LOCUS       NM_001290684            7501 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus shroom family member 2 (Shroom2), transcript variant
            2, mRNA.
ACCESSION   NM_001290684 XM_006528684
VERSION     NM_001290684.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7501)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7501)
  AUTHORS   Royer,C., Sandham,E., Slee,E., Schneider,F., Lagerholm,C.B.,
            Godwin,J., Veits,N., Hathrell,H., Zhou,F., Leonavicius,K.,
            Garratt,J., Narendra,T., Vincent,A., Jones,C., Child,T., Coward,K.,
            Graham,C., Fritzsche,M., Lu,X. and Srinivas,S.
  TITLE     ASPP2 maintains the integrity of mechanically stressed
            pseudostratified epithelia during morphogenesis
  JOURNAL   Nat Commun 13 (1), 941 (2022)
   PUBMED   35177595
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7501)
  AUTHORS   Grego-Bessa,J., Hildebrand,J. and Anderson,K.V.
  TITLE     Morphogenesis of the mouse neural plate depends on distinct roles
            of cofilin 1 in apical and basal epithelial domains
  JOURNAL   Development 142 (7), 1305-1314 (2015)
   PUBMED   25742799
REFERENCE   4  (bases 1 to 7501)
  AUTHORS   Farber,M.J., Rizaldy,R. and Hildebrand,J.D.
  TITLE     Shroom2 regulates contractility to control endothelial
            morphogenesis
  JOURNAL   Mol Biol Cell 22 (6), 795-805 (2011)
   PUBMED   21248203
  REMARK    GeneRIF: Data suggest that Shroom2 facilitates the formation of a
            contractile network within endothelial cells, the loss of which
            leads to an increase in endothelial sprouting, migration, and
            angiogenesis.
REFERENCE   5  (bases 1 to 7501)
  AUTHORS   Fulp,C.T., Cho,G., Marsh,E.D., Nasrallah,I.M., Labosky,P.A. and
            Golden,J.A.
  TITLE     Identification of Arx transcriptional targets in the developing
            basal forebrain
  JOURNAL   Hum Mol Genet 17 (23), 3740-3760 (2008)
   PUBMED   18799476
REFERENCE   6  (bases 1 to 7501)
  AUTHORS   Etournay,R., Zwaenepoel,I., Perfettini,I., Legrain,P., Petit,C. and
            El-Amraoui,A.
  TITLE     Shroom2, a myosin-VIIa- and actin-binding protein, directly
            interacts with ZO-1 at tight junctions
  JOURNAL   J Cell Sci 120 (Pt 16), 2838-2850 (2007)
   PUBMED   17666436
  REMARK    GeneRIF: Shroom2 and ZO-1 form a tight-junction-associated
            scaffolding complex, possibly linked to myosin VIIa, that bridges
            the junctional membrane to the underlying cytoskeleton, thereby
            contributing to the stabilization of these junctions.
REFERENCE   7  (bases 1 to 7501)
  AUTHORS   Fairbank,P.D., Lee,C., Ellis,A., Hildebrand,J.D., Gross,J.M. and
            Wallingford,J.B.
  TITLE     Shroom2 (APXL) regulates melanosome biogenesis and localization in
            the retinal pigment epithelium
  JOURNAL   Development 133 (20), 4109-4118 (2006)
   PUBMED   16987870
REFERENCE   8  (bases 1 to 7501)
  AUTHORS   Dietz,M.L., Bernaciak,T.M., Vendetti,F., Kielec,J.M. and
            Hildebrand,J.D.
  TITLE     Differential actin-dependent localization modulates the
            evolutionarily conserved activity of Shroom family proteins
  JOURNAL   J Biol Chem 281 (29), 20542-20554 (2006)
   PUBMED   16684770
REFERENCE   9  (bases 1 to 7501)
  AUTHORS   Blair,H.J., Uwechue,I.C., Barsh,G.S., Rowe,P.S. and Boyd,Y.
  TITLE     An integrated genetic and man-mouse comparative map of the
            DXHXS674-Pdha1 region of the mouse X chromosome
  JOURNAL   Genomics 48 (1), 128-131 (1998)
   PUBMED   9503026
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807777.6 and AL805960.10.
