LOCUS       NM_138676               2347 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus Sh3kbp1 binding protein 1 (Shkbp1), mRNA.
ACCESSION   NM_138676 XM_991328
VERSION     NM_138676.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2347)
  AUTHORS   Guo,X., Li,H., Meng,X., Zhao,Z., Zhang,R., Wang,L. and Li,J.
  TITLE     CD8 + T-cell number and function are altered by Shkbp1 knockout
            mediated suppression of tumor growth in mice
  JOURNAL   Mol Immunol 160, 32-43 (2023)
   PUBMED   37343421
  REMARK    GeneRIF: CD8 + T-cell number and function are altered by Shkbp1
            knockout mediated suppression of tumor growth in mice.
REFERENCE   2  (bases 1 to 2347)
  AUTHORS   Liu,Q., Li,H., Yang,M., Mei,Y., Niu,T., Zhou,Z., Zhang,X., He,X.,
            Wang,L. and Li,J.
  TITLE     Suppression of tumor growth and metastasis in Shkbp1 knockout mice
  JOURNAL   Cancer Gene Ther 29 (6), 709-721 (2022)
   PUBMED   34112919
  REMARK    GeneRIF: Suppression of tumor growth and metastasis in Shkbp1
            knockout mice.
REFERENCE   3  (bases 1 to 2347)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2347)
  AUTHORS   Feng,L., Wang,J.T., Jin,H., Qian,K. and Geng,J.G.
  TITLE     SH3KBP1-binding protein 1 prevents epidermal growth factor receptor
            degradation by the interruption of c-Cbl-CIN85 complex
  JOURNAL   Cell Biochem Funct 29 (7), 589-596 (2011)
   PUBMED   21830225
REFERENCE   5  (bases 1 to 2347)
  AUTHORS   Chen,Y. and Li,M.
  TITLE     Interactions between CAP70 and actinfilin are important for
            integrity of actin cytoskeleton structures in neurons
  JOURNAL   Neuropharmacology 49 (7), 1026-1041 (2005)
   PUBMED   16054660
REFERENCE   6  (bases 1 to 2347)
  AUTHORS   Borinstein,S.C., Hyatt,M.A., Sykes,V.W., Straub,R.E., Lipkowitz,S.,
            Boulter,J. and Bogler,O.
  TITLE     SETA is a multifunctional adapter protein with three SH3 domains
            that binds Grb2, Cbl, and the novel SB1 proteins
  JOURNAL   Cell Signal 12 (11-12), 769-779 (2000)
   PUBMED   11152963
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB847999.1 and BC061477.1.
            
            On Jun 27, 2006 this sequence version replaced NM_138676.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061477.1, AF246218.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                BB847999.1         2-48
            48-2347             BC061477.1         1-2300
FEATURES             Location/Qualifiers
     source          1..2347
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 15.88 cM"
     gene            1..2347
                     /gene="Shkbp1"
                     /gene_synonym="B930062H15Rik; Sb1"
                     /note="Sh3kbp1 binding protein 1"
                     /db_xref="GeneID:192192"
                     /db_xref="MGI:MGI:2385803"
     exon            1..138
                     /gene="Shkbp1"
                     /gene_synonym="B930062H15Rik; Sb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..2167
                     /gene="Shkbp1"
                     /gene_synonym="B930062H15Rik; Sb1"
                     /note="SETA binding protein 1"
                     /codon_start=1
                     /product="SH3KBP1-binding protein 1"
                     /protein_id="NP_619617.2"
                     /db_xref="CCDS:CCDS21018.1"
                     /db_xref="GeneID:192192"
                     /db_xref="MGI:MGI:2385803"
