LOCUS       NM_015756               7210 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus shroom family member 3 (Shroom3), transcript variant
            1, mRNA.
ACCESSION   NM_015756
VERSION     NM_015756.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7210)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7210)
  AUTHORS   Li,A., Cunanan,J., Khalili,H., Plageman,T., Ask,K., Khan,A.,
            Hunjan,A., Drysdale,T. and Bridgewater,D.
  TITLE     Shroom3, a Gene Associated with CKD, Modulates Epithelial Recovery
            after AKI
  JOURNAL   Kidney360 3 (1), 51-62 (2021)
   PUBMED   35368578
  REMARK    GeneRIF: Shroom3, a Gene Associated with CKD, Modulates Epithelial
            Recovery after AKI.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7210)
  AUTHORS   Ji,Y.X., Wang,Y., Li,P.L., Cai,L., Wang,X.M., Bai,L., Liu,Z.,
            Tian,H., Tian,S., Zhang,P., Zhang,X.J., Cheng,X., Yuan,Y.,
            She,Z.G., Hu,Y. and Li,H.
  TITLE     A kinome screen reveals that Nemo-like kinase is a key suppressor
            of hepatic gluconeogenesis
  JOURNAL   Cell Metab 33 (6), 1171-1186 (2021)
   PUBMED   33951476
REFERENCE   4  (bases 1 to 7210)
  AUTHORS   Matsuura,R., Hiraishi,A., Holzman,L.B., Hanayama,H., Harano,K.,
            Nakamura,E., Hamasaki,Y., Doi,K., Nangaku,M. and Noiri,E.
  TITLE     SHROOM3, the gene associated with chronic kidney disease, affects
            the podocyte structure
  JOURNAL   Sci Rep 10 (1), 21103 (2020)
   PUBMED   33273487
  REMARK    GeneRIF: SHROOM3, the gene associated with chronic kidney disease,
            affects the podocyte structure.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7210)
  AUTHORS   Pieters,T., Sanders,E., Tian,H., van Hengel,J. and van Roy,F.
  TITLE     Neural defects caused by total and Wnt1-Cre mediated ablation of
            p120ctn in mice
  JOURNAL   BMC Dev Biol 20 (1), 17 (2020)
   PUBMED   32741376
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7210)
  AUTHORS   Sousa-Nunes,R., Rana,A.A., Kettleborough,R., Brickman,J.M.,
            Clements,M., Forrest,A., Grimmond,S., Avner,P., Smith,J.C.,
            Dunwoodie,S.L. and Beddington,R.S.
  TITLE     Characterizing embryonic gene expression patterns in the mouse
            using nonredundant sequence-based selection
  JOURNAL   Genome Res 13 (12), 2609-2620 (2003)
   PUBMED   14613977
REFERENCE   7  (bases 1 to 7210)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 7210)
  AUTHORS   Hildebrand,J.D. and Soriano,P.
  TITLE     Shroom, a PDZ domain-containing actin-binding protein, is required
            for neural tube morphogenesis in mice
  JOURNAL   Cell 99 (5), 485-497 (1999)
   PUBMED   10589677
REFERENCE   9  (bases 1 to 7210)
  AUTHORS   Esterbauer,H., Oberkofler,H., Krempler,F. and Patsch,W.
  TITLE     Human peroxisome proliferator activated receptor gamma coactivator
            1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal
            localization, and tissue expression
  JOURNAL   Genomics 62 (1), 98-102 (1999)
   PUBMED   10585775
REFERENCE   10 (bases 1 to 7210)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124560.4, AC125233.4, AK147493.1 and BM942679.1.
