LOCUS       NM_001101038            2323 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Mus musculus sialic acid binding Ig-like lectin 15 (Siglec15),
            mRNA.
ACCESSION   NM_001101038 XM_884636 XM_916291
VERSION     NM_001101038.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2323)
  AUTHORS   Kobayashi,H., Terkawi,M.A., Ota,M., Hasegawa,T., Yamamoto,T.,
            Shimizu,T., Sato,D., Fujita,R., Murakami,T., Amizuka,N., Iwasaki,N.
            and Takahata,M.
  TITLE     Involvement of Siglec-15 in regulating RAP1/RAC signaling in
            cytoskeletal remodeling in osteoclasts mediated by macrophage
            colony-stimulating factor
  JOURNAL   Bone Res 12 (1), 35 (2024)
   PUBMED   38849345
  REMARK    GeneRIF: Involvement of Siglec-15 in regulating RAP1/RAC signaling
            in cytoskeletal remodeling in osteoclasts mediated by macrophage
            colony-stimulating factor.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2323)
  AUTHORS   Wu,Y., Ai,H., Xi,Y., Tan,J., Qu,Y., Xu,J., Luo,F. and Dou,C.
  TITLE     Osteoclast-derived apoptotic bodies inhibit naive CD8+ T cell
            activation via Siglec15, promoting breast cancer secondary
            metastasis
  JOURNAL   Cell Rep Med 4 (9), 101165 (2023)
   PUBMED   37607544
  REMARK    GeneRIF: Osteoclast-derived apoptotic bodies inhibit naive CD8[+] T
            cell activation via Siglec15, promoting breast cancer secondary
            metastasis.
REFERENCE   3  (bases 1 to 2323)
  AUTHORS   Pillsbury,C.E., Dougan,J., Rabe,J.L., Fonseca,J.A., Zhou,C.,
            Evans,A.N., Abukharma,H., Ichoku,O., Gonzalez-Flamenco,G.,
            Park,S.I., Aljudi,A., DeRyckere,D., Castellino,S.M., Rafiq,S.,
            Langermann,S., Liu,L.N., Henry,C.J. and Porter,C.C.
  TITLE     Siglec-15 Promotes Evasion of Adaptive Immunity in B-cell Acute
            Lymphoblastic Leukemia
  JOURNAL   Cancer Res Commun 3 (7), 1248-1259 (2023)
   PUBMED   37465593
  REMARK    GeneRIF: Siglec-15 Promotes Evasion of Adaptive Immunity in B-cell
            Acute Lymphoblastic Leukemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2323)
  AUTHORS   Chen,Q., Chen,B., Wang,C., Hu,L., Wu,Q., Zhu,Y. and Zhang,Q.
  TITLE     Dynamic change in Siglec-15 expression in peritumoral macrophages
            confers an immunosuppressive microenvironment and poor outcome in
            glioma
  JOURNAL   Front Immunol 14, 1159085 (2023)
   PUBMED   37234161
  REMARK    GeneRIF: Dynamic change in Siglec-15 expression in peritumoral
            macrophages confers an immunosuppressive microenvironment and poor
            outcome in glioma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2323)
  AUTHORS   Li,S.H., Sun,J. and Chen,W.
  TITLE     [Study on the effect and mechanisms of SIGLEC-15 on laryngeal
            squamous cell carcinoma]
  JOURNAL   Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 57 (6), 724-731
            (2022)
   PUBMED   35725316
  REMARK    GeneRIF: [Study on the effect and mechanisms of SIGLEC-15 on
            laryngeal squamous cell carcinoma].
REFERENCE   6  (bases 1 to 2323)
  AUTHORS   Kameda,Y., Takahata,M., Komatsu,M., Mikuni,S., Hatakeyama,S.,
            Shimizu,T., Angata,T., Kinjo,M., Minami,A. and Iwasaki,N.
  TITLE     Siglec-15 regulates osteoclast differentiation by modulating
            RANKL-induced phosphatidylinositol 3-kinase/Akt and Erk pathways in
            association with signaling Adaptor DAP12
  JOURNAL   J Bone Miner Res 28 (12), 2463-2475 (2013)
   PUBMED   23677868
  REMARK    GeneRIF: Siglec-15 regulates osteoclast development and bone
            resorption by modulating receptor activator of nuclear factor
            kappaB ligand (RANKL) signaling in association with DAP12.
REFERENCE   7  (bases 1 to 2323)
  AUTHORS   Hiruma,Y., Tsuda,E., Maeda,N., Okada,A., Kabasawa,N., Miyamoto,M.,
            Hattori,H. and Fukuda,C.
