LOCUS       NM_001308385            2002 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus siah E3 ubiquitin protein ligase 1B (Siah1b),
            transcript variant 1, mRNA.
ACCESSION   NM_001308385 XM_006528767
VERSION     NM_001308385.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2002)
  AUTHORS   Famulski,J.K., Trivedi,N., Howell,D., Yang,Y., Tong,Y.,
            Gilbertson,R. and Solecki,D.J.
  TITLE     Siah regulation of Pard3A controls neuronal cell adhesion during
            germinal zone exit
  JOURNAL   Science 330 (6012), 1834-1838 (2010)
   PUBMED   21109632
  REMARK    GeneRIF: findings define a Siah-Pard3A signaling pathway that
            controls adhesion-dependent exit of neuronal progenitors or
            immature neurons from a germinal zone niche
REFERENCE   2  (bases 1 to 2002)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   3  (bases 1 to 2002)
  AUTHORS   Xu,Z., Sproul,A., Wang,W., Kukekov,N. and Greene,L.A.
  TITLE     Siah1 interacts with the scaffold protein POSH to promote JNK
            activation and apoptosis
  JOURNAL   J Biol Chem 281 (1), 303-312 (2006)
   PUBMED   16230351
  REMARK    GeneRIF: Siah1 is a binding partner for POSH (plenty of SH3s), a
            scaffold component of the apoptotic JNK pathway
REFERENCE   4  (bases 1 to 2002)
  AUTHORS   Fiucci,G., Beaucourt,S., Duflaut,D., Lespagnol,A.,
            Stumptner-Cuvelette,P., Geant,A., Buchwalter,G., Tuynder,M.,
            Susini,L., Lassalle,J.M., Wasylyk,C., Wasylyk,B., Oren,M., Amson,R.
            and Telerman,A.
  TITLE     Siah-1b is a direct transcriptional target of p53: identification
            of the functional p53 responsive element in the siah-1b promoter
  JOURNAL   Proc Natl Acad Sci U S A 101 (10), 3510-3515 (2004)
   PUBMED   14985507
REFERENCE   5  (bases 1 to 2002)
  AUTHORS   Frew,I.J., Dickins,R.A., Cuddihy,A.R., Del Rosario,M., Reinhard,C.,
            O'Connell,M.J. and Bowtell,D.D.
  TITLE     Normal p53 function in primary cells deficient for Siah genes
  JOURNAL   Mol Cell Biol 22 (23), 8155-8164 (2002)
   PUBMED   12417719
  REMARK    GeneRIF: Results from loss-of-function experiments do not support a
            general role for Siah genes in p53-mediated responses or mitosis.
REFERENCE   6  (bases 1 to 2002)
  AUTHORS   Amson,R.B., Nemani,M., Roperch,J.P., Israeli,D., Bougueleret,L., Le
            Gall,I., Medhioub,M., Linares-Cruz,G., Lethrosne,F., Pasturaud,P.,
            Piouffre,L., Prieur,S., Susini,L., Alvaro,V., Millasseau,P.,
            Guidicelli,C., Bui,H., Massart,C., Cazes,L., Dufour,F.,
            Bruzzoni-Giovanelli,H., Owadi,H., Hennion,C., Charpak,G.,
            Telerman,A. et al.
  TITLE     Isolation of 10 differentially expressed cDNAs in p53-induced
            apoptosis: activation of the vertebrate homologue of the drosophila
            seven in absentia gene
  JOURNAL   Proc Natl Acad Sci U S A 93 (9), 3953-3957 (1996)
   PUBMED   8632996
REFERENCE   7  (bases 1 to 2002)
  AUTHORS   Kennedy,M.A., Rowland,S.A., Miller,A.L., Morris,C.M., Neville,L.A.,
            Dodd,A., Fifield,W.J. and Love,D.R.
