LOCUS       NM_031181               1849 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus sialic acid binding Ig-like lectin E (Siglece), mRNA.
ACCESSION   NM_031181
VERSION     NM_031181.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1849)
  AUTHORS   Cuello,H.A., Sinha,S., Verhagen,A.L., Varki,N., Varki,A. and
            Ghosh,P.
  TITLE     Human-specific elimination of epithelial Siglec-XII suppresses the
            risk of inflammation-driven colorectal cancers
  JOURNAL   JCI Insight 9 (16), e181539 (2024)
   PUBMED   38990656
  REMARK    GeneRIF: Human-specific elimination of epithelial Siglec-XII
            suppresses the risk of inflammation-driven colorectal cancers.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1849)
  AUTHORS   He,X., Zhang,X., Wu,B., Deng,J., Zhang,Y., Zhu,A., Yuan,Y., Lin,Y.,
            Chen,A., Feng,J., Wang,X., Wu,S., Liu,Y., Liu,J., Wang,Y., Li,R.,
            Liang,C., Yuan,Q., Liang,Y., Fang,Q., Xi,Z., Li,W., Liang,L.,
            Zhang,Z., Tang,H., Peng,Y., Ke,C., Ma,X., Cai,W., Pan,T., Liu,B.,
            Deng,K., Chen,J., Zhao,J., Wei,X., Chen,R., Zhang,Y. and Zhang,H.
  TITLE     The receptor binding domain of SARS-CoV-2 Omicron subvariants
            targets Siglec-9 to decrease its immunogenicity by preventing
            macrophage phagocytosis
  JOURNAL   Nat Immunol 25 (4), 622-632 (2024)
   PUBMED   38454157
  REMARK    GeneRIF: The receptor binding domain of SARS-CoV-2 Omicron
            subvariants targets Siglec-9 to decrease its immunogenicity by
            preventing macrophage phagocytosis.
REFERENCE   3  (bases 1 to 1849)
  AUTHORS   Lozano-Rodriguez,R., Avendano-Ortiz,J., Montalban-Hernandez,K.,
            Ruiz-Rodriguez,J.C., Ferrer,R., Martin-Quiros,A., Maroun-Eid,C.,
            Gonzalez-Lopez,J.J., Fabrega,A., Terron-Arcos,V.,
            Gutierrez-Fernandez,M., Alonso-Lopez,E., Cubillos-Zapata,C.,
            Fernandez-Velasco,M., Perez de Diego,R., Pelegrin,P.,
            Garcia-Palenciano,C., Cueto,F.J., Del Fresno,C. and
            Lopez-Collazo,E.
  TITLE     The prognostic impact of SIGLEC5-induced impairment of CD8+ T cell
            activation in sepsis
  JOURNAL   EBioMedicine 97, 104841 (2023)
   PUBMED   37890368
  REMARK    GeneRIF: The prognostic impact of SIGLEC5-induced impairment of
            CD8[+] T cell activation in sepsis.
REFERENCE   4  (bases 1 to 1849)
  AUTHORS   Schmassmann,P., Roux,J., Buck,A., Tatari,N., Hogan,S., Wang,J.,
            Rodrigues Mantuano,N., Wieboldt,R., Lee,S., Snijder,B., Kaymak,D.,
            Martins,T.A., Ritz,M.F., Shekarian,T., McDaid,M., Weller,M.,
            Weiss,T., Laubli,H. and Hutter,G.
  TITLE     Targeting the Siglec-sialic acid axis promotes antitumor immune
            responses in preclinical models of glioblastoma
  JOURNAL   Sci Transl Med 15 (705), eadf5302 (2023)
   PUBMED   37467314
REFERENCE   5  (bases 1 to 1849)
  AUTHORS   Schroder,L.J., Thiesler,H., Gretenkort,L., Mollenkamp,T.M.,
            Stangel,M., Gudi,V. and Hildebrandt,H.
  TITLE     Polysialic acid promotes remyelination in cerebellar slice cultures
            by Siglec-E-dependent modulation of microglia polarization
  JOURNAL   Front Cell Neurosci 17, 1207540 (2023)
   PUBMED   37492129
  REMARK    Erratum:[Front Cell Neurosci. 2023 Aug 23;17:1275048. doi:
            10.3389/fncel.2023.1275048. PMID: 37680864]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1849)
  AUTHORS   Angata,T., Margulies,E.H., Green,E.D. and Varki,A.