            
            On Mar 19, 2014 this sequence version replaced XM_006528684.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ358971.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               AL807777.6         5669-5869           c
            202-353             AL805960.10        139069-139220       c
            354-485             AL805960.10        116961-117092       c
            486-2940            AL805960.10        102693-105147       c
            2941-3041           AL805960.10        100853-100953       c
            3042-3233           AL805960.10        66555-66746         c
            3234-3779           AL805960.10        62330-62875         c
            3780-3942           AL805960.10        60622-60784         c
            3943-4215           AL805960.10        56824-57096         c
            4216-7501           AL805960.10        52938-56223         c
FEATURES             Location/Qualifiers
     source          1..7501
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 68.46 cM"
     gene            1..7501
                     /gene="Shroom2"
                     /gene_synonym="4832440C16; Apxl; C630003H05Rik; Shrm2"
                     /note="shroom family member 2"
                     /db_xref="GeneID:110380"
                     /db_xref="MGI:MGI:107194"
     exon            1..201
                     /gene="Shroom2"
                     /gene_synonym="4832440C16; Apxl; C630003H05Rik; Shrm2"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..4482
                     /gene="Shroom2"
                     /gene_synonym="4832440C16; Apxl; C630003H05Rik; Shrm2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein Shroom2"
                     /codon_start=1
                     /product="protein Shroom2 isoform 2"
                     /protein_id="NP_001277613.1"
                     /db_xref="CCDS:CCDS72455.1"
                     /db_xref="GeneID:110380"
                     /db_xref="MGI:MGI:107194"
                     /translation="MEGAEPRARPERLAEAEAPATDGVRLVEVQLSGGAPWGFTLKGG
                     REHGEPLVITKIEEGSKAAAVDKLLAGDEIVAINDVSLSGFRQEAICLVKGSHKTLKL
                     VVKRKSDPSWRPHSWHATKYFDVHPEPAASLFLNTSGSPSWKSQHQASSSSHDLSGSW
                     EHTSLQRTSDHFSSMGSIDSLDHSSQLYPSGHLSSAKSNSSIDHLGGHSKRDSAYGSF
                     STCSSTPDHTLPKADASSTENILYKVGLWEASRPGSSRQSQSTGDPQGLQDRPSCFIP
                     RVPGNSSKSPRPEDNVEPKIATHGRSNFGPVWYVPDKKKAPSPPPLGLPLRSDSFSVA
                     ARGHEKARGPPFSDLASMQHFITLPHVQPRGDHRMETTDRQWKLTHLSSGKEIGNVGY
                     QSEGHLDCRWLCSDDRAGRPSGPPGRLQFSDVHFLKSYHGSQHQQQCSDESPRAPSSP
                     RELLHITPGGGLQEPPEPSQDDNPTQVRWPGSAHQKLDDRGRSHYFPGSLRQPVQGSA
                     QVVIPRGDYWHSDTTPVDLEYPLLRPVGQRTYLQQHEETPASHEKEGYHQLNAGIEGC
                     CSGIQEPPRASRTVRTGLQCPSNDFKLVDGESGRISRQRTPMLHSLTQDGTWRPGNSK
                     DCGNDKPPLFDAQVGKPTRRSDRFATTLRNEIQMRRAKLQKSKSTVTLAGDSEAEDCA
                     GDWRADVGAVPEGSFPSTYKEHLKEAQTRVLKATSFQRRDLDPTPADQYSGPSEHRTF
                     DHSASSSLSSFPGEPDSAPRFCETGLAKAPSSGVGVPHVLRIGGRKRFTAEQKLKSYS
