LOCUS       NM_028637               1249 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus shieldin complex subunit 1 (Shld1), transcript variant
            2, mRNA.
ACCESSION   NM_028637
VERSION     NM_028637.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1249)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1249)
  AUTHORS   Vincendeau,E., Wei,W., Zhang,X., Planchais,C., Yu,W.,
            Lenden-Hasse,H., Cokelaer,T., Pipoli da Fonseca,J., Mouquet,H.,
            Adams,D.J., Alt,F.W., Jackson,S.P., Balmus,G., Lescale,C. and
            Deriano,L.
  TITLE     SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but
            critical for productive class switch recombination
  JOURNAL   Nat Commun 13 (1), 3707 (2022)
   PUBMED   35764636
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1249)
  AUTHORS   Shinoda,K., Zong,D., Callen,E., Wu,W., Dumitrache,L.C., Belinky,F.,
            Chari,R., Wong,N., Ishikawa,M., Stanlie,A., Multhaupt-Buell,T.,
            Sharma,N., Ozelius,L., Ehrlich,M., McKinnon,P.J. and Nussenzweig,A.
  TITLE     The dystonia gene THAP1 controls DNA double-strand break repair
            choice
  JOURNAL   Mol Cell 81 (12), 2611-2624 (2021)
   PUBMED   33857404
  REMARK    GeneRIF: The dystonia gene THAP1 controls DNA double-strand break
            repair choice.
REFERENCE   4  (bases 1 to 1249)
  AUTHORS   Gupta,R., Somyajit,K., Narita,T., Maskey,E., Stanlie,A., Kremer,M.,
            Typas,D., Lammers,M., Mailand,N., Nussenzweig,A., Lukas,J. and
            Choudhary,C.
  TITLE     DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of
            NHEJ and PARP Inhibitor Sensitivity
  JOURNAL   Cell 173 (4), 972-988 (2018)
   PUBMED   29656893
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL935270.6.
            
            On Jan 12, 2022 this sequence version replaced NM_028637.2.
            
            ##Evidence-Data-START##
            CDS exon combination :: BE288357.1, AW987815.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849375, SAMN00849377 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            inferred exon combination        :: based on alignments, homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AL935270.6         46342-46434
            94-224              AL935270.6         46804-46934
            225-406             AL935270.6         48156-48337
            407-1249            AL935270.6         106419-107261
FEATURES             Location/Qualifiers
     source          1..1249
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 64.74 cM"
     gene            1..1249
                     /gene="Shld1"
                     /gene_synonym="1110034G24Rik"
                     /note="shieldin complex subunit 1"
                     /db_xref="GeneID:73747"
                     /db_xref="MGI:MGI:1920997"
     exon            1..93
                     /gene="Shld1"
                     /gene_synonym="1110034G24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            94..224
                     /gene="Shld1"
                     /gene_synonym="1110034G24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            225..406
                     /gene="Shld1"
                     /gene_synonym="1110034G24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            407..1249
                     /gene="Shld1"
                     /gene_synonym="1110034G24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1229..1234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shld1"
                     /gene_synonym="1110034G24Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1249
                     /gene="Shld1"
                     /gene_synonym="1110034G24Rik"
                     /note="major polyA site"
ORIGIN      
        1 actctgaagg ccttcaagct gagcgcattc actgggagca gcttctacgg tgtaatgata
       61 ggattatctg ctccacgcac ggggtcattg cagagtcatt ctccgttacc tagactactg
      121 caggaacgag tgtctgttgc tcctgggatt gcctgtagaa tccagtaccc cacagattca
      181 agacccagga agggaaacac tagtgttttc ttgtttgttg gttggcttat ggaatcccag
      241 gcagccacac ccagcagcct gtcaggagag agctgtacct tggatctacc cgcggtgtgt
      301 gacaccagca gttatgaagc atcccagaga gtcagccagg gaagcagcaa ctctctgagt
      361 tctctggaat cccatccttt cctttcttct tcgactactg atccagatag caattctcta
      421 aatactgagc aaaaaggctc ctgggactct gagaacttct ggcttgatcc ttcttcgaaa
      481 ggccagttgg agaccaatga agaagaggat ggacttcgga aatccctgga tagattctat
      541 gaagcatttg cccatccact gccaggctct ggggatccgc tctctgcatc tgtgtgtcag
      601 tgcttgtctc agacaatctc tgagctcgag ggccaggaga gccaaaggta tgctctccgc
      661 agtttccaaa tggcccaggt catcttcagc cgggatggct gctctatctt acagcgacat
      721 tccagggaca cacgctttta cccactagag caagaaggca gctctgtaga tgatgaagag
      781 cccaccccag gactgtcaag agaggtcatt cgtttcctct tggagcagac tgtaatgaaa
      841 gactcgtagc tgctgctgat gtgaatgtgg gcagtgctag agaggaagtg ctgttgcctg
      901 gtccccagag tccatgggta catgtgggct tctctggcat ctttctattt ccagctgtta
      961 gccataagct ttgcagttag aggctagctt cagcaacctg gtgatggagt cagtaagcat
     1021 cttggtgtgc tacctcttgc ttaccttggc caaggctgct actgactcaa ttagggttga
     1081 gtcctagccc agcttcttgc cttagtctgt gctcctgagt gctgtcctgg ggacctggcc
     1141 agagctggga ctttggcagg aaatcacttc cctgcttggc ttcatccctt cccccactca
     1201 cctactggtg tctctagggc cttttcttaa taaacttctt atatctgca
//