  TITLE     Impaired osteoclast differentiation and function and mild
            osteopetrosis development in Siglec-15-deficient mice
  JOURNAL   Bone 53 (1), 87-93 (2013)
   PUBMED   23238125
  REMARK    GeneRIF: results reveal the importance of Siglec-15 in the
            regulation of osteoclast formation and/or function in vivo,
            providing new insights into osteoclast biology
REFERENCE   8  (bases 1 to 2323)
  AUTHORS   Ishida-Kitagawa,N., Tanaka,K., Bao,X., Kimura,T., Miura,T.,
            Kitaoka,Y., Hayashi,K., Sato,M., Maruoka,M., Ogawa,T., Miyoshi,J.
            and Takeya,T.
  TITLE     Siglec-15 protein regulates formation of functional osteoclasts in
            concert with DNAX-activating protein of 12 kDa (DAP12)
  JOURNAL   J Biol Chem 287 (21), 17493-17502 (2012)
   PUBMED   22451653
  REMARK    GeneRIF: the Siglec-15-DAP12-Syk-signaling cascade plays a critical
            role in functional osteoclast formation.
REFERENCE   9  (bases 1 to 2323)
  AUTHORS   Hiruma,Y., Hirai,T. and Tsuda,E.
  TITLE     Siglec-15, a member of the sialic acid-binding lectin, is a novel
            regulator for osteoclast differentiation
  JOURNAL   Biochem Biophys Res Commun 409 (3), 424-429 (2011)
   PUBMED   21586272
  REMARK    GeneRIF: These results suggest that Siglec-15 plays an important
            role in osteoclast differentiation.
REFERENCE   10 (bases 1 to 2323)
  AUTHORS   Angata,T., Tabuchi,Y., Nakamura,K. and Nakamura,M.
  TITLE     Siglec-15: an immune system Siglec conserved throughout vertebrate
            evolution
  JOURNAL   Glycobiology 17 (8), 838-846 (2007)
   PUBMED   17483134
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126553.4.
            
            On Feb 20, 2019 this sequence version replaced NM_001101038.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY971517.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               AC126553.4         59902-60126
            226-285             AC126553.4         68054-68113
            286-669             AC126553.4         68471-68854
            670-1044            AC126553.4         69758-70132
            1045-1075           AC126553.4         71187-71217
            1076-2323           AC126553.4         73603-74850
FEATURES             Location/Qualifiers
     source          1..2323
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 52.43 cM"
     gene            1..2323
                     /gene="Siglec15"
                     /gene_synonym="Cd33l3; EG620235; SIGLEC-I"
                     /note="sialic acid binding Ig-like lectin 15"
                     /db_xref="GeneID:620235"
                     /db_xref="MGI:MGI:3646642"
     exon            1..225
                     /gene="Siglec15"
                     /gene_synonym="Cd33l3; EG620235; SIGLEC-I"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..1202
                     /gene="Siglec15"
                     /gene_synonym="Cd33l3; EG620235; SIGLEC-I"
                     /note="CD33 molecule-like 3"
                     /codon_start=1
                     /product="sialic acid-binding Ig-like lectin 15 precursor"
                     /protein_id="NP_001094508.1"
                     /db_xref="CCDS:CCDS50329.1"
                     /db_xref="GeneID:620235"
                     /db_xref="MGI:MGI:3646642"
                     /translation="MEGSLQLLACLACVLQMGSLVKTRRDASGDLLNTEAHSAPAQRW
                     SMQVPAEVNAEAGDAAVLPCTFTHPHRHYDGPLTAIWRSGEPYAGPQVFRCTAAPGSE
                     LCQTALSLHGRFRLLGNPRRNDLSLRVERLALADSGRYFCRVEFTGDAHDRYESRHGV
                     RLRVTAAAPRIVNISVLPGPAHAFRALCTAEGEPPPALAWSGPAPGNSSAALQGQGHG
                     YQVTAELPALTRDGRYTCTAANSLGRAEASVYLFRFHGAPGTSTLALLLGALGLKALL
                     LLGILGARATRRRLDHLVPQDTPPRSQAQESNYENLSQMSPPGHQLPRVCCEELLSHH
                     HLVIHHEK"
     exon            226..285
                     /gene="Siglec15"
                     /gene_synonym="Cd33l3; EG620235; SIGLEC-I"
                     /inference="alignment:Splign:2.1.0"