                     EPEKINEVGLSGDHRPHPTVRTPEDTVGTFADRWKFFEETSKSLLQKAGHRQVHCGLP
                     REKAERPQTGHHECESTEPWFQKRSLATSCGEILSDRKVEKASEKLNPPRRLGTFAEY
                     QASWKEQKKPLEARSSGRYHSADDILDAGLDQQQRPQYIHERSRSSPSTDHYSQEVPV
                     EPNRQAEDSGDHKEAILCTLQAEEGCSAPSAQPQDSQHVNEDTTFPQPETQLSSKCQH
                     LQTSAMETSRSPSPQFAPQKLTDKPPLLIHEDNSARIERVMDNNTTVKMVPIKIVHSE
                     SQPEKESRQSLACPAELPPLPSGLERDQIKTLSTSEQCYSRFCVYTRQEVEAPHRARP
                     PEPRPPSTPAPPVRDSCSSPPSLNYGKAKEKTMDDLKSEELAREIVGKDKSLADILDP
                     SVKIKTTMDLMEGIFPKDEYLLEEAQQRRKLLPKVPLPRVTEDKKQDPGMPGVVSLAT
                     NSTYYSTSAPKAELLIKMKDLQEPEEYSAGDLDHDLSVKKQELIDSISRKLQVLREAR
                     ESLLEDIQANNALGDEVEAIVKDVCKPNEFDKFRMFIGDLDKVVNLLLSLSGRLARVE
                     NALNNLDDNPSPGDRQSLLEKQRVLTQQHEDAKELKENLDRRERIVFDILATYLSEEN
                     LADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLFDSLQPERSK"
     exon            202..353
                     /gene="Shroom2"
                     /gene_synonym="4832440C16; Apxl; C630003H05Rik; Shrm2"
                     /inference="alignment:Splign:2.1.0"
     exon            354..485
                     /gene="Shroom2"
                     /gene_synonym="4832440C16; Apxl; C630003H05Rik; Shrm2"
                     /inference="alignment:Splign:2.1.0"
     exon            486..2940
                     /gene="Shroom2"
                     /gene_synonym="4832440C16; Apxl; C630003H05Rik; Shrm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2941..3041
                     /gene="Shroom2"
                     /gene_synonym="4832440C16; Apxl; C630003H05Rik; Shrm2"
                     /inference="alignment:Splign:2.1.0"
     exon            3042..3233
                     /gene="Shroom2"
                     /gene_synonym="4832440C16; Apxl; C630003H05Rik; Shrm2"
                     /inference="alignment:Splign:2.1.0"
     exon            3234..3779
                     /gene="Shroom2"
                     /gene_synonym="4832440C16; Apxl; C630003H05Rik; Shrm2"
                     /inference="alignment:Splign:2.1.0"
     exon            3780..3942
                     /gene="Shroom2"
                     /gene_synonym="4832440C16; Apxl; C630003H05Rik; Shrm2"
                     /inference="alignment:Splign:2.1.0"
     exon            3943..4215
                     /gene="Shroom2"
                     /gene_synonym="4832440C16; Apxl; C630003H05Rik; Shrm2"
                     /inference="alignment:Splign:2.1.0"
     exon            4216..7501
                     /gene="Shroom2"
                     /gene_synonym="4832440C16; Apxl; C630003H05Rik; Shrm2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6993..6998
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shroom2"
                     /gene_synonym="4832440C16; Apxl; C630003H05Rik; Shrm2"
                     /note="hexamer: AATAAA"
     polyA_site      7018
                     /gene="Shroom2"
                     /gene_synonym="4832440C16; Apxl; C630003H05Rik; Shrm2"
                     /note="major polyA site"
ORIGIN      
        1 aagggctgag tgtggagggg ctgagcgccc cgcgtcatgg agggcgccga gccccgtgca
