LOCUS       NM_009172               2121 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus siah E3 ubiquitin protein ligase 1A (Siah1a), mRNA.
ACCESSION   NM_009172
VERSION     NM_009172.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2121)
  AUTHORS   Scortegagna,M., Du,Y., Bradley,L.M., Wang,K., Molinolo,A.,
            Ruppin,E., Murad,R. and Ronai,Z.A.
  TITLE     Ubiquitin Ligases Siah1a/2 Control Alveolar Macrophage Functions to
            Limit Carcinogen-Induced Lung Adenocarcinoma
  JOURNAL   Cancer Res 83 (12), 2016-2033 (2023)
   PUBMED   37078793
  REMARK    GeneRIF: Ubiquitin Ligases Siah1a/2 Control Alveolar Macrophage
            Functions to Limit Carcinogen-Induced Lung Adenocarcinoma.
REFERENCE   2  (bases 1 to 2121)
  AUTHORS   Scortegagna,M., Berthon,A., Settas,N., Giannakou,A., Garcia,G.,
            Li,J.L., James,B., Liddington,R.C., Vilches-Moure,J.G.,
            Stratakis,C.A. and Ronai,Z.A.
  TITLE     The E3 ubiquitin ligase Siah1 regulates adrenal gland organization
            and aldosterone secretion
  JOURNAL   JCI Insight 2 (23), 97128 (2017)
   PUBMED   29212953
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2121)
  AUTHORS   Fan,Z., Li,Z., Yang,Y., Liu,S., Guo,J. and Xu,Y.
  TITLE     HIF-1alpha coordinates epigenetic activation of SIAH1 in
            hepatocytes in response to nutritional stress
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1860 (10), 1037-1046 (2017)
   PUBMED   28843785
  REMARK    GeneRIF: Depletion of KDM3A coincided with the loss of SIAH1
            induction and the accumulation of dimethylated H3K9 surrounding the
            SIAH1 promoter. Interestingly, KDM3A expression was also
            up-regulated by nutritional stress in a HIF-1alpha dependent
            manner.
REFERENCE   4  (bases 1 to 2121)
  AUTHORS   Ji,L., Jiang,B., Jiang,X., Charlat,O., Chen,A., Mickanin,C.,
            Bauer,A., Xu,W., Yan,X. and Cong,F.
  TITLE     The SIAH E3 ubiquitin ligases promote Wnt/beta-catenin signaling
            through mediating Wnt-induced Axin degradation
  JOURNAL   Genes Dev 31 (9), 904-915 (2017)
   PUBMED   28546513
REFERENCE   5  (bases 1 to 2121)
  AUTHORS   Li,Q., Wang,P., Ye,K. and Cai,H.
  TITLE     Central role of SIAH inhibition in DCC-dependent cardioprotection
            provoked by netrin-1/NO
  JOURNAL   Proc Natl Acad Sci U S A 112 (3), 899-904 (2015)
   PUBMED   25561546
  REMARK    GeneRIF: Combination of netrin-1 and SIAH RNAi may prove to be a
            substantially effective therapy for myocardial infarction.
REFERENCE   6  (bases 1 to 2121)
  AUTHORS   Relaix,F., Wei,Xj., Li,W., Pan,J., Lin,Y., Bowtell,D.D.,
            Sassoon,D.A. and Wu,X.
  TITLE     Pw1/Peg3 is a potential cell death mediator and cooperates with
            Siah1a in p53-mediated apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 97 (5), 2105-2110 (2000)
   PUBMED   10681424
REFERENCE   7  (bases 1 to 2121)
  AUTHORS   Holloway,A.J., Della,N.G., Fletcher,C.F., Largespada,D.A.,
            Copeland,N.G., Jenkins,N.A. and Bowtell,D.D.
