LOCUS       NM_029031               2781 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus sedoheptulokinase (Shpk), mRNA.
ACCESSION   NM_029031
VERSION     NM_029031.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2781)
  AUTHORS   Gallerand,A., Dolfi,B., Stunault,M.I., Caillot,Z., Castiglione,A.,
            Strazzulla,A., Chen,C., Heo,G.S., Luehmann,H., Batoul,F.,
            Vaillant,N., Dumont,A., Pilot,T., Merlin,J., Zair,F.N.,
            Gilleron,J., Bertola,A., Carmeliet,P., Williams,J.W.,
            Arguello,R.J., Masson,D., Dombrowicz,D., Yvan-Charvet,L., Doyen,D.,
            Haschemi,A., Liu,Y., Guinamard,R.R. and Ivanov,S.
  TITLE     Glucose metabolism controls monocyte homeostasis and migration but
            has no impact on atherosclerosis development in mice
  JOURNAL   Nat Commun 15 (1), 9027 (2024)
   PUBMED   39424804
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2781)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2781)
  AUTHORS   Goodman,S., Khan,M., Sharma,J., Li,Z., Cano,J., Castellanos,C.,
            Estrada,M.V., Gertsman,I. and Cherqui,S.
  TITLE     Deficiency of the sedoheptulose kinase (Shpk) does not alter the
            ability of hematopoietic stem cells to rescue cystinosis in the
            mouse model
  JOURNAL   Mol Genet Metab 134 (4), 309-316 (2021)
   PUBMED   34823997
REFERENCE   4  (bases 1 to 2781)
  AUTHORS   Haschemi,A., Kosma,P., Gille,L., Evans,C.R., Burant,C.F.,
            Starkl,P., Knapp,B., Haas,R., Schmid,J.A., Jandl,C., Amir,S.,
            Lubec,G., Park,J., Esterbauer,H., Bilban,M., Brizuela,L.,
            Pospisilik,J.A., Otterbein,L.E. and Wagner,O.
  TITLE     The sedoheptulose kinase CARKL directs macrophage polarization
            through control of glucose metabolism
  JOURNAL   Cell Metab 15 (6), 813-826 (2012)
   PUBMED   22682222
REFERENCE   5  (bases 1 to 2781)
  AUTHORS   Gauci,S., Helbig,A.O., Slijper,M., Krijgsveld,J., Heck,A.J. and
            Mohammed,S.
  TITLE     Lys-N and trypsin cover complementary parts of the phosphoproteome
            in a refined SCX-based approach
  JOURNAL   Anal Chem 81 (11), 4493-4501 (2009)
   PUBMED   19413330
REFERENCE   6  (bases 1 to 2781)
  AUTHORS   Kardon,T., Stroobant,V., Veiga-da-Cunha,M. and Schaftingen,E.V.
  TITLE     Characterization of mammalian sedoheptulokinase and mechanism of
            formation of erythritol in sedoheptulokinase deficiency
  JOURNAL   FEBS Lett 582 (23-24), 3330-3334 (2008)
   PUBMED   18775706
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC054721.1 and AL663116.7.
