LOCUS       NM_001114312            4081 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus shootin 1 (Shtn1), transcript variant 1, mRNA.
ACCESSION   NM_001114312
VERSION     NM_001114312.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4081)
  AUTHORS   Zhang,K., Zhang,T., He,Q., Liang,H., Guo,J., Zeng,M. and Chen,S.
  TITLE     Shootin1 Regulates Retinal Ganglion Cell Neurite Development:
            Insights From an RGC Direct Somatic Cell Reprogramming Model
  JOURNAL   Invest Ophthalmol Vis Sci 65 (6), 41 (2024)
   PUBMED   38935030
REFERENCE   2  (bases 1 to 4081)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4081)
  AUTHORS   Kastian,R.F., Baba,K., Kaewkascholkul,N., Sasaki,H., Watanabe,R.,
            Toriyama,M. and Inagaki,N.
  TITLE     Dephosphorylation of neural wiring protein shootin1 by PP1
            phosphatase regulates netrin-1-induced axon guidance
  JOURNAL   J Biol Chem 299 (5), 104687 (2023)
   PUBMED   37044214
  REMARK    GeneRIF: Dephosphorylation of neural wiring protein shootin1 by PP1
            phosphatase regulates netrin-1-induced axon guidance.
REFERENCE   4  (bases 1 to 4081)
  AUTHORS   Du,H., Wang,Z., Guo,R., Yang,L., Liu,G., Zhang,Z., Xu,Z., Tian,Y.,
            Yang,Z., Li,X. and Chen,B.
  TITLE     Transcription factors Bcl11a and Bcl11b are required for the
            production and differentiation of cortical projection neurons
  JOURNAL   Cereb Cortex 32 (17), 3611-3632 (2022)
   PUBMED   34963132
REFERENCE   5  (bases 1 to 4081)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4081)
  AUTHORS   Sapir,T., Levy,T., Sakakibara,A., Rabinkov,A., Miyata,T. and
            Reiner,O.
  TITLE     Shootin1 acts in concert with KIF20B to promote polarization of
            migrating neurons
  JOURNAL   J Neurosci 33 (29), 11932-11948 (2013)
   PUBMED   23864681
  REMARK    GeneRIF: our data demonstrate the importance of the Shootin1/KIF20B
            interaction to the dynamic process of pyramidal neuronal
            polarization and migration.
REFERENCE   7  (bases 1 to 4081)
  AUTHORS   Pericacho,M., Velasco,S., Prieto,M., Llano,E., Lopez-Novoa,J.M. and
            Rodriguez-Barbero,A.
  TITLE     Endoglin haploinsufficiency promotes fibroblast accumulation during
            wound healing through Akt activation
  JOURNAL   PLoS One 8 (1), e54687 (2013)
   PUBMED   23349951
REFERENCE   8  (bases 1 to 4081)
  AUTHORS   Toriyama,M., Shimada,T., Kim,K.B., Mitsuba,M., Nomura,E.,
            Katsuta,K., Sakumura,Y., Roepstorff,P. and Inagaki,N.
  TITLE     Shootin1: A protein involved in the organization of an asymmetric
            signal for neuronal polarization
  JOURNAL   J Cell Biol 175 (1), 147-157 (2006)
   PUBMED   17030985
REFERENCE   9  (bases 1 to 4081)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   10 (bases 1 to 4081)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124459.5 and AC102604.13.
