LOCUS       NM_023059               1990 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus single immunoglobulin and toll-interleukin 1 receptor
            (TIR) domain (Sigirr), transcript variant 1, mRNA.
ACCESSION   NM_023059
VERSION     NM_023059.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1990)
  AUTHORS   Tian F, Lei J, Ni Y, Zhong D, Xie N, Ma J, Wang H, Si S, Wu Y and
            Jiang T.
  TITLE     Regulation of CD18 stability by SIGIRR-modulated ubiquitination:
            new insights into the relationship between innate immune response
            and acute lung injury
  JOURNAL   FEBS J 290 (10), 2721-2743 (2023)
   PUBMED   36527283
  REMARK    GeneRIF: Regulation of CD18 stability by SIGIRR-modulated
            ubiquitination: new insights into the relationship between innate
            immune response and acute lung injury.
REFERENCE   2  (bases 1 to 1990)
  AUTHORS   Wang Z, Zeng FL, Hu YW, Wang XY, Zhao FL, Zhou P, Hu J, Xiao YY, Hu
            ZL, Guo MF, Wei XQ, Liu X, Huang NY, Zhang J, Chen SW, Cheng J,
            Zheng HP, Zhou H, Zhao QX, Zhang C, Hao Y, Zou S, Gui YY, Yu JD, Gu
            LN, Yue CC, Zhang HZ, Wu WL, Zhou YF, Zhou XK, Shen GB, Teng X and
            Li J.
  TITLE     Interleukin-37 promotes colitis-associated carcinogenesis via
            SIGIRR-mediated cytotoxic T cells dysfunction
  JOURNAL   Signal Transduct Target Ther 7 (1), 19 (2022)
   PUBMED   35046386
  REMARK    GeneRIF: Interleukin-37 promotes colitis-associated carcinogenesis
            via SIGIRR-mediated cytotoxic T cells dysfunction.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1990)
  AUTHORS   Giannoudaki E, Stefanska AM, Lawler H, Leon G, Hernandez Santana
            YE, Hassan N, Russell SE, Horan R, Sweeney C, Preston RS, Mantovani
            A, Garlanda C, Fallon PG and Walsh PT.
  TITLE     SIGIRR Negatively Regulates IL-36-Driven Psoriasiform Inflammation
            and Neutrophil Infiltration in the Skin
  JOURNAL   J Immunol 207 (2), 651-660 (2021)
   PUBMED   34253575
  REMARK    GeneRIF: SIGIRR Negatively Regulates IL-36-Driven Psoriasiform
            Inflammation and Neutrophil Infiltration in the Skin.
            Erratum:[J Immunol. 2021 Dec 1;207(11):2895. PMID: 34697229]
REFERENCE   4  (bases 1 to 1990)
  AUTHORS   Allaire JM, Poon A, Crowley SM, Han X, Sharafian Z, Moore N, Stahl
            M, Bressler B, Lavoie PM, Jacobson K, Li X and Vallance BA.
  TITLE     Interleukin-37 regulates innate immune signaling in human and mouse
            colonic organoids
  JOURNAL   Sci Rep 11 (1), 8206 (2021)
   PUBMED   33859245
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1990)
  AUTHORS   Sanchez-Fernandez A, Zandee S, Amo-Aparicio J, Charabati M, Prat A,
            Garlanda C, Eisenmesser EZ, Dinarello CA and Lopez-Vales R.
  TITLE     IL-37 exerts therapeutic effects in experimental autoimmune
            encephalomyelitis through the receptor complex IL-1R5/IL-1R8
  JOURNAL   Theranostics 11 (1), 1-13 (2021)
   PUBMED   33391457
  REMARK    GeneRIF: IL-37 exerts therapeutic effects in experimental
            autoimmune encephalomyelitis through the receptor complex
            IL-1R5/IL-1R8.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1990)
  AUTHORS   Xiao H, Gulen MF, Qin J, Yao J, Bulek K, Kish D, Altuntas CZ, Wald
            D, Ma C, Zhou H, Tuohy VK, Fairchild RL, de la Motte C, Cua D,
            Vallance BA and Li X.