       61 cggcccgagc gcctggccga agctgaggcg ccggcgaccg acggcgtccg cctggtggag
      121 gtgcagctga gcggcggcgc cccttggggc ttcaccttga agggcggccg cgagcatggc
      181 gagcctctgg tcatcaccaa gattgaagaa ggaagcaaag ctgcagcagt ggacaagcta
      241 cttgctggag atgagatagt ggccattaat gatgtgagtc tctcagggtt cagacaagaa
      301 gcaatttgcc tggtgaaagg ctcccacaag accctgaagc ttgtggtcaa aaggaaaagt
      361 gatccaagtt ggaggcccca ctcctggcac gctaccaagt actttgatgt ccaccctgag
      421 ccagcagcct cactgtttct gaacaccagc ggttcccctt cctggaagag ccagcaccag
      481 gctagttctt cctctcatga tttatctggc tcatgggagc atacaagcct acagcgcact
      541 tctgaccact tcagctccat gggcagcata gacagcctcg accacagctc ccaactctac
      601 ccatctggac acctctcatc tgccaagtcc aatagcagca ttgaccacct gggaggccac
      661 agcaagcgag actcagctta cggctccttt tccacatgct ccagcacccc tgaccacacc
      721 ttgcccaagg ctgatgcctc ttccactgag aacattctct ataaagttgg cctttgggag
      781 gcctccagac caggcagcag ccgacaaagc cagtctacag gtgatcctca gggactgcag
      841 gacaggccat catgtttcat acctagggtt cctggtaaca gtagtaaaag tccaaggccg
      901 gaggataatg ttgaacccaa aatagccact catgggagat ccaattttgg gcctgtgtgg
      961 tatgttcctg acaagaaaaa agccccttct cccccacctc ttggacttcc tttgcgcagt
     1021 gatagctttt ctgtggcagc caggggccat gaaaaagccc ggggccctcc attctcagac
     1081 ttggccagta tgcagcactt tatcaccctg ccccatgtgc aaccccgggg ggaccataga
     1141 atggaaacta cagatcgtca gtggaagctc acacacctaa gcagtggaaa agaaatagga
     1201 aatgtgggtt accagtcaga aggccacctg gattgccgtt ggctatgctc tgatgataga
     1261 gcaggtaggc cctcagggcc tccgggcagg ctccagttct ccgatgtgca ctttctgaag
     1321 tcttaccacg ggagccagca ccaacagcag tgcagtgacg agagcccaag ggccccctca
     1381 tcaccaaggg aactgcttca tataactcct ggtggcggtc tgcaagagcc tcctgaacca
     1441 tctcaggatg acaaccctac tcaggtgagg tggcctggtt ctgctcacca gaagctagat
     1501 gacagagggc ggagccacta ttttcctggg tccctcaggc agcctgtaca ggggagtgcc
     1561 caggttgtga taccccgagg tgactattgg cattcagata caactcctgt ggaccttgaa
     1621 tatcctctct tacgcccagt aggacagagg acctacctac agcagcatga ggagactccg
     1681 gcctctcatg aaaaagaggg gtatcaccag ctaaatgcag ggattgaagg ctgctgctct
     1741 ggaatccaag agcctcctag agccagccgc actgtgagaa ctggtctgca gtgtcctagc
     1801 aatgacttca aattagtgga tggagagagt gggagaattt ctcgtcagag gacacccatg
     1861 ctgcattctc tgacccaaga tggtacatgg agacccggga acagcaagga ttgtggaaat
     1921 gataagccac cactgtttga tgcccaggtg ggtaaaccca cacggaggag tgaccgtttt
     1981 gccacaacac tgaggaatga gatccaaatg cgtagagcaa agctgcagaa gagcaaaagt
     2041 acagtgacac tagctggaga cagtgaagct gaagattgtg ctggagactg gagagctgat
     2101 gtgggggctg tcccagaagg ttccttcccc agcacctata aagagcacct gaaggaggcc
     2161 cagacacgtg ttctgaaggc cacctctttc caacgccgag atttagatcc caccccagca
     2221 gatcagtatt caggaccatc agaacacagg acttttgacc acagtgcctc atcttcttta
     2281 tcttctttcc ctggggagcc agactctgcc ccacgcttct gtgagacagg tctggccaag
     2341 gcaccctctt ctggagttgg tgtaccccac gttcttcgaa ttggaggccg gaaacggttc
     2401 acagcagagc agaaactaaa gtcctattct gagccagaga aaataaatga agtggggctc
     2461 tcaggggacc accgtcctca tcctactgtc aggacacctg aggatacagt gggtacattt