            
            On Nov 8, 2006 this sequence version replaced NM_015756.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF199421.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-397               AC124560.4         169678-170074       c
            398-552             AC124560.4         72602-72756         c
            553-684             AC125233.4         172248-172379       c
            685-6759            AK147493.1         296-6370
            6760-7210           BM942679.1         157-607
FEATURES             Location/Qualifiers
     source          1..7210
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 47.29 cM"
     gene            1..7210
                     /gene="Shroom3"
                     /gene_synonym="D5Ertd287e; Shrm; Shrm3"
                     /note="shroom family member 3"
                     /db_xref="GeneID:27428"
                     /db_xref="MGI:MGI:1351655"
     exon            1..397
                     /gene="Shroom3"
                     /gene_synonym="D5Ertd287e; Shrm; Shrm3"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..6175
                     /gene="Shroom3"
                     /gene_synonym="D5Ertd287e; Shrm; Shrm3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein Shroom3"
                     /codon_start=1
                     /product="protein Shroom3 isoform 1"
                     /protein_id="NP_056571.2"
                     /db_xref="CCDS:CCDS39154.1"
                     /db_xref="GeneID:27428"
                     /db_xref="MGI:MGI:1351655"
                     /translation="MKTPENLEEPSATPNPSRTPTERFVYLEALLEGGAPWGFTLKGG
                     LERGEPLIISKIEEGGKADSVSSGLQAGDEVIHINEVALSSSRREAVSLVKGSYKTLR
                     LVVRRDVCAAPGHADPGTSKSLSSELLTCSPQHRKATWSGGVKLRLKQRCSEPATRPH
                     SWHTTKFGETQPDVSMMQISQGTMGPPWHQSYHSSSSTSDLSNYDHAYLRRSPDQCSS
                     QGSMESLEPSGGYPPCHLLSPAKSTSSIDQLGHLHNKRDSAYSSFSTSSSIFEYPPPG
                     GSARERSGSMDVISARGGLLEGMRQADIRYVKTVYDTRRGVSSEYEVNPSALLLQGRD
                     AHASADSQGCAKWHSIPRGKGTPSPSWSQQCSGSLETATDNLPQKAGAPLPPTRSDSY
                     AAFRHRERPSSWSSLDQKRFCRPQTNSSGSQKTPFAEDQLHTVPERSPENSPPVKSKH
                     NYTQKAQPGQPLLPTGIYPVPSPEPHFAQVPQPSVSSNGTVYPALVKESGYTAAQGTC
                     NKMATLDENGNQNEASRPGFAFCQPLEHNSVTPVEKRPEPTAKYIYKVHFSSVPENED
                     SSLKRHITPPHGHSPYPSERKNIHGGSRACSNHHSLSSPQAQALHVGDDRRPSRLSQP
                     WEGDFQEDHNANLRQKVEREGQGQGLSGNSGRTRSAFSSLQNIPESLRRQSNVELGEA
                     QEVHPGGRSKVEDPGRKAGASDIRGYLDRSVSYPRPEGKMNAVDSVHSADSRYEESPA
                     PALPQTSGASQRRLSSSSSAAPQYRKPHCSVLEKVSRIEEREQGRHRPLSVGSSAYGP
                     GYRPGRTGPTPSTSSSDLDDPKAGSVHFSESTEHLRNGEQNPPNGEAKQEEASRPQCS
                     HLIRRAPADGRGPPARGGEPSRPEARLLRSQSTFQLYSEAEREASWSEDRPGTPESPL
                     LDAPFSRAYRNSIKDAQSRVLGATSFRRRDLEPGTPATSRPWRPRPASAHVGMRSPEA
                     AVPSSSPHTPRERHSVTPAAPQAARRGPRRRLTVEQKKRSYSEPEKMNEVGVSEEAEP
                     TPCGPPRPAQPRFSESTVADRRRIFERDGKACSTLSLSGPELKQFQQSALADYIQRKT
                     GKRPTGAACTPEAGLRERAQSAYLQAGPAAPDGPGLASACSLSSLREPEALPRKEHTH
                     PSAADGPQAPRDRSSSFASGRLVGERRRWDPQVPRQLLSGANCEPRGVQRMDGAPGGP