            
            On Jan 30, 2007 this sequence version replaced NM_029031.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054721.1, AK015273.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1989              BC054721.1         1-1989
            1990-1991           AL663116.7         25539-25540
            1992-2781           BC054721.1         1990-2779
FEATURES             Location/Qualifiers
     source          1..2781
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.25 cM"
     gene            1..2781
                     /gene="Shpk"
                     /gene_synonym="4930431K22Rik; Carkl"
                     /note="sedoheptulokinase"
                     /db_xref="GeneID:74637"
                     /db_xref="MGI:MGI:1921887"
     exon            1..199
                     /gene="Shpk"
                     /gene_synonym="4930431K22Rik; Carkl"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1468
                     /gene="Shpk"
                     /gene_synonym="4930431K22Rik; Carkl"
                     /EC_number="2.7.1.14"
                     /note="SHK; carbohydrate kinase-like protein"
                     /codon_start=1
                     /product="sedoheptulokinase"
                     /protein_id="NP_083307.1"
                     /db_xref="CCDS:CCDS25002.1"
                     /db_xref="GeneID:74637"
                     /db_xref="MGI:MGI:1921887"
                     /translation="MASRPVTLGIDLGTTSVKAALLEAAPSLPSGFVVLASCARAARA
                     ETESAVAGPQGREQDVTRIIQALNECLDALPRQQLQRVRGIGVSGQMHGILFWKAGQG
                     CEWMEGGPAFVFEPRAVSHLVTWQDGRCNSSFLASLPKPDSHLSVATGFGCATIFWLL
                     KNSPEFLKSYDAAGTIQDYVVAMLCGLPRPLMSDQNAASWGYFNTQSQSWNLDTLEKA
                     GFPIHLLPDIAEPGSMAGRTSHTWFEIPKGTQVGIALGDLQASVYSCMGQRTDAVLNI
                     STSVQLAASMPVGFQPLQTPDPAAPVAFFPYFDRTYLGVAASLNGGNVLATFVHMLVQ
                     WMADLGLEVEESTVYSRMIQAAAQQKDTHLTITPTVLGERHLPDQLASVTRISSSDLS
                     LGHVTRALCRGIVQNLHSMLPFQQLKEWGVARVVGSGSALSRNEVLKQEVQRAFPFPV
                     CFGQDVDAAFGAALVMLQRDLSQKEP"
     exon            200..341
                     /gene="Shpk"
                     /gene_synonym="4930431K22Rik; Carkl"
                     /inference="alignment:Splign:2.1.0"
     exon            342..525
                     /gene="Shpk"
                     /gene_synonym="4930431K22Rik; Carkl"
                     /inference="alignment:Splign:2.1.0"
     exon            526..678
                     /gene="Shpk"
                     /gene_synonym="4930431K22Rik; Carkl"
                     /inference="alignment:Splign:2.1.0"
     exon            679..854
                     /gene="Shpk"
                     /gene_synonym="4930431K22Rik; Carkl"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1055
                     /gene="Shpk"
                     /gene_synonym="4930431K22Rik; Carkl"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..2781
                     /gene="Shpk"
                     /gene_synonym="4930431K22Rik; Carkl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2760..2765
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shpk"
                     /gene_synonym="4930431K22Rik; Carkl"
                     /note="hexamer: AATAAA"
     polyA_site      2781
                     /gene="Shpk"
                     /gene_synonym="4930431K22Rik; Carkl"
                     /note="major polyA site"
ORIGIN      
