LOCUS       NM_001370843            6433 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus shortage in chiasmata 1 (Shoc1), mRNA.
ACCESSION   NM_001370843 XM_017320490
VERSION     NM_001370843.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6433)
  AUTHORS   Li,Y., Wu,Y., Khan,I., Zhou,J., Lu,Y., Ye,J., Liu,J., Xie,X.,
            Hu,C., Jiang,H., Fan,S., Zhang,H., Zhang,Y., Jiang,X., Xu,B., Ma,H.
            and Shi,Q.
  TITLE     M1AP interacts with the mammalian ZZS complex and promotes male
            meiotic recombination
  JOURNAL   EMBO Rep 24 (2), e55778 (2023)
   PUBMED   36440627
REFERENCE   2  (bases 1 to 6433)
  AUTHORS   Wang,W., Meng,L., He,J., Su,L., Li,Y., Tan,C., Xu,X., Nie,H.,
            Zhang,H., Du,J., Lu,G., Luo,M., Lin,G., Tu,C. and Tan,Y.Q.
  TITLE     Bi-allelic variants in SHOC1 cause non-obstructive azoospermia with
            meiosis arrest in humans and mice
  JOURNAL   Mol Hum Reprod 28 (6) (2022)
   PUBMED   35485979
  REMARK    GeneRIF: Bi-allelic variants in SHOC1 cause non-obstructive
            azoospermia with meiosis arrest in humans and mice.
REFERENCE   3  (bases 1 to 6433)
  AUTHORS   Zhang,Q., Ji,S.Y., Busayavalasa,K. and Yu,C.
  TITLE     SPO16 binds SHOC1 to promote homologous recombination and
            crossing-over in meiotic prophase I
  JOURNAL   Sci Adv 5 (1), eaau9780 (2019)
   PUBMED   30746471
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6433)
  AUTHORS   Zhang,Q., Shao,J., Fan,H.Y. and Yu,C.
  TITLE     Evolutionarily-conserved MZIP2 is essential for crossover formation
            in mammalian meiosis
  JOURNAL   Commun Biol 1, 147 (2018)
   PUBMED   30272023
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6433)
  AUTHORS   Guiraldelli,M.F., Felberg,A., Almeida,L.P., Parikh,A., de
            Castro,R.O. and Pezza,R.J.
  TITLE     SHOC1 is a ERCC4-(HhH)2-like protein, integral to the formation of
            crossover recombination intermediates during mammalian meiosis
  JOURNAL   PLoS Genet 14 (5), e1007381 (2018)
   PUBMED   29742103
  REMARK    GeneRIF: Analysis of SHOC1-deficient mice and the selective
            localization of SHOC1 to a subset of recombination sites show that
            SHOC1 acts at key mid-stage steps of the genetic crossovers (COs)
            ormation process.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL808112.34, BX001048.5 and AL805972.11.
            
            On Jun 6, 2019 this sequence version replaced XM_017320490.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN00849376, SAMN00849381
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                AL808112.34        23204-23293         c
            91-170              BX001048.5         24075-24154         c
            171-282             BX001048.5         21270-21381         c
            283-364             BX001048.5         19763-19844         c
            365-543             BX001048.5         9429-9607           c
            544-697             BX001048.5         4307-4460           c
            698-782             BX001048.5         4026-4110           c
            783-933             BX001048.5         2528-2678           c
            934-1035            AL805972.11        218116-218217       c
            1036-1144           AL805972.11        216470-216578       c
            1145-1239           AL805972.11        215487-215581       c
            1240-1482           AL805972.11        213485-213727       c
            1483-1908           AL805972.11        207374-207799       c
            1909-2034           AL805972.11        203521-203646       c
            2035-2211           AL805972.11        202812-202988       c