                     PSWGMVAGKAGKSKSAEDLLERSDTLAVPVHVRSRSSPTSDKKGQDVLLREGSNFGFV
                     KDPCCLAGPGPRSLSCSDKGQNELALPLHHPTPCWNGSGCKATVASSAPPESSGAADH
                     LKQRRAPGPRPLSAGMHGHFPDARAASLSSPLPSPVPSSYRSQLAMDQQTGQQPPSSP
                     ASAVTQPTSPRSPELSSPAYGLGEGMWKRTSLPQRPPPPWVKWAHAVREDGLAEDTLA
                     PEFANLKHYRNQPSRPSSCSTSDPDTPGRISLRISESALQPSPPPRGDYDDEVFMKDL
                     HPKVTSSPTFEALPPPPPPSPPSEEPLVNGTDDFPPPPPPQALCEVLLDGEASTEAGS
                     GPCRIPRVMVTREGHVPGAAHSEGSQIMTATPPQTSAKGSEAESNTPSSASAQPQLNG
                     SPGKQLCPSQTRNLTYEPVERTQDLGKKTHAEPQKTSEDIRTEALAKEIVHQDKSLAD
                     ILDPDSRMKTTMDLMEGLFPGDASVLMDSGAKRKALDITARRAGCEAKASDHKEAVSV
                     LVNCPAYYSVSAAKAELLNKIKDMPEELQEEEGQEDVNEKKAELIGSLTHKLESLQEA
                     KGSLLTDIKLNNALGEEVEALISELCKPNEFDKYKMFIGDLDKVVNLLLSLSGRLARV
                     ENVLRGLGEDASKEERSSLNEKRKVLAGQHEDARELKENLDRRERVVLDILANYLSAE
                     QLQDYQHFVKMKSTLLIEQRKLDDKIKLGQEQVRCLLESLPSDFRPKAGAISLPPALT
                     GHGTPGGTSVFGGVFPTLTSPL"
     exon            398..552
                     /gene="Shroom3"
                     /gene_synonym="D5Ertd287e; Shrm; Shrm3"
                     /inference="alignment:Splign:2.1.0"
     exon            553..684
                     /gene="Shroom3"
                     /gene_synonym="D5Ertd287e; Shrm; Shrm3"
                     /inference="alignment:Splign:2.1.0"
     exon            685..816
                     /gene="Shroom3"
                     /gene_synonym="D5Ertd287e; Shrm; Shrm3"
                     /inference="alignment:Splign:2.1.0"
     exon            817..3979
                     /gene="Shroom3"
                     /gene_synonym="D5Ertd287e; Shrm; Shrm3"
                     /inference="alignment:Splign:2.1.0"
     exon            3980..4053
                     /gene="Shroom3"
                     /gene_synonym="D5Ertd287e; Shrm; Shrm3"
                     /inference="alignment:Splign:2.1.0"
     exon            4054..4890
                     /gene="Shroom3"
                     /gene_synonym="D5Ertd287e; Shrm; Shrm3"
                     /inference="alignment:Splign:2.1.0"
     exon            4891..5382
                     /gene="Shroom3"
                     /gene_synonym="D5Ertd287e; Shrm; Shrm3"
                     /inference="alignment:Splign:2.1.0"
     exon            5383..5533
                     /gene="Shroom3"
                     /gene_synonym="D5Ertd287e; Shrm; Shrm3"
                     /inference="alignment:Splign:2.1.0"
     exon            5534..5806
                     /gene="Shroom3"
                     /gene_synonym="D5Ertd287e; Shrm; Shrm3"
                     /inference="alignment:Splign:2.1.0"
     exon            5807..7210
                     /gene="Shroom3"
                     /gene_synonym="D5Ertd287e; Shrm; Shrm3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6743..6748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shroom3"
                     /gene_synonym="D5Ertd287e; Shrm; Shrm3"
                     /note="hexamer: AATGAA"
     polyA_site      6773
                     /gene="Shroom3"