        1 gcggttcaag ccaccgagct gtgctgtcac cactgccatg gcttcgcgac ctgtcactct
       61 cggtatcgac ttgggcacca cgtccgtgaa ggccgcccta ttggaggctg cacccagcct
      121 cccatccggg ttcgtggtgc tggcgagctg cgcccgggct gcgagggcag agactgagag
      181 cgcggtggcc gggccccagg ggcgggagca ggatgtgact agaatcatcc aagccctaaa
      241 tgaatgcctt gatgcccttc cccggcagca gctccagaga gtccggggca tcggagtgtc
      301 gggacagatg catggcatcc tattttggaa agcaggccaa ggctgtgaat ggatggaggg
      361 agggcctgcc tttgtatttg agcccagagc tgtgagccac ttggtcacat ggcaggatgg
      421 ccgttgtaac agtagtttcc tggcttctct gcccaagcca gattcccatc tcagtgtggc
      481 cacaggattc ggctgtgcaa ccatcttctg gcttttgaaa aacagcccgg agtttctgaa
      541 gtcctatgat gcagctggca ccattcaaga ttatgtggtt gccatgctgt gtggcttgcc
      601 aagacccctg atgtctgacc agaatgccgc tagctggggc tattttaaca cccagagcca
      661 gagctggaac ttggacacac tggaaaaggc aggctttcct atccaccttc tccccgacat
      721 tgcagagcca ggcagcatgg caggcagaac ttctcacaca tggtttgaaa tcccaaaggg
      781 gacacaggtg ggcatagccc tgggtgactt acaagcctct gtctattcct gcatgggcca
      841 aaggactgat gcagttctca acatcagcac ctcggtccag ctggcagcct ccatgcctgt
      901 gggattccag ccactgcaga ctccggatcc tgcagcccca gttgccttct tcccttactt
      961 cgacaggacc tacctagggg tggcagcgtc actcaatgga ggcaatgtgc tggccacgtt
     1021 tgtccacatg cttgttcagt ggatggcaga tcttggtctg gaggttgaag aatccactgt
     1081 gtattcacgc atgatccagg cggctgcaca gcagaaagac acccatctca ccatcacccc
     1141 aacagtgctg ggggagaggc acctgccaga ccagctggcc tctgtgacta gaatctcctc
     1201 ctctgacctc tccctgggcc atgtgacccg ggccctctgc agaggcatcg ttcagaacct
     1261 gcactccatg cttcctttcc aacagctcaa agagtggggt gtggcccggg tggtggggag
     1321 tgggagtgca ctgtccagga acgaggtgct gaagcaggag gtccagaggg cgtttccttt
     1381 cccagtgtgc tttgggcagg atgtagatgc agcctttggg gcagctctgg tcatgctcca
     1441 gagagacctt agccagaagg agccttagtt catcaagctc cttggctaaa ggaatgctgg
     1501 gaatcttacc taattgacaa tgtcagcatg atctctgggt tgtccttttc tgggacggct
     1561 ctgtgggtgg actgtaattt atacttgatc ttgaggtatg atctagactg atgaagatct
     1621 taccttcagg gcatatgata atcatacagc caggaatctc taaccagacc ccaaactagt
     1681 gccttccaag aataggatct tctgagagct gactgaaaat gcagatgtgg gagatggaga
     1741 gaatgggagg gaggaaaatg ggaagaggga gaggaaggga gaaacaaaca gtttcccggt
     1801 cactgggctc ggctgtgatt cattcgtaga cagggaaaaa agaaagatga cttatgtagc
     1861 catggctcca gcaaagcaga gaagacctgc ttatgcccag cacttggatt ggttcagctt
     1921 taagttaagt gcattgctgg aaaaatcctc cccaccaggt tgtagcaggt ggagggaggc
     1981 ccctctccca gtctcgggga agagaaggag ccttccttag ttcatcaagc tctttgcgat
     2041 tctgggaatc ttatctcacc tgtcagcttg atagccctgt cagttgaaga gaacagctat
     2101 agcatggtct ccagccagag agagaccaaa ggatatgaag caccacacct tggaggagaa
     2161 agctgaggtc tctgggcttg ccttgccatg tgcttctggg acagtgctgc accgtggcta
     2221 ccccgagtct tctcagcaca gctggcttaa aggcacatcc aggagaagaa aagtcacctg
     2281 gtaagaacag ctaaagggac cacagagcac tgtgaggaac actgactgac agactgtttt
     2341 caagatggca gcaaggcacc agcccttttc tatgactgcg tatggccaca tgtctctcta
     2401 acccctgcca caaggggtgg ccagtttcat gagagaacct ttatcccaca ggccccaccc
     2461 ctttctccag ggtgaagatc ttgctgccct ctggtggttc tggcccagta ggaatgtcct
     2521 gttcagatag gcatgcatgg agggtcagag aatcaccagt cttcccatgt tacagtgcct
     2581 tcaagaagag ggtcaccatc actgtctact cataggctcc caaaggaccc cacggctcag
     2641 gggcacctgt gactttgggg agaaaccatg tcatctcttt gtaagagtta tttcataagg
     2701 tatactattg tggtaacccc tttgatggat ttacctccca ctgctggctc agctaactga
     2761 ataaatttca tttttccaga a
//