                     /translation="MAVATTAVEGVPSRGAPGEVIHLNVGGKRFSTSRQTLTWIPDSF
                     FSSLLSGRISTLKDETGAIFIDRDPTVFAPILNFLRTKELDPRGVHGSSLLHEAQFYG
                     LTPLVRRLQVREELDRSSCGNVLFNGYLPPPVFPVKRRNRHSLVGPQQIGGRPAPVRR
                     SNTMPPNLGNAGLLGRMLDERAPPSPSGQPEEPGMVRLVCGHHNWIAVAYTHFLVCYR
                     LKEASGWQLAFSSPRLDWPIERLALAARVLGGAPGEHDKMVAAATGSEILLWALQAQG
                     GGSEIGVFHLGVPVEALFFVGNQLIATSHTGRIGVWNAVTKHWQVQEVQPITSYDAAG
                     SFLLLGCSNGSIYYVDVQKFPLRMKDNDLLVSELYRDPAEDGVTALSVYLTPKTSDSG
                     NWIEIAYGTSSGVVRVIVQHPETVGSGPQLFQTFSVHRSPVTKIMLSEKHLISVCADN
                     NHVRTWSVTRFRGMISTQPGSTPLASFKILALESVDGLGGCSAGNDIGPYGERDDQQV
                     FIQKVVPNASQLFVRLSSTGQRVCSVRSVDGSPTTAFTVLECEGSRRLGSRPRRYLLT
                     GQANGSLAMWDLTTAMDGLGQTPAGGLTEEELMDQLEQCELSPLASSRGSFPSPSPRT
                     SLTSLHSASSNTSLYGPRGSPSPPQAEARRRGAGSFVDRCQELARGAPELRWPPTPAP
                     RPSTSLGNPLTALKKTLNETSF"
     exon            139..192
                     /gene="Shkbp1"
                     /gene_synonym="B930062H15Rik; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            193..238
                     /gene="Shkbp1"
                     /gene_synonym="B930062H15Rik; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            239..312
                     /gene="Shkbp1"
                     /gene_synonym="B930062H15Rik; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            313..371
                     /gene="Shkbp1"
                     /gene_synonym="B930062H15Rik; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            372..452
                     /gene="Shkbp1"
                     /gene_synonym="B930062H15Rik; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..614
                     /gene="Shkbp1"
                     /gene_synonym="B930062H15Rik; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            615..705
                     /gene="Shkbp1"
                     /gene_synonym="B930062H15Rik; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            706..896
                     /gene="Shkbp1"
                     /gene_synonym="B930062H15Rik; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1012
                     /gene="Shkbp1"
                     /gene_synonym="B930062H15Rik; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1100
                     /gene="Shkbp1"
                     /gene_synonym="B930062H15Rik; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1217
                     /gene="Shkbp1"
                     /gene_synonym="B930062H15Rik; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1388
                     /gene="Shkbp1"
                     /gene_synonym="B930062H15Rik; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1544
                     /gene="Shkbp1"
                     /gene_synonym="B930062H15Rik; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1641
                     /gene="Shkbp1"
                     /gene_synonym="B930062H15Rik; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1820
                     /gene="Shkbp1"
                     /gene_synonym="B930062H15Rik; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1935
                     /gene="Shkbp1"
                     /gene_synonym="B930062H15Rik; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2347
                     /gene="Shkbp1"
