LOCUS       NM_001077707            6966 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus SNF2 histone linker PHD RING helicase (Shprh),
            transcript variant 1, mRNA.
ACCESSION   NM_001077707
VERSION     NM_001077707.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6966)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6966)
  AUTHORS   Qu,Y., Gharbi,N., Yuan,X., Olsen,J.R., Blicher,P., Dalhus,B.,
            Brokstad,K.A., Lin,B., Oyan,A.M., Zhang,W., Kalland,K.H. and Ke,X.
  TITLE     Axitinib blocks Wnt/beta-catenin signaling and directs asymmetric
            cell division in cancer
  JOURNAL   Proc Natl Acad Sci U S A 113 (33), 9339-9344 (2016)
   PUBMED   27482107
REFERENCE   3  (bases 1 to 6966)
  AUTHORS   Zeman,M.K., Lin,J.R., Freire,R. and Cimprich,K.A.
  TITLE     DNA damage-specific deubiquitination regulates Rad18 functions to
            suppress mutagenesis
  JOURNAL   J Cell Biol 206 (2), 183-197 (2014)
   PUBMED   25023518
REFERENCE   4  (bases 1 to 6966)
  AUTHORS   Krijger,P.H., Lee,K.Y., Wit,N., van den Berk,P.C., Wu,X.,
            Roest,H.P., Maas,A., Ding,H., Hoeijmakers,J.H., Myung,K. and
            Jacobs,H.
  TITLE     HLTF and SHPRH are not essential for PCNA polyubiquitination,
            survival and somatic hypermutation: existence of an alternative E3
            ligase
  JOURNAL   DNA Repair (Amst) 10 (4), 438-444 (2011)
   PUBMED   21269891
REFERENCE   5  (bases 1 to 6966)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   6  (bases 1 to 6966)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   7  (bases 1 to 6966)
  AUTHORS   Sood,R., Makalowska,I., Galdzicki,M., Hu,P., Eddings,E.,
            Robbins,C.M., Moses,T., Namkoong,J., Chen,S. and Trent,J.M.
  TITLE     Cloning and characterization of a novel gene, SHPRH, encoding a
            conserved putative protein with SNF2/helicase and PHD-finger
            domains from the 6q24 region
  JOURNAL   Genomics 82 (2), 153-161 (2003)
   PUBMED   12837266
REFERENCE   8  (bases 1 to 6966)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB650602.1, BC055003.1, AK082160.1 and BP757728.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055003.1, SRR10223971.10111.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BB650602.1         1-29
            30-1694             BC055003.1         1-1665
            1695-1695           AK082160.1         1699-1699
            1696-6945           BC055003.1         1667-6916
            6946-6966           BP757728.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..6966
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 3.66 cM"
     gene            1..6966
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /note="SNF2 histone linker PHD RING helicase"
                     /db_xref="GeneID:268281"
                     /db_xref="MGI:MGI:1917581"
     exon            1..157
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     exon            158..813
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..5220
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /EC_number="2.3.2.27"
                     /note="isoform a is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase SHPRH; SNF2, histone-linker, PHD
                     and RING finger domain-containing helicase; RING-type E3
                     ubiquitin transferase SHPRH"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase SHPRH isoform a"