  TITLE     The Toll-interleukin-1 receptor member SIGIRR regulates colonic
            epithelial homeostasis, inflammation, and tumorigenesis
  JOURNAL   Immunity 26 (4), 461-475 (2007)
   PUBMED   17398123
  REMARK    GeneRIF: Theses results indicate that epithelium-derived SIGIRR is
            critical in controlling the homeostasis and innate immune responses
            of the colon to enteric microflora.
REFERENCE   7  (bases 1 to 1990)
  AUTHORS   Huang X, Hazlett LD, Du W and Barrett RP.
  TITLE     SIGIRR promotes resistance against Pseudomonas aeruginosa keratitis
            by down-regulating type-1 immunity and IL-1R1 and TLR4 signaling
  JOURNAL   J Immunol 177 (1), 548-556 (2006)
   PUBMED   16785552
  REMARK    GeneRIF: SIGIRR is critical in resistance to Pseudomonas aeruginosa
            corneal infection by down-regulating type 1 immunity and negative
            regulation of IL-1 and TLR4 signaling.
REFERENCE   8  (bases 1 to 1990)
  AUTHORS   Garlanda C, Riva F, Polentarutti N, Buracchi C, Sironi M, De
            Bortoli M, Muzio M, Bergottini R, Scanziani E, Vecchi A, Hirsch E
            and Mantovani A.
  TITLE     Intestinal inflammation in mice deficient in Tir8, an inhibitory
            member of the IL-1 receptor family
  JOURNAL   Proc Natl Acad Sci U S A 101 (10), 3522-3526 (2004)
   PUBMED   14993616
  REMARK    GeneRIF: TIR8 represents a negative pathway of regulation of the
            IL-1 receptor/TLR system, expressed in epithelial cells and DC,
            crucial for tuning inflammation in the gastrointestinal tract.
REFERENCE   9  (bases 1 to 1990)
  AUTHORS   Wald D, Qin J, Zhao Z, Qian Y, Naramura M, Tian L, Towne J, Sims
            JE, Stark GR and Li X.
  TITLE     SIGIRR, a negative regulator of Toll-like receptor-interleukin 1
            receptor signaling
  JOURNAL   Nat Immunol 4 (9), 920-927 (2003)
   PUBMED   12925853
REFERENCE   10 (bases 1 to 1990)
  AUTHORS   Thomassen E, Renshaw BR and Sims JE.
  TITLE     Identification and characterization of SIGIRR, a molecule
            representing a novel subtype of the IL-1R superfamily
  JOURNAL   Cytokine 11 (6), 389-399 (1999)
   PUBMED   10346978
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK145889.1.
            
            [WARNING] On Jan 10, 2024 this sequence was replaced by
            NM_023059.4.
