LOCUS       NM_013665               1603 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus SHOX homeobox 2 (Shox2), transcript variant 1, mRNA.
ACCESSION   NM_013665
VERSION     NM_013665.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1603)
  AUTHORS   Abassah-Oppong,S., Zoia,M., Mannion,B.J., Rouco,R., Tissieres,V.,
            Spurrell,C.H., Roland,V., Darbellay,F., Itum,A., Gamart,J.,
            Festa-Daroux,T.A., Sullivan,C.S., Kosicki,M.,
            Rodriguez-Carballo,E., Fukuda-Yuzawa,Y., Hunter,R.D., Novak,C.S.,
            Plajzer-Frick,I., Tran,S., Akiyama,J.A., Dickel,D.E.,
            Lopez-Rios,J., Barozzi,I., Andrey,G., Visel,A., Pennacchio,L.A.,
            Cobb,J. and Osterwalder,M.
  TITLE     A gene desert required for regulatory control of pleiotropic Shox2
            expression and embryonic survival
  JOURNAL   Nat Commun 15 (1), 8793 (2024)
   PUBMED   39389973
  REMARK    GeneRIF: A gene desert required for regulatory control of
            pleiotropic Shox2 expression and embryonic survival.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1603)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   3  (bases 1 to 1603)
  AUTHORS   Schott,M., Leon-Perinan,D., Splendiani,E., Strenger,L., Licha,J.R.,
            Pentimalli,T.M., Schallenberg,S., Alles,J., Samut Tagliaferro,S.,
            Boltengagen,A., Ehrig,S., Abbiati,S., Dommerich,S., Pagani,M.,
            Ferretti,E., Macino,G., Karaiskos,N. and Rajewsky,N.
  TITLE     Open-ST: High-resolution spatial transcriptomics in 3D
  JOURNAL   Cell 187 (15), 3953-3972 (2024)
   PUBMED   38917789
REFERENCE   4  (bases 1 to 1603)
  AUTHORS   Yoshida,S., Tsuneoka,Y., Tsukada,T., Nakakura,T., Kawamura,A.,
            Kai,W. and Yoshida,K.
  TITLE     Primary Cilia are Required for Cell-Type Determination and
            Angiogenesis in Pituitary Development
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   39001875
REFERENCE   5  (bases 1 to 1603)
  AUTHORS   Li,H., Tang,Q., Yang,T., Wang,Z., Li,D., Wang,L., Li,L., Chen,Y.,
            Huang,H., Zhang,Y. and Chen,Y.
  TITLE     Segregation of morphogenetic regulatory function of Shox2 from its
            cell fate guardian role in sinoatrial node development
  JOURNAL   Commun Biol 7 (1), 385 (2024)
   PUBMED   38553636
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1603)
  AUTHORS   Blaschke,R.J., Monaghan,A.P., Schiller,S., Schechinger,B., Rao,E.,
            Padilla-Nash,H., Ried,T. and Rappold,G.A.
  TITLE     SHOT, a SHOX-related homeobox gene, is implicated in craniofacial,
            brain, heart, and limb development
  JOURNAL   Proc Natl Acad Sci U S A 95 (5), 2406-2411 (1998)
   PUBMED   9482898
REFERENCE   7  (bases 1 to 1603)
  AUTHORS   Semina,E.V., Reiter,R.S. and Murray,J.C.
  TITLE     A new human homeobox gene OGI2X is a member of the most conserved
            homeobox gene family and is expressed during heart development in
            mouse
  JOURNAL   Hum Mol Genet 7 (3), 415-422 (1998)
   PUBMED   9466998
REFERENCE   8  (bases 1 to 1603)
  AUTHORS   van Schaick,H.S., Smidt,M.P., Rovescalli,A.C., Luijten,M., van der
            Kleij,A.A., Asoh,S., Kozak,C.A., Nirenberg,M. and Burbach,J.P.
  TITLE     Homeobox gene Prx3 expression in rodent brain and extraneural
            tissues
  JOURNAL   Proc Natl Acad Sci U S A 94 (24), 12993-12998 (1997)
   PUBMED   9371788
REFERENCE   9  (bases 1 to 1603)
  AUTHORS   Ellison,J.W., Wardak,Z., Young,M.F., Gehron Robey,P.,
            Laig-Webster,M. and Chiong,W.
  TITLE     PHOG, a candidate gene for involvement in the short stature of
            Turner syndrome
  JOURNAL   Hum Mol Genet 6 (8), 1341-1347 (1997)
   PUBMED   9259282
REFERENCE   10 (bases 1 to 1603)
  AUTHORS   Rovescalli,A.C., Asoh,S. and Nirenberg,M.
