LOCUS       NM_172257               4239 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus SID1 transmembrane family, member 2 (Sidt2),
            transcript variant 2, mRNA.
ACCESSION   NM_172257
VERSION     NM_172257.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4239)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4239)
  AUTHORS   Geng,M.Y., Wang,L., Song,Y.Y., Gu,J., Hu,X., Yuan,C., Yang,M.,
            Pei,W.J., Zhang,Y. and Gao,J.L.
  TITLE     Sidt2 is a key protein in the autophagy-lysosomal degradation
            pathway and is essential for the maintenance of kidney structure
            and filtration function
  JOURNAL   Cell Death Dis 13 (1), 7 (2021)
   PUBMED   34923568
  REMARK    GeneRIF: Sidt2 is a key protein in the autophagy-lysosomal
            degradation pathway and is essential for the maintenance of kidney
            structure and filtration function.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4239)
  AUTHORS   Wang,L., Yu,C., Pei,W., Geng,M., Zhang,Y., Li,Z., Liang,F., Tan,F.,
            Du,H. and Gao,J.
  TITLE     The lysosomal membrane protein Sidt2 is a vital regulator of
            mitochondrial quality control in skeletal muscle
  JOURNAL   FASEB J 35 (4), e21223 (2021)
   PUBMED   33715196
  REMARK    GeneRIF: The lysosomal membrane protein Sidt2 is a vital regulator
            of mitochondrial quality control in skeletal muscle.
REFERENCE   4  (bases 1 to 4239)
  AUTHORS   Hase,K., Contu,V.R., Kabuta,C., Sakai,R., Takahashi,M., Kataoka,N.,
            Hakuno,F., Takahashi,S.I., Fujiwara,Y., Wada,K. and Kabuta,T.
  TITLE     Cytosolic domain of SIDT2 carries an arginine-rich motif that binds
            to RNA/DNA and is important for the direct transport of nucleic
            acids into lysosomes
  JOURNAL   Autophagy 16 (11), 1974-1988 (2020)
   PUBMED   31944164
  REMARK    GeneRIF: Cytosolic domain of SIDT2 carries an arginine-rich motif
            that binds to RNA/DNA and is important for the direct transport of
            nucleic acids into lysosomes.
REFERENCE   5  (bases 1 to 4239)
  AUTHORS   Sun,H., Ding,J.M., Zheng,H.H., Lv,K.J., Hu,Y.F., Luo,Y.H., Wu,X.,
            Pei,W.J., Wang,L.Z., Wu,M.C., Zhang,Y. and Gao,J.L.
  TITLE     The Effects of Sidt2 on the Inflammatory Pathway in Mouse Mesangial
            Cells
  JOURNAL   Mediators Inflamm 2020, 3560793 (2020)
   PUBMED   32565723
  REMARK    GeneRIF: The Effects of Sidt2 on the Inflammatory Pathway in Mouse
            Mesangial Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4239)
  AUTHORS   Jialin,G., Xuefan,G. and Huiwen,Z.
  TITLE     SID1 transmembrane family, member 2 (Sidt2): a novel lysosomal
            membrane protein
  JOURNAL   Biochem Biophys Res Commun 402 (4), 588-594 (2010)
   PUBMED   20965152
  REMARK    GeneRIF: Sidt2 is a highly glycosylated lysosomal integral membrane
            protein that shows tissue-specific expression.
REFERENCE   7  (bases 1 to 4239)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   8  (bases 1 to 4239)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   9  (bases 1 to 4239)
  AUTHORS   Ficker,M., Powles,N., Warr,N., Pirvola,U. and Maconochie,M.
  TITLE     Analysis of genes from inner ear developmental-stage cDNA
            subtraction reveals molecular regionalization of the otic capsule
  JOURNAL   Dev Biol 268 (1), 7-23 (2004)
   PUBMED   15031101
REFERENCE   10 (bases 1 to 4239)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB247121.1, CK639655.1, BQ179223.1, CA315096.1, BQ749207.1,
            CF950439.1 and AC122273.4.