     2521 gctgacaggt ggaagttttt tgaggaaaca agcaaatctc ttctccagaa ggcaggccat
     2581 aggcaagttc actgtgggct ccctagagag aaggctgaga ggccacagac agggcaccat
     2641 gaatgtgaga gtacagagcc ctggttccag aagaggtcac tggccacctc ctgcggagag
     2701 atcctcagtg atagaaaagt agaaaaggcc tcagagaaat tgaacccacc cagaaggctt
     2761 ggaaccttcg cagaatatca agcatcttgg aaggaacaga agaaacctct ggaagccagg
     2821 agttctggac gataccattc agcagatgat attctggatg ctggtctaga tcagcagcag
     2881 aggccacagt acattcatga gcggtctcgt tcatcaccgt ccacagatca ctactcacag
     2941 gaagtgcctg ttgaaccaaa caggcaggca gaggactctg gtgaccacaa agaagcaatt
     3001 ctctgtacac tacaagctga ggagggatgc tctgctccaa gtgcccagcc gcaagacagc
     3061 cagcatgtga atgaagacac aactttccct caaccagaaa cccagctctc ttccaagtgt
     3121 caacacctac agacgtcagc catggaaact tctcgctccc cttcgcctca gtttgcccca
     3181 cagaagctga cagataaacc tcccctgctt atccatgaag acaactcagc aagaatcgag
     3241 cgggtgatgg acaacaacac cactgtgaag atggtgccca taaaaattgt gcactcagaa
     3301 agccagcccg agaaggagag tcgtcagagt ctcgcgtgcc cagctgagct gcccccactg
     3361 cccagtgggc tggagaggga ccagatcaag acactgagta catcagagca atgctactcc
     3421 cgcttctgtg tgtacacacg acaggaggtg gaagctcctc atagagcccg ccctccagag
     3481 ccccggccac ccagcacgcc tgcacctcct gtcagagata gctgttcctc ccctccctca
     3541 ctcaactatg ggaaggccaa ggagaaaacc atggatgact tgaagtctga agaattagcc
     3601 agggagattg tgggaaagga caagtctttg gctgacatcc tggaccccag tgtgaagatc
     3661 aaaactacca tggatctgat ggagggaatt tttcccaaag atgagtacct cctagaggaa
     3721 gctcagcagc ggagaaagct gctccccaaa gtccccttac ccagagtcac agaggacaag
     3781 aaacaggacc caggtatgcc aggggttgtg tccttggcca ccaattctac ctattacagc
     3841 acatcagccc ccaaagcaga gcttcttatc aagatgaagg acctgcagga gcctgaagag
     3901 tattcagcag gtgacttgga tcatgacctt tctgttaaga agcaagagct cattgacagt
     3961 atcagccgca agctgcaggt gctccgggaa gcacgtgaga gcctgctgga agacatccaa
     4021 gccaacaatg ctcttgggga tgaggtggaa gccattgtga aagatgtctg caagcccaat
     4081 gagtttgaca agttccggat gttcattgga gacctggaca aagtggtgaa cctcctgctg
     4141 tcactgtcag gacgcctggc ccgtgtggaa aatgccctta ataatttaga tgacaatcct
     4201 tctcctggag atcggcagtc actgttggag aaacagagag tcctaactca gcagcacgag
     4261 gatgccaagg agcttaaaga gaacctggac cgccgtgagc gcattgtgtt cgacatcctg
     4321 gctacctacc tcagcgagga gaacctggct gactatgagc acttcgtgaa gatgaagtca
     4381 gctctcatca ttgagcagcg agagctggaa gataaaatcc acctgggtga agagcagctc
     4441 aagtgtttgt ttgacagcct acagcctgag agaagcaaat gagaggcaca ttcctacaga
     4501 aggtggacac caagccctgg agattaatgc ctgagactat aagagtgaac ccaagcctat
     4561 ttgcccatct ctggagagac atactctgga gccacgaggc tagtaaaaaa gcaataatgt
     4621 cctgctagta tgtgatgatt tatttatgat tttcatttct gttggtttgc tgaacatagt
     4681 ttcatatcac atgtgatttc acagaatgcc aggctttgct aaacaacaag ggttctctag
     4741 ccctcctttg cagcagtggc accaatgttc ctccctcgtg tagatgccaa atacagtcct
     4801 acagtgcatg agaggaaaga cccttgtgat ttagccagac acgggctgct gtgtgttctg
     4861 tccttgttca tttaacaatg tgagcattcc tcattctgtc atggtgacat tctctgactc
     4921 agtaaaaatc agtgatgata tttattcatg tgtggaaaac atgaacagtt tcctagtagt
     4981 taaagactaa ctataaaatg aacaatctac atattggatc cattcattcc aagattaaaa
