LOCUS       NM_198034               4266 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus SID1 transmembrane family, member 1 (Sidt1),
            transcript variant 2, mRNA.
ACCESSION   NM_198034 XM_358844
VERSION     NM_198034.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4266)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4266)
  AUTHORS   Morell,M., Varela,N., Castillejo-Lopez,C., Coppard,C., Luque,M.J.,
            Wu,Y.Y., Martin-Morales,N., Perez-Cozar,F., Gomez-Hernandez,G.,
            Kumar,R., O'Valle,F., Alarcon-Riquelme,M.E. and Maranon,C.
  TITLE     SIDT1 plays a key role in type I IFN responses to nucleic acids in
            plasmacytoid dendritic cells and mediates the pathogenesis of an
            imiquimod-induced psoriasis model
  JOURNAL   EBioMedicine 76, 103808 (2022)
   PUBMED   35065421
REFERENCE   3  (bases 1 to 4266)
  AUTHORS   Liu,C., Xu,M., Yan,L., Wang,Y., Zhou,Z., Wang,S., Sun,Y., Zhang,J.
            and Dong,L.
  TITLE     Honeysuckle-derived microRNA2911 inhibits tumor growth by targeting
            TGF-beta1
  JOURNAL   Chin Med 16 (1), 49 (2021)
   PUBMED   34187513
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4266)
  AUTHORS   Chen,Q., Zhang,F., Dong,L., Wu,H., Xu,J., Li,H., Wang,J., Zhou,Z.,
            Liu,C., Wang,Y., Liu,Y., Lu,L., Wang,C., Liu,M., Chen,X., Wang,C.,
            Zhang,C., Li,D., Zen,K., Wang,F., Zhang,Q. and Zhang,C.Y.
  TITLE     SIDT1-dependent absorption in the stomach mediates host uptake of
            dietary and orally administered microRNAs
  JOURNAL   Cell Res 31 (3), 247-258 (2021)
   PUBMED   32801357
  REMARK    GeneRIF: SIDT1-dependent absorption in the stomach mediates host
            uptake of dietary and orally administered microRNAs.
REFERENCE   5  (bases 1 to 4266)
  AUTHORS   Nguyen,T.A., Smith,B.R.C., Elgass,K.D., Creed,S.J., Cheung,S.,
            Tate,M.D., Belz,G.T., Wicks,I.P., Masters,S.L. and Pang,K.C.
  TITLE     SIDT1 Localizes to Endolysosomes and Mediates Double-Stranded RNA
            Transport into the Cytoplasm
  JOURNAL   J Immunol 202 (12), 3483-3492 (2019)
   PUBMED   31061008
  REMARK    GeneRIF: this study shows that SIDT1 localizes to endolysosomes and
            mediates double-stranded RNA transport into the cytoplasm, however,
            SIDT1-deficient animals showed no impairment in survival
            postinfection with either HSV type 1 or encephalomyocarditis virus
REFERENCE   6  (bases 1 to 4266)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   7  (bases 1 to 4266)
  AUTHORS   Li,W., Koutmou,K.S., Leahy,D.J. and Li,M.
  TITLE     Systemic RNA Interference Deficiency-1 (SID-1) Extracellular Domain
            Selectively Binds Long Double-stranded RNA and Is Required for RNA
            Transport by SID-1
  JOURNAL   J Biol Chem 290 (31), 18904-18913 (2015)
   PUBMED   26067272
REFERENCE   8  (bases 1 to 4266)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC079584.1.