  TITLE     Chromosomal mapping of five highly conserved murine homologues of
            the Drosophila RING finger gene seven-in-absentia
  JOURNAL   Genomics 41 (2), 160-168 (1997)
   PUBMED   9143490
REFERENCE   8  (bases 1 to 2121)
  AUTHORS   Nemani,M., Linares-Cruz,G., Bruzzoni-Giovanelli,H., Roperch,J.P.,
            Tuynder,M., Bougueleret,L., Cherif,D., Medhioub,M., Pasturaud,P.,
            Alvaro,V., der Sarkissan,H., Cazes,L., Le Paslier,D., Le Gall,I.,
            Israeli,D., Dausset,J., Sigaux,F., Chumakov,I., Oren,M., Calvo,F.,
            Amson,R.B., Cohen,D. and Telerman,A.
  TITLE     Activation of the human homologue of the Drosophila sina gene in
            apoptosis and tumor suppression
  JOURNAL   Proc Natl Acad Sci U S A 93 (17), 9039-9042 (1996)
   PUBMED   8799150
REFERENCE   9  (bases 1 to 2121)
  AUTHORS   Della,N.G., Senior,P.V. and Bowtell,D.D.
  TITLE     Isolation and characterisation of murine homologues of the
            Drosophila seven in absentia gene (sina)
  JOURNAL   Development 117 (4), 1333-1343 (1993)
   PUBMED   8404535
REFERENCE   10 (bases 1 to 2121)
  AUTHORS   Fortini,M.E., Simon,M.A. and Rubin,G.M.
  TITLE     Signalling by the sevenless protein tyrosine kinase is mimicked by
            Ras1 activation
  JOURNAL   Nature 355 (6360), 559-561 (1992)
   PUBMED   1311054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC046317.1, AC142211.3, BE634662.1 and AA420282.1.
            
            On Aug 28, 2009 this sequence version replaced NM_009172.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046317.1, Z19579.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1588              BC046317.1         1-1588
            1589-1711           AC142211.3         98355-98477
            1712-2082           BE634662.1         33-403              c
            2083-2121           AA420282.1         287-325
FEATURES             Location/Qualifiers
     source          1..2121
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 42.1 cM"
     gene            1..2121
                     /gene="Siah1a"
                     /gene_synonym="Sinh1a"
                     /note="siah E3 ubiquitin protein ligase 1A"
                     /db_xref="GeneID:20437"
                     /db_xref="MGI:MGI:108064"
     exon            1..190
                     /gene="Siah1a"
                     /gene_synonym="Sinh1a"
                     /inference="alignment:Splign:2.1.0"
     exon            191..2114
                     /gene="Siah1a"
                     /gene_synonym="Sinh1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1041
                     /gene="Siah1a"
                     /gene_synonym="Sinh1a"
                     /EC_number="2.3.2.27"
                     /note="siah-1a; mSiah-1a; seven in absentia homolog 1a;
                     RING-type E3 ubiquitin transferase SIAH1A; seven in
                     absentia 1A"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase SIAH1A"
                     /protein_id="NP_033198.1"
                     /db_xref="CCDS:CCDS22504.1"
                     /db_xref="GeneID:20437"
                     /db_xref="MGI:MGI:108064"
                     /translation="MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVC
                     FDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYAS
                     SGCEITLPHTEKAEHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQG
                     EDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQA
                     ENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGIN
                     VTISMC"
     regulatory      1563..1568
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Siah1a"
                     /gene_synonym="Sinh1a"
                     /note="hexamer: AATAAA"
     polyA_site      1588
                     /gene="Siah1a"
                     /gene_synonym="Sinh1a"
                     /note="major polyA site"
     regulatory      2085..2090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Siah1a"
                     /gene_synonym="Sinh1a"
                     /note="hexamer: ATTAAA"
     polyA_site      2114
                     /gene="Siah1a"
                     /gene_synonym="Sinh1a"
                     /note="major polyA site"
ORIGIN      
        1 ccgggctgcc gggcgggcgc gctctcgagg gcggcggccc agggtgtccc gtcggtctcg
       61 gtgccgggag aggtggaggc gcggcccgcg gtggcggcgg tgacggtggc ggtggcggtg
      121 gcggcggcgg cagctggcga ccgggcgcgt tagacggggc cggggtccgc ggcgcgctct
      181 ccgcccacag agatgagccg ccagactgct acagcattac ccactggcac ctcaaagtgt
      241 ccaccatccc agagggtacc tgccttgacc ggcacaactg catccaacaa tgacttggcg
      301 agtctttttg agtgtcctgt ctgctttgac tatgtgttgc cacctattct tcagtgtcag
      361 agtggccatc ttgtttgtag caactgtcgc cccaaactta catgttgtcc cacttgccgg
      421 ggcccattgg gatccattcg caacttggct atggagaaag tggccaactc agtactcttc
      481 ccttgtaaat atgcctcttc tggatgtgaa ataactctgc cacacaccga aaaggcagag
      541 cacgaggagc tctgtgagtt caggccttac tcctgcccct gccctggtgc ttcctgtaag
      601 tggcaaggct ccttggatgc cgtcatgccc cacctgatgc atcagcacaa gtccattacc
      661 accctgcaag gagaagatat agttttcctt gctacagaca ttaaccttcc tggtgctgtt
      721 gactgggtga tgatgcagtc ttgttttggc tttcatttca tgttagtctt ggagaaacaa
      781 gaaaaatatg atggtcatca gcagttcttt gcaattgtac aactgatagg aacacgcaag
      841 caagctgaaa attttgcata tcgacttgag ctaaatggtc ataggcggcg attgacttgg
      901 gaagcgactc ctcggtctat tcatgaggga attgcaacag ccattatgaa tagtgactgc
      961 ctagtgtttg acaccagcat tgcacagctt tttgcagaaa atggcaattt aggcatcaat
     1021 gtaactattt ccatgtgttg aaacggcaat caaatatttc tggccagtgt ttaaaatttg
     1081 catttgactt cacagagaat aaggcaccca tctgcttgcc aacctaaaac tttcctggta
     1141 ggtagaagct agacatgaag gtaaataaaa agaaaagctg ttaatacagg aaacagttgc
     1201 atgtagtaac actaatatat ttaaaaataa ttcaacagta aaccactgaa aaaaatatat
     1261 atacccaaga tgggcatctt ttgtattaag aaaggaaaca ttgtaaaata tttctgaact
     1321 ttgtgtttgt tgtagattga ttgtattgtt gacaattttt tgggggtgtg tgtctgtgca
     1381 cgcatgcgtg cacgtgtgtg gttggttttc ttttaactga caagccatct gcgtggtcat
     1441 agaccactgt tttccccttg tgagtcaaca catagtgctg ctgtgggttt gtttttgttt
     1501 ttctgttttg tttttgtttt ttgatgtgtg tatttgctaa tttttattct agtttttcat
     1561 taaataaatt tgactttctt ttctgtaatt caggtttttc tcacttttgt accttttaag
     1621 ttagtgtctt tttgatattc ataattgctt aatgtcaaaa gtttgtgttc agtacatact
     1681 ttcttttcct tcaatcaatt tattagaaat atttttaatt tagccctttt gtgaaaatag
     1741 gaattccaga aaggcaaggt agcagagcag cagtcaaggc tgaagtgagt gcaggatgct
     1801 cttgtctctc tcggtgactg tcccatggag ccacacgtca ggtcaggctg actcttagaa
     1861 agggtaggtt agggagtaaa ctctgattta tataaattta aaaaaaaatc aggcttttcc
     1921 tctcttcaaa tgtctggggc aaatcacatg ttttaattgg ttcttgtatt tattggtttt
     1981 gcaaaagagt gcagcatcat acacagtatt tgtaattaaa gtaaatcatt tgttttttta
     2041 aaaaggcagt ttgcaaaaaa tgtttttggt cttttataat tctcattaaa agattatctg
     2101 gcaaattaaa aaaaaaaaaa a
//
