LOCUS       NP_082913                206 aa            linear   ROD 11-MAR-2025
DEFINITION  shieldin complex subunit 1 [Mus musculus].
ACCESSION   NP_082913
VERSION     NP_082913.1
DBSOURCE    REFSEQ: accession NM_028637.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 206)
  AUTHORS   Kabrani,E., Rahjouei,A., Berruezo-Llacuna,M., Ebeling,S., Saha,T.,
            Altwasser,R., Delgado-Benito,V., Pavri,R. and Di Virgilio,M.
  TITLE     RIF1 integrates DNA repair and transcriptional requirements during
            the establishment of humoral immune responses
  JOURNAL   Nat Commun 16 (1), 777 (2025)
   PUBMED   39824820
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 206)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 206)
  AUTHORS   Vincendeau,E., Wei,W., Zhang,X., Planchais,C., Yu,W.,
            Lenden-Hasse,H., Cokelaer,T., Pipoli da Fonseca,J., Mouquet,H.,
            Adams,D.J., Alt,F.W., Jackson,S.P., Balmus,G., Lescale,C. and
            Deriano,L.
  TITLE     SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but
            critical for productive class switch recombination
  JOURNAL   Nat Commun 13 (1), 3707 (2022)
   PUBMED   35764636
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 206)
  AUTHORS   Shinoda,K., Zong,D., Callen,E., Wu,W., Dumitrache,L.C., Belinky,F.,
            Chari,R., Wong,N., Ishikawa,M., Stanlie,A., Multhaupt-Buell,T.,
            Sharma,N., Ozelius,L., Ehrlich,M., McKinnon,P.J. and Nussenzweig,A.
  TITLE     The dystonia gene THAP1 controls DNA double-strand break repair
            choice
  JOURNAL   Mol Cell 81 (12), 2611-2624 (2021)
   PUBMED   33857404
  REMARK    GeneRIF: The dystonia gene THAP1 controls DNA double-strand break
            repair choice.
REFERENCE   5  (residues 1 to 206)
  AUTHORS   Gupta,R., Somyajit,K., Narita,T., Maskey,E., Stanlie,A., Kremer,M.,
            Typas,D., Lammers,M., Mailand,N., Nussenzweig,A., Lukas,J. and
            Choudhary,C.
  TITLE     DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of
            NHEJ and PARP Inhibitor Sensitivity
  JOURNAL   Cell 173 (4), 972-988 (2018)
   PUBMED   29656893
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL935270.6.
            
            ##Evidence-Data-START##
            CDS exon combination :: BE288357.1, AW987815.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849375, SAMN00849377 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            inferred exon combination        :: based on alignments, homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..206
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 64.74 cM"
     Protein         1..206
                     /product="shieldin complex subunit 1"
                     /note="uncharacterized protein C20orf196 homolog;
                     RINN1-REV7-interacting novel NHEJ regulator 3"
                     /calculated_mol_wt=22566
     Region          1..204
                     /region_name="DUF4521"
                     /note="Protein of unknown function (DUF4521); pfam15021"
                     /db_xref="CDD:464452"
     Region          27..94
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D112.1)"
     CDS             1..206
                     /gene="Shld1"
                     /gene_synonym="1110034G24Rik"
                     /coded_by="NM_028637.3:229..849"
                     /db_xref="CCDS:CCDS50727.1"
                     /db_xref="GeneID:73747"
                     /db_xref="MGI:MGI:1920997"
ORIGIN      
        1 mesqaatpss lsgesctldl pavcdtssye asqrvsqgss nslssleshp flsssttdpd
       61 snslnteqkg swdsenfwld psskgqletn eeedglrksl drfyeafahp lpgsgdplsa
      121 svcqclsqti selegqesqr yalrsfqmaq vifsrdgcsi lqrhsrdtrf ypleqegssv
      181 ddeeptpgls revirflleq tvmkds
//
