LOCUS       NM_011734               3399 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus sialic acid acetylesterase (Siae), mRNA.
ACCESSION   NM_011734
VERSION     NM_011734.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3399)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3399)
  AUTHORS   Danyukova,T., Ariunbat,K., Thelen,M., Brocke-Ahmadinejad,N.,
            Mole,S.E. and Storch,S.
  TITLE     Loss of CLN7 results in depletion of soluble lysosomal proteins and
            impaired mTOR reactivation
  JOURNAL   Hum Mol Genet 27 (10), 1711-1722 (2018)
   PUBMED   29514215
REFERENCE   3  (bases 1 to 3399)
  AUTHORS   Mahajan,V.S., Demissie,E., Mattoo,H., Viswanadham,V., Varki,A.,
            Morris,R. and Pillai,S.
  TITLE     Striking Immune Phenotypes in Gene-Targeted Mice Are Driven by a
            Copy-Number Variant Originating from a Commercially Available
            C57BL/6 Strain
  JOURNAL   Cell Rep 15 (9), 1901-1909 (2016)
   PUBMED   27210752
REFERENCE   4  (bases 1 to 3399)
  AUTHORS   Cariappa,A., Takematsu,H., Liu,H., Diaz,S., Haider,K., Boboila,C.,
            Kalloo,G., Connole,M., Shi,H.N., Varki,N., Varki,A. and Pillai,S.
  TITLE     B cell antigen receptor signal strength and peripheral B cell
            development are regulated by a 9-O-acetyl sialic acid esterase
  JOURNAL   J Exp Med 206 (1), 125-138 (2009)
   PUBMED   19103880
  REMARK    GeneRIF: Sialate:O-acetyl esterase is a catalytic regulator of B
            cell signaling and plays an essential role in the maintenance of
            immunological tolerance in the B lineage.
REFERENCE   5  (bases 1 to 3399)
  AUTHORS   Takematsu,H., Diaz,S., Stoddart,A., Zhang,Y. and Varki,A.
  TITLE     Lysosomal and cytosolic sialic acid 9-O-acetylesterase activities
            can Be encoded by one gene via differential usage of a signal
            peptide-encoding exon at the N terminus
  JOURNAL   J Biol Chem 274 (36), 25623-25631 (1999)
   PUBMED   10464298
REFERENCE   6  (bases 1 to 3399)
  AUTHORS   Stoddart,A., Zhang,Y. and Paige,C.J.
  TITLE     Molecular cloning of the cDNA encoding a murine sialic
            acid-specific 9-O-acetylesterase and RNA expression in cells of
            hematopoietic and non-hematopoietic origin
  JOURNAL   Nucleic Acids Res 24 (20), 4003-4008 (1996)
   PUBMED   8918804
REFERENCE   7  (bases 1 to 3399)
  AUTHORS   Guimaraes,M.J., Bazan,J.F., Castagnola,J., Diaz,S., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Varki,A. and Zlotnik,A.
  TITLE     Molecular cloning and characterization of lysosomal sialic acid
            O-acetylesterase
  JOURNAL   J Biol Chem 271 (23), 13697-13705 (1996)
   PUBMED   8662838
REFERENCE   8  (bases 1 to 3399)
  AUTHORS   Guimaraes,M.J., Bazan,J.F., Zlotnik,A., Wiles,M.V., Grimaldi,J.C.,
            Lee,F. and McClanahan,T.
  TITLE     A new approach to the study of haematopoietic development in the
            yolk sac and embryoid bodies
  JOURNAL   Development 121 (10), 3335-3346 (1995)
   PUBMED   7588067
REFERENCE   9  (bases 1 to 3399)
  AUTHORS   Butor,C., Higa,H.H. and Varki,A.
  TITLE     Structural, immunological, and biosynthetic studies of a sialic
            acid-specific O-acetylesterase from rat liver
  JOURNAL   J Biol Chem 268 (14), 10207-10213 (1993)
   PUBMED   8486688
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ062379.1 and AK028656.1.