            2212-2316           AL805972.11        200449-200553       c
            2317-2495           AL805972.11        197588-197766       c
            2496-2568           AL805972.11        196386-196458       c
            2569-2638           AL805972.11        195635-195704       c
            2639-2817           AL805972.11        193778-193956       c
            2818-2935           AL805972.11        193462-193579       c
            2936-3047           AL805972.11        192065-192176       c
            3048-3169           AL805972.11        190830-190951       c
            3170-3263           AL805972.11        185385-185478       c
            3264-3395           AL805972.11        180505-180636       c
            3396-3545           AL805972.11        180159-180308       c
            3546-4449           AL805972.11        178509-179412       c
            4450-6433           AL805972.11        173220-175203       c
FEATURES             Location/Qualifiers
     source          1..6433
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 32.36 cM"
     gene            1..6433
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /note="shortage in chiasmata 1"
                     /db_xref="GeneID:100155"
                     /db_xref="MGI:MGI:2140313"
     exon            1..90
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /inference="alignment:Splign:2.1.0"
     exon            91..170
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..4550
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /note="likely orthologue of H. sapiens chromosome 9 open
                     reading frame 84; protein ZIP2 homolog"
                     /codon_start=1
                     /product="protein shortage in chiasmata 1 ortholog"
                     /protein_id="NP_001357772.1"
                     /db_xref="CCDS:CCDS89749.1"
                     /db_xref="GeneID:100155"
                     /db_xref="MGI:MGI:2140313"
                     /translation="MALNGRTMFPAFKYYAIDYLQEDIIKERLYRDALLLQIPSCLNQ
                     DKNIIDDKYRTPWTRAIPVQEMEDNSVLEQWRTRFCVEGVPEKKTVTGVMINGTFEEI
                     VPSSNPNSPPGIENDKLFPSKDYVDDFIPVKCSLYYPGVKAEHQGLLIDEEMIFMNKA
                     MDNHLPTVNGLLSRLKLYLVKDPFLDFKEELSGKDNFTEYFSVQECSEPFVRDFHMAE
                     ETFCKKKLPSVFPSGFKSLISTNPKQEILILPPSKLKKPLNSIPKIMDSVDESECFKG
                     DITSKHEFDTEDIKCNSTENLTFASLCEPECSEPGDLEMPPTHLILPRQHSAVSSLHM
                     GFQTFPFSATCKINLLSAGESANKYCMLWQLGGCRNSWVSFLLTVPRFQEPSSQYSLA
                     DMRNIFSVKGDSLVINPAKAKGWRQARLHPIMAETLAHLKAYLCHNGLSSQETKLEIF
                     LPTKVFQLESWLELKSRPLPIVPISEKSTDVHQLHPQKRPIPSSEKEVPHLCLSGESI
                     SVKKSKVEANPKNDQEPEARIMQKPENSCVGLGCSSQVPSAESASSSQIQASYDKKQD
                     DLDLLSEFIILRSKHQTFPSEADVDVKSHDHDQNNEFQDKEKYSLTLQEESLVASNSK
                     APEERCEERTDGVIEIPASDTQCQAYCLLEATANPILKELVCLCTYPAANWKFATVNF
                     DQTRFFLKEQEKKINDATHPDKNDDRKMTFRHAALLHLLITIRDVLLTCNLDTALGYL
                     SNAKDIYKSVLDSRLDNIWRQLKILQFIKEKRPKSNYKIQELQCQILSRLQNQQQMKV
                     LIIIRMDSDGEKHLLIKTLKKIEGLTMTVLRSNDRKKILETTSILKGTNACVVVHNHS
                     IGADFPWSSFSLVVEYNHVGHSCWAEHCQLLDIPFLAFKVAVPDTALQRDALLDGFGG
                     FLLKIPIPYVFFASEGLLNTPEILRLLESNYNITLVERCCCGSLKLFGSTECYVVVTV
                     DEHTAIVVQDLEELHHEKASDNIIMRLMALSFQYSCCWIILYSKETLNSQYHLTEETL
                     RHLAQVYAALVSSGLKSEELDVKLIIAPGVEETALIIRQIADHNLMTSTRDPHEWLDK
                     SWVEVSPSKEEMSLLDFPCINPLVAQLMLHRAPSLHWLLIATPAELQELLPQVPGKVL
                     KHFCSITSLFKISSPSMTKSSQISSLQEDMNQTDLFISQSSAPIIQEQEEYYPYEDSE
                     GTSSSPVELRATPCMLPSAAPHSQRGCWEDPSCGPDPVQNNPSLMNAESKKVTWPSVP