  TITLE     Cloning and characterization of four murine homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 93 (20), 10691-10696 (1996)
   PUBMED   8855241
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1996 Dec 24;93(26):15522]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U66918.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U66918.1, BB866956.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1603
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 30.76 cM"
     gene            1..1603
                     /gene="Shox2"
                     /gene_synonym="6330543G17Rik; OG12; Og12x; Prx3; SHOT"
                     /note="SHOX homeobox 2"
                     /db_xref="GeneID:20429"
                     /db_xref="MGI:MGI:1201673"
     exon            1..561
                     /gene="Shox2"
                     /gene_synonym="6330543G17Rik; OG12; Og12x; Prx3; SHOT"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..1211
                     /gene="Shox2"
                     /gene_synonym="6330543G17Rik; OG12; Og12x; Prx3; SHOT"
                     /note="isoform 1 is encoded by transcript variant 1; short
                     stature homeobox protein 2; OG-12; homeobox protein Og12X;
                     paired family homeodomain protein Prx3; short stature
                     homeobox 2"
                     /codon_start=1
                     /product="short stature homeobox protein 2 isoform 1"
                     /protein_id="NP_038693.1"
                     /db_xref="CCDS:CCDS17393.1"
                     /db_xref="GeneID:20429"
                     /db_xref="MGI:MGI:1201673"
                     /translation="MEELTAFVSKSFDQKVKEKKEAITYREVLESGPLRGAKEPGCVE
                     PGRDDRSSPAVRAAGGGGGAGGGGGGGGGGGGGAGGGGAGGGAGGGRSPVRELDMGAA
                     ERSREPGSPRLTEVSPELKDRKDDAKGMEDEGQTKIKQRRSRTNFTLEQLNELERLFD
                     ETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQLHKGVLIGAASQFEACR
                     VAPYVNVGALRMPFQQDSHCNVTPLSFQVQAQLQLDSAVAHAHHHLHPHLAAHAPYMM
                     FPAPPFGLPLATLAADSASAASVVAAAAAAKTTSKNSSIADLRLKAKKHAAALGL"
     exon            562..770
                     /gene="Shox2"
                     /gene_synonym="6330543G17Rik; OG12; Og12x; Prx3; SHOT"
                     /inference="alignment:Splign:2.1.0"
     exon            771..828
                     /gene="Shox2"
                     /gene_synonym="6330543G17Rik; OG12; Og12x; Prx3; SHOT"
                     /inference="alignment:Splign:2.1.0"
     exon            829..917
                     /gene="Shox2"
                     /gene_synonym="6330543G17Rik; OG12; Og12x; Prx3; SHOT"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1595
                     /gene="Shox2"
                     /gene_synonym="6330543G17Rik; OG12; Og12x; Prx3; SHOT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctcctctta cttctttttc tccttctact tctcctcttc tttcttctcc tctttttctt
       61 cttcctcctc ctccctctcc tcccccatcc ccctgcccca ttgatgtgtt attattgggg
      121 gggctggagc agtaaaaaaa gaaggaggaa aaaaagagcg gggctcggca gggagagctt
      181 gagcgcgagg ttgaccggcg gcggcagcgg ccgcgatgga agaacttacg gcgttcgtct
      241 ccaagtcttt tgaccagaaa gtgaaggaga agaaggaggc catcacgtac cgggaggtgc
      301 tagagagcgg gccgctgcgc ggggccaaag agcccggttg cgtcgagccg ggccgcgacg
      361 accgcagcag cccggcagtc cgggcggccg gcggaggcgg cggcgcggga ggaggcggag
      421 gcggaggcgg aggaggcgga ggaggtgctg gaggaggagg agcaggcgga ggagctggag
      481 gagggcgctc tcccgtccgg gagctggaca tgggagccgc ggagcggagc agggagcccg
      541 gcagcccgcg gctgacggag gtgtcccctg aactgaagga tcgcaaagac gatgcgaaag
      601 ggatggagga cgaaggccag accaaaatca agcagaggcg aagtcggacc aattttaccc
      661 tggaacaact caacgagctg gagaggcttt tcgatgagac ccactatcca gacgctttca
      721 tgcgcgagga attgagccag cgactggggc tctctgaggc ccgagtacag gtttggtttc
      781 aaaatcgaag agctaagtgt agaaaacagg aaaatcaact tcacaaaggt gtccttatag
      841 gagccgctag ccagtttgaa gcttgtagag ttgcacccta tgtcaacgta ggtgctttaa
      901 ggatgccatt tcagcaggat agtcattgca acgtgacgcc cttgtccttt caggttcagg
      961 cgcagctgca gctggacagc gccgtggcgc acgcgcacca ccacctgcat ccgcacctgg
     1021 ccgcgcacgc gccttacatg atgttcccgg caccgccctt cggactgccg ctggccacgc
     1081 tggccgcgga ctcggcctcg gccgcctcgg tggtggccgc tgccgccgcc gccaagacca
     1141 ccagcaagaa ctccagcatc gcggatctca gactgaaagc taaaaagcac gcggccgccc
     1201 tgggtctgtg acgccggcgc cagcgccacg gtcggtggag cctcctaagc ggcgcgatcc
     1261 tgcacgccct ccgcgaccgg cttctcccgc acccgcttct gaccgtcgcc caggcctgtc
     1321 ccttccccgc tgactgccgc cttttctttc tgcaccctgg atccccaggg cgggactctg
     1381 cgctggaccc gggatcccac gagggccacc agcccagggg ctcctgccca cccgcccttg
     1441 ggactaaaat tcggctttgt aggagcgggt ttggggaagt ctggatagag actggacaaa
     1501 ggagtgtggc cacagtgaga agtggatagc gccacagctg cggcgatgga ctcgttcata
     1561 ggaataaaat cttgctaaca gcaaatgagc aaaaaaaaaa aaa
//