                     /protein_id="NP_001071175.1"
                     /db_xref="CCDS:CCDS35838.1"
                     /db_xref="GeneID:268281"
                     /db_xref="MGI:MGI:1917581"
                     /translation="MSSRRKRAPPMKVDEERQQQLHWNMHEDLRSEPLTMTVGEQACS
                     DADSSSDCIIIDEGPPESALHRDKKRRSETVSVLEATEEETRLSVTLNVTVSPYRVDN
                     SWKAFLGDFALQLLPKESLVEHFSERTFTLSPSESSSQFLIYVHSECKNVEKQENVLE
                     GSAGVCSKGIRVESSFSSDMLQDLAWLQKRRGIKLYQRPDGTHTIKVGIYILEAGLTR
                     LDFMSDAGSRMKKFNQLMKRVMEKLHNFIIPDVLEEEEEGSESEPEGQDIDELYHFVK
                     QTHQQETRSVQVDVQHPALIPVLRPYQREAVNWMLQQEQFRSAPPADNSLHFLWREIV
                     TPDGLKLYYNPYTGCIIRDFPHAGPQLLGGILADEMGLGKTVEVLALILTHTRQDVKQ
                     DALTLPEGKVVNYFIPTHCPREKVKNREIQDTEYEPKEKVHCPPTRVMILTAVKEMNG
                     KKGVSILSIYKYVSSIFRYDVQRNRGLLKRMLKCLIFEGLVKQIKGHGFSGTFTLGKN
                     YKEDVFDKTKKQAVGSPRKIEKELRKSVNKDADSEYLPSNTSDDDEPYYYYCKAGKSR
                     SKLKKPALLTKKGKGQSVHLDSQGDAPAAGVCASTDVHVSENTCVSEDKQTQEAKDCA
                     ESPNPAAEELAQSNTSSPCETSDYRFECICGEFDQIGHKPRVQCLKCHLWQHAKCVNY
                     EEKNLKVKPFYCPHCLVAMEPVSTRATLIISPSSICHQWVDEINRHVRSSSLRVLVYQ
                     GVKKHGFLQPHFLAEQDIVIITYDVLRSELNYVNIPHSNSEDGRRLRNQKRYMAIPSP
                     LVAVEWWRICLDEAQMVECPTVKAAEMAQRLSGINRWCISGTPVQRGLEDLFGLVVFL
                     GIEPYCVKHWWIRLLYHPYCKKNPQHLYSFIAKIMWRSAKKDVIDQIQIPPQTEEMHW
                     LHFSPVERHFYHRQHEVCCQDAIVKLRKISDWALKLSSLDRRTVSSILYPLLRLRQAC
                     CHPQAVRGEFLPLQKSTMTMEELLTSLQKKCGTECEEAHRQLVCALNGLAGIHIIKGE
                     YALAAELYREVLRSSEEHKGKLKTDSLQRLHATHNLMELLGAKHPGIPPTLRDGRLEE
                     EAKQLREHYMSKCNTEVAEAQQALQPVQQSIRELQRKIHSNSPWWLNVIHRAMEFSVD
                     EELVQRVRNEISSNYKQQTDKLSMSEKFRDCRGLQFLLTTQMEELHKFQKLVREAVKK
                     LEKPPSREVIESATVCHLRPARLPLNCCVFCKADELFTEYESKLFFNTVKGQTAIFEE
                     MIEDEEGLVDDRVPTTTRGLWAVSETERSMKAILSFARSHRFDVEYVDEGSVSMDLFE
                     AWKKEYKLLHEYWMTLRNRVSAVDELAMATERLRVRHPKEPKPNPPVHHIIEPHEVEQ
                     NRIKLVNDKAVATSQLQKKLGQLLYLTNLEKSQDKTSGGINPEPCPICARQLGKQWAV
                     LTCGHCFCNECTSIIIEQYSVGSHRSSIKCAICRQTTSHKEVSYVFTSEKANQEDDIP
                     VKGSHSTKVEAVVRTLMKIQLRDPGAKALVFSTWQDVLDIISKALTDNNMEFTQISRI
                     KTFQENLSAFKYDPHINILLLPLHTGSNGLTIIEATHVLLVEPILNPAHELQAIGRVH
                     RIGQTKPTIVHRFLIKATIEERMQAMLKTAERSHTSSSGKHSEASVLTVAGLADLFTK
                     ENEELE"
     exon            814..943
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1162
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1241
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1392
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1501
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1755
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..2406
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2658
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..2737
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..2901
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..3158
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     exon            3159..3280
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     exon            3281..3369
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     exon            3370..3462