            
            On Apr 16, 2009 this sequence version replaced NM_198034.2.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079584.1, AK171920.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3646              BC079584.1         1-3646
            3647-4266           BC079584.1         3648-4267
FEATURES             Location/Qualifiers
     source          1..4266
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 28.57 cM"
     gene            1..4266
                     /gene="Sidt1"
                     /gene_synonym="B830021E24Rik"
                     /note="SID1 transmembrane family, member 1"
                     /db_xref="GeneID:320007"
                     /db_xref="MGI:MGI:2443155"
     exon            1..532
                     /gene="Sidt1"
                     /gene_synonym="B830021E24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..2794
                     /gene="Sidt1"
                     /gene_synonym="B830021E24Rik"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="SID1 transmembrane family member 1 isoform 2
                     precursor"
                     /protein_id="NP_932151.2"
                     /db_xref="CCDS:CCDS28185.1"
                     /db_xref="GeneID:320007"
                     /db_xref="MGI:MGI:2443155"
                     /translation="MLDCLRLALLCALPWLLRAAVPGHQEEPLAKSAELRRDPRDPAR
                     GADFDRVYSGVVSLSTENIYSFNHTSHPGQVTAVRVHVNSSSDNLDYPVLVVVRQQKE
                     VLSWQVPLLFQGLYQRSYNYQEVSRTLCPSKATNETGPLEQLIFVDVASMAPHGAHYK
                     LLVTKIKHFQLPTNVAFYFTASPSQPQYFLYKFPEDVDSVIIKVVSEKAYPCSVVSVQ
                     NIMCPVYDLDHNVEFNGVYQSMTKKAAITLQKKDFPDEQFFVVFVIKPEDYACGGSFS
                     IQENENQTWNLQRSKNLKVTIVPSIKESVYVKSSLFSIFVFLSFYLGCLLVVLVHHVR
                     FQRKSIDGSFGSSDGSGNMAVSHPITASTPEGSNYGAIDESSSSPGRQMSSSDGGQPC
                     HSDTDSSVEESDFDTMPDIESDKNVIRTKMFLYLSDLSRKDRRIVSKKYKIYFWNIIT
                     IAVFYALPVMQLVITYQTVVNVTGNQDICYYNFLCAHPLGVLSAFNNILSNLGHVLLG
                     FLFLLIVLRRDLLHRRALEAKDIFAMEYGIPKHFGLFYAMGIALMMEGVLSACYHVCP
                     NYSNFQFDTSFMYMIAGLCMLKLYQTRHPDINASAYSAYASFAVVITLTVLGVVFGKN
                     DVWFWIIFSAIHILSSLALSTQIYYMGRFKIDLGIFRRAAMVFYTDCIQQCSRPLYMD
                     RMVLLIVGNLVNWSFAFFGLIYRPRDFASYMLGIFICNLLLYLAFYIIMKLRSSEKVL
                     PLPVFCIAATAVVWAAALYFFFQNLSSWEGTPAESREKNRECVLLDFFDDHDIWHFLS
                     ATALFFSFLVLLTLDDDLDVVRRDQIPVF"
     exon            533..654
                     /gene="Sidt1"
                     /gene_synonym="B830021E24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            655..825
                     /gene="Sidt1"
                     /gene_synonym="B830021E24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            826..871
                     /gene="Sidt1"
                     /gene_synonym="B830021E24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            872..973
                     /gene="Sidt1"
                     /gene_synonym="B830021E24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1057
                     /gene="Sidt1"
                     /gene_synonym="B830021E24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1145
                     /gene="Sidt1"
                     /gene_synonym="B830021E24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1217
                     /gene="Sidt1"
                     /gene_synonym="B830021E24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1311
                     /gene="Sidt1"
                     /gene_synonym="B830021E24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1355
                     /gene="Sidt1"
                     /gene_synonym="B830021E24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1427
