LOCUS       NM_009174               2488 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus siah E3 ubiquitin protein ligase 2 (Siah2), mRNA.
ACCESSION   NM_009174 XM_916014
VERSION     NM_009174.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2488)
  AUTHORS   Scortegagna,M., Du,Y., Bradley,L.M., Wang,K., Molinolo,A.,
            Ruppin,E., Murad,R. and Ronai,Z.A.
  TITLE     Ubiquitin Ligases Siah1a/2 Control Alveolar Macrophage Functions to
            Limit Carcinogen-Induced Lung Adenocarcinoma
  JOURNAL   Cancer Res 83 (12), 2016-2033 (2023)
   PUBMED   37078793
  REMARK    GeneRIF: Ubiquitin Ligases Siah1a/2 Control Alveolar Macrophage
            Functions to Limit Carcinogen-Induced Lung Adenocarcinoma.
REFERENCE   2  (bases 1 to 2488)
  AUTHORS   Mekbib,T., Suen,T.C., Rollins-Hairston,A., Smith,K., Armstrong,A.,
            Gray,C., Owino,S., Baba,K., Baggs,J.E., Ehlen,J.C., Tosini,G. and
            DeBruyne,J.P.
  TITLE     'The ubiquitin ligase SIAH2 is a female-specific regulator of
            circadian rhythms and metabolism'
  JOURNAL   PLoS Genet 18 (7), e1010305 (2022)
   PUBMED   35789210
  REMARK    GeneRIF: ''The ubiquitin ligase SIAH2 is a female-specific
            regulator of circadian rhythms and metabolism''.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2488)
  AUTHORS   Dang,T.N., Taylor,J.L., Kilroy,G., Yu,Y., Burk,D.H. and Floyd,Z.E.
  TITLE     SIAH2 is Expressed in Adipocyte Precursor Cells and Interacts with
            EBF1 and ZFP521 to Promote Adipogenesis
  JOURNAL   Obesity (Silver Spring) 29 (1), 98-107 (2021)
   PUBMED   33155406
  REMARK    GeneRIF: SIAH2 is Expressed in Adipocyte Precursor Cells and
            Interacts with EBF1 and ZFP521 to Promote Adipogenesis.
REFERENCE   4  (bases 1 to 2488)
  AUTHORS   Ong,T., Trivedi,N., Wakefield,R., Frase,S. and Solecki,D.J.
  TITLE     Siah2 integrates mitogenic and extracellular matrix signals linking
            neuronal progenitor ciliogenesis with germinal zone occupancy
  JOURNAL   Nat Commun 11 (1), 5312 (2020)
   PUBMED   33082319
  REMARK    GeneRIF: Siah2 integrates mitogenic and extracellular matrix
            signals linking neuronal progenitor ciliogenesis with germinal zone
            occupancy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2488)
  AUTHORS   Chillappagari,S., Belapurkar,R., Moller,A., Molenda,N., Kracht,M.,
            Rohrbach,S. and Schmitz,M.L.
  TITLE     SIAH2-mediated and organ-specific restriction of HO-1 expression by
            a dual mechanism
  JOURNAL   Sci Rep 10 (1), 2268 (2020)
   PUBMED   32042051
  REMARK    GeneRIF: SIAH2-mediated and organ-specific restriction of HO-1
            expression by a dual mechanism.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2488)
  AUTHORS   Relaix,F., Wei,Xj., Li,W., Pan,J., Lin,Y., Bowtell,D.D.,
            Sassoon,D.A. and Wu,X.
  TITLE     Pw1/Peg3 is a potential cell death mediator and cooperates with
            Siah1a in p53-mediated apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 97 (5), 2105-2110 (2000)
   PUBMED   10681424
REFERENCE   7  (bases 1 to 2488)
  AUTHORS   Zhang,J., Guenther,M.G., Carthew,R.W. and Lazar,M.A.
  TITLE     Proteasomal regulation of nuclear receptor corepressor-mediated
            repression
  JOURNAL   Genes Dev 12 (12), 1775-1780 (1998)
   PUBMED   9637679
REFERENCE   8  (bases 1 to 2488)
  AUTHORS   Holloway,A.J., Della,N.G., Fletcher,C.F., Largespada,D.A.,
            Copeland,N.G., Jenkins,N.A. and Bowtell,D.D.
