNAL   Proc Natl Acad Sci U S A 98 (2), 491-496 (2001)
   PUBMED   11149946
REFERENCE   8  (bases 1 to 1640)
  AUTHORS   Pan,Y.X., Mei,J., Xu,J., Wan,B.L., Zuckerman,A. and Pasternak,G.W.
  TITLE     Cloning and characterization of a mouse sigma1 receptor
  JOURNAL   J Neurochem 70 (6), 2279-2285 (1998)
   PUBMED   9603192
REFERENCE   9  (bases 1 to 1640)
  AUTHORS   Seth,P., Leibach,F.H. and Ganapathy,V.
  TITLE     Cloning and structural analysis of the cDNA and the gene encoding
            the murine type 1 sigma receptor
  JOURNAL   Biochem Biophys Res Commun 241 (2), 535-540 (1997)
   PUBMED   9425306
REFERENCE   10 (bases 1 to 1640)
  AUTHORS   King,M., Pan,Y.X., Mei,J., Chang,A., Xu,J. and Pasternak,G.W.
  TITLE     Enhanced kappa-opioid receptor-mediated analgesia by antisense
            targeting the sigma1 receptor
  JOURNAL   Eur J Pharmacol 331 (1), R5-R6 (1997)
   PUBMED   9274937
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BB851853.1, AF030198.1 and
            BB741155.1.
            
            On Nov 13, 2013 this sequence version replaced NM_011014.2.
            
            Summary: This gene encodes a transmembrane protein located in the
            endoplasmic reticulum. The encoded protein is a receptor that binds
            several endogenous ligands, including N,N-dimethyltryptamine,
            progesterone and pregnenolone and a variety of of non-opiate
            compounds. The encoded protein plays a role in regulating the
            activity of ion channels, acting as a chaperone and protecting
            cells from oxidative stress. In humans, this receptor has been
            associated with Alzheimer's and Parkinson's diseases, stroke and
            numerous disease conditions such as depression, pain and addiction.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms.[provided by RefSeq, Nov 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154300.1, AF004927.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                BB851853.1         2-87
            87-1637             AF030198.1         1-1551
            1638-1640           BB741155.1         382-384
FEATURES             Location/Qualifiers
     source          1..1640
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 22.05 cM"
     gene            1..1640
                     /gene="Sigmar1"
                     /gene_synonym="Oprs1; Sig1R; sigma1R"
                     /note="sigma non-opioid intracellular receptor 1"
                     /db_xref="GeneID:18391"
                     /db_xref="MGI:MGI:1195268"
     exon            1..258
                     /gene="Sigmar1"
                     /gene_synonym="Oprs1; Sig1R; sigma1R"
                     /inference="alignment:Splign:2.1.0"
     exon            259..459
                     /gene="Sigmar1"
                     /gene_synonym="Oprs1; Sig1R; sigma1R"
                     /inference="alignment:Splign:2.1.0"
     exon            460..552
                     /gene="Sigmar1"
                     /gene_synonym="Oprs1; Sig1R; sigma1R"
                     /inference="alignment:Splign:2.1.0"
     exon            553..1640
                     /gene="Sigmar1"
                     /gene_synonym="Oprs1; Sig1R; sigma1R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1619..1624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sigmar1"
                     /gene_synonym="Oprs1; Sig1R; sigma1R"
                     /note="hexamer: AATAAA"
     polyA_site      1637
                     /gene="Sigmar1"
                     /gene_synonym="Oprs1; Sig1R; sigma1R"
                     /note="major polyA site"
ORIGIN      
        1 gtaccacggt ggcgggggcg accgtaggca gcggcttttg agtcgtgaac ccacagcctg
       61 tggccctagt tcggtcttac gttggtggtg ccaggctgcc cgctagaatg ccgtgggccg
      121 cgggacggcg gtgggcatgg atcaccctga ttctgactat tatcgcagtg ctgatccagg
      181 ccgcctggtt gtggctgggc actcaaaact tcgtcttctc tagagaagaa atagcgcagc
      241 ttgctcgaca gtatgcgggg ctggaccatg agcttgcctt ctctcggctg atcgtggagc
      301 tgcggaggct gcacccaggc cacgtgctgc cggatgagga gctgcagtgg gtatttgtga
      361 acgcgggcgg ctggatgggc gccatgtgta ttctgcacgc ctcgctgtct gagtacgtgc
      421 tgctcttcgg caccgccctg ggctcccatg gccattcggg acgatactgg gctgagattt
      481 ctgacaccat catctctggc accttccacc aatggaaaga gggcaccacg aaaagtgagg
      541 tcttctaccc aggagagaca gttgtacacg ggcctggaga agcaacggct ctggagtggg
      601 gaccaaacac gtggatggtg gagtacggcc ggggtgttat tccgtctacc ctgttctttg
      661 cactagccga cactttcttc agcacccagg actacctcac actcttctat acccttcggg
      721 cctatgcccg gggcctccgg cttgagctta ccacctacct ctttggccaa gactcctgac
      781 cagccaggcc tgaaggaaga tctgtggatg gacaggagcg cggcaggacc acatccatct
      841 ctctactcgc tggaactcat attcagacag cagcgtatac catgcagata ttaagtacct
      901 gctgtatgag gaaggacata catacttgta catccagaca cagctcttgg gaagcaaatg
      961 agacacagag atgctaagac ttgtatgtac tgtaagatca tgcactcaca tccacccaga
     1021 aagggtcctc tacatatact ccagggggcc agtcatgttt gaacacacat cacaagcttg
     1081 actcactgac tcaggctttc ctagagcctc ctgctggcat tcagggctct gggatcaagg
     1141 gttgaggtag atgttacaca ctacctcact ctgatgcctc attcctgtag taatctctgg
     1201 tgaagggaaa gaggagctgc ccttcggagg tccccttcac ctgcagctat gatgcccttc
     1261 ccttcatccc tttcctcacc atatgcctta tctccattcc actcccctgc tatgcaaatg
     1321 cccccctggc ttgtcctccc tgcccccccc ccccggcaac cagttcagct gggaaagcag
     1381 aggcatgtag aggatgctaa agggaaggga ggtcctccac tacggagacc cttgttgggg
     1441 ttagaatggg aaagctggct agtgccccag ggccagttcc caaggagagg acctggagaa
     1501 gtaagccggg gtccaaggag ccaccccatt ccaaaagaag cctttagtgt gtgtgtgcac
     1561 accctatcag tttccagaca tatctgttgc aatctctgtc ttcttgtctc tctctgttaa
     1621 taaaaacata ttaaacagtt
//