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     exon            3463..3570
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     exon            3571..3713
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     exon            3714..3887
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     exon            3888..3950
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     exon            3951..4176
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     exon            4177..4320
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     exon            4321..4422
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     exon            4423..4494
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     exon            4495..4683
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     exon            4684..4776
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     exon            4777..4863
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     exon            4864..5042
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     exon            5043..5123
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     exon            5124..6950
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6925..6930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /note="hexamer: AATAAA"
     polyA_site      6950
                     /gene="Shprh"
                     /gene_synonym="2610103K11Rik; D230017O13Rik; E130018M05"
                     /note="major polyA site"
ORIGIN      
        1 agctggcgct ggcggcttcc ggcctgggtg ccaggcttca cccagcgtgc agcgcgcatg
       61 cgcaactccc gcaggtgagt gtggcgactg tgggcccggg atctgcagcc tgcgaggagg
      121 gccgggcccg gcgacaggtg cctgcagagc ggctgagaat tcacatttac ttatcaagaa
      181 agtggaagcg tgaaaatgag cagccgaagg aaacgtgctc ccccgatgaa ggtcgatgaa
      241 gaaaggcaac agcagcttca ctggaacatg catgaggacc tgaggagtga gccgctcacc
      301 atgacggtcg gggaacaggc ctgttcagat gcagactctt cttctgattg catcatcatc
      361 gatgaaggcc ctcctgagag tgcacttcac agagataaga agaggcgttc agagactgtg
      421 agcgtcttag aggccaccga ggaagagacc cgtttgtctg tgactttgaa tgttacagtt
      481 tctccctatc gtgtggataa ttcttggaaa gcatttctgg gagattttgc tcttcagctt
      541 ctccccaaag agagtttagt tgaacatttt tctgaaagga cttttacatt gagtccttca
      601 gagtcaagca gtcagttcct gatctatgtt cattcagaat gtaaaaatgt agagaaacaa
      661 gaaaatgttc ttgaaggatc agccggtgtt tgtagcaagg gaatccgagt ggaatcctcc
      721 ttcagtagtg acatgttaca ggatttggcc tggctacaga agagaagagg aataaaactc
      781 taccagagac cagacggcac tcacacaatc aaggttggaa tttacatttt ggaagctggc
      841 ctaacaagac tagacttcat gagtgatgca ggttccagaa tgaaaaagtt caatcagctc
      901 atgaagagag tgatggaaaa gttacataat ttcattattc cagatgtgct ggaagaagag
      961 gaggagggtt cagagagcga gcccgagggt caggatattg atgagctcta tcactttgtg
     1021 aagcaaacac accagcaaga aacacggtca gtccaagtgg acgtccagca ccctgcgttg
     1081 attccggtcc tgagacctta ccagagagag gcagtcaact ggatgctgca gcaagagcag
     1141 ttcagaagcg ctcctcctgc tgataactcc ctgcacttct tatggcgaga aattgttaca
     1201 cctgatggct tgaaactcta ctataatcca tatacaggct gcatcattcg agatttccca
     1261 catgcgggtc cacagttgct tggtggaatc ttagcagatg agatgggtct tggaaagaca
     1321 gtggaggttc tggctctgat tctgacacat acccgacaag acgtcaagca ggacgctctc
     1381 acccttcctg agggaaaagt ggtaaattat ttcatcccaa ctcactgtcc tagagaaaaa
     1441 gtgaaaaata gagaaatcca ggatacagaa tatgaaccaa aagagaaagt tcactgccct
     1501 cctacacgtg tgatgatcct gacagctgtg aaagaaatga atgggaagaa aggagtttct