  TITLE     Large-scale sequencing of the CD33-related Siglec gene cluster in
            five mammalian species reveals rapid evolution by multiple
            mechanisms
  JOURNAL   Proc Natl Acad Sci U S A 101 (36), 13251-13256 (2004)
   PUBMED   15331780
REFERENCE   7  (bases 1 to 1849)
  AUTHORS   Zhang,J.Q., Biedermann,B., Nitschke,L. and Crocker,P.R.
  TITLE     The murine inhibitory receptor mSiglec-E is expressed broadly on
            cells of the innate immune system whereas mSiglec-F is restricted
            to eosinophils
  JOURNAL   Eur J Immunol 34 (4), 1175-1184 (2004)
   PUBMED   15048729
REFERENCE   8  (bases 1 to 1849)
  AUTHORS   Garcia-Frigola,C., Burgaya,F., Calbet,M., Lopez-Domenech,G., de
            Lecea,L. and Soriano,E.
  TITLE     A collection of cDNAs enriched in upper cortical layers of the
            embryonic mouse brain
  JOURNAL   Brain Res Mol Brain Res 122 (2), 133-150 (2004)
   PUBMED   15010206
REFERENCE   9  (bases 1 to 1849)
  AUTHORS   Ulyanova,T., Shah,D.D. and Thomas,M.L.
  TITLE     Molecular cloning of MIS, a myeloid inhibitory siglec, that binds
            protein-tyrosine phosphatases SHP-1 and SHP-2
  JOURNAL   J Biol Chem 276 (17), 14451-14458 (2001)
   PUBMED   11278955
REFERENCE   10 (bases 1 to 1849)
  AUTHORS   Yu,Z., Maoui,M., Wu,L., Banville,D. and Shen,S.
  TITLE     mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding
            immunoglobulin-like lectin) that recruits Src homology 2
            (SH2)-domain-containing protein tyrosine phosphatases SHP-1 and
            SHP-2
  JOURNAL   Biochem J 353 (Pt 3), 483-492 (2001)
   PUBMED   11171044
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151989.4.
            
            On Mar 23, 2007 this sequence version replaced NM_031181.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF329269.1, BC023280.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-468               AC151989.4         157989-158456
            469-747             AC151989.4         158662-158940
            748-795             AC151989.4         159130-159177
            796-1053            AC151989.4         160355-160612
            1054-1147           AC151989.4         161531-161624
            1148-1229           AC151989.4         161977-162058
            1230-1849           AC151989.4         166461-167080
FEATURES             Location/Qualifiers
     source          1..1849
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.25 cM"
     gene            1..1849
                     /gene="Siglece"
                     /gene_synonym="Cd170; mSiglec-E; Siglec12; Siglec5;
                     Siglec9; Siglecl1"
                     /note="sialic acid binding Ig-like lectin E"
                     /db_xref="GeneID:83382"
                     /db_xref="MGI:MGI:1932475"
     exon            1..468
                     /gene="Siglece"
                     /gene_synonym="Cd170; mSiglec-E; Siglec12; Siglec5;
                     Siglec9; Siglecl1"
                     /inference="alignment:Splign:2.1.0"
     exon            469..747
                     /gene="Siglece"
                     /gene_synonym="Cd170; mSiglec-E; Siglec12; Siglec5;
                     Siglec9; Siglecl1"
                     /inference="alignment:Splign:2.1.0"
     exon            748..795
                     /gene="Siglece"
                     /gene_synonym="Cd170; mSiglec-E; Siglec12; Siglec5;
                     Siglec9; Siglecl1"
                     /inference="alignment:Splign:2.1.0"
     exon            796..1053
                     /gene="Siglece"