                     /gene_synonym="D5Ertd287e; Shrm; Shrm3"
                     /note="major polyA site"
     regulatory      6967..6972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shroom3"
                     /gene_synonym="D5Ertd287e; Shrm; Shrm3"
                     /note="hexamer: AATAAA"
     polyA_site      6991
                     /gene="Shroom3"
                     /gene_synonym="D5Ertd287e; Shrm; Shrm3"
ORIGIN      
        1 gggacgtcag tgtgaacgca gtgggtagac cccactcagg acttccgctg aattccagcg
       61 ggtgtagtgg gagaagcatc cccggggagc cgcaggcttc gctgtcccga ctgagtttat
      121 cttggcctga gggcagcgtg ctgagcgatc taacccagca gggaagctcc tcttgcctcc
      181 atctgggtca ggcactttaa accgaagccg acttgaccat gcctctggcg cgatgaagac
      241 tccggagaac ttggaggagc ctagcgccac gccaaacccc agtaggaccc ccacggagag
      301 attcgtttat ctggaagcgc tcctagaggg aggggctccc tggggcttca ccctgaaagg
      361 tggcctggag cgtggagaac cgttaatcat ttccaagatt gaagaagggg gcaaagccga
      421 ctcagtgagc tccggactgc aagctgggga cgaagtcata cacatcaatg aggtggcgct
      481 gagcagttcc aggagagagg ctgtctccct agtgaaaggg tcctacaaga ccctgcggct
      541 ggtggtgcgc agagacgtgt gtgcggcccc gggccatgct gatcctggta cctctaagtc
      601 cctcagctca gagctgctca cctgcagtcc ccagcaccgg aaagcaacat ggtcaggagg
      661 ggtgaagctt cggctaaagc agaggtgcag tgagcctgcc actcgccctc actcgtggca
      721 taccaccaaa tttggggaga cacagcctga tgtcagcatg atgcagatat ctcagggcac
      781 aatgggccct ccttggcacc agagctacca ttccagctct tcgaccagtg acctctccaa
      841 ctacgaccat gcttatctga ggcggagccc tgaccagtgc agctcccagg ggagcatgga
      901 aagcctggag cccagtggcg gatacccacc ctgccatctc ctttctcctg ccaagtccac
      961 gagcagcatc gaccagctag gccaccttca taacaaaagg gactccgcat atagctcctt
     1021 ctccaccagt tcgagcatct tcgagtaccc accccctggt ggctctgccc gagaacgttc
     1081 gggttccatg gacgtgattt ctgcccgggg tggcctccta gaagggatga ggcaggcaga
     1141 catccgctac gtcaagacgg tctatgatac ccggagagga gtatcttcag agtatgaggt
     1201 gaacccttca gccttgctcc ttcaaggtag ggatgcccat gcctcagccg acagtcaggg
     1261 ctgtgctaaa tggcacagca ttcctcgggg caagggaacg ccttccccgt cttggagcca
     1321 gcagtgttct ggttccctgg agactgctac tgacaacctg ccccagaagg caggcgcacc
     1381 cctgcccccc acccgcagtg atagctatgc agccttccgc catcgcgagc gtcccagctc
     1441 ctggtccagc cttgatcaga aaaggttctg ccggcctcag acaaactctt caggctccca
     1501 gaaaacccca ttcgctgagg accagctgca tacagtccca gagaggagtc cagagaacag
     1561 ccccccagtg aaatctaagc ataattatac ccagaaggcg cagcctggcc aacctctgct
     1621 gcccactggc atctatccgg taccttctcc ggagcctcac tttgcccagg tgccccagcc
     1681 ctctgtgagt agtaatggca ccgtctaccc tgcgctagtc aaagagagtg gatacacagc
     1741 tgctcaggga acctgtaaca agatggctac cttagatgag aacgggaatc aaaatgaagc
     1801 tagcaggcct gggtttgcct tctgtcagcc cctagaacac aactcggtga ctccggtgga
     1861 gaaaaggcca gaacccacgg ccaaatacat ctacaaagtc catttttctt cagtgcctga
     1921 aaatgaagac tcctccctaa agaggcacat cacacctccc cacggccata gtccatatcc
     1981 cagcgagaga aagaacatcc acggtggcag cagagcgtgt tccaatcacc acagtctctc
     2041 gtccccccag gcccaggccc tgcacgtggg tgatgacagg aggccttcca ggctctctca
     2101 gccctgggag ggtgactttc aggaagatca caatgccaac ctcaggcaga aagtggagag