                     SWSDSESDVFSLARTQVSCEPIMTLTDSQRRGTNGFVNCPEAKGPRNMQVSTPVFLPE
                     NSQSHLHWDFKKNSCRKQIYSFNPSCGTEQTTYNKWYSWKDDFSSNQPECLWDEMEDV
                     TYRNANAGTRETFWRELPAVPSWDSPCASDSNANQRGFKGLDFCQRAGNYLGQRSLPV
                     SSSNWGDYKTPTDLMYSQVPQPKKRRLMYEKVPGRVDGQTRLKFL"
     exon            171..282
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /inference="alignment:Splign:2.1.0"
     exon            283..364
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /inference="alignment:Splign:2.1.0"
     exon            365..543
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /inference="alignment:Splign:2.1.0"
     exon            544..697
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /inference="alignment:Splign:2.1.0"
     exon            698..782
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /inference="alignment:Splign:2.1.0"
     exon            783..933
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1035
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1144
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1239
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1482
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1908
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2034
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2211
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2316
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2495
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2568
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2638
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2817
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2818..2935
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /inference="alignment:Splign:2.1.0"
     exon            2936..3047
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /inference="alignment:Splign:2.1.0"
     exon            3048..3169
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /inference="alignment:Splign:2.1.0"
     exon            3170..3263
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /inference="alignment:Splign:2.1.0"
     exon            3264..3395
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /inference="alignment:Splign:2.1.0"
     exon            3396..3545
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /inference="alignment:Splign:2.1.0"
     exon            3546..4449
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /inference="alignment:Splign:2.1.0"
     exon            4450..6433
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4925..4930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /note="hexamer: ATTAAA"
     polyA_site      4955
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /note="major polyA site"
     regulatory      5800..5805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /note="hexamer: AATAAA"
     polyA_site      5824
                     /gene="Shoc1"
                     /gene_synonym="Gm426; Mzip2"
                     /note="major polyA site"
ORIGIN      
        1 gcttgctgcg tgagactgag taactgctag atccttggac ttccattcac agctgtgact
       61 gaacgattgt tgggaattga gctgccgact atattggact ttgtatggca ttgaacggaa
      121 gaactatgtt tccagccttc aaatattatg caatagacta tttacaagag gacataatta
      181 aagagaggct ttacagagat gctttattgc ttcagattcc ttcatgttta aatcaagata
      241 aaaacattat tgatgataaa tataggactc catggacaag agctattcca gttcaggaaa
      301 tggaagataa ttcagtcttg gagcagtgga gaacaagatt ctgtgtggag ggtgttcctg
      361 agaaaaagac agttacagga gtgatgatta atggcacatt tgaggaaatt gttccaagtt
      421 ccaatccaaa ctctccacct ggaatagaga acgataaact gttccccagt aaggactacg
      481 tagacgactt tattcctgtc aagtgttcct tgtactaccc cggagtgaaa gcggagcacc