            
            On Jan 25, 2014 this sequence version replaced NM_172257.3.
            
            Transcript Variant: This variant (2) lacks an exon in the coding
            region, compared to variant 1. The encoded isoform (2) is shorter,
            compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023957.1, AK155875.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-672               CB247121.1         10-681
            673-1309            CK639655.1         4-640
            1310-1920           BQ179223.1         149-759
            1921-2225           CA315096.1         321-625
            2226-2673           BQ749207.1         207-654
            2674-3274           CF950439.1         20-620
            3275-4239           AC122273.4         142196-143160
FEATURES             Location/Qualifiers
     source          1..4239
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 25.36 cM"
     gene            1..4239
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /note="SID1 transmembrane family, member 2"
                     /db_xref="GeneID:214597"
                     /db_xref="MGI:MGI:2446134"
     exon            1..526
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /inference="alignment:Splign:2.1.0"
     CDS             344..2842
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="SID1 transmembrane family member 2 isoform 2
                     precursor"
                     /protein_id="NP_758461.1"
                     /db_xref="CCDS:CCDS23138.1"
                     /db_xref="GeneID:214597"
                     /db_xref="MGI:MGI:2446134"
                     /translation="MIAWRLPLCVLLVASVESHLGALGPKNVSQKDAEFERTYADDVN
                     SELVNIYTFNHTVTRNRTEGVRVSVNVLNKQKGAPLLFVVRQKEAVVSFQVPLILRGL
                     YQRKYLYQKVERTLCQPPTKNESEIQFFYVDVSTLSPVNTTYQLRVNRVDNFVLRTGE
                     LFTFNTTAAQPQYFKYEFPDGVDSVIVKVTSKKAFPCSVISIQDVLCPVYDLDNNVAF
                     IGMYQTMTKKAAITVQRKDFPSNSFYVVVVVKTEDQACGGSLPFYPFVEDEPVDQGHR
                     QKTLSVLVSQAVTSEAYVGGMLFCLGIFLSFYLLTVLLACWENWRQRKKTLLLAIDRA
                     CPESGHARVLADSFPGSAPYEGYNYGSFENGSGSTDGLVESAGSGDLSYSYQDRSFDA
                     VGPRPRLDSMSSVEEDDYDTLTDIDSDKNVIRTKQYLCVADLARKDKRVLRKKYQIYF
                     WNIATIAVFYALPVVQLVITYQTVVNVTGNQDICYYNFLCAHPLGNLSAFNNILSNLG
                     YILLGLLFLLIILQREINHNRALLRNDLYALECGIPKHFGLFYAMGTALMMEGLLSAC
                     YHVCPNYTNFQFDTSFMYMIAGLCMLKLYQKRHPDINASAYSAYACLAIVIFFSVLGV
                     VFGKGNTAFWIVFSVIHIISTLLLSTQLYYMGRWKLDSGIFRRILHVLYTDCIRQCSG
                     PLYTDRMVLLVMGNIINWSLAAYGLIMRPNDFASYLLAIGICNLLLYFAFYIIMKLRS
                     GERIKLIPLLCIVCTSVVWGFALFFFFQGLSTWQKTPAESREHNRDCILLDFFDDHDI
                     WHFLSSIAMFGSFLVLLTLDDDLDTVQRDKIYVF"
     exon            527..648
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            649..813
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            814..859
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            860..961
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1045
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1145
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1211
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1305
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1358