     5041 ttatcacata acttgtgtgc atgttttgaa ataccctaaa cagatatcta gtatccttct
     5101 tgtcacatct taaatacttt ctagccaagt gattttaatt ggataaaagt gtgtctacta
     5161 ataatgttat tgcttgcttt ttatttcctg agaccaatgg aatattttga agtttccttc
     5221 cctggaacac taatttgtgt atatgatctt taatgataat cagtggttta tctcttttta
     5281 tgtctgttac catgggccac atgccacatg ccacatacct taagacttaa gactccatct
     5341 agtggtcaga ggtcctgtgg agtgactagt gcttacattt gaaacagagt tttgtcctta
     5401 acagttcaaa tggcaagatg acaaatagag tgttattcat gaaagctaca ctgtcattct
     5461 gttggtttcc agttgacagg acagattggg aaaagacatt tttaaatcat gtgtctgact
     5521 tgttgctcat tttgtttttg ttattatttg tttgttttag aagagtctaa cccagattgg
     5581 cttcaaactc cctatgtagt ccaatgacct tgaactcctg atcctcctgc ctccacatcc
     5641 tgagttctgg gtttagcagc atatcccact tcatgacttc atacatctat ctgataaagg
     5701 atttgtataa agaacttcca acatccaata gtaggaattg tttgaaaaaa aaaaagtggg
     5761 caaaagactt gactagaccc ttcaccaaag aggatatatg tatggcagat aaacacatgg
     5821 gaaatgttca gctaccaatg gcgtgtataa cttgcttatg ttaaatgtgt gtagatttgg
     5881 tgttgttcaa aaggtgtttc tgtaactaag tgcatggtaa gtgatgagca agtctcttgg
     5941 tgacttggta tttaggcatc actagtcttt gttctaccaa gggattattt aattcgtatg
     6001 ttcccctgag actgcagcat atacgaagat ttccctctct tagcagtagc cacacctttt
     6061 ccaaaataca catgcacatt tacatccatg tgtatgtgca cgtgttcaca ctcccacaca
     6121 cagttgtctt aaaggaccag aatccatgct tcttgagcca gaggaacaga cgttgacagc
     6181 agaagctctg gtgaagatga tacagtgtcc tccatacagc tgagtcaaga ttggcgagat
     6241 tttatatgca gaccatggat gacatggttg acatcctatc actgtcagtc agaagaaaat
     6301 ctttgcaaaa gtgttgattc ctgttaaatg aaactattct accttttgaa gttcctgatc
     6361 tgccactgca gcctctttct ccttccactt ggtcatcctt tgctgtgaat gtgggtcatg
     6421 tcagaaaaca cgatattggc tctccacaaa ctatccaagg tgttgcagac tattttgttt
     6481 ttaatttaca ccaagctatt tacctgtggt tctttaatcc caaatacagt gttgtgaaca
     6541 ttttaatgat atgtgtgtaa catgtgagta atggaatttt gtttgtctgt aacctgcttt
     6601 ttcatgttgc ttcaagcttg tctgttatgg gaaacaatat gtagtgctct agcatgcttg
     6661 taatgaaaca cataacaatt atgaccttct tatccatccc ctgcttgcct gttccatgtc
     6721 tgattagcag ggacccaaga attccagaga gtccatgtac atatgtctat gacttgtgat
     6781 attactgcat aagaaacaat ctggtgctaa tggttggtcc ttggcatgca taggcatggg
     6841 catgggcaca gctatggaac tctctgtaaa tatactgacc ttgcttgtgg tcagcttttg
     6901 tggctttacc ctgaactctg ccctggcaaa tatgcacatt catgcttgat gcttaccact
     6961 tatcaacaga tcctcttgct tgactttaac aaaataaata gtgtctcttc agatgaaagt
     7021 agaatgtctt tatttcctac tgtatagctt tgtaaaaaga ataaaaatac cagtgctggg
     7081 catgtagccc atggggaagg gtttgaacat ggtgttctga cttcaaatag tagcatttct
     7141 cctccagaaa atagcctaag ccaggcactg tggggaacac ctgcaatcct ggtccttaga
     7201 gtggtgcaca gctggaccca cagcacagtt tttccttcta tatacgggtg ccaaacacat
     7261 ccttaaaggg gcatagtaga taaaattctt gtgatttagc ttgattcagg ctgctatgta
     7321 ttttgtcctt tctaagtcaa cagtgtgact tcttatcaca catgtcataa ttgtgtgacc
     7381 caacaaaaat cagtggtaat aatgtttaga aatataaatg gtttccttgt agttaaaaac
     7441 aaactaaaat aaacagcata catgttgagt gtactcaatc aaaaattaaa atcttaaatg
     7501 c
//
