LOCUS       NM_001355242            4263 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus Shoc2, leucine rich repeat scaffold protein (Shoc2),
            transcript variant 3, mRNA.
ACCESSION   NM_001355242 XM_017318260
VERSION     NM_001355242.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4263)
  AUTHORS   Geng,W., Cao,M., Dong,K., An,J. and Gao,H.
  TITLE     SHOC2 mediates the drug-resistance of triple-negative breast cancer
            cells to everolimus
  JOURNAL   Cancer Biol Ther 24 (1), 2206362 (2023)
   PUBMED   37170083
  REMARK    GeneRIF: SHOC2 mediates the drug-resistance of triple-negative
            breast cancer cells to everolimus.
REFERENCE   2  (bases 1 to 4263)
  AUTHORS   Tan,M., Chang,Y., Liu,X., Li,H., Tang,Z., Nyati,M.K. and Sun,Y.
  TITLE     The Sag-Shoc2 axis regulates conversion of mPanINs to cystic
            lesions in Kras pancreatic tumor model
  JOURNAL   Cell Rep 41 (12), 111837 (2022)
   PUBMED   36543126
  REMARK    GeneRIF: The Sag-Shoc2 axis regulates conversion of mPanINs to
            cystic lesions in Kras pancreatic tumor model.
REFERENCE   3  (bases 1 to 4263)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4263)
  AUTHORS   Motta,M., Chillemi,G., Fodale,V., Cecchetti,S., Coppola,S.,
            Stipo,S., Cordeddu,V., Macioce,P., Gelb,B.D. and Tartaglia,M.
  TITLE     SHOC2 subcellular shuttling requires the KEKE motif-rich region and
            N-terminal leucine-rich repeat domain and impacts on ERK signalling
  JOURNAL   Hum Mol Genet 25 (17), 3824-3835 (2016)
   PUBMED   27466182
  REMARK    GeneRIF: Results provide evidence that SHOC2 trapping at different
            subcellular sites has a diverse impact on ERK signaling strength
            and dynamics, suggesting a dual counteracting modulatory role of
            SHOC2 in the control of ERK signaling exerted at different
            intracellular compartments.
REFERENCE   5  (bases 1 to 4263)
  AUTHORS   Yi,J., Chen,M., Wu,X., Yang,X., Xu,T., Zhuang,Y., Han,M. and Xu,R.
  TITLE     Endothelial SUR-8 acts in an ERK-independent pathway during
            atrioventricular cushion development
  JOURNAL   Dev Dyn 239 (7), 2005-2013 (2010)
   PUBMED   20549726
  REMARK    GeneRIF: Data suggest that SUR-8 may act in an ERK-independent
            pathway to regulate AVC development.
REFERENCE   6  (bases 1 to 4263)
  AUTHORS   Sano,M., Izumi,Y., Helenius,K., Asakura,M., Rossi,D.J., Xie,M.,
            Taffet,G., Hu,L., Pautler,R.G., Wilson,C.R., Boudina,S., Abel,E.D.,
            Taegtmeyer,H., Scaglia,F., Graham,B.H., Kralli,A., Shimizu,N.,
            Tanaka,H., Makela,T.P. and Schneider,M.D.
  TITLE     Menage-a-trois 1 is critical for the transcriptional function of
            PPARgamma coactivator 1
  JOURNAL   Cell Metab 5 (2), 129-142 (2007)
   PUBMED   17276355
REFERENCE   7  (bases 1 to 4263)
  AUTHORS   Clee,S.M., Yandell,B.S., Schueler,K.M., Rabaglia,M.E.,
            Richards,O.C., Raines,S.M., Kabara,E.A., Klass,D.M., Mui,E.T.,
            Stapleton,D.S., Gray-Keller,M.P., Young,M.B., Stoehr,J.P., Lan,H.,
            Boronenkov,I., Raess,P.W., Flowers,M.T. and Attie,A.D.
  TITLE     Positional cloning of Sorcs1, a type 2 diabetes quantitative trait
            locus
  JOURNAL   Nat Genet 38 (6), 688-693 (2006)
   PUBMED   16682971
REFERENCE   8  (bases 1 to 4263)
  AUTHORS   Dai,P., Xiong,W.C. and Mei,L.