     1561 attctttcta tctataagta tgtcagctcc atattcagat atgatgttca gcggaaccgg
     1621 ggtcttctga agcggatgtt gaaatgttta atctttgaag gtcttgtgaa acagatcaaa
     1681 ggccatggtt tctctgggac ttttacactg gggaagaatt acaaagaaga tgtatttgat
     1741 aaaacaaaaa agcaggcagt agggagtcca aggaaaattg agaaggaatt gaggaaatca
     1801 gtgaacaagg atgcagattc tgagtacctg ccatcaaaca cttctgatga cgatgagcct
     1861 tactattatt actgtaaggc gggaaaaagc cggagtaagt tgaagaagcc tgctttacta
     1921 actaaaaagg gaaagggtca gtctgttcat ctggattccc aaggtgatgc tccagctgct
     1981 ggagtctgtg caagtactga tgttcatgtg tcagaaaata catgtgtctc tgaagacaag
     2041 caaacccaag aagcaaaaga ctgtgctgag tcgccaaacc ctgctgccga ggagttggca
     2101 cagtctaaca cttcaagtcc ttgtgaaacc tctgattacc gctttgagtg tatatgtggt
     2161 gaatttgatc aaattggcca caagccaaga gttcaatgtc tgaagtgtca cctgtggcag
     2221 catgcaaagt gtgtgaatta tgaggagaaa aacctgaagg ttaagccttt ttactgcccc
     2281 cactgtcttg ttgcgatgga gccagtatca acaagagcaa ctctgatcat ctctccgagc
     2341 tccatttgcc accagtgggt ggatgaaatc aatcggcacg tgaggtcatc atctctccga
     2401 gttctggtat atcaaggagt gaagaaacac ggcttcttac agcctcattt tttggcagaa
     2461 caagatatag ttatcattac ctatgatgtt cttcgttcag aactaaacta tgtcaatatc
     2521 ccacatagca atagtgaaga tgggcgtcgc ctgaggaacc agaagcgcta tatggccatt
     2581 cccagcccct tggtagcggt ggaatggtgg aggatctgcc ttgatgaagc tcagatggtc
     2641 gagtgtccta cagtaaaagc cgcggaaatg gcccagcgtt tgagcgggat taatcggtgg
     2701 tgcatcagtg gcactccagt tcagagagga ttggaagatc tttttgggct ggtggtcttt
     2761 cttggaattg aaccttattg tgtcaaacac tggtggattc ggcttctcta tcatccatac
     2821 tgcaagaaaa atcctcagca cctgtacagt tttattgcca agataatgtg gaggtctgca
     2881 aagaaagatg tcattgacca aatccagatt ccacctcaga ctgaagaaat gcactggctc
     2941 catttttccc cggtggagag gcatttctat caccgccagc acgaggtgtg ctgccaggat
     3001 gccatagtga agctcaggaa gatctctgac tgggccctga agctcagcag cttggacagg
     3061 agaactgtct cctccatcct ctacccactg ctgaggctcc ggcaggcctg ctgccatcca
     3121 caggctgttc gtggggaatt cttgccactc cagaagagca ccatgacaat ggaagagttg
     3181 ctgacatctc tgcagaagaa atgtggaacg gaatgtgaag aggcccaccg acaactagtt
     3241 tgtgccctta acggcttagc aggcattcac atcattaaag gtgaatatgc cttggcagcg
     3301 gagctctaca gagaagtatt acgttcatct gaggagcaca aaggaaaact caaaactgat
     3361 tcccttcaaa gactgcatgc cacacataac ttaatggagc tgttgggagc caaacaccca
     3421 ggaatacctc ccaccttgag agatggcaga cttgaagaag aggccaagca gctgcgagag
     3481 cactatatga gtaagtgtaa cacagaagtt gccgaagccc agcaagcttt gcagcctgtg
     3541 cagcagtcca ttagggagct ccaaaggaag attcattcta attctccttg gtggctgaat
     3601 gtaatccata gagcaatgga attttctgtt gatgaggaac ttgttcagcg ggtgcgaaat
     3661 gaaataagca gtaactacaa gcaacaaact gacaagctgt ctatgtcaga gaagttccgt
     3721 gactgcagag gtcttcagtt cttacttaca acacaaatgg aagagctcca taagttccag
     3781 aagctggtga gggaggctgt gaagaagctg gagaagcctc catcccggga ggtgattgag
     3841 tctgcaacag tttgccacct gcggccagct agactccctc tcaactgctg cgtcttttgt
     3901 aaagctgatg aattgttcac agagtatgaa tcaaagctat tttttaacac agtcaaaggc
     3961 cagactgcaa tctttgaaga aatgatagaa gatgaagaag gacttgtaga tgatagagta
     4021 cctaccacta ccagaggtct gtgggccgta agtgagacgg agcgatctat gaaagcaata
     4081 ttatcatttg caagatcaca taggtttgat gttgaatatg tagatgaagg aagtgtttca
     4141 atggatctct ttgaggcatg gaagaaggaa tataagttac ttcatgaata ctggatgact
     4201 ctgagaaatc gtgtatctgc tgttgatgaa cttgcaatgg ctacagagcg actaagagtg
