LOCUS       NM_028230               2305 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus serine hydroxymethyltransferase 2 (mitochondrial)
            (Shmt2), transcript variant 1, mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_028230
VERSION     NM_028230.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2305)
  AUTHORS   Li,J., Zhang,B., Li,Y., Liu,C., Tang,X., Zhao,J., Pei,X. and Li,Y.
  TITLE     Serine Hydroxymethyltransferase 2 Deficiency in the Hematopoietic
            System Disrupts Erythropoiesis and Induces Anemia in Murine Models
  JOURNAL   Int J Mol Sci 25 (20), 11072 (2024)
   PUBMED   39456851
  REMARK    GeneRIF: Serine Hydroxymethyltransferase 2 Deficiency in the
            Hematopoietic System Disrupts Erythropoiesis and Induces Anemia in
            Murine Models.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2305)
  AUTHORS   Zhou,Y., Kang,L., Xu,R., Zhao,D., Wang,J., Wu,J., Lin,H., Ding,Z.
            and Zou,Y.
  TITLE     Mitochondrial outer membrane protein Samm50 protects against
            hypoxia-induced cardiac injury by interacting with Shmt2
  JOURNAL   Cell Signal 120, 111219 (2024)
   PUBMED   38723737
  REMARK    GeneRIF: Mitochondrial outer membrane protein Samm50 protects
            against hypoxia-induced cardiac injury by interacting with Shmt2.
REFERENCE   3  (bases 1 to 2305)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2305)
  AUTHORS   Song,L., Pan,Q.L., Zhou,G.F., Liu,S.W., Zhu,B.L., Lin,P.J.,
            Hu,X.T., Zha,J.S., Long,Y., Luo,B., Chen,J., Tang,Y., Tang,J.,
            Xiang,X.J., Xie,X.Y., Deng,X.J. and Chen,G.J.
  TITLE     SHMT2 Mediates Small-Molecule-Induced Alleviation of Alzheimer
            Pathology Via the 5'UTR-dependent ADAM10 Translation Initiation
  JOURNAL   Adv Sci (Weinh) 11 (11), e2305260 (2024)
   PUBMED   38183387
  REMARK    GeneRIF: SHMT2 Mediates Small-Molecule-Induced Alleviation of
            Alzheimer Pathology Via the 5'UTR-dependent ADAM10 Translation
            Initiation.
REFERENCE   5  (bases 1 to 2305)
  AUTHORS   Chen,G., Zhou,G., Zhai,L., Bao,X., Tiwari,N., Li,J., Mottillo,E.
            and Wang,J.
  TITLE     SHMT2 reduces fatty liver but is necessary for liver inflammation
            and fibrosis in mice
  JOURNAL   Commun Biol 7 (1), 173 (2024)
   PUBMED   38347107
  REMARK    GeneRIF: SHMT2 reduces fatty liver but is necessary for liver
            inflammation and fibrosis in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2305)
  AUTHORS   Furuya,S., Yoshida,K., Kawakami,Y., Yang,J.H., Sayano,T., Azuma,N.,
            Tanaka,H., Kuhara,S. and Hirabayashi,Y.
  TITLE     Inactivation of the 3-phosphoglycerate dehydrogenase gene in mice:
            changes in gene expression and associated regulatory networks
            resulting from serine deficiency
  JOURNAL   Funct Integr Genomics 8 (3), 235-249 (2008)
   PUBMED   18228065
REFERENCE   7  (bases 1 to 2305)
  AUTHORS   Liu,S.P., Li,Y.S., Chen,Y.J., Chiang,E.P., Li,A.F., Lee,Y.H.,
            Tsai,T.F., Hsiao,M., Huang,S.F. and Chen,Y.M.
  TITLE     Glycine N-methyltransferase-/- mice develop chronic hepatitis and
            glycogen storage disease in the liver
  JOURNAL   Hepatology 46 (5), 1413-1425 (2007)
   PUBMED   17937387
  REMARK    Erratum:[Hepatology. 2008 Feb;47(2):769. Hwang, Shiu-Feng
            [corrected to Huang, Shiu-Feng]]
REFERENCE   8  (bases 1 to 2305)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 2305)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   10 (bases 1 to 2305)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK162421.1 and BY760884.1.