  TITLE     Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf
            complex
  JOURNAL   J Biol Chem 281 (2), 927-933 (2006)
   PUBMED   16301319
  REMARK    GeneRIF: Erbin has a regulatory role in the Ras-Raf-MEK pathway and
            may inhibit ERK activation by disrupting the Sur-8-Ras/Raf
            interaction
REFERENCE   9  (bases 1 to 4263)
  AUTHORS   Hitzemann,R., Reed,C., Malmanger,B., Lawler,M., Hitzemann,B.,
            Cunningham,B., McWeeney,S., Belknap,J., Harrington,C., Buck,K.,
            Phillips,T. and Crabbe,J.
  TITLE     On the integration of alcohol-related quantitative trait loci and
            gene expression analyses
  JOURNAL   Alcohol Clin Exp Res 28 (10), 1437-1448 (2004)
   PUBMED   15597075
  REMARK    Erratum:[Alcohol Clin Exp Res. 2004 Dec;28(12):1930]
REFERENCE   10 (bases 1 to 4263)
  AUTHORS   Sieburth,D.S., Sun,Q. and Han,M.
  TITLE     SUR-8, a conserved Ras-binding protein with leucine-rich repeats,
            positively regulates Ras-mediated signaling in C. elegans
  JOURNAL   Cell 94 (1), 119-130 (1998)
   PUBMED   9674433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117612.9.
            
            On Dec 2, 2022 this sequence version replaced NM_001355242.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784647.595260.1,
                                           SRR1660821.133959.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AC117612.9         92230-92387
            159-283             AC117612.9         97193-97317
            284-1213            AC117612.9         134828-135757
            1214-1351           AC117612.9         150383-150520
            1352-1482           AC117612.9         164923-165053
            1483-1671           AC117612.9         173724-173912
            1672-1794           AC117612.9         175092-175214
            1795-1932           AC117612.9         176843-176980
            1933-2050           AC117612.9         177235-177352
            2051-4263           AC117612.9         178442-180654
FEATURES             Location/Qualifiers
     source          1..4263
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 48.83 cM"
     gene            1..4263
                     /gene="Shoc2"
                     /gene_synonym="mKIAA0862; Sur8"
                     /note="Shoc2, leucine rich repeat scaffold protein"
                     /db_xref="GeneID:56392"
                     /db_xref="MGI:MGI:1927197"
     exon            1..158
                     /gene="Shoc2"
                     /gene_synonym="mKIAA0862; Sur8"
                     /inference="alignment:Splign:2.1.0"
     exon            159..283
                     /gene="Shoc2"
                     /gene_synonym="mKIAA0862; Sur8"
                     /inference="alignment:Splign:2.1.0"
     exon            284..1213
                     /gene="Shoc2"
                     /gene_synonym="mKIAA0862; Sur8"
                     /inference="alignment:Splign:2.1.0"
     CDS             511..2259
                     /gene="Shoc2"
                     /gene_synonym="mKIAA0862; Sur8"
                     /note="suppressor of clear, C. elegans, homolog of;
                     Ras-binding protein SUR-8; protein soc-2 homolog; protein
                     sur-8 homolog; soc-2-like protein; soc-2 (suppressor of
                     clear) homolog"
                     /codon_start=1
                     /product="leucine-rich repeat protein SHOC-2"
                     /protein_id="NP_001342171.1"
                     /db_xref="CCDS:CCDS29904.1"
                     /db_xref="GeneID:56392"
                     /db_xref="MGI:MGI:1927197"
                     /translation="MSSSLGKEKDSKEKDPKVPSAKEREKESKASGGFGKESKEKEPK
                     AKGKDAKDGKKESSAAQPGVAFSVDNTIKRPNPAPGTRKKSSNAEVIKELNKCREENS
                     MRLDLSKRSIHILPPSVKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTS
                     LPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLPKLS
                     MLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNDLLDL
                     PDTIGNLSSLNRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLN
                     SLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLT
                     SLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKL
                     RELDLEENKLESLPNEIAYLKDLQKLVLTNNQLSTLPRGIGHLTNLTHLGLGENLLTH
                     LPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVAGGPS
                     FIIQFLKMQGPYRAMV"
     exon            1214..1351
                     /gene="Shoc2"
                     /gene_synonym="mKIAA0862; Sur8"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1482
                     /gene="Shoc2"
                     /gene_synonym="mKIAA0862; Sur8"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1671
                     /gene="Shoc2"
                     /gene_synonym="mKIAA0862; Sur8"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1794
                     /gene="Shoc2"
                     /gene_synonym="mKIAA0862; Sur8"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1932
                     /gene="Shoc2"
                     /gene_synonym="mKIAA0862; Sur8"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2050
                     /gene="Shoc2"
                     /gene_synonym="mKIAA0862; Sur8"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..4263
                     /gene="Shoc2"
                     /gene_synonym="mKIAA0862; Sur8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4086..4091
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shoc2"
                     /gene_synonym="mKIAA0862; Sur8"
                     /note="hexamer: TATAAA"
     polyA_site      4111
                     /gene="Shoc2"
                     /gene_synonym="mKIAA0862; Sur8"
                     /note="major polyA site"
     regulatory      4244..4249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shoc2"
                     /gene_synonym="mKIAA0862; Sur8"
                     /note="hexamer: AATATA"
     polyA_site      4263
                     /gene="Shoc2"
                     /gene_synonym="mKIAA0862; Sur8"
ORIGIN      
        1 agcgtcgctc ggggagcgga ggacgaggag gaggaaggag gtgagcaggg atggtggagt
       61 ccgggctccg gacggcagcc tggggcggga gcggcacagg agcgcccgtg ggccggttct
      121 ctgctttcct gcctgtcggg gggcccggcc ggccgtcggc aaatggatgt cacagtgaag
      181 cacacgtgtg aaggtacctg ccgtagttgg ttctctcctt gcatcggatg gattcttgga
      241 tggaactcag actctggcct caccgcacca aaccatgcct ttgggactct aatgagctga
      301 ccaggaccat tttaccagtt gaaatgagtt ctcagaaatg agcatagtgc tgttagagtc
      361 accatgtaac ggacggatgt gactccaagc gcaccacttc ttcatgccaa ccctctttga
      421 ctgggaagga tctttgtctt ttcatcgttg atctggattg ctggcgagga ggaggagttc
      481 atgtagtgtt tgagtgaagc ttgagtcacc atgagtagta gtttaggaaa agaaaaagac
      541 tctaaagaga aagaccccaa agtaccgtct gccaaggaaa gagaaaagga gtcaaaagcc
      601 tcaggaggct ttgggaaaga gagcaaagaa aaggaaccta aagccaaagg gaaagacgcc
      661 aaagatggaa agaaggagtc cagcgctgcc cagccaggtg tggctttttc agtcgacaat
      721 accatcaaac ggccaaatcc agcacccggc actagaaaaa agtccagcaa tgctgaggtc
      781 attaaggagc ttaacaaatg ccgggaggag aactcaatgc ggttggactt gtccaagagg
      841 tctatacata tactgccacc atcagtcaaa gagttgactc aactcacaga actttattta
      901 tacagtaaca aattgcagtc cctcccagca gaggtgggct gtctagtcaa tctcatgacg
      961 ctggctctca gtgagaattc actcaccagt ttgcctgact ctcttgataa cttgaagaag
     1021 ctgcggatgc ttgatttacg gcataataaa ctgagagaaa ttccttcagt ggtgtatagg
     1081 ctagactctc tcaccactct ctatcttcgc tttaatcgca taactactgt ggaaaaggac
     1141 atcaaaaacc tgccgaagct cagcatgctc agcatccgag agaacaaaat caagcagctg