     4261 cgccatccca aagagccaaa gccaaaccca cccgtccatc acatcattga accacacgag
     4321 gttgaacaga atcgtataaa actggtgaat gataaagctg ttgctacatc acagcttcag
     4381 aagaaacttg gacagcttct ttacctaacg aatttggaga agtctcaaga taaaacatca
     4441 ggaggtatta atccagagcc ttgtccaatc tgtgctcgac agctgggaaa acagtgggca
     4501 gtgctgacct gcggacactg cttctgtaat gaatgcactt cgattataat tgaacagtac
     4561 agtgtggggt ctcatcgaag ttccatcaag tgtgctatct gccgccagac cacatcacac
     4621 aaagaagtct cctatgtctt cacctcagag aaggcaaacc aagaggatga tatccctgtg
     4681 aagggtagcc attctacaaa agtggaagct gtggtcagaa ctctgatgaa aatacaactt
     4741 agagatccag gggccaaagc gctcgttttc tcaacgtggc aagatgtatt agatattatt
     4801 tcaaaagctc tcacggacaa caacatggaa tttacacaaa tcagtcgcat taagacattc
     4861 caggagaacc tctcagcgtt taaatacgat ccccacatca atattctgct gctgcccctg
     4921 cacacaggct ctaatggatt aactatcatt gaagccaccc atgtcctcct ggtggagccc
     4981 atactgaacc ctgcccatga gctgcaggcc attgggagag tgcaccgaat tggacagacc
     5041 aaacctacta ttgtacatag attcttaatt aaagcaacaa tagaagaacg gatgcaggca
     5101 atgctaaaaa ctgctgagag gagccacaca agctcatccg gaaagcattc tgaagcctct
     5161 gtgttgactg tggctggcct ggctgacctg tttaccaagg agaacgagga gcttgaatga
     5221 agccgtcaca tcattccaca caatgttaag atagaacttc acttccagag atgtcaagag
     5281 agttacaaat taaaaacaaa aaatcagtaa atattagtaa atactatttt aagttgaatg
     5341 aatttatttt gttatactct agcctagtaa taattggcaa ttggttcctt ttcactatac
     5401 cgatttcaca ccatttacaa tgaattttaa ctttacactc ctaatagaac attaattttt
     5461 ttgttccact tgtatatcta ttactaataa ggcaggggaa ttaagaaaag gggtattaaa
     5521 taatttttcc attagtagat agatgtttgt tataacagga gagaatatat aagaaggtta
     5581 cttagtctag ttttgtatga cctgatgtgt acagccagtg taaataacat ttttgaaagg
     5641 gccttcagca tctttagcat aggattcacc attatattct cagtaatgtt ttaagaaaat
     5701 gctaaactat ataataagta gttatttgca tgagtttaaa ctgtaacact gtcattagct
     5761 cctaataata aatcactagg tggttatatt gtgttttgtt actaaatgtt aaaatactga
     5821 aaaattcatt tttctattat gtttaagtgg tatcattgtt aatattttta agtggattaa
     5881 catttaccta caatgatctc tttaaccttt ttagtaagtt ttttttgtgt atgtgtttta
     5941 agatgatgta tctgtaaata tggcttttta aaaatcatca ttgtactgaa ttcatttctt
     6001 gtgttcctgt aactagtcat tttagccact agttatctaa acctacaata gagtttattc
     6061 atttcagtta ctctgttctt agaaactaac tagtgtttga tctactacaa gagaacgctg
     6121 tgttcacaca tgcataaact gtaagtggtt aaactctctc ttctgtgaag aattcatgga
     6181 tgactttgaa attacaaaat aagaagtagc ttgttgtatc ctagccttgt gttggaatat
     6241 aaatgttctt gtttccttcc ctttagctgt tgaaatcaag ggaccctcaa ggttcattag
     6301 ctcctaccta actgtccata aaactgtact agaagtagtt cctgggtctc ctttatcccg
     6361 tgagctctgg tgcttaagct aaggtgcatt ttcttatcca ggtttatagg tgacaggtca
     6421 gctgaagaag acacgttttt tgggtgctta ttctttagtt gaagggagat atacattgat
     6481 tcttttatat gaaattaaac ataatatttt tacagctctt ttacattcac taagagcttt
     6541 tctgtgtatt catgtggtta atattcacaa cagtcctgtg aaatggatat gattaatgat
     6601 attcctattt tgaaggtaaa gatctaatgc tcaggaggaa actcgcctat gatatgtagc
     6661 aaacagacag agcagtccag gccccctggc ttcatgtcta ctgttcttcc accgagttgt
     6721 gtgccatgct ggggttcaga agccttgtgg gtatgactta gaatgggatt gtgtaagtac
     6781 ttatttttgt ttcctaatat ttcatgtgct atgttctagg aaaaacaatt tgatatgctt
     6841 caattagaaa ataacataga tatctatact gatcagtatt agaggaaaac tattcttatt
     6901 tatttcagta agatacctca attaaataaa tattttagtg gaaaatgaaa aaaaaaaaaa
     6961 aaaaaa
//