            
            On Nov 10, 2011 this sequence version replaced NM_028230.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and it encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK051207.1, AK162421.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2112              AK162421.1         2-2113
            2113-2305           BY760884.1         497-689
FEATURES             Location/Qualifiers
     source          1..2305
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.51 cM"
     gene            1..2305
                     /gene="Shmt2"
                     /gene_synonym="2700043D08Rik; SHMT"
                     /note="serine hydroxymethyltransferase 2 (mitochondrial)"
                     /db_xref="GeneID:108037"
                     /db_xref="MGI:MGI:1277989"
     exon            1..157
                     /gene="Shmt2"
                     /gene_synonym="2700043D08Rik; SHMT"
                     /inference="alignment:Splign:2.1.0"
     exon            158..355
                     /gene="Shmt2"
                     /gene_synonym="2700043D08Rik; SHMT"
                     /inference="alignment:Splign:2.1.0"
     exon            356..435
                     /gene="Shmt2"
                     /gene_synonym="2700043D08Rik; SHMT"
                     /inference="alignment:Splign:2.1.0"
     exon            436..636
                     /gene="Shmt2"
                     /gene_synonym="2700043D08Rik; SHMT"
                     /inference="alignment:Splign:2.1.0"
     exon            637..718
                     /gene="Shmt2"
                     /gene_synonym="2700043D08Rik; SHMT"
                     /inference="alignment:Splign:2.1.0"
     exon            719..841
                     /gene="Shmt2"
                     /gene_synonym="2700043D08Rik; SHMT"
                     /inference="alignment:Splign:2.1.0"
     exon            842..981
                     /gene="Shmt2"
                     /gene_synonym="2700043D08Rik; SHMT"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1147
                     /gene="Shmt2"
                     /gene_synonym="2700043D08Rik; SHMT"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1247
                     /gene="Shmt2"
                     /gene_synonym="2700043D08Rik; SHMT"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1403
                     /gene="Shmt2"
                     /gene_synonym="2700043D08Rik; SHMT"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1511
                     /gene="Shmt2"
                     /gene_synonym="2700043D08Rik; SHMT"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..2305
                     /gene="Shmt2"
                     /gene_synonym="2700043D08Rik; SHMT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2094..2099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shmt2"
                     /gene_synonym="2700043D08Rik; SHMT"
                     /note="hexamer: AATAAA"
     polyA_site      2111
                     /gene="Shmt2"
                     /gene_synonym="2700043D08Rik; SHMT"
                     /note="major polyA site"
ORIGIN      
        1 ctctttcact cgaacttcac gggggcaatt ttctcgcgca cgcgttctaa gagcagctgg
       61 ttttcgaccc cggtactaca ccgatacaga gttagtggct agtcctcctg tgcctcctgt
      121 agcgatggta tccttctctt tgcttcggac cactcggcct ctgcagagat gtggtcagct
      181 ggtctgcatg gctgcccggg cccagcacag caaggtggcc cagacgcagg ctggggaagc
      241 agctggaggt tggacgggcc aggagagttt atcagacagt gaccctgaga tgtgggagct
      301 tctgcagagg gagaaggaca gacagtgtcg cggcctggag ctcatcgcct cagagaactt
      361 ctgcagccga gctgcgctgg aggccctggg gtcctgtctc aacaacaagt actcggaggg
      421 ttaccctggc aagagatact acggaggagc ggaagtggtg gacgagatcg agctgctctg
      481 ccagcgccgg gccttggaag cctttgacct ggatccggca cagtggggag tcaatgtgca
      541 gccatactca gggtccccag ccaatctggc tgcctatacg gcccttctgc agcctcatga
      601 tcgaatcatg gggttggacc tgcccgatgg gggccatctc acccatggct acatgtctga
      661 tgtcaagcgg atctccgcca catccatttt cttcgagtct atgccctata agctcaatcc
      721 ccaaactggc ctcatcgact acgaccagct ggcgctgacc gctcggcttt tccgaccgcg
      781 gctcatcata gctggcacga gtgcctatgc ccgcctcatt gactatgcac gcatgagaga
      841 ggtctgtgat gaggtcaggg cacacctgct ggcagacatg gcccacatca gtggcctggt
      901 ggctgccaag gtgatcccct cccctttcaa gtacgcggat gttgttacca ccaccactca
      961 caagacactg cgaggggcca ggtcagggct catcttctac cggaagggag tacgaaccgt
     1021 agaccccaag actggcaaag agatccctta tacctttgag gaccgaatca acttcgctgt
     1081 gttcccatcc ctacagggtg gcccccacaa ccacgccatt gctgcagtag ccgtggctct
     1141 caagcaggcc tgcaccccta tgttccgcga gtactcctta caagtgctga ggaacgccca
     1201 ggccatggct gatgccctgc tcaagcgagg atactcgctg gtgtctggtg gcactgacac
     1261 ccacctggtg ctggtggacc tgcggcccaa gggcctggat ggagcccgag ccgaacgcgt
     1321 gttggaactc gtctccatca cagccaacaa gaacacctgt cctggagacc ggagcgccat
     1381 tactccgggg ggcttgaggc ttggggcccc cgcgttgacc tctcgccagt tccgtgagga
     1441 cgacttccgt agagtcgtcg attttatcga tgagggagtc aacattggct tggaggtgaa
     1501 gcgcaagact gccaagctcc aggatttcaa atccttcctg ctcaaagacc cagagacaag
     1561 ccagcgtttg gccaacctcc ggcaacaggt ggaacagttt gccaggggct tccccatgcc
     1621 tggatttgat gaacgttgag gacagttgag gacacctggc ggtcggtcag aagcccacag
     1681 acccggaagt tacctttctt cccgcctccc tggaccatag aagagatgtc actcctctct
     1741 gggttttagt ggagggaggg aggccttcca tttagggcaa gagccaggca taaactccct
     1801 tccagaattt gtagctgaga tttctgatct ttaaccgtgt ctacacgaag cacccagttg
     1861 acatccgact tgtttttgag acgggggtct cacttagctg tgagtggcct tgaactgacc
     1921 cttccacctt catttcccaa gtgctggggt tataggtttg caccatgaca cccgacttcg
     1981 ccctcagctt tccaccccga ccctcccact acatctcaag tgttacagac tcccctcccg
     2041 ctctttcttg gggaagaggg ggtgggtaag cgccctcctt cctgttttta tctaataaaa
     2101 tgctaacctg cccagggttc ctattactgt gggaggggtc ccctgggcca gccagcgatt
     2161 ctactccctc aacgtgtatc tctccttccc tcccaccacc accaggaccc ccggggctgt
     2221 agcctcctct ctgatcagag ccgacaccag acgtgattag caggcgcagc aaattcaatt
     2281 tgttaaatga aattgtattt tgccc
//