      541 aaggattgct tattgatgag gaaatgattt ttatgaataa agcaatggac aaccatctac
      601 caactgtgaa tggtctcctg agcagactga agctctatct ggtgaaggat ccatttttag
      661 atttcaaaga agagctctct ggaaaggata atttcacgga gtatttctct gttcaagaat
      721 gttcggaacc ttttgtgaga gatttccata tggctgagga gaccttttgt aagaagaaac
      781 taccatcagt ttttccttct gggtttaaat ccttgatatc tacaaatccc aaacaagaaa
      841 ttctcattct accaccatca aaactgaaga aaccattaaa ctcgataccg aaaataatgg
      901 actctgtaga tgaaagtgaa tgtttcaaag gagacattac ttccaagcat gaatttgata
      961 ctgaggatat aaaatgcaac tccacagaaa acttaacatt tgcaagcctt tgtgaaccag
     1021 agtgcagtga gccaggagac ctagaaatgc caccaaccca tctaatctta ccaaggcagc
     1081 attctgcagt gagttcatta cacatgggat ttcagacatt tccgttttct gctacatgta
     1141 aaattaattt gcttagtgct ggagaatcag ctaataaata ttgtatgctg tggcaactgg
     1201 gaggctgcag aaactcttgg gtctcgttct tgcttacagt tccaagattt caagaaccca
     1261 gcagtcaata ttcacttgca gatatgagga acatcttttc tgtcaaagga gacagccttg
     1321 tgattaaccc tgcaaaagca aaggggtgga gacaagcacg actacatcca ataatggctg
     1381 aaacgctggc gcatctgaag gcgtatttgt gtcataatgg tctgtcttct caggagacta
     1441 agctggagat ctttctgcct acaaaagtgt ttcagctgga gtcctggcta gaacttaaga
     1501 gtcgtccctt gcccattgtg ccaatcagtg agaaatctac agatgttcac cagttacatc
     1561 cacagaagag accaataccc tcttcagaaa aggaagtacc acacctttgt ttgtccggtg
     1621 aaagtatctc tgttaaaaaa tccaaagtag aagcaaaccc aaagaatgat caagaaccag
     1681 aagctagaat aatgcagaag ccggagaaca gctgtgttgg acttggctgt tcaagtcaag
     1741 tgccatctgc tgaatcagct tcctcttccc agatccaggc atcttatgat aaaaaacaag
     1801 atgatttgga ccttctgagc gagtttatta ttctgagaag taaacaccag actttccctt
     1861 cagaagctga cgtcgatgtc aaaagccatg accatgacca aaacaatgaa tttcaagata
     1921 aagaaaaata ttctttgact cttcaagaag aaagtcttgt tgcttctaat agtaaagctc
     1981 cagaggagag atgtgaagaa aggacagatg gcgtcatcga gatccccgct tcagacaccc
     2041 agtgccaagc atactgtctc ctagaagcca cagcgaatcc tatcttaaag gagcttgttt
     2101 gcctctgtac ttaccctgca gccaattgga aattcgccac tgtcaatttt gaccaaacaa
     2161 gattcttctt aaaggaacaa gaaaaaaaga taaatgatgc tactcacccc gataaaaatg
     2221 atgacagaaa gatgacattc aggcatgctg ctctcttaca tctcctgata acaattagag
     2281 acgtcctttt aacatgcaac ttggatactg cattaggata tttgtcaaat gcaaaagata
     2341 tctacaaaag tgtgttagac tcccgtttgg ataacatttg gagacagctg aaaattttac
     2401 agtttattaa ggaaaaaagg cctaaaagca actataagat ccaagaattg cagtgtcaaa
     2461 tactaagtag gctacagaat caacaacaaa tgaaggtact gattataata agaatggact
     2521 cagatggaga aaagcatctg cttattaaaa cacttaagaa aatagaaggt ttaacaatga
     2581 ctgttttacg ttctaatgat agaaaaaaaa ttctggaaac taccagtatt ttaaaaggta
     2641 cgaatgcctg cgtggttgtg cacaaccaca gtatcggagc ggatttcccc tggagcagct
     2701 tctcgctcgt ggtggagtac aaccatgtgg ggcactcttg ctgggccgag cactgccaac
     2761 tgttggatat accttttctg gcctttaaag tcgctgttcc agacacagct ctgcagagag
     2821 atgccttgct ggatggattt ggtgggtttc tcttgaaaat tcccattcca tatgtatttt
     2881 ttgcatctga aggacttctc aatactccag agatactccg gctgctggag tccaactata
     2941 atatcacact agtggagaga tgctgctgtg ggtcactgaa actctttgga agtacagagt
     3001 gctatgtggt ggtgacagtc gacgagcata ctgctatagt tgtgcaggac ctagaagagt
     3061 tacatcatga gaaggcatca gacaatatca tcatgagatt aatggcactg tcgttccagt
     3121 atagctgttg ctggataata ctatattcca aggaaacact aaattcacaa taccatctta
     3181 cagaagagac acttcgtcac ctcgcacagg tttatgcagc tctggtttcc tcgggcctga
     3241 aatctgaaga gctggatgta aagcttataa ttgcccctgg agtagaagag actgctttaa
     3301 taattcgaca aattgcagac cacaatttaa tgacgtcgac gagagatccc catgaatggt
     3361 tggataaatc ctgggtggaa gtttcacctt ctaaggagga aatgagccta cttgattttc
     3421 cctgtataaa cccactggtg gctcagctca tgttacacag ggcgccttcg ctgcactggc