     2161 ggagggccaa ggccagggcc tgtcgggcaa ctctggcagg accagatcgg ccttctcatc
     2221 tctgcagaat attccagaga gtctgagaag acaaagcaac gtggagcttg gagaagccca
     2281 ggaggttcac cccgggggca ggtccaaggt ggaggaccct ggaaggaaag caggggcttc
     2341 agacatcagg ggctacctgg acagatctgt ttcctatccg aggcccgagg ggaaaatgaa
     2401 cgccgtagac tccgtccaca gtgcagactc caggtatgag gagtccccgg ccccagcgct
     2461 gccacagaca tccggtgcga gccagcggcg gctcagctcc agcagctccg ccgccccgca
     2521 gtacaggaag ccccattgct ccgtgctgga gaaggtttct agaatagagg aacgagagca
     2581 ggggcgccac agacccctga gcgtgggcag ctctgcatac ggccccggct acaggcctgg
     2641 gaggaccggc ccgaccccca gtacttccag cagtgacctc gacgatccaa aagccggcag
     2701 cgtccatttc tcggagtcca ctgaacacct gcgcaatggg gagcagaacc ccccaaacgg
     2761 ggaggctaag caggaagagg cttcccggcc ccagtgcagc catttgatcc ggagggcccc
     2821 tgcggacggc cgtggacctc ctgcccgagg cggcgagccc tcaaggccgg aggcccgcct
     2881 gctccgcagc cagagcacct ttcagctcta cagtgaggcg gagagggaag cctcgtggtc
     2941 agaggacagg cccggtaccc ctgagtcgcc cctgctcgat gcgcctttca gccgcgccta
     3001 cagaaacagc atcaaggatg cccagtcccg cgtcctgggg gccacgtcgt ttcgtcgccg
     3061 agacctggaa ccgggcaccc ccgccacctc gaggccctgg cgcccgcgac ccgcctccgc
     3121 ccacgtgggg atgcggagcc ccgaggccgc ggtgccctcg tcctccccgc acacccctcg
     3181 ggagcgacac agcgtgaccc cggccgcgcc ccaggctgcc cgccgaggcc cacgccggcg
     3241 cctcactgtc gagcagaaga agcgctccta ctcggagccc gagaagatga acgaggtagg
     3301 ggtctcggag gaggccgagc ccacgccctg cggcccgccg aggcccgcgc agccgcgctt
     3361 ctcggagagc accgtggccg accggcgccg catcttcgag cgcgacggca aggcctgctc
     3421 cacgctcagc ctgtcgggcc ccgagctcaa gcagttccag cagagcgccc tggccgacta
     3481 catccagcgt aagacgggca agcggcccac aggagccgcc tgcacaccgg aggccgggct
     3541 gcgcgagcgc gcacagagcg cctacctcca ggccggcccc gcggcgcccg atggccccgg
     3601 cctggcctct gcctgtagcc tgagctccct gcgagagccc gaggcgctgc cccgcaagga
     3661 gcacactcat ccgtcggccg cggacggccc gcaggcgccc cgtgatcgca gcagctcctt
     3721 cgccagcgga cgcctagtcg gggagcgacg tcgctgggac cctcaggtcc ccaggcagct
     3781 gctcagcgga gcgaactgcg aaccgagggg cgtccagagg atggacgggg ccccgggcgg
     3841 gccgccttcc tggggcatgg tggccgggaa ggccgggaag tccaagtcag ccgaggatct
     3901 gctggagcgc tccgacacac tggcggtccc tgtgcatgtg aggtccaggt cgtctcccac
     3961 ctccgacaag aaaggtcagg atgtgctcct gagggaaggc agcaactttg gttttgtaaa
     4021 ggatccatgc tgtttggctg gccctggacc taggtctctc agctgctcag acaaaggcca
     4081 gaatgagctg gcattgcccc tgcaccaccc tacgccctgc tggaacggct caggctgcaa
     4141 agccactgtg gcttcctcag ctcctcccga atcttctgga gccgcggatc atctgaagca
     4201 acgtagagcg cctggtccta ggccactctc agcaggaatg cacggccact tcccagacgc
     4261 cagagctgcc tcactcagct cccctctgcc atcacctgtc ccctccagtt accggtcaca
     4321 gcttgccatg gatcagcaga ctgggcaaca gcctccctca tcccctgcct ctgcagtgac
     4381 ccagcctacc agtccaagaa gccctgagct cagcagccca gcatatgggc taggggaggg
     4441 gatgtggaag aggacatccc tgcctcagcg accccctccc ccttgggtga aatgggccca
     4501 cgcggtcaga gaggacggcc ttgctgagga caccttggcg cctgagtttg cgaacctgaa
     4561 gcactataga aaccagccga gtcgtccgag ttcctgcagc acttctgacc cagacactcc
     4621 aggaaggatc tcgctccgaa tatcggagtc agcccttcaa ccttccccac cgccccgggg