  TITLE     Chromosomal mapping of five highly conserved murine homologues of
            the Drosophila RING finger gene seven-in-absentia
  JOURNAL   Genomics 41 (2), 160-168 (1997)
   PUBMED   9143490
REFERENCE   9  (bases 1 to 2488)
  AUTHORS   Della,N.G., Bowtell,D.D. and Beck,F.
  TITLE     Expression of Siah-2, a vertebrate homologue of Drosophila sina, in
            germ cells of the mouse ovary and testis
  JOURNAL   Cell Tissue Res 279 (2), 411-419 (1995)
   PUBMED   7895278
REFERENCE   10 (bases 1 to 2488)
  AUTHORS   Della,N.G., Senior,P.V. and Bowtell,D.D.
  TITLE     Isolation and characterisation of murine homologues of the
            Drosophila seven in absentia gene (sina)
  JOURNAL   Development 117 (4), 1333-1343 (1993)
   PUBMED   8404535
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC119873.38.
            
            On Nov 17, 2006 this sequence version replaced NM_009174.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058400.1, AK149316.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-993               AC119873.38        168874-169866       c
            994-2488            AC119873.38        152427-153921       c
FEATURES             Location/Qualifiers
     source          1..2488
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 28.68 cM"
     gene            1..2488
                     /gene="Siah2"
                     /gene_synonym="Sinh2"
                     /note="siah E3 ubiquitin protein ligase 2"
                     /db_xref="GeneID:20439"
                     /db_xref="MGI:MGI:108062"
     exon            1..993
                     /gene="Siah2"
                     /gene_synonym="Sinh2"
                     /inference="alignment:Splign:2.1.0"
     CDS             574..1551
                     /gene="Siah2"
                     /gene_synonym="Sinh2"
                     /EC_number="2.3.2.27"
                     /note="mSiah2; siah-2; seven in absentia homolog 2;
                     RING-type E3 ubiquitin transferase SIAH2; seven in
                     absentia 2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase SIAH2"
                     /protein_id="NP_033200.2"
                     /db_xref="CCDS:CCDS17368.1"
                     /db_xref="GeneID:20439"
                     /db_xref="MGI:MGI:108062"
                     /translation="MSRPSSTGPSANKPCSKQPPPPQTPHAPSPAAPPAAATISAAGP
                     GSSAVPAAAAVISGPGAGGGADPVSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVC
                     NQCRQKLSCCPTCRGALTPSIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHED
                     ICEYRPYSCPCPGASCKWQGSLEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVD
                     WVMMQSCFGHHFMLVLEKQEKYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLT
                     WEATPRSIHDGVAAAIMNSDCLVFDTAIAHLFADNGNLGINVTISTCCQ"
     exon            994..2488
                     /gene="Siah2"
                     /gene_synonym="Sinh2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1609..1614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Siah2"
                     /gene_synonym="Sinh2"
                     /note="hexamer: AATAAA"
     polyA_site      1628
                     /gene="Siah2"
                     /gene_synonym="Sinh2"
                     /note="major polyA site"
     regulatory      2465..2470