     3481 tcctgatagc aacgcctgct gagctccagg aactcctgcc ccaggttcca ggcaaagtac
     3541 tgaagcattt ttgcagcatc acttccttgt tcaagattag ttctccctcc atgacaaagt
     3601 cttctcagat ttcatcactt caggaagata tgaatcaaac tgatctcttt atttctcaga
     3661 gttcagctcc tatcattcaa gaacaggagg aatattatcc ctatgaagac tcggaaggca
     3721 caagctcttc tcctgtggag ctaagagcaa ctccatgcat gctgccatct gcagcaccgc
     3781 acagtcagag gggctgctgg gaggacccca gctgtggccc tgaccccgtg cagaataacc
     3841 cttccctaat gaatgcagaa tcaaagaaag tcacctggcc ctccgttccc agctggagtg
     3901 attcagaatc agatgtcttt tctctggccc gaacacaagt aagttgtgaa cccataatga
     3961 cactaactga ttctcaaagg agaggcacaa atggttttgt aaattgtccc gaagccaaag
     4021 gacccagaaa catgcaagtg tccacccctg tctttttacc agagaactcc cagtcccacc
     4081 ttcactggga ctttaagaaa aacagttgta gaaaacagat ttactcgttc aatccaagct
     4141 gtggaacaga acagactact tacaacaaat ggtactcttg gaaagatgac ttctccagta
     4201 atcagcccga gtgtctgtgg gatgagatgg aagatgtcac atacagaaat gcaaatgctg
     4261 ggacccggga gactttttgg agagaactgc cagctgttcc aagttgggat tcaccctgtg
     4321 cttctgattc taatgcaaat caaagagggt tcaagggcct tgatttctgc caaagagctg
     4381 gaaactactt aggacagaga agcctccctg tgtcttcatc taattgggga gattacaaaa
     4441 caccaacaga cttaatgtac tcacaagtac cacaacccaa gaaacgacgt ctaatgtatg
     4501 agaaagtccc tggaagagtg gatgggcaaa cccggctgaa gtttttatga aaaaaacaga
     4561 agggacagtg ccacctgcca gattctattt ccttatgcca atccagtaac caagtattta
     4621 ggcttgactc cacatcaaag aaaatgccat tgtttttaca tgtcctcggt gtttatatct
     4681 aagtctgctt gtctgactta tcaattaaca taataagcat aacccccccc ccccaaaata
     4741 cacagattcc tgtgtacttc gcagggcatt tgtctcttta aagacctgac ttttcactta
     4801 tgtatatgca tgtggagtgt gtgcacttga gtagagatgc cctgggaggc caggggatcc
     4861 caaggcccca tcagaatctt gttttttgtt tttgtttttt tttttaaatg tttaattttt
     4921 tattattaaa ttgtgtatct gcatgttgga atgtgcatat tgagtgcagt gcctgtggaa
     4981 tccaaaagag ggcacctgag cccccagagc cttggttact ggtgtttgtg ggcctcggga
     5041 gctatgtgca agaaaccaca gtgcagtcct ctgccggagc agcaagcact cctaaccact
     5101 gagccatctc ttgagctccc cacctcacag tctgacagtt tgagtcaaac agtgaggagc
     5161 accccacaag ggcagaactg aaaccaaagg agctctgcac agttccccca aaccaactag
     5221 aaagagtacc gagaaatgct tgcatccgag actgcggaag gagttcacat tctgttgtct
     5281 gtctgtctgt ctgtctgtct gttttgaaac agagtctcac tctgtagacc tgaaacttac
     5341 tctgtagacc aggctggcct caaactcaca gagatccacc tacctctgcc tcccaagagc
     5401 tgcgactaaa ggtgtgggcc gtcaccacca ctatccagca agagttccca ttcttaatat
     5461 acaaaacacc ctttcacacc ggagggaaaa aggaaacata atagaataag tcaagtatct
     5521 aaacagatat tctcagaaca agacaaactt gtaaatattt aggataagca acttcgttgt
     5581 ttgttacaga ggtactgtct actaaataaa tcactgtttt tcacctatca cattgacaaa
     5641 agattgaaaa tacagattcc tagggtcagc atgtcagaga agagtacttt cctgtattgt
     5701 ctgtacatcc ttttagaccc cactccaggc aacagctaac aaaatgtaag atgactagat
     5761 agtttgactc gggaattata ttactaagaa tttatcttaa ataaatatta actgtaacat
     5821 gaaacctatt ttaagtacag cttgtgtgta ataggtaaaa tttatagaca cttgctacca
     5881 gaacaaagta aacatttaga gtataccatg aaactttatg aagaaataag tgtgccctga
     5941 ccatagtgaa aatggacagt tccaatttgc tcaaaatggt ttagtacata tggggatatc
     6001 tgagcaagcg tgagttccac actttgtgat gcatgggcat tcgttggagt ggagctagga
     6061 agtagctgag tggtggagac tgcccacaca gaggtctggg tttggttccc agcagatcat
     6121 aacccgggcc tgccaaagtc aaacgcggtg atccttggct acaagctagg ttaaacggat
     6181 aatagaaaca cgaaaaggac tcctaaatcc acgattaact cggaatccca tttactgata
     6241 tctgaatgat gcttggaatc agggaggccc ctctgatggc ttcattttct ccacttttgt
     6301 attcctgaga acgcatcagt agtgactgcc atgcggggct aggtcagaga gcactgtggc
     6361 tggggactga gggttggttt tcatgttatg cttacatcta cgtgtgaaga taataacaga
     6421 attcagggat tcc
//