     exon            286..669
                     /gene="Siglec15"
                     /gene_synonym="Cd33l3; EG620235; SIGLEC-I"
                     /inference="alignment:Splign:2.1.0"
     exon            670..1044
                     /gene="Siglec15"
                     /gene_synonym="Cd33l3; EG620235; SIGLEC-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1075
                     /gene="Siglec15"
                     /gene_synonym="Cd33l3; EG620235; SIGLEC-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..2323
                     /gene="Siglec15"
                     /gene_synonym="Cd33l3; EG620235; SIGLEC-I"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1422..1427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Siglec15"
                     /gene_synonym="Cd33l3; EG620235; SIGLEC-I"
                     /note="hexamer: AGTAAA"
     polyA_site      1442
                     /gene="Siglec15"
                     /gene_synonym="Cd33l3; EG620235; SIGLEC-I"
                     /note="major polyA site"
ORIGIN      
        1 acaccgctgg ctacttggct gcggctgcct agctcctcca gtttgcttag agcccagcgg
       61 ccctgcagac ttggcacaga gcacacccac ctgcctttgt cacagcacac taagaaggtt
      121 ctctgtggtg accaggctgg gtagagggct gctgggtctg caggcgtcag agcatggagg
      181 ggtccctcca actcctggcc tgcttggcct gtgtgctcca gatgggatcc cttgtgaaaa
      241 ctagaagaga cgcttcgggg gatctgctca acacagaggc gcacagtgcc ccggcgcagc
      301 gctggtccat gcaggtgccc gcggaggtga acgcggaggc tggcgacgcg gcggtgctgc
      361 cctgcacctt cacgcacccg caccgccact acgacgggcc gctgacggcc atctggcgct
      421 cgggcgagcc gtacgcgggc ccgcaggtgt tccgctgcac cgcggcgccg ggcagcgagc
      481 tgtgccagac ggcgctgagc ctgcacggcc gcttccgcct gctgggcaac ccgcgccgca
      541 acgacctgtc cctgcgcgtc gagcgcctcg ccctggcgga cagcggccgc tacttctgcc
      601 gcgtggagtt caccggcgac gcccacgatc gctatgagag tcgccatggg gtccgtctgc
      661 gcgtgactgc agctgcgccg cggatcgtca acatctcggt gctgccgggc cccgcgcacg
      721 ccttccgcgc gctctgcacc gccgaggggg agcccccgcc cgccctcgcc tggtcgggtc
      781 ccgccccagg caacagctcc gctgccctgc agggccaggg tcacggctac caggtgaccg
      841 ccgagttgcc cgcgctgacc cgcgacggcc gctacacgtg cacggcggcc aatagcctgg
      901 gccgcgccga ggccagcgtc tacctgttcc gcttccacgg cgcccccgga acctcgaccc
      961 tagcgctcct gctgggcgcg ctgggcctca aggccttgct gctgcttggc attctgggag
     1021 cgcgtgccac ccgacgccga ctagatcacc tggtccccca ggacacccct ccacggtctc
     1081 aggctcagga gtccaattat gaaaatttga gccagatgag tcctccaggc caccagctgc
     1141 cacgtgtttg ctgtgaggaa ctcctcagcc atcaccatct agtcattcac catgagaaat
     1201 aaaggacagt accaggctag acctggacag ctcataattc ccaggttcct tggccaggca
     1261 acatccaagg ggaccaggac cctgctcaca gaggctccga gcctcacggt attataacaa
     1321 cagtggagcc agcaatctgg gtgtatatgt atgccgacat gagcctcagc atgaaacttc
     1381 tggaaaaact ccccttgttt tattctttct tagaactacg tagtaaagca gacaggaaac
     1441 tagccataat gtctggaggt ccaggctcca gtctgctctg tcatggactt ccagtgcgga
     1501 ccaggacact tcacctatct ggggctcagc tgaagaaata gaagatctga aagacctgca
     1561 taaactccaa cgctagctca aaggtgggcc tctggattgc tgaattctta ggtaggtgtg
     1621 gcactgctca gccctgtgga gaacaaagcc tgagactgga gctgtgcaaa ctgatcagag
     1681 gtacagcaaa ccctgggaat gttatagcaa gaagtgtgga gcccctgcct acctgtgatc
     1741 atatcagctg acccacactt ccttaatctg ggacccacca agagaaggag actgaagacc
     1801 catagtctca aagcatctga aagctgtatg tcaaaacctg ggagacctga aggggctctg
     1861 ggtcccagta gttaaggcag ctgtggctct gacccctcct ggggagtgca ctccctccta
     1921 ggatgtgaaa gtccaggaga tctggcagtg tcttcccact tgcccaaacc cagccaggct
     1981 aacttcaaga gtggtgcttt ccttatttac acttcgggtg catttgttgg tcctattaaa
     2041 ggagagaggt gtacttggga ccaagtgagc cacaagacag gaggctaagg agaccatgtt
     2101 tttctgggga cggcatctct atgtacaggg caatcggttt caggcttccc actgcgccag
     2161 agcttcaggc gaggcggagc tcagccaagg gcaatggcag atcatagtta ttcccagatc
     2221 catcgagagc tgttaagaaa gcacatggga gatctttcca tcttctgaga ctcgaagttc
     2281 ttatcataca gatctttcac ttgcttagtt agagtcacac caa
//