  TITLE     Structure and location of the murine adrenoleukodystrophy gene
  JOURNAL   Genomics 32 (3), 395-400 (1996)
   PUBMED   8838803
REFERENCE   8  (bases 1 to 2002)
  AUTHORS   Yu,J., Nagarajan,S., Liu,J., Young,N. and Medof,M.E.
  TITLE     Cloning and characterization of the mouse PIG-A gene
  JOURNAL   Biochim Biophys Acta 1255 (3), 344-350 (1995)
   PUBMED   7734452
REFERENCE   9  (bases 1 to 2002)
  AUTHORS   Abbott,C. and Chambers,D.
  TITLE     Analysis of CAG trinucleotide repeats from mouse cDNA sequences
  JOURNAL   Ann Hum Genet 58 (2), 87-94 (1994)
   PUBMED   7979162
REFERENCE   10 (bases 1 to 2002)
  AUTHORS   Della,N.G., Senior,P.V. and Bowtell,D.D.
  TITLE     Isolation and characterisation of murine homologues of the
            Drosophila seven in absentia gene (sina)
  JOURNAL   Development 117 (4), 1333-1343 (1993)
   PUBMED   8404535
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ094899.1, CF723667.1,
            BC052887.1, AL732294.18 and DV648408.1.
            
            On May 5, 2015 this sequence version replaced XM_006528767.2.
            
            Summary: This gene encodes a member of the seven in absentia
            homolog (Siah) family of E3 ubiquitin ligase enzymes that catalyze
            the transfer of ubiquitin to substrate proteins. The encoded
            protein targets Pard3A (partitioning defective 3A) protein for
            proteasome-mediated degradation during the exit of cerebellar
            granule neurons from their germinal zone niche. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, May 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363660.51081.1,
                                           ERR3363658.2926798.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 CJ094899.1         1-5
            6-21                CJ094899.1         7-22
            22-753              CF723667.1         1-732
            754-863             BC052887.1         477-586
            864-864             AL732294.18        63667-63667         c
            865-1983            BC052887.1         588-1706
            1984-2002           DV648408.1         260-278
FEATURES             Location/Qualifiers
     source          1..2002
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 76.11 cM"
     gene            1..2002
                     /gene="Siah1b"
                     /gene_synonym="siah-1b; Sinh1b"
                     /note="siah E3 ubiquitin protein ligase 1B"
                     /db_xref="GeneID:20438"
                     /db_xref="MGI:MGI:108063"
     exon            1..307
                     /gene="Siah1b"
                     /gene_synonym="siah-1b; Sinh1b"
                     /inference="alignment:Splign:2.1.0"
     exon            308..399
                     /gene="Siah1b"
                     /gene_synonym="siah-1b; Sinh1b"
                     /inference="alignment:Splign:2.1.0"
     exon            400..460
                     /gene="Siah1b"
                     /gene_synonym="siah-1b; Sinh1b"
                     /inference="alignment:Splign:2.1.0"
     exon            461..1985
                     /gene="Siah1b"
                     /gene_synonym="siah-1b; Sinh1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             606..1454
                     /gene="Siah1b"
                     /gene_synonym="siah-1b; Sinh1b"
                     /EC_number="2.3.2.27"
                     /note="seven in absentia homolog 1b; drosophila
                     seven-in-absentia gene product homolog; RING-type E3