                     /gene_synonym="B930062H15Rik; Sb1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2326..2331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shkbp1"
                     /gene_synonym="B930062H15Rik; Sb1"
                     /note="hexamer: AATAAA"
     polyA_site      2345
                     /gene="Shkbp1"
                     /gene_synonym="B930062H15Rik; Sb1"
                     /note="major polyA site"
ORIGIN      
        1 atgcacaccc ggaagtgggt gcgagccggc cggcttgcgg gggggtgggg ctatggccgt
       61 cgcgacgact gcagtggagg gggtcccgag tcggggagca cccggggaag tgattcatct
      121 gaacgtaggg ggcaagcggt tcagtacctc tcgccagacg cttacctgga tcccagactc
      181 cttcttttcc agtcttttga gcggacgcat ctcaaccctg aaagatgaga ccggagctat
      241 cttcatcgac cgggacccca ccgtctttgc ccccatcctt aatttcctgc ggaccaaaga
      301 gttagatccc aggggtgtcc atggttccag cctcctccat gaagcccaat tctacggact
      361 cactccactg gttcgtcgcc tgcaggtgag ggaagagttg gatcgatctt cctgcggaaa
      421 tgtcctcttc aatggttatc tacctcctcc agtgttccca gtgaagcggc gaaaccggca
      481 cagcctggtg gggccccagc aaataggggg acgcccagcc cctgttcgac ggagcaacac
      541 gatgcccccc aacttgggta atgcagggct gctgggccga atgttagatg agagagcacc
      601 tccatcccca tcaggccaac cagaggagcc agggatggtg cgcctggtgt gtggtcacca
      661 caactggatt gctgtggcat atacccactt tctcgtctgt tataggttga aggaagcctc
      721 gggctggcag cttgcattct ccagcccgcg cctggactgg cccatcgagc gcctggctct
      781 tgcggctcgg gtgcttggcg gtgctccggg tgagcatgac aagatggtgg ctgcagctac
      841 tggcagcgag atccttctgt gggccctaca agcacaaggt ggtggctctg agataggtgt
      901 cttccacctg ggtgtgccag tggaggcctt gttctttgtt gggaatcagc tcattgccac
      961 aagtcacaca gggcgcatcg gtgtctggaa cgctgtgacc aagcactggc aggtccagga
     1021 ggtccagcct atcacgagct atgatgcagc cggctccttc ctcctcctgg gctgcagcaa
     1081 tggctccatc tattatgtag atgtgcagaa attccccctg cggatgaagg acaacgatct
     1141 ccttgtcagt gagctctacc gagacccagc agaggatggg gtcaccgccc tcagcgtcta
     1201 cctcaccccc aagaccagtg acagtgggaa ctggattgag attgcctatg gcaccagctc
     1261 cggggtggtg cgggtcattg tgcagcaccc tgagacggtg ggctcgggac cccagctctt
     1321 ccagaccttc agtgtgcacc gcagcccggt cactaagatc atgctgtcag agaagcatct
     1381 tatctctgtg tgtgccgaca acaaccatgt tcggacgtgg tctgtgaccc gctttcgagg
     1441 catgatctcc acccagcctg gttccactcc gctggcatcc ttcaagatcc tggcgctgga
     1501 atctgttgat gggctcggtg gctgcagtgc tggcaatgac attggtccct atggtgaacg
     1561 ggatgaccag caggtgttca tccagaaagt ggtgccaaat gccagtcagc tatttgtgcg
     1621 tctctcttcc actgggcagc gggtgtgttc tgtgcgctcg gtggatgggt ctcccacgac
     1681 tgccttcaca gtgttggagt gtgagggctc caggcggctg ggctccagac cccgacgtta
     1741 cctgctcact ggtcaggcca acggcagcct ggccatgtgg gacctgacca ctgccatgga
     1801 tggcctgggc caaactcctg caggcggcct gacagaagaa gagctgatgg accaactgga
     1861 gcaatgtgag ctgagcccat tggcttcctc tcggggctct ttccccagcc cctcacccag
     1921 gacctctctt accagtctcc actcagcctc cagcaacacc tccctgtatg gccccagagg
     1981 gagccccagc ccaccacagg cagaggcccg tcgccgcggg gcaggaagct tcgtggatcg
     2041 gtgtcaggaa ctggcaaggg gtgcgccaga gctcagatgg ccgccaacac cagcccctcg
     2101 accctccacc agtcttggga atcccctgac agctctcaag aaaactctta acgaaacttc
     2161 cttttgaatc tagccaccaa tgtgccttca tgtggactgg tcccagggga cttggaactg
     2221 gggagggggc ttcctgttgg agccagggcc aggggctcct tggtgtaatc tgtgtcgcca
     2281 ggttcccacc tctctccttt tctaaaagcc aaagccacta tctccaataa aaccgtcact
     2341 gccaaca
//