            
            On Apr 6, 2007 this sequence version replaced NM_023059.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145889.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1990              AK145889.1         4-1993
FEATURES             Location/Qualifiers
     source          1..1990
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 86.35 cM"
     gene            1..1990
                     /gene="Sigirr"
                     /gene_synonym="TIR8"
                     /note="single immunoglobulin and toll-interleukin 1
                     receptor (TIR) domain"
                     /db_xref="GeneID:24058"
                     /db_xref="MGI:MGI:1344402"
     exon            1..68
                     /gene="Sigirr"
                     /gene_synonym="TIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            69..604
                     /gene="Sigirr"
                     /gene_synonym="TIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            605..803
                     /gene="Sigirr"
                     /gene_synonym="TIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            804..934
                     /gene="Sigirr"
                     /gene_synonym="TIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1075
                     /gene="Sigirr"
                     /gene_synonym="TIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1219
                     /gene="Sigirr"
                     /gene_synonym="TIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1322
                     /gene="Sigirr"
                     /gene_synonym="TIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1473
                     /gene="Sigirr"
                     /gene_synonym="TIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1663
                     /gene="Sigirr"
                     /gene_synonym="TIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1990
                     /gene="Sigirr"
                     /gene_synonym="TIR8"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1990
                     /gene="Sigirr"
                     /gene_synonym="TIR8"
                     /note="putative"
ORIGIN      
        1 ggacaggtaa actgtcagct tccgcgcgag tctcaggtgg gtggcagtcg tgactcagac
       61 acgcggaggt cctggccagg tgacaagcac ccatgcaccc acctgcatac agcaatccat
      121 ccattacagg ggacagccag gaatgaggct aactgctctc tcctgaggtc agatccttct
      181 tggagcatgt ctgctgtggc cctgagtcac cacagtggcc acaggacatg tgaaggtggt
      241 ccatgggcct gcccccttcc aaaccgtgtg aggcagaatc tgctctgtgc ttgtgagatc
      301 tgggagctca cccagaactc cgagactggc caaggttgca aggcaagctc tctggtgtgc
      361 agccagtact gctggtggct gacagttact ggttaactca tcctgttcct gtttaacttg
      421 tcccctgggg atggtggcag cctctgacct ccaggacctc ctgtccgtct ggctgaatct
      481 acagaaagga gcccttctca gcctgcagtg gaccccatct gctcggttaa ggagccacgg
      541 cggtgccagg gagggaaacc agcgtttggc ctgccgtgaa gaggtcccag aagagccatg
      601 gcaggtgtct gtgacatggc ccctaatttc ctttccccat ctgaagacca ggccttgggt
      661 cttgcccttg gcagagaagt tgctttgaat tgcacagctt gggtgttctc taggccccag
      721 tgtccccagc catcagtgca gtggctgaaa gatggtctgg cattgggcaa tggaagccac
      781 ttcagcctcc atgaggactt ctgggtcagc gccaacttct cagagattgt gtccagtgtc
      841 ctggtgctca acttgaccaa tgcagaggac tatggaacct tcacctgttc tgtctggaat
      901 gtcagctccc attccttcac tctttggcga gctggccctg ctggccatgt ggctgcagta
      961 ctggcttccc tcctggtcct ggtggttctg ctgctggtgg ccctgctcta tgttaagtgt
     1021 cggctgaaca tgctgctttg gtaccaagac acttacgggg aggtggagat gaacgatggg
     1081 aagttatacg atgcctacgt gtcctatagc gactgcccag aggaccgcaa atttgtaaat
     1141 tttattctga agcctcagtt ggagcggcgt cggggataca aactcttcct agaggaccgc
     1201 gacctcttgc ctcgcgcgga gccctctgcc gaccttttgg tgaacctgag tcgctgtcgg
     1261 cgtctcatcg tggttctttc agatgccttc ctaagccggc cctggtgtag ccagagcttc
     1321 cgggagggac tgtgccgcct actggagctc acccgcagac ctatcttcat cacctttgag
     1381 ggccagaggc gtgagcccat acaccctgct ctccggctcc tgcgccagca ccgccacctc
     1441 gtgaccctgg tgctttggaa gcctggctcc gtgactcctt cctctgattt ttggaaagag
     1501 ctacagctag cactgccacg gaaggtgcag tacaggccgg tggagggaga ccctcaaacc
     1561 cgacttcagg atgacaaaga tcccatgcta atcgtgagag gacgtgctgc ccagggccgg
     1621 ggcatggagt cagagctgga tccagaccct gagggagacc tgggtgtccg tggacctgtc
     1681 tttggggagc caccaactcc actgcaggaa accaggatct gcataggaga gagccacggc
     1741 agtgaaatgg atgtctctga cctcggctct cgaaactaca gtgcacggac agacttctac
     1801 tgcctcgtgt ctgaggatga tgtgtagccc atatcccagc agcccagacc atgagatcac
     1861 ggtggcagct tccagggtag aggcagcagg cactccttcc taggatcaca acccttgcct
     1921 ctatccctgg gcccctcagg aaaggagtgt ggccccaggg tgtcacaaaa taaaatcctg
     1981 ttggttcctg
//