            
            Transcript Variant: This variant (1) encodes the longer isoform (1,
            also known as shootin 1b).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220405.1, ERR3363658.4727777.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-615               AC124459.5         95068-95682
            616-668             AC124459.5         110454-110506
            669-729             AC124459.5         120243-120303
            730-824             AC102604.13        3332-3426
            825-993             AC102604.13        6898-7066
            994-1091            AC102604.13        10147-10244
            1092-1173           AC102604.13        13034-13115
            1174-1268           AC102604.13        17039-17133
            1269-1415           AC102604.13        22966-23112
            1416-1569           AC102604.13        26330-26483
            1570-1669           AC102604.13        29662-29761
            1670-1752           AC102604.13        35441-35523
            1753-1862           AC102604.13        41339-41448
            1863-1916           AC102604.13        45342-45395
            1917-2037           AC102604.13        50150-50270
            2038-2230           AC102604.13        54907-55099
            2231-4081           AC102604.13        70080-71930
FEATURES             Location/Qualifiers
     source          1..4081
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 54.56 cM"
     gene            1..4081
                     /gene="Shtn1"
                     /gene_synonym="4930506M07Rik; mKIAA1598; Shootin1"
                     /note="shootin 1"
                     /db_xref="GeneID:71653"
                     /db_xref="MGI:MGI:1918903"
     exon            1..615
                     /gene="Shtn1"
                     /gene_synonym="4930506M07Rik; mKIAA1598; Shootin1"
                     /inference="alignment:Splign:2.1.0"
     CDS             558..2453
                     /gene="Shtn1"
                     /gene_synonym="4930506M07Rik; mKIAA1598; Shootin1"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="shootin-1 isoform 1"
                     /protein_id="NP_001107784.1"
                     /db_xref="CCDS:CCDS50481.1"
                     /db_xref="GeneID:71653"
                     /db_xref="MGI:MGI:1918903"
                     /translation="MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQE
                     RDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISM
                     LYMAKLGPDVITEEINIDDDDPATDTDAAAETCVSVQCQKQIKELRDQIVSVQEEKKV
                     LAIELENLKSKLGEVMEEVNKVKQEKAVLNSEVLEQRKVLEKCNRVSMLAVEEYEELQ
                     VNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSLPDQQLLKALDENAKLIQQL
                     EEERIQHQKKVKELEERLENEALHKEIHNLRQQLELLEDDKRELEQKYQSSEEKARNL
                     KHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGNSAKKEK
                     TTQPETAEEVTDLKRQAVEEMMDRIKKGVHLRPVNQTARPKAKPDSLKGSESAVDELK
                     GILGTLNKSTSSRSLKSLGPENSETELERILRRRKLTAEADSSSPTGILATSESKSMP
                     VLGSVSSVTKSALNKKTLEAEFNNPCPLTPEPGEGPRKLEGCTNPKVTFQPPSKGGYR
                     RKCVGSENQAEPVVVLDPVSTHEPQTKDQAAEKDPTQFEEEGGETQPEYKEDSGGKTG
                     ETDSSNC"
     exon            616..668
                     /gene="Shtn1"
                     /gene_synonym="4930506M07Rik; mKIAA1598; Shootin1"
                     /inference="alignment:Splign:2.1.0"
     exon            669..729
                     /gene="Shtn1"
                     /gene_synonym="4930506M07Rik; mKIAA1598; Shootin1"
                     /inference="alignment:Splign:2.1.0"
     exon            730..824
                     /gene="Shtn1"
                     /gene_synonym="4930506M07Rik; mKIAA1598; Shootin1"
                     /inference="alignment:Splign:2.1.0"