                     ubiquitin transferase SIAH1B; seven in absentia 1B"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase SIAH1B"
                     /protein_id="NP_001295314.1"
                     /db_xref="CCDS:CCDS30516.1"
                     /db_xref="GeneID:20438"
                     /db_xref="MGI:MGI:108063"
                     /translation="MSRQAATALSTGTSKCPPSQRVPALTDTTASNNDLASLFECPVC
                     FDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYSA
                     SGCEITLPHTKKAEHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQG
                     EDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQA
                     ENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGIN
                     VTISMC"
     regulatory      1964..1969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Siah1b"
                     /gene_synonym="siah-1b; Sinh1b"
                     /note="hexamer: AATAAA"
     polyA_site      1985
                     /gene="Siah1b"
                     /gene_synonym="siah-1b; Sinh1b"
                     /note="major polyA site"
ORIGIN      
        1 taagcgacgg atggaggcgg gctggtgaca tgggcggagc gcgaaaatcg gcctgtggtc
       61 ttaggcgcaa gggtgatcgc atgccgctgt tcgagatcaa aggcctgggc aagtcacttg
      121 tggctgttct cagggtctcc tcagcggtct ccctgtagag ctgcggtcga aagccggagc
      181 cggagccgga gcgagccaga gccggattga gccggaaccg gagctaccgg agggcgggac
      241 ttccggtttc tgggcccaag acagagggcg ggtcaggagt caaggtctcg cgaggctgcg
      301 gcgtgagatc gagagaccag gaacttcaaa atagtgcctg ggatccggat gacagcaggc
      361 attaagggct ggctactgga ctgaagctgc tggaaacttg ggaagaccag gtgtacactc
      421 aagacctaga atgaccaaga atgtggaacc ttaaaaaaag ggtggcggcc cagggtgtcc
      481 cataggtctc cgtgcgacta ggaggggcag cggtggcggc ggtggcagcg gcagcagcgg
      541 cagcggcggc agcggcagca gcagcagcta gcaacctggt cagggtacgc tctccatcca
      601 cagagatgag ccgtcaggct gctacagcat tatccactgg cacctcaaag tgtccaccat
      661 cccagagggt acctgccttg actgacacaa ctgcatccaa caatgacttg gcgagtcttt
      721 ttgagtgtcc tgtctgcttt gactatgtgt tgccacctat tcttcagtgt cagagtggcc
      781 atcttgtttg tagcaactgt cgccccaaac ttacatgttg tcccacctgc cggggcccat
      841 tgggatccat tcgcaacttg gctatggaga aagtggccaa ctcagtactc ttcccctgta
      901 aatattccgc ttctggatgt gaaataactc tgccacacac caaaaaggca gagcacgagg
      961 agctgtgtga gttcaggcct tactcctgcc cctgccctgg tgcttcctgt aaatggcaag
     1021 gctccttgga tgctgtcatg ccccacctga tgcatcagca caagtccatt accaccctgc
     1081 aaggagaaga catagttttc cttgctacag acatcaacct tcctggtgct gttgactggg
     1141 tgatgatgca gtcttgtttt ggctttcatt tcatgttagt cttggagaaa caggaaaaat
     1201 atgatggtca tcagcagttc tttgcaattg tacaactgat aggaacacgc aaacaagctg
     1261 aaaattttgc ctatcgactt gagctaaatg gtcataggcg ccgattaact tgggaagcga
     1321 ctcctcgatc tattcatgag gggattgcaa cagccattat gaatagtgat tgcctagtgt
     1381 ttgacaccag cattgcacag ctttttgcag aaaatggtaa tctaggcatc aatgtaacta
     1441 tttccatgtg ttgaaacggc aatcaaatat ttctggccag tgtttaaaat ttgcatttga
     1501 cttcacagag aataagccac ccatctgcct gccaacctaa aacattcctg gtaggtagaa
     1561 gctagacatg aaggtaaaga aaaagaaaag ctgttaatac aggaaacagt tgcatgtagt
     1621 aacactaata gatttaaaaa taattcaaca gtaaaccact gaaaaaccat atatactcaa
     1681 gatgggcatc ttttgtatta agaaaggaaa cgttgtaaaa tatttctgaa ctttgtattt
     1741 gttgtagatt gattgtattg ttgacaattt ttcggggtgg gggtgtgcct gcacacatgc
     1801 gtgcacgtgt gtgcttggtt ttcctttaac aagccatcta cgtgtcatag cccactgttt
     1861 tccccttgtg agtcaacaca tagtgctgct gtggttttgg tttggtttgc ttttggtttt
     1921 tgatgtgtgt gtatttgata atttttattc tagtttttca ttaaataaat ttgacttttc
     1981 tgtcaaaaaa aaaaaaaaaa aa
//