                     /gene="Sidt1"
                     /gene_synonym="B830021E24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1573
                     /gene="Sidt1"
                     /gene_synonym="B830021E24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1647
                     /gene="Sidt1"
                     /gene_synonym="B830021E24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1714
                     /gene="Sidt1"
                     /gene_synonym="B830021E24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1788
                     /gene="Sidt1"
                     /gene_synonym="B830021E24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1912
                     /gene="Sidt1"
                     /gene_synonym="B830021E24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2030
                     /gene="Sidt1"
                     /gene_synonym="B830021E24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2167
                     /gene="Sidt1"
                     /gene_synonym="B830021E24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2276
                     /gene="Sidt1"
                     /gene_synonym="B830021E24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2353
                     /gene="Sidt1"
                     /gene_synonym="B830021E24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2400
                     /gene="Sidt1"
                     /gene_synonym="B830021E24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2506
                     /gene="Sidt1"
                     /gene_synonym="B830021E24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2617
                     /gene="Sidt1"
                     /gene_synonym="B830021E24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2731
                     /gene="Sidt1"
                     /gene_synonym="B830021E24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..4251
                     /gene="Sidt1"
                     /gene_synonym="B830021E24Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggttttcag cgatgagaaa gggaagactt aaaaagtcga agggaaaagc agccctccct
       61 ggtccccacg cctcctgttg cccctactcc acacgcgtga cctccttcgg agaccccagg
      121 tggcacatca gtatttgatc tgctcgctcc cctccagcgc gctgccggcg ttgggccaca
      181 caccacccag ctgctgaagc cagcactcag cgccacaagc agcttcggaa ggaccatctc
      241 cgtgctcgcc ccctccttgg gctgcttgtg tttcggggac cccggggcga ggcgaggtga
      301 ggtgcccacc atgctggact gcctgcgcct ggcgctgctc tgcgcgctgc cctggctcct
      361 gcgggcggcg gtccctggcc accaggaaga gcccctcgcg aaatccgcag agctgcggcg
      421 cgatccgcga gaccccgcca ggggagcgga tttcgatcgc gtctacagcg gggtggtgag
      481 cctcagcacc gagaacatct actccttcaa ccacaccagc catcctggcc aggtgacagc
      541 cgtgcgggtg catgtcaaca gttcctctga caacctggac tacccagtcc tggttgtggt
      601 tcgccagcag aaagaagtgt tgtcctggca ggtccctctg ctcttccaag gactatacca
      661 aaggagctac aactaccagg aagtcagccg cactctatgc ccttcaaaag caaccaatga
      721 gacgggccct ttggagcagc tgatctttgt agatgtagcg tccatggcgc cccatggtgc
      781 ccactacaag ttgctggtca ccaaaatcaa gcacttccag ctcccgacga atgttgcctt
      841 ctacttcact gccagcccct ctcaacctca gtattttcta tacaaatttc ctgaagacgt
      901 ggactccgtt atcattaaag tggtgtctga gaaggcttac ccgtgttcag ttgtctccgt
      961 tcagaacatc atgtgtccag tgtatgatct ggaccacaat gtggaattca atggtgtcta
     1021 tcagtccatg accaagaaag ccgccatcac gctgcagaag aaggattttc cagatgagca
     1081 gttcttcgtg gtgtttgtga taaaacctga agattatgcc tgtggcggat cattctccat
     1141 ccaggaaaat gaaaaccaga cctggaatct acaacgatca aagaacctga aagtgaccat
     1201 tgtcccatcc atcaaagaat ctgtatatgt gaaatctagt cttttcagca tattcgtttt
     1261 cttgtccttc tacttgggat gcctgctcgt tgtgcttgtc catcatgtga ggtttcagag