            
            On Jun 19, 2018 this sequence version replaced NM_011734.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.34224.1, AK165103.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                CJ062379.1         5-30
            27-3399             AK028656.1         1-3373
FEATURES             Location/Qualifiers
     source          1..3399
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 20.79 cM"
     gene            1..3399
                     /gene="Siae"
                     /gene_synonym="LSE; Ysg2"
                     /note="sialic acid acetylesterase"
                     /db_xref="GeneID:22619"
                     /db_xref="MGI:MGI:104803"
     exon            1..106
                     /gene="Siae"
                     /gene_synonym="LSE; Ysg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1665
                     /gene="Siae"
                     /gene_synonym="LSE; Ysg2"
                     /EC_number="3.1.1.53"
                     /note="yolk sac protein 2; sialic acid-specific
                     9-O-acetylesterase; yolk sac gene 2; clone 165"
                     /codon_start=1
                     /product="sialate O-acetylesterase"
                     /protein_id="NP_035864.2"
                     /db_xref="CCDS:CCDS22983.1"
                     /db_xref="GeneID:22619"
                     /db_xref="MGI:MGI:104803"
                     /translation="MVSPGPVFGIVLLIIARVSRSAGIGFRFASYIDNYMVLQKEPSG
                     AVIWGFGTPGATVTVTLCQGQETIMKKVTSVKEPSNTWMVVLDPMKPGGPFEVMAQQT
                     LGTMNFTLRVHDVLFGDVWLCSGQSNMQMTVSQIFNASKELSDTAAYQSVRIFSVSLI
                     QSEEELDDLTEVDLSWSKPTAGNLGHGNFTYMSAVCWLFGRYLYDTLQYPIGLVSSSW
                     GGTYIEVWSSRRTLKACGVPNTRDERVGQPEIKPMRNECNSEESSCPFRVVPSVRVTG
                     PTRHSVLWNAMIHPLQNMTLKGVVWYQGESNADYNRDLYTCMFPELIEDWRQTFHYGS
                     QGQTDRFFPFGFVQLSSYMLKNSSDYGFPEIRWHQTADFGHVPNPKMPNTFMAVAIDL
                     CDRDSPFGSIHPRDKQTVAYRLHLGARAVAYGEKNLTFQGPLPKKIELLASNGLLNLT
                     YDQEIQVQMQDNKTFEISCCSDRHCKWLPAPVNTFSTQTLILDLNACLGTVVAVRYAW
                     TTWPCEYKQCAVYHTSSMLPAPPFIAQISHRGI"
     exon            107..268
                     /gene="Siae"
                     /gene_synonym="LSE; Ysg2"
                     /inference="alignment:Splign:2.1.0"
     exon            269..444
                     /gene="Siae"
                     /gene_synonym="LSE; Ysg2"
                     /inference="alignment:Splign:2.1.0"
     exon            445..583
                     /gene="Siae"
                     /gene_synonym="LSE; Ysg2"
                     /inference="alignment:Splign:2.1.0"
     exon            584..839
                     /gene="Siae"
                     /gene_synonym="LSE; Ysg2"
                     /inference="alignment:Splign:2.1.0"
     exon            840..949
                     /gene="Siae"
                     /gene_synonym="LSE; Ysg2"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1083
                     /gene="Siae"
                     /gene_synonym="LSE; Ysg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1241
                     /gene="Siae"
                     /gene_synonym="LSE; Ysg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1437
                     /gene="Siae"
                     /gene_synonym="LSE; Ysg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..3399
                     /gene="Siae"
                     /gene_synonym="LSE; Ysg2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3378..3383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Siae"
                     /gene_synonym="LSE; Ysg2"
                     /note="hexamer: AATATA"
     polyA_site      3399
                     /gene="Siae"
                     /gene_synonym="LSE; Ysg2"
                     /note="major polyA site"
ORIGIN      
        1 cttcctgaat tcggcgggtt aatcaggatc ttcacaaaca tggtttcccc ggggcctgtg
       61 tttgggatag tgctgctcat aatcgcgcga gtcagcagaa gtgcaggtat tggttttcgc
      121 tttgcttcat acatcgataa ttacatggtg ctgcagaagg agccttcagg ggctgtgatc