     exon            825..993
                     /gene="Shtn1"
                     /gene_synonym="4930506M07Rik; mKIAA1598; Shootin1"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1091
                     /gene="Shtn1"
                     /gene_synonym="4930506M07Rik; mKIAA1598; Shootin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1173
                     /gene="Shtn1"
                     /gene_synonym="4930506M07Rik; mKIAA1598; Shootin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1268
                     /gene="Shtn1"
                     /gene_synonym="4930506M07Rik; mKIAA1598; Shootin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1415
                     /gene="Shtn1"
                     /gene_synonym="4930506M07Rik; mKIAA1598; Shootin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1569
                     /gene="Shtn1"
                     /gene_synonym="4930506M07Rik; mKIAA1598; Shootin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1669
                     /gene="Shtn1"
                     /gene_synonym="4930506M07Rik; mKIAA1598; Shootin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1752
                     /gene="Shtn1"
                     /gene_synonym="4930506M07Rik; mKIAA1598; Shootin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1862
                     /gene="Shtn1"
                     /gene_synonym="4930506M07Rik; mKIAA1598; Shootin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1916
                     /gene="Shtn1"
                     /gene_synonym="4930506M07Rik; mKIAA1598; Shootin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2037
                     /gene="Shtn1"
                     /gene_synonym="4930506M07Rik; mKIAA1598; Shootin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2230
                     /gene="Shtn1"
                     /gene_synonym="4930506M07Rik; mKIAA1598; Shootin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..4081
                     /gene="Shtn1"
                     /gene_synonym="4930506M07Rik; mKIAA1598; Shootin1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3919..3924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shtn1"
                     /gene_synonym="4930506M07Rik; mKIAA1598; Shootin1"
                     /note="hexamer: ATTAAA"
     polyA_site      3943
                     /gene="Shtn1"
                     /gene_synonym="4930506M07Rik; mKIAA1598; Shootin1"
                     /note="major polyA site"
ORIGIN      
        1 agactgcaaa catgcacttg cttggtggac aggtgcatgg tgtagaacag agggttttcc
       61 agccctggct ccaatgagca gtgactgaga actaggatag gagcctggtc ctctggggtc
      121 cgtccggtcc tgctcagatc cgctgtccag ctctagggtg gcggacctgg ggaacccggg
      181 tcgagtctcc atggtgcgcg cctcgggtgg aaagcctggc gcagcggcgg ccttagcaga
      241 accgcataca gccacctggg aggatcgcag gcgccccagg gccgtgacac ttcacccgcc
      301 tccagcggcc cacgccccta ccgggccagg cgcccagacc cgcccgccgc aggtggggca
      361 gccagggccc gcgagtaggt gcgtgggatg atctcaccgc gtgcggcgcg ccaggaggag
      421 gaggagcggg agcgatccca acttccgggt agtgcagccg cacgccgcgc caccggcatc
      481 ttgctttctg ctccccctcc cccgtgtccc cctcgcctct ccctccttgc cttttatccc
      541 cagccccacc cgccaaaatg aacagctcgg acgaggagaa gcagctgcag ctcatcacca
      601 gcttgaagga gcaagccatt ggcgaatatg aagaccttcg agcagagaac cagaaaacaa
      661 aggagaagtg tgacaaaatt aggcaagaac gagatgaagc tgttaaaaaa ctggaagagt
      721 ttcagaaaat ttcacatatg gttatagagg aggtgaattt catgcagaac catcttgaaa
      781 tagagaagac atgtcgagag agcgctgaag ccttggcgac aaagctaaat aaagaaaata
      841 aaacactgaa aagaatcagc atgctataca tggccaaact ggggccagac gtaattacag
      901 aggagataaa cattgatgat gatgacccag ccaccgacac agatgctgcg gctgagacct
      961 gtgtgtctgt tcagtgtcag aagcaaatca aagaacttcg agatcaaatt gtgtctgttc
     1021 aggaagaaaa gaaggtgtta gccatcgagc tggaaaacct caagagcaaa ctcggggagg