     1321 gaaatctatt gacggaagct ttggttccag cgatggctct ggaaatatgg ctgtctcaca
     1381 tcccatcact gccagcacgc ccgaagggag caattatggg gcaatagatg agtccagttc
     1441 cagtcctggg aggcagatgt cttcttccga tggtgggcag ccttgccact cagacacgga
     1501 cagctctgtg gaggagagtg actttgatac catgcctgac atcgaaagcg acaaaaacgt
     1561 catccggacc aagatgttct tgtacctgtc agatctgtcc aggaaggacc ggaggattgt
     1621 cagcaaaaag tataagattt atttttggaa catcatcacc atcgctgtgt tttatgcact
     1681 gcctgtgatg cagcttgtta tcacctacca gacagtggtg aatgtcactg gcaaccagga
     1741 tatctgttac tacaacttcc tttgtgctca ccccctgggt gtcctgagcg ccttcaataa
     1801 tattctcagt aacctgggcc acgtactcct gggcttcctc ttcctgctga tagttctgcg
     1861 cagagacctt ctccaccgaa gagccctgga agctaaagac atctttgcta tggaatacgg
     1921 tattcccaaa cactttggtc tcttctacgc tatggggata gcactgatga tggagggcgt
     1981 gctcagtgct tgttaccatg tctgccctaa ttactccaac ttccagttcg acacttcctt
     2041 catgtacatg atcgctggcc tctgcatgct gaagctctat cagacccgcc acccggacat
     2101 caacgccagc gcctactctg cttatgcctc cttcgctgtg gtcatcacac tgacggtcct
     2161 cggagtggtg tttggaaaaa acgatgtgtg gttctggatc atcttctctg ccatccacat
     2221 tctctcttct ctggccctca gcacccaaat ctactacatg ggccgtttca agatagatct
     2281 gggaatcttc cggcgggctg ctatggtgtt ctacacggac tgtatccagc aatgcagcag
     2341 acctctgtat atggacagga tggtgttgct cattgtggga aatctggtta attggtcctt
     2401 tgccttcttt ggattgatct accggcccag ggactttgcc tcctacatgc tgggcatctt
     2461 catctgcaac ctgctgctgt acttggcttt ctacatcatc atgaagcttc gaagctctga
     2521 gaaagtcctc ccgctaccag tcttctgcat cgcggccact gccgtggtgt gggctgcggc
     2581 actgtacttc ttcttccaga acctcagcag ctgggagggg acccctgcag aatcccggga
     2641 gaagaaccgt gagtgtgtcc tgctggattt ctttgatgac catgacatct ggcacttcct
     2701 ctctgcgact gccctgtttt tctcattcct ggtgctgttg accctggatg atgacctgga
     2761 tgtggtccgg agagaccaga tccctgtctt ctgagcaccc agcatcacag ggggaagacg
     2821 gagcaaccca ccttggtgct gttttgtgga aaacacggtg agtgtagcag cttgcccact
     2881 gccagacgct ccacctgcct ggagggagtc aagggtgtct gaattcacac aggaagagct
     2941 tgggactgaa ctaaacctca agaatggtag aagggatgcc ctgttgcgca cagagacata
     3001 gtctggaggc tcaagaacct ctgtttgcaa cgtagagttc agtctagaca caagctgcat
     3061 caggccagct tctccacctg gcccctccca tcctcataga tattgaccag agaaaccagc
     3121 tactcagacc tcccacctag aaccttcagt gtggccactt ccacacctct gagacacctg
     3181 ctgctataga aggccaaagc accatcgaat tcttccccgg cctcttaggg gaccgaactc
     3241 ctcagaatac ggtgcagaag tgggaccaag tccccaccca actggagaca gacattctag
     3301 taagtcaagc taagtcacct cttcagaagg aatgcggaat tcctggcagg gctgggaatg
     3361 ctctgggatg ggatgtagac atgcacactt ctgaacgttt gtggatccaa ggcctgggtg
     3421 attacctgct tcttcaggtc ttcatctcac tgttggatgc tgactctgca ctctgatgcg
     3481 gccttcttag aaggtccctc tttctcccta gacttctaac agctccaaga tggacacaga
     3541 tggagaaaat gctttccaca gcagtggaag tgatggacag cgcttagtgg ctgagcatta
     3601 gacaggcagc attcacctca gtgactctgg atcctggagc aaaaaagcaa ccgtgcttgg
     3661 tggtccccag acacacagct caatctatgc ccattatagc cttttcccgg gattaccctg
     3721 ctgtcctcca cacctgaacc tgtcacttac gcagatcagg gttcccgact atctgcccaa
     3781 agttcccagc agtaactcag gatgggcacg tgctcctccc tccccccaca actggatgag
     3841 tcacagaggt catgactaat cacctcttac aggatcccat tctctgttcc caggaggatg
     3901 taaaagaaaa aacaaaaaac aaaaaagcgc aatgttcgag ctttcttctc tcatgccacc
     3961 tggcaaactc gaggagaagc cccattttga tcaggcttcc tggttgtgtg gagtatgatg
     4021 tcatcagaaa atagacatat aagtgtgtgc acacatgcct acttgcttgt gaaatcgaag
     4081 ttactcctca cctgtgctct cttgagcatt tagtaaggaa gtggatgggg caggcctctt
     4141 tttgaaaaac tatcattctt tctttcaaat atctgtgttc aaatatgtgt tttggacgtt
     4201 tgaacagcaa gcttctcctg gttttaaaaa ttcaaagata atttccatga aaaaaaaaaa
     4261 aaaaaa
//