                     /gene_synonym="Cd170; mSiglec-E; Siglec12; Siglec5;
                     Siglec9; Siglecl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1147
                     /gene="Siglece"
                     /gene_synonym="Cd170; mSiglec-E; Siglec12; Siglec5;
                     Siglec9; Siglecl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1229
                     /gene="Siglece"
                     /gene_synonym="Cd170; mSiglec-E; Siglec12; Siglec5;
                     Siglec9; Siglecl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1849
                     /gene="Siglece"
                     /gene_synonym="Cd170; mSiglec-E; Siglec12; Siglec5;
                     Siglec9; Siglecl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1807..1812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Siglece"
                     /gene_synonym="Cd170; mSiglec-E; Siglec12; Siglec5;
                     Siglec9; Siglecl1"
                     /note="hexamer: ATTAAA"
     polyA_site      1830
                     /gene="Siglece"
                     /gene_synonym="Cd170; mSiglec-E; Siglec12; Siglec5;
                     Siglec9; Siglecl1"
                     /note="major polyA site"
ORIGIN      
        1 agagcctgga gagacagttt tagctggaca tgctgctgtt gctgctgctg ctgctgctct
       61 gggggataaa gggtgtggag ggtcagaacc cccaagaggt tttcaccctg aatgtggaaa
      121 ggaaggtggt ggtgcaggag ggcctgtgtg tccttgtgcc ctgtaacttc tcctatctca
      181 agaagaggtt gactgactgg actgactcag acccagttca tggattctgg tacagggaag
      241 gaaccgacag acgcaaagat tccatcgtgg ccacaaataa cccaattcgt aaagcagtga
      301 aggaaacccg gaatcgattc ttcctgctcg gagacccttg gaggaatgac tgctccctga
      361 acatcagaga gatcagaaag aaggatgcgg ggttatactt ctttcgcctg gagcgtggaa
      421 aaacaaagta taattacatg tgggacaaga tgactctggt tgtaacagcc ctcactaaca
      481 ccccccaaat tcttctcccg gagacgcttg aagctggcca tcccagcaac ctgacctgct
      541 ctgtgccttg ggactgtggg tggacggcac ctcccatctt ctcctggact ggtacctctg
      601 tgtcattttt gagcaccaac actacgggtt cctcagtgct aaccatcacc cctcagcctc
      661 aggaccatgg caccaacctc acttgtcagg tgaccctgcc tggaactaat gtgtccacaa
      721 gaatgaccat ccgtctcaac gtgtcatatg ctccaaagaa tctgactgtg accatctatc
      781 aaggagctga ctcagtttcc acaatcctga agaatggctc atctcttcct atctctgagg
      841 gccagtcact gcgtctcatc tgcagcaccg acagctatcc ccctgcgaac ctaagctggt
      901 cctgggataa cctgaccctg tgcccatcaa agttgtccaa gcccgggctc ctggagctgt
      961 ttccagtgca tcttaagcac ggaggagtgt atacctgcca agctcaacat gccctgggct
     1021 cccaacacat ttccttgagc ctgtctccac agagcagtgc aactttatct gaaatgatga
     1081 tggggacctt tgtgggttca ggagtcacag ccctcctttt cctgtctgtc tgcatcctcc
     1141 tcctggcagt aagatcctac aggaggaaac cagccaggcc agctgtggta gctccgcacc
     1201 cagatgccct caaggtctca gtttctcaga atcccctggt tgaatcccag gcagatgaca
     1261 gctctgagcc cctgccttcc atacttgagg cggccccctc ctccacagag gaagagatac
     1321 attatgcgac cctcagcttt cacgagatga agcccatgaa cctgtggggg caacaggaca
     1381 ctaccacgga gtactcagag ataaagtttc cacaaaggac cgcatggcca tgaccgtggc
     1441 tggagaaagc atggtggccc caggaggctg gctctggaga aggaaagagt cacctaggtt
     1501 gacatgtgat acacagggct tcagagccat tccttctgtg acacaggcgt tctgtgctgc
     1561 ccatgcccct gtgctgccct gtccacacaa ctgctattgt gccctgggaa tcataagctt
     1621 gaccttttta ctcctcttct ccccttcccc tccttccccg ccccctcttc tcctcctcct
     1681 ctctcccctc tcctcccctc ttccttttgt tttttccaag acagggtttc tctgtgtagc
     1741 cttggctgtc ctagaacttg ctctgcagac cagactgccc ttgaactctt ctttccaagt
     1801 gctgggatta aagatgtgca ccaccaccca gcacttgact ttattgtaa
//