     1081 tgatggagga ggtaaataaa gttaagcaag aaaaagctgt tttaaattca gaagtccttg
     1141 agcagaggaa agtcttagaa aaatgcaaca gagtgtccat gttggctgtt gaagagtatg
     1201 aggaactgca agtgaacctg gaactggaga aggaccttcg caagaaagca gagtcttttg
     1261 cacaagagat gttcattgaa caaaacaaac tgaagagaca aagccacctt ctgctgcaga
     1321 gctcccttcc tgaccagcag cttttgaaag ctttagacga aaacgcaaaa cttatccagc
     1381 agcttgaaga agagaggatc cagcatcaga aaaaggtcaa agagctggag gagcggctgg
     1441 agaatgaagc acttcacaaa gagatccata acctcagaca acagctggag cttctggaag
     1501 acgacaagag ggagctagag cagaaatacc agagctcgga ggagaaggcc cggaacctga
     1561 agcattcagt ggatgaactt cagaagcgag tgaaccagtc tgagaattcg gtacctcccc
     1621 cgcctcctcc tcctccacct ctcccccctc cacctcccaa tccaatccgg tccctcatgt
     1681 ctatgatccg gaagcgatct caccccagtg gcaatagtgc taagaaagaa aagacaactc
     1741 agccagagac agctgaggaa gtcacagacc tgaagaggca agcagtggaa gagatgatgg
     1801 acagaattaa gaagggagtt catcttagac cggttaacca gacagccaga cccaaggcaa
     1861 agccagactc tctcaagggc tcagaaagtg cggtggatga gctgaaggga atcctgggga
     1921 cacttaacaa atccactagt tcgagaagct taaaatccct tggccctgag aacagtgaaa
     1981 ctgagttaga gaggatttta cgtcgcagaa agctgacggc agaagcagat agcagtagtc
     2041 ctaccgggat attagccacc tcagagtcca agtccatgcc agtgttgggt tctgtatcca
     2101 gtgtaacaaa atcagccttg aacaagaaaa ctctggaggc agaattcaac aacccgtgtc
     2161 ccctaacacc tgagccaggt gaagggcccc gtaaattgga aggatgcacg aatcccaagg
     2221 ttacctttca gcctcccagt aaaggtggat acaggagaaa atgtgtgggc agtgaaaacc
     2281 aagctgagcc agttgtagta ttagatcctg tttccacaca cgaaccccaa accaaagacc
     2341 aggctgctga aaaagaccca actcaattcg aggaggaggg aggtgaaacc caaccagaat
     2401 acaaagaaga cagcggtggg aaaacaggag agacggacag ttccaactgc tgatctgaaa
     2461 ccagaggctg gcaggttggt ggggccttct caaggagcac gtggctcgtc tgcgtgtaac
     2521 cggcaggaac tgttggacat tcctttgttc tggccacaca cttctttgct ggtatcactt
     2581 tgtaagtagc aatcataagt aagctgttta gcaaaatgca tcttctgggt agtttttaat
     2641 ctttacagga gtgagggttc tttccggttt ctatatgaag tatgacttcc ctgaggcggt
     2701 ggcggaactc agaggttggt gtctttacag ggaacatatg tacccctcat caaattattc
     2761 acgggaaaat tcaaggtggt tgctggtaac tgtataaaca gagaccacca aacttaacaa
     2821 ttatcttaaa ggcacccttt aatccaagcc ctagggcatg gagagaccaa ggcaagagga
     2881 tcacgtgagc ctgagtctta gtttggatca cacagtacaa ctccatataa agaacatata
     2941 aagaaaagaa ggcccgcaag agtctctggg gtctggtctt ctgatgggaa actgcagcag
     3001 cctcaacgtc agtgggtcct atagcgtctc tgttttgaag ggtgcgtgag accttccgtc
     3061 tctgagctca ggaggtggca tcatggactc ttaggtctca attgaacaca gttgactatt
     3121 gtgtggaaat catgaccctg tgtccaaggc tttacagagt ccttcagggt gatgtcttgg
     3181 cagcatcaac agagaattgg cttagaggga cgctcaaacc ttgaatttaa cagggattcc
     3241 tcggtaagct actagttctg ttccatgagt taactgtgtt ttcccacaca ttcacgtgcc
     3301 acaagtacca tattttacac cagctctcac gcacagtgaa gataagtgac aagcacacat
     3361 tgtttttctc ccttcactgc ggatctatac tacatgggtc ttttcttgtt ttgttttgtt
     3421 ttgttttgtt ttttagagga aattaagtgg tagtttctaa gaatacaatg tttcacacta
     3481 ccacggtgaa taaatagaaa tgtaatcagg gatttaaaaa aaaaaactta tgcaggtttt
     3541 caaagttgat tgtttcaaaa ttggtgttta tttaaaataa gtggtaatgt acttgagtgc
     3601 actttttatg ataatgattc agtaatggta attttactat taaggaaatg gaaaggctta
     3661 gttttgttag catgactcgg catgtagctg tcaggtgctc tgcacctgag ggcaaaagaa
     3721 aatgataaca attgcagtag ttgtatccta ttgtattttt gcacgtgtgc tactagcgtg
     3781 ggcctgggga ggtgggaagg caggtgagga cacttcctcg gcttggggac aattctcttt
     3841 ctgtagggtc aatgggcttg actgttttcc ctgtctgtca gtgctgattt tatatccctg
     3901 tcagtttact catggggaat taaaacgcga tttttttttt caaccgtgtg tttctctgac
     3961 tgaataagac tgctaaacaa tatgctaact gctggcagat taattctttt agatgggttc
     4021 tgttatgctg caatttgaat tctcctcaac acgacattaa aagagacact cgacggtttc
     4081 t
//