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1430
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1502
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1621
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1695
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1762
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1836
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1960
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2078
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2215
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2324
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2401
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2448
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2554
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..2665
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..2779
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            2780..4239
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4201..4206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /note="hexamer: AATAAA"
     polyA_site      4239
                     /gene="Sidt2"
                     /gene_synonym="B930096O19; CGI-40"
                     /note="major polyA site"
ORIGIN      
        1 gctcctggta gctccgagtt ctgcgccgcg tccgccgccc ttaaagggcc cgcgtccggg
       61 aagccttcgg gccagggcca ccgccgcctc ggctctccgg gcgcgagcgg acgccgggtc
      121 tccagccggg ctgggccggg ctgggccggg ctggggtagc gggtcgcggt gccgccctcg
      181 cgagccggga tccgcgcgag gcccaggagc ggctccaggg aggggacgcg tcctatctga
      241 ggccggggtt aaagttctgg tcccggtgag atgctggaag ctgctgcggc agccgcaacg
      301 cgcccggtcg ccgtcccgtc gccaatcccc gccgtcccgg gccatgatcg cctggcgtct
      361 gcccttgtgc gtgctcttgg tggcctccgt cgagagccac ctgggggccc tggggcccaa
      421 gaacgtctcg cagaaagacg cggagtttga gcgcacctac gcggacgacg tcaacagcga
      481 gctggtcaac atctacacct tcaaccacac cgtgacccgc aaccggaccg agggtgtgcg
      541 agtgtctgtg aatgtcctga acaagcagaa aggggcgcct ttgctgtttg tggtccgcca
      601 gaaggaggct gttgtgtcct tccaggtgcc cctaatcctt cgaggactat atcagcggaa
      661 gtacctctac caaaaagtgg aacgaactct gtgtcagccc cccaccaaga atgagtctga
      721 gatccagttt ttctatgtgg acgtgtctac cctgtcaccc gtcaatacca cttaccagct
      781 ccgagtcaac cgtgtggaca attttgtgct caggactgga gagctgttta cttttaatac
      841 cactgcagcc cagccccagt acttcaaata cgagtttcct gatggtgtgg actcggtaat
      901 tgtcaaggtg acctccaaga aggccttccc ctgctcagtc atctccatcc aagatgtcct
      961 gtgccctgtc tatgatctgg acaacaatgt agccttcatt ggcatgtacc agacgatgac
     1021 taagaaggca gccatcactg tgcagcggaa agacttcccc agcaacagct tctatgtggt
     1081 ggtggtagtg aagactgagg accaggcctg cggagggtcc ttgcccttct acccttttgt
     1141 ggaagatgag ccagtggatc aagggcaccg tcagaaaaca ctgtcagtgc tggtctctca
     1201 ggctgtcaca tctgaggcct atgttggtgg gatgctcttt tgcctgggca tattcttgtc
     1261 cttctacctg ctgactgtgc tgctggcctg ttgggagaac tggaggcaaa ggaagaagac
     1321 cttgctgttg gccatagacc gagcctgccc agaaagtggt cacgcccggg tcttggctga
     1381 ttcatttcct ggcagtgccc cttacgaggg ttacaactat ggctcctttg aaaatggttc
     1441 cggatccact gacgggttgg ttgaaagcgc aggttcaggg gacctctcct acagttacca
     1501 ggaccgctcc tttgacgcag tgggtcctcg gcctcgactg gactccatga gctccgtgga
     1561 agaggatgac tacgacacac tgactgacat cgactcagac aaaaacgtca ttcgaaccaa