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Siah2"
                     /gene_synonym="Sinh2"
                     /note="hexamer: AATAAA"
     polyA_site      2488
                     /gene="Siah2"
                     /gene_synonym="Sinh2"
ORIGIN      
        1 gctggagtcg gtgcgggtcg gcgtaggtcc cctgggaagg gtcgggagac tcgggctacg
       61 tcctttccct gggctgccgg cttccactgt cgcagagaag cgaccccacg cggcggcgat
      121 cgactcattc aagggctccc agcgaggaaa ccgctcgggc gctgccagct gggtcgggcg
      181 gagctgcgcg ggccgcaggg tggctctgcc agtccctgag tgccgggtcg gccgcacacg
      241 tgtcttagcg tcacgtccgc gcgcgccccc ggggcttgcg tcagctgccg ctcctgaagc
      301 gagtgggcca gggctctgcg caccagaacg ccgccggagg agggcaccgc acggccgcga
      361 gccccgagag cgacgaccat ccgggtgccg ccgagaggat cggcgcggtc cggtccccgc
      421 cctcccggtg ccggtcgggt ccgcgctggg tcccccgggc tgggcgccgt ggcgttgccc
      481 cggagcccgc cacccgcggg gcgcgcaccg ccttaacccg ggcggccccg cggcaggcag
      541 acgcccgcag gtccatggtg ggctcggagc gcgatgagcc gcccgtcctc caccggcccc
      601 agcgctaaca aaccctgcag caagcagccg ccgccgcctc agaccccgca cgccccgtcc
      661 ccggctgcgc ccccggccgc cgccaccatc tcggcagcgg gccccggctc gtccgcggtg
      721 cccgccgcgg cagcggtgat ctcaggcccc ggagccggcg gcggggccga cccggtgtcc
      781 ccgcagcacc acgagctgac ctcgctcttc gagtgcccgg tctgctttga ctatgtcctg
      841 ccccccattc tgcagtgcca ggccgggcac ctggtgtgta accaatgccg ccagaagtta
      901 agctgctgcc cgacgtgcag gggcgcccta acgcccagca tcaggaacct ggctatggag
      961 aaggtcgcct cggcagttct gtttccctgt aagtatgcta ccacgggctg ttccctgact
     1021 ctacaccata cagagaaacc agagcatgaa gacatctgtg aataccgtcc ttattcctgt
     1081 ccttgtcctg gtgcgtcctg caagtggcag ggatccctgg aagctgtgat gtcccatctc
     1141 atgcatgccc acaagagtat cactaccctt cagggagagg acatagtctt tctagctaca
     1201 gacattaacc tgccaggggc tgtggactgg gtgatgatgc agtcctgttt tggccaccac
     1261 ttcatgctgg tacttgaaaa gcaagagaag tacgaaggcc accagcagtt ctttgccatc
     1321 gtcctcctca ttggcacccg aaagcaagct gagaactttg cctacagact ggagttgaat
     1381 gggaaccgga ggagactgac ctgggaggcc acacctcggt ccattcatga tggcgtggct
     1441 gcagccatca tgaacagtga ctgtcttgtt tttgacacag ccatagcaca tctctttgca
     1501 gataatggga accttggaat caatgtcacg atatctacat gctgtcagtg aggctccagg
     1561 aggctttcct aaccctggga agttatttgg gcatagcgct ctatgtttaa taaaggtttt
     1621 ttaatagatg ttttattcag tacatcttcc cgaggcgaga cccacaactg tcctatgttt
     1681 tatttaaatg atagcttcct gtctggcact gatgaatcta agttcaccga actgtgataa
     1741 tcggagttgg cctgttagta atttggaggt ggttcggtga tctcaaatca actctattct
     1801 atttccttcc tgaacagctc ttgacagatc gctcagggct gcctccccct gcctcatcct
     1861 gagccaacaa aagcacagtg actttcctga gagtcccgtt atttctagga ggtagcagtt
     1921 gctttaatac ctttcaggct gggtatttac acagaatcac ctgtagtact catctccaac
     1981 acagagctag agaatcaaca gagttgagca acctcctcat ctcagagttt gaggattact
     2041 ggcttgaatt gtgggcaagg gtccaggatc taaaggtgct ttaaggcgtc ctctgctgac
     2101 actgttggtc tctactgtcc gtcctcagcc tctgcacaca ccacatggag accagaactc
     2161 taaatccatg gggatgcaac ccctggggtt ggcctgcttt caggcgctca gtgagttgag
     2221 agttctcaca gttagttgtt gctcaccata gtacggatga cttgtttaca tatggcttcc
     2281 cttggaagcc ctccttgact gtaactgatg tgagagacta gatcagtgct tgggagaact
     2341 tgataaccag tgtcacatgc ttgccatttt aaaagcatgt gtcagttgtg tgggtttagt
     2401 ttttgttgtt tttgttttta tctttacata cgcgcacaca catacacaca cactttaatt
     2461 ttttaataaa attttttcaa taaatgaa
//
