LOCUS       NM_009171               2074 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus serine hydroxymethyltransferase 1 (soluble) (Shmt1),
            mRNA.
ACCESSION   NM_009171
VERSION     NM_009171.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2074)
  AUTHORS   Zhao K, Huang X, Zhao W, Lu B and Yang Z.
  TITLE     LONP1-mediated mitochondrial quality control safeguards metabolic
            shifts in heart development
  JOURNAL   Development 149 (6) (2022)
   PUBMED   35237793
REFERENCE   2  (bases 1 to 2074)
  AUTHORS   Imbard A, Schwendimann L, Lebon S, Gressens P, Blom HJ and Benoist
            JF.
  TITLE     Liver and brain differential expression of one-carbon metabolism
            genes during ontogenesis
  JOURNAL   Sci Rep 11 (1), 21132 (2021)
   PUBMED   34702858
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2074)
  AUTHORS   Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
            Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
            Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
            JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
            Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
            Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
            S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
            Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
            Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
            S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
            Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
            Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
            de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
            SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
            SA.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   4  (bases 1 to 2074)
  AUTHORS   Field MS, Kamynina E, Agunloye OC, Liebenthal RP, Lamarre SG,
            Brosnan ME, Brosnan JT and Stover PJ.
  TITLE     Nuclear enrichment of folate cofactors and
            methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo
            thymidylate biosynthesis during folate deficiency
  JOURNAL   J Biol Chem 289 (43), 29642-29650 (2014)
   PUBMED   25213861
REFERENCE   5  (bases 1 to 2074)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2074)
  AUTHORS   Hackney JA, Charbord P, Brunk BP, Stoeckert CJ, Lemischka IR and
            Moore KA.
  TITLE     A molecular profile of a hematopoietic stem cell niche
  JOURNAL   Proc Natl Acad Sci U S A 99 (20), 13061-13066 (2002)
   PUBMED   12226475
REFERENCE   7  (bases 1 to 2074)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 2074)
  AUTHORS   Szebenyi DM, Liu X, Kriksunov IA, Stover PJ and Thiel DJ.
  TITLE     Structure of a murine cytoplasmic serine hydroxymethyltransferase
            quinonoid ternary complex: evidence for asymmetric obligate dimers
  JOURNAL   Biochemistry 39 (44), 13313-13323 (2000)
   PUBMED   11063567
REFERENCE   9  (bases 1 to 2074)
  AUTHORS   Probst FJ, Chen KS, Zhao Q, Wang A, Friedman TB, Lupski JR and
            Camper SA.
  TITLE     A physical map of the mouse shaker-2 region contains many of the
            genes commonly deleted in Smith-Magenis syndrome (del17p11.2p11.2)
  JOURNAL   Genomics 55 (3), 348-352 (1999)
   PUBMED   10049592
REFERENCE   10 (bases 1 to 2074)
  AUTHORS   Nakshatri H, Bouillet P, Bhat-Nakshatri P and Chambon P.
  TITLE     Isolation of retinoic acid-repressed genes from P19 embryonal
            carcinoma cells
  JOURNAL   Gene 174 (1), 79-84 (1996)
   PUBMED   8863732
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF159149.1, BQ942592.1, BQ832130.1 and AI385541.1.
            
            [WARNING] On Nov 15, 2023 this sequence was replaced by
            NM_009171.3.
            
            On Jun 16, 2005 this sequence version replaced NM_009171.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010439.1, AK132342.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-517               CF159149.1         1-517
            518-1088            BQ942592.1         248-818
            1089-1480           BQ832130.1         201-592
            1481-2074           AI385541.1         1-594               c
FEATURES             Location/Qualifiers
     source          1..2074
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.84 cM"
     gene            1..2074
                     /gene="Shmt1"
                     /gene_synonym="mshmt; mshmt1; mshmt2; Shmt"
                     /note="serine hydroxymethyltransferase 1 (soluble)"
                     /db_xref="GeneID:20425"
                     /db_xref="MGI:MGI:98299"
     exon            1..362
                     /gene="Shmt1"
                     /gene_synonym="mshmt; mshmt1; mshmt2; Shmt"
                     /inference="alignment:Splign:2.1.0"
     exon            363..459
                     /gene="Shmt1"
                     /gene_synonym="mshmt; mshmt1; mshmt2; Shmt"
                     /inference="alignment:Splign:2.1.0"
     CDS             382..1818
                     /gene="Shmt1"
                     /gene_synonym="mshmt; mshmt1; mshmt2; Shmt"
                     /EC_number="2.1.2.1"
                     /note="serine methylase; glycine hydroxymethyltransferase"