     1201 cctgctgaaa ttggtgaatt atgtaacctc attaccctgg atgtagctca caatcaactt
     1261 gaacaccttc caaaggagat tggaaactgc acacagataa ccaaccttga cttgcagcac
     1321 aatgacctac tggacctccc agatacaata ggaaacctgt ccagtttaaa tcgccttggc
     1381 ctgagataca atagattgtc agcaataccc agatcattag caaaatgcag tgcacttgag
     1441 gagttaaatt tagagaacaa taacatttct actctaccag agagtctttt atccagtctt
     1501 gtaaaattga atagcttgac cttagctaga aattgcttcc agttatatcc agtgggaggt
     1561 ccatctcagt tttccaccat ttattccctc aacatggaac acaatcgaat caacaaaatc
     1621 ccatttggaa ttttttccag agctaaagtg ttaagtaagc tgaatatgaa ggacaatcag
     1681 ttaacatcac ttcctttgga ttttggaact tggaccagta tggtagaatt gaatttagcg
     1741 actaatcagc tcacaaagat cccagaggat gtgtctggtc tcgtttccct tgaggttctg
     1801 atcttatcga acaaccttct aaagaagctg ccccacggcc ttgggaacct cagaaagcta
     1861 cgagagctgg acctggagga gaacaagctg gagtccttgc ccaatgagat cgcgtatctc
     1921 aaggatctgc agaaattagt cttgacaaac aaccagttga gcacgcttcc cagaggcatc
     1981 ggtcacctta ccaacctcac gcaccttggt cttggagaga acctgctcac tcaccttcct
     2041 gaggaaatcg gtacactgga aaacctagaa gaactgtatt tgaacgacaa ccccaacctt
     2101 cacagcctcc cctttgagct tgctctctgc agcaagctgt caatcatgag tattgagaac
     2161 tgtccactca gtcacctccc acctcaaatt gttgctggag ggccttcgtt cattattcag
     2221 ttcttaaaga tgcagggtcc atatcgtgcc atggtctgat agaaactgct ggtcccacac
     2281 actgttcaaa aatagactgc cattaatctt tcatatctgt atctgtatct gtgtggatat
     2341 tgatctatgg cagatttata aagactgcat tatgtgtttc tgctaataga ggaatcatag
     2401 ccatttagat ttttttaatt ctgtaaaaaa aaaaggctta tataagtttt ctttgctaaa
     2461 tttgatggat gtttttctgt tgtgtaatct gatatgccag tttgtttaaa aatcttccaa
     2521 caaattatga agtcattaaa tttaagggac aaaatagtat agttaaatat atgtttctct
     2581 taggaaaatg tgggccaaaa atttgttgca tcttttcata tatacatttc cccttaaaat
     2641 tgtcatatct tttaacagca taggccctga aggtagaatt tttctttaac ttattttgaa
     2701 atttgaaatt taaattttat atattgttta caatcggagt gaatcactgg attaatttga
     2761 tttgctctgt tttaatcagt cagagtttat attcttttaa agaattttca tcagtttaaa
     2821 tattaaaaga tactttgttg aaacagctgg caaacagaaa atatacattt agaaatcaga
     2881 atttccatta gttttatttc tccagtgaac tttaaagcaa atatctgaag tgaatctttg
     2941 gggcgggggt actgaaacct ttcctagaat aagtatgttt cactgtgtgg gagcagaaat
     3001 ctgtggtgaa aggtttttct tttcttttct ttttattccc attcctgaaa gttgcagatc
     3061 cacaaaaatt taacagaaat ttggcaagga aataaaaaac acataaacac acattctata
     3121 tatgtatata caatgctata tagatatgta tttattatat cataaactac aataggtaac
     3181 tttaaagact tctccctcca cttgtacatt gagatgaatg tctctctaaa gactgcagta
     3241 tatgtgtgtt tcgaggttag gtgacagtgt actatggttt tatatcttga ctcgccatgt
     3301 ccatctgtct gttcgggggt atctgtgtct aagcacaata tcttcacact gtgctgtatt
     3361 gctgctgaac taaatgcact ttccccatcc ccggggcact ggcttcaaac aattcagttc
     3421 agtactgtta ctttcagtct cgtcacgcca tggttagtgg tggtagtaca gatacggaga
     3481 acggcacatg gcattgatgc cattgggagt tctgtgggac ttatgtagta tgtgcatgga
     3541 ctctttgata atgttttctt ttgcttttct gcctttatga atatcaactg taaatgtgtg
     3601 ccccttatgt agtattctta tttttggtag tgtttgtctt aagtcagttt aattattgag
     3661 aactccccca cccccagagc aggcgcatcc tagatataat cttgaaacac aacttccata
     3721 caatgaatga ctattacaca taaggaaata ttgctgcttg ttcttttgtg caaacccccc
     3781 cccccccatt tttaagtatt ttgtcctaaa caactgtttt taaaaattaa aactgtaata
     3841 tcaagataaa catttggatt tttgcttttc ctggcactca aactcaagac tgggtttgag
     3901 gtcaaatctg tgttcataat tggcaaattt gtaaggaaca actaagaaat ggaaggcagg
     3961 taaagatata aaaccctaga atacctaaat gtgctgtaaa actattgtag atgttcactg
     4021 gattttacaa agtaatagcc tttctccttt tccatctact gtggcttttc agttaagatt
     4081 ttgtttataa aaggaattta ttacagttct acctagagct tgtgtgtgtg gtgttttaaa
     4141 aataatctcg tactcttgtt ttgatattaa gatcatagaa cttaaacttg tgaggtagtg
     4201 gtctagtgtc ttttcttgta aaaacatggt ttctcaaaat gaaaatatat gaaaaatgtt
     4261 taa
//