     1621 gcaatacctc tgtgtggctg atctggcacg aaaggacaaa cgtgttttgc ggaaaaagta
     1681 ccagatttac ttctggaaca tagccaccat tgcggtcttc tacgcacttc ctgtggtgca
     1741 gctggtgatc acctaccaga cggtggtgaa tgtcacaggg aaccaggaca tctgctacta
     1801 caacttcctc tgtgcccacc cgctgggcaa cctcagcgcc ttcaacaaca tcctcagcaa
     1861 cttggggtac atcctgctgg ggctgctctt cctgctcatc atcctgcagc gagagatcaa
     1921 tcataaccgg gccctgctgc ggaatgacct ctatgctctg gagtgtggga tccccaaaca
     1981 ctttggtctg ttttacgcca tgggcacagc actgatgatg gaggggctac ttagtgcctg
     2041 ttaccacgtc tgccccaact acaccaactt ccagtttgat acctccttca tgtacatgat
     2101 tgctggcctc tgcatgctga agctctacca gaagcggcac ccagatatca acgccagtgc
     2161 ctacagtgca tatgcctgct tggccatcgt catcttcttc tccgttctgg gcgtggtgtt
     2221 tggcaaaggg aacacggcct tctggattgt cttctccgtc attcacatca tctccaccct
     2281 gctcctcagc actcagctct attacatggg ccgctggaag ctggactccg ggatcttccg
     2341 ccgcatcctc catgtgctct acacagactg catccggcag tgcagcgggc ccctttacac
     2401 ggaccgcatg gtgcttctgg tcatgggcaa cattatcaac tggtcgctgg ctgcatacgg
     2461 actcatcatg cgccccaatg actttgcttc ctacttgctg gcaattggca tctgcaacct
     2521 gctgctttat ttcgccttct acatcatcat gaagctccgg agcggcgaga ggatcaagct
     2581 catccctctg ctctgcatcg tctgcacctc cgtggtctgg ggcttcgcgc tcttcttctt
     2641 cttccaggga ctgagcacgt ggcagaaaac ccccgcagag tccagggagc acaaccgcga
     2701 ctgcatcctc ctcgacttct ttgatgacca cgatatctgg cacttcctgt cctccattgc
     2761 catgtttggg tccttcctgg ttttgctgac gttggatgac gacttggaca cagtacagcg
     2821 ggacaagatc tatgtcttct agcagcatct gtggtccagg cttcacctca caggcctagc
     2881 gcctgcctct gcatcacctg ccagttgcca caagaacacc acgggtatga gtcccagctc
     2941 tgctgcccag cattggatgt cgtggcaaga cagcgagatt ccagcccagg cctgactcag
     3001 gatagttcct ggtggcactg agccttggag ttgcctctgc ggaggaggag gcctgctccg
     3061 cattccccag acactggcca aattgctgct ttcttctcag tgttgggtcc tccccaggac
     3121 cctagtctgt ccatctgtct tgtttatcca ctggctctcc atttgtccct ttggagagga
     3181 aggtgggaag gcaatgtcct gtcccatttc atgccttgca ttctgcccat cccttccctc
     3241 ctctcagctt aggacacaca gccctttctt cttcccatgc tctgtccagg accacagtct
     3301 ggtgcctgat tctttgtcca tcaccaggac ctaagctctc cctgggtctg tagctggctg
     3361 ctatcactgc ccactctgac ctgccaggac agatgcaggt aggagacttt gggggctggc
     3421 cagctggtgc caggctttcg gtgctaaggc ctgcaagggg cctaggtacg accctcctcc
     3481 ctgacctgtg cttggagctg gctcttcagc agtgagggcc agcccaagtt gagtcttctg
     3541 atcggggact gaattcagag gccacctcat cccaccagcc actagaatga tgccagcact
     3601 agggttggtg ggaagtggca actcactgtc cccttccaca ccctcagtcc tgccaagccc
     3661 cagatggggg cctctcagtg ccattgacac tgcccaagaa tgtctagagg ccacggaacg
     3721 gtgccaagca cacagtccct tttgcctctt tcacgggagc aggagtccca gtgcctgtcg
     3781 tggaaaggga ggaacatgcc aggtccctgt gtgtccttgg ccctgtctca ccaaaggact
     3841 cagggctggt ttctgagttt ccgtccagta tttagccaag ttctgtgtta gtcacgtagg
     3901 cctaagagcc ttggcgttta cagagtcacc cagctctggc ccctggccat tctggtcctt
     3961 ggcgtttaca gagtcaccca gctccaggcc cctggccact ttggtacttg gttgcccttc
     4021 actccaccag gtccattcca gatgccaaga gtgggcccca ggaatgtgtt tccttctctc
     4081 caccatgttt ttatagctct tgggctggga gaagaggcgg gtctgggtct ttgtttctga
     4141 gctttgttct atgttcctcc atgctacggt tgcaattgtt ttctatgaac gagtacattc
     4201 aataaagaca accagacctg ggatttgggg tcttactga
//