      181 tggggctttg gtacacctgg agccacagtg acagtgacct tgtgccaagg tcaggaaacc
      241 atcatgaaga aagtgaccag tgtgaaagaa ccctccaaca cctggatggt ggtactggac
      301 cctatgaagc ctgggggacc ttttgaagtg atggcgcaac agactttggg gacaatgaat
      361 ttcaccctga gagtccatga tgtcttattt ggagatgtct ggctttgcag tgggcagagt
      421 aacatgcaga tgactgtttc acagatcttt aacgcctcaa aggagttgtc cgacactgct
      481 gcctaccagt ctgtgcgcat cttctctgtc tccctcatcc aatcagagga ggagttggat
      541 gaccttactg aggttgacct gtcatggtcc aagcccaccg caggaaactt gggccatgga
      601 aatttcactt acatgtctgc ggtgtgctgg ctctttgggc gttacctgta tgacactctg
      661 caatatccca ttgggttggt ctcctccagt tggggtggga cgtacattga agtctggtca
      721 tctagaagga cactgaaagc ctgtggagtc cctaatacaa gggatgaaag agttggtcag
      781 cccgagataa agcccatgag gaatgaatgt aacagtgagg agtcctcatg tccttttagg
      841 gttgtcccat ctgttcgtgt gactggaccg acaagacact ccgtcctttg gaacgccatg
      901 atccatccac tgcaaaacat gactttgaaa ggggtggtgt ggtaccaggg agagtccaat
      961 gcggattata acagggacct gtacacctgc atgtttcctg aactcattga agactggcgc
     1021 cagaccttcc actacggctc ccagggtcag acagatcgtt tctttccatt tgggtttgtc
     1081 cagctgtctt catacatgtt aaagaactca tcggattatg gatttccaga gatccgttgg
     1141 catcaaactg cagactttgg ccatgtcccc aacccgaaga tgcctaatac ttttatggct
     1201 gtcgctattg acctctgtga tagagactca ccctttggaa gtatccaccc tcgagacaaa
     1261 cagactgtgg cctatcgtct gcacttgggt gctcgagctg tggcatatgg tgagaaaaat
     1321 ttgacctttc aaggaccact acctaagaag atagaactct tggcttccaa tggcctgctc
     1381 aacctcacat atgaccagga aatccaggtg caaatgcaag ataacaaaac atttgagatc
     1441 tcctgttgta gtgaccgtca ttgcaaatgg cttccagctc ctgttaacac tttctccacc
     1501 cagactctga ttttggatct caatgcttgt cttggcacag tggttgctgt tcgctatgcc
     1561 tggaccacat ggccttgtga atataagcaa tgtgctgttt accacaccag cagtatgttg
     1621 ccagctcctc ccttcattgc tcaaatttca cacaggggta tctaaggaca tttggagtag
     1681 tgctcgctct tctatacaag ggcaaatcct ttagtttggg tatgcaggac tttaaaagat
     1741 gactgctgtt tttagggcaa tgggataaac ccctcattga atagctccca gctagcatat
     1801 ggcccctcca gtattctgac ataagcacag gctagcagat acttgaaatg ctcatctctg
     1861 tcctctagtt aacctaagcc tctgtgctgg tctaattctc aactatatca ctgggcctta
     1921 ctagcattca cttccttggt attagtggga gtaatatgcc ctattcgtgc ccttcttcac
     1981 tactctcgga ctgtggactc tcggaccagc aagggacttt aaaggctgtg gaggctggtg
     2041 ctttgtgtgt tctttacaac cccctgaaaa cggctatgca agtttccatg tgtttccttc
     2101 tgtaaaacaa tgctcttgtc aaaccttact accccatgac aggcctttca ggtcgcctct
     2161 gacagatcat gtgtttttat cactaggctc tccaaagctg ttgtcagcct aactcatact
     2221 ctaaagggaa tctgtgcata ttgccatgtg ctaaggagtg gccttaagga agaaagaggg
     2281 cccactgcag gttctcaggc agagggtggg gaaatcacag gcacagggac acgcggaagt
     2341 agatgtgctt ggggcaaata gctctttaaa tgtaagtctt aggtccctga ggtaaaagtt
     2401 caactaagcc taagcctaat tcccacggaa ggaagaagtt aggctgaaag ttacagaaca
     2461 tgcttataga cctacaggtg attttgtagt ttaccatttg gttaaagaca gctgctagct
     2521 gtgaaaagtg cacctcttag aaactggaaa taagtccagc acggtagcat acactaatcc
     2581 cagcactcag gagggcagag gtgagctgtt ctacagaatg agctctagga tagcaagtta
     2641 cctagagaaa cacagtcttg atccttcctg ccccacaaag aagaaaaaaa aaaaattagc
     2701 gatgcatcca tttgccttac actgtgccct tgaagcatgg gagaggagtg taactgtcac
     2761 ctgtgcacag ctcttttgtt ctttgatgtg agaaagtggg aactgaagca atgaggactt
     2821 cccaccattc tctgggggct ctggagccat tagaaacagc aagagagatg tgtcaggagt
     2881 ttacctggtt aaacacaaag aaaacaccaa aacctataca ttctgcagag gcctttgacc
     2941 tctgaggtgt tctagcctgc atttatcttc taatgctctc tctgcatctg gccccctgag
     3001 aacacaaacc taggaaccac cagctcctga gaaaaagtaa aatctacctg cctgtcctgc
     3061 caacccgtgt tagtcacgat gaccaagtag tgaagaaccc caagcccaag gtccttaaca
     3121 actcacaagt gataaatctt ctggattgta catcagcgca ccacatccaa taactggtac
     3181 atacagcata tactctgcca cattagtaca tgtgttaatg aagtcgtgga tgagccaaac
     3241 ttttagtagt tgaatagttt aaaacattgt gtggggattg tgcacttctc taaatggaga
     3301 gagttttaac tgaaggagaa acagtgccct gctgaacatt ggcccggctt gttttgtttc
     3361 ctatagcata tgtaaataat atacatccta tacttgaaa
//