                     /codon_start=1
                     /product="serine hydroxymethyltransferase, cytosolic"
                     /protein_id="NP_033197.2"
                     /db_xref="CCDS:CCDS24799.1"
                     /db_xref="GeneID:20425"
                     /db_xref="MGI:MGI:98299"
                     /translation="MADRDATLWASHEKMLSQPLKDSDAEVYSIIKKESNRQRVGLEL
                     IASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDELEMLCQKRALQAYHLDP
                     QCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIF
                     FESMPYKVYPETGYINYDQLEENASLFHPKLIIAGTSCYSRNLDYARLRKIADDNGAY
                     LMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVRSVDPKTGK
                     ETYYELESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTTEFKIYQLQVLANCRALSD
                     ALTELGYKIVTGGSDNHLILMDLRSKGTDGGRAEKVLEACSIACNKNTCPGDKSALRP
                     SGLRLGTPALTSRGLLEEDFQKVAHFIHRGIELTLQIQSHMATKATLKEFKEKLAGDE
                     KIQSAVATLREEVENFASNFSLPGLPDF"
     exon            460..605
                     /gene="Shmt1"
                     /gene_synonym="mshmt; mshmt1; mshmt2; Shmt"
                     /inference="alignment:Splign:2.1.0"
     exon            606..721
                     /gene="Shmt1"
                     /gene_synonym="mshmt; mshmt1; mshmt2; Shmt"
                     /inference="alignment:Splign:2.1.0"
     exon            722..882
                     /gene="Shmt1"
                     /gene_synonym="mshmt; mshmt1; mshmt2; Shmt"
                     /inference="alignment:Splign:2.1.0"
     exon            883..964
                     /gene="Shmt1"
                     /gene_synonym="mshmt; mshmt1; mshmt2; Shmt"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1177
                     /gene="Shmt1"
                     /gene_synonym="mshmt; mshmt1; mshmt2; Shmt"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1294
                     /gene="Shmt1"
                     /gene_synonym="mshmt; mshmt1; mshmt2; Shmt"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1417
                     /gene="Shmt1"
                     /gene_synonym="mshmt; mshmt1; mshmt2; Shmt"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1534
                     /gene="Shmt1"
                     /gene_synonym="mshmt; mshmt1; mshmt2; Shmt"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1645
                     /gene="Shmt1"
                     /gene_synonym="mshmt; mshmt1; mshmt2; Shmt"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..2065
                     /gene="Shmt1"
                     /gene_synonym="mshmt; mshmt1; mshmt2; Shmt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtttagtgga gctccggcct ctgcgcgcca agtttgggtt tcccccggac gtggtgtgtc
       61 acgtggtggg gaggctggtt cccggagcac gtgctgggct gttaggacag cccgctgcgg
      121 ggttccggct ggaggtgttg ctgtggtcac tttccgcgcg ctctccagga attcggcgat
      181 ccacttgcct ctgcctccct agtgctggga ttaaaggcgt gcgccaccac aacgcgttta
      241 gtccctttca taaagaccgg aggaacagac gtttacggcc agctcccgaa accaagtgaa
      301 ctggaggcca ccctgcacca agggttggaa ccttttcaca aaatccacgc tcctaataca
      361 aggcaactct gaaccagtgc aatggcagac agggatgcca ccctgtgggc ttctcatgag
      421 aagatgttgt cgcagcccct caaggacagt gatgccgagg tttacagcat cattaaaaag
      481 gagagcaacc ggcagagggt cggattagag ctgattgcct cggagaattt tgccagccga
      541 gctgtgttgg aggccctggg atcttgctta aataacaaat actctgaggg atatccaggc
      601 caaaggtatt atggcgggac cgagttcatc gatgagctgg agatgctgtg tcagaagcgt
      661 gcattacagg cctaccatct ggatcctcag tgctggggtg tcaatgtcca gccttattca
      721 ggctcccctg caaactttgc tgtgtatact gccctggtag agcctcatgg gcgaatcatg
      781 ggcttggacc tgccagacgg tggccatctg acccatggct tcatgacaga caagaagaaa
      841 atctctgcca catctatctt ctttgaatcc atgccttata aggtgtaccc agagactggg
      901 tacatcaact atgaccagct ggaggagaat gccagcctct tccacccgaa gctgatcatc
      961 gcagggacca gctgctactc ccggaacctg gactacgcac ggctgcggaa gattgcggat
     1021 gataatgggg cgtatctcat ggcagacatg gcacatatca gtgggctcgt ggcagctggg
     1081 gtggtgccct ccccctttga acactgccat gtagtgacca ctacaaccca caagaccctg
     1141 agaggctgcc gtgctggtat gatattctac agaaagggtg tgcgcagtgt ggatcccaag
     1201 actggcaaag agacttacta tgaactggag tccctcatca actctgccgt gttcccaggc
     1261 cttcaggggg gtcctcacaa ccatgccatt gctggtgttg ctgtggccct gaagcaagcc
     1321 atgactacag aattcaaaat ctaccagctc caggtgttgg ccaactgcag ggctctgtct
     1381 gatgcactca cagagctagg ctacaaaata gtcacaggtg gctctgataa tcacttgatc
     1441 ctaatggatc tgcgttctaa gggtactgat ggtggaaggg ctgagaaggt actagaagcc
     1501 tgttctatcg cctgcaacaa gaatacctgc ccaggtgaca agagcgcgtt acggcccagt
     1561 ggactgcgac tggggactcc agcattgaca tcccgaggac ttttggaaga agacttccaa
     1621 aaagtagcac actttatcca cagggggata gagttgacac tgcagattca gagccacatg
     1681 gccacgaagg ccacactgaa agagttcaaa gagaagctgg caggagatga gaagatccag
     1741 agtgctgtgg caactctccg ggaagaagtg gagaactttg cttccaactt ctcactacct
     1801 ggccttcctg acttctgaca ggaacagcct gtgtttgcca agagggtagg attgttccgg
     1861 gaccctgtga accctgtgcc ctcttgaggc tgagaagtgg accactgagc tgtaccatgc
     1921 tttctttggt gggtgtttct gtttacctgt tttcaaatat tttgggaaca ggttattaag
     1981 gacttgaaat ttgaaacgtt atgtagccat tagatctcct cgctcatgca tgtgaggcaa
     2041 agctattaaa gattccagaa ttgtcaaaaa aaaa
//