     4681 ggactatgat gacgaagtgt tcatgaagga cttgcacccc aaggttactt caagccccac
     4741 atttgaagct cttcccccac ccccgccacc ttcgccaccg agcgaggaac ctctagtgaa
     4801 tggcacagat gactttcctc cgcctcctcc tccccaagcc ctgtgtgagg tactgctgga
     4861 tggtgaggca tccacggaag ctggcagcgg cccctgcaga attcccaggg tgatggtcac
     4921 aagggaaggg cacgtgcctg gggcagccca ttccgaaggt agtcagataa tgactgccac
     4981 accaccccaa acctcggcca aaggttcaga agccgagtcc aacacgcctt ccagcgcgag
     5041 cgcccagcct cagctcaacg gttctcctgg caagcagctc tgtcccagcc agacccgaaa
     5101 cctcacttat gaacctgtcg agagaactca ggatctagga aagaaaactc acgccgagcc
     5161 tcagaagacc tcagaagata tccggacaga ggctctagcc aaggaaattg tccaccaaga
     5221 caagtctctg gcagacattt tagatcctga ctccaggatg aagacaacga tggacctgat
     5281 ggagggttta ttccctggag acgccagtgt gctgatggat agtggcgcaa agaggaaagc
     5341 cttagacatc accgccaggc gtgcgggatg tgaagccaag gcgagcgacc acaaggaggc
     5401 agtgagtgtg ctggtcaact gtcctgccta ctacagtgtc tctgctgcca aggcggagct
     5461 gctcaacaaa atcaaagaca tgccggagga gctgcaggag gaggaggggc aggaggatgt
     5521 caatgagaaa aaggctgagc ttatcggaag ccttacccac aagctggaga gcctccagga
     5581 agccaagggg agcctgctca cggacatcaa gctgaacaat gccctgggag aggaggtgga
     5641 ggctctgatc agtgagctct gcaaacccaa cgagtttgac aagtacaaga tgttcatagg
     5701 ggacctggac aaggtggtca acctgctgct gtccctgtct ggacgcctgg cccgcgtgga
     5761 gaacgtcctc agaggccttg gtgaagacgc cagcaaagag gaaaggagtt ctctgaacga
     5821 gaaaaggaag gttctggctg gccagcatga ggatgcacgg gagctcaagg agaacctgga
     5881 ccggagggag cgcgtggtgc tggatatcct ggccaactac ctgtccgccg agcagctgca
     5941 ggactaccag cacttcgtga agatgaagtc cacactcctc attgagcagc ggaagctgga
     6001 tgacaagata aagctgggcc aggagcaggt caggtgcctg ctggagtcgc ttccctcgga
     6061 cttcaggccc aaggcagggg ccatctccct ccctccagcc ctcaccggcc atgggactcc
     6121 tggggggaca tctgtattcg gtggtgtttt cccaacgttg acctctcctc tttaatcgct
     6181 cctgtaagcc ctgggcaaaa gctgccactc tcaccactgt tcaatctgaa agcgatttca
     6241 ctacaaactg cggtttgagt tgtgggttac tgggggcttc ctgagtaaca ggaagaggct
     6301 ttccaggaat ctctcttgcc tttcacggtt ggtcttctgc gagcttgcac gctctgtgga
     6361 agagagtcgg tgacctgcgg cctgatggag ggtgtctggc acgggtttcc ccaggctgag
     6421 gcggcggaga tgggtgtgtg gcaccctcag gaatgtatcc acagcggcct tccttgctgg
     6481 tgggcagtgc accctgatac cagggcacaa gtaccagtct gcaacacaaa gccttaaaaa
     6541 gacacacaca cacacacaca cacacacaca cacacacaca cacacacacg ttaagaaaac
     6601 tgtaaaaccc ctgaacgttt ttgttattta tatttttaaa aatgaaaaag atcgttatgt
     6661 ttgtgtgcta accacttact tgattctatt ttgtggtgga tgtaggcaat tatgtttgag
     6721 ctttgtattt cgtgaaaacc ttaatgaaga attccaaaga tagtcaaatt gaatatggag
     6781 atttttgcgg gtttttcttc tgctcgtttt gtgtgtatct gctgttgggt ggctgtgtgc
     6841 gccacagtag gtgtgtagag ttgtacagct ttgtgtgggt tccgaggcct gaccctgggt
     6901 catcaggttc tcccatcgca agtctcttca cccactgagc cctctctcca gccccagtca
     6961 gacgttaata aagatgggtg gccattctgc acttgtgcta tgctgtgaga ggtcccagtt
     7021 tccatggtga tcgggccttg ccacgtttct ccaggaggac ggctcagtgg tgacatctcg
     7081 gggtgtgttc ctccttgacc agtttattca caaagacaat agttcccaag cctgtgagag
     7141 atgagtctaa gccagttcaa aaccgagtcc gtgctgccat cgtagaggaa atacacttac
     7201 taagcgacac
//
