LOCUS       NM_001207021            1792 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus shisa family member 8 (Shisa8), transcript variant 1,
            mRNA.
ACCESSION   NM_001207021
VERSION     NM_001207021.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1792)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1792)
  AUTHORS   He,M., Wu,B., Ye,W., Le,D.D., Sinclair,A.W., Padovano,V., Chen,Y.,
            Li,K.X., Sit,R., Tan,M., Caplan,M.J., Neff,N., Jan,Y.N.,
            Darmanis,S. and Jan,L.Y.
  TITLE     Chloride channels regulate differentiation and barrier functions of
            the mammalian airway
  JOURNAL   Elife 9, e53085 (2020)
   PUBMED   32286221
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1792)
  AUTHORS   Farrow,P., Khodosevich,K., Sapir,Y., Schulmann,A., Aslam,M.,
            Stern-Bach,Y., Monyer,H. and von Engelhardt,J.
  TITLE     Auxiliary subunits of the CKAMP family differentially modulate AMPA
            receptor properties
  JOURNAL   Elife 4, e09693 (2015)
   PUBMED   26623514
  REMARK    GeneRIF: This study indicates that AMPAR function is very precisely
            controlled by the cell-type specific expression of the CKAMP family
            members 39, 52 and 59.
            Erratum:[Elife. 2018 Oct 11;7:e42543. doi: 10.7554/eLife.42543..
            PMID: 30306889]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1792)
  AUTHORS   Lin,Q., Donahue,S.L., Moore-Jarrett,T., Cao,S., Osipovich,A.B. and
            Ruley,H.E.
  TITLE     Mutagenesis of diploid mammalian genes by gene entrapment
  JOURNAL   Nucleic Acids Res 34 (20), e139 (2006)
   PUBMED   17062627
REFERENCE   5  (bases 1 to 1792)
  AUTHORS   Hentges,K.E., Yarlagadda,S.P. and Justice,M.J.
  TITLE     Tnfrsf13c (Baffr) is mis-expressed in tumors with murine leukemia
            virus insertions at Lvis22
  JOURNAL   Genomics 80 (2), 204-212 (2002)
   PUBMED   12160734
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC105358.8.
            
            On Jan 5, 2023 this sequence version replaced NM_001207021.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KU707903.1, SRR13422600.1755814.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-915               AC105358.8         5321-6235
            916-1049            AC105358.8         9528-9661
            1050-1196           AC105358.8         10227-10373
            1197-1792           AC105358.8         10577-11172
FEATURES             Location/Qualifiers
     source          1..1792
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15"
     gene            1..1792
                     /gene="Shisa8"
                     /gene_synonym="ckamp39; Orf26"
                     /note="shisa family member 8"
                     /db_xref="GeneID:435145"
                     /db_xref="MGI:MGI:2146080"
     exon            1..915
                     /gene="Shisa8"
                     /gene_synonym="ckamp39; Orf26"
                     /inference="alignment:Splign:2.1.0"
     CDS             392..1591
                     /gene="Shisa8"
                     /gene_synonym="ckamp39; Orf26"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cysteine-knot AMPAR-modulating protein 39;
                     cystine-knot AMPAR modulating protein of 39 kDa; putative
                     protein shisa-8"
                     /codon_start=1
                     /product="protein shisa-8 isoform 1 precursor"
                     /protein_id="NP_001193950.1"
                     /db_xref="CCDS:CCDS56994.1"
                     /db_xref="GeneID:435145"
                     /db_xref="MGI:MGI:2146080"
                     /translation="MERAGARGQRCGRRSHGLPLALRLALLLAGSPSGRAGAPEEQEI
                     AGSGTVAPAGGDRCRGYYDVMGQWDPPFNCSSGVYSFCCGTCGYRFCCHDGPRRLDQS
                     RCSNYDTPAWVQTGRPPARARDTAAPRDPARERSHTAVYAVCGVAALLVLVGIGARLG
                     LERAHSPRARRTVTRTLTELLKQPGPQEPLPPPLGPPLGNCVQVQMGDGVLRGSPHNS
                     TDKKRLNNAPLGSATPGPPRGPRLQGGGSLTLQPDYAKFATLKAAALKATEVAPQDFY
                     QRFPSTETGPRTLPARVPRPPEDLPALLDACPWAPPGYVPPAGPVSSVPYAAWTAGRP
                     ARPLPRSHLVAQVSPAPRRPNHAPRRQFSVEKLPEAFSAQQASFYSSAGRGPRHLSTN
                     SKAEVTV"
     exon            916..1049
                     /gene="Shisa8"
                     /gene_synonym="ckamp39; Orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1196
                     /gene="Shisa8"
                     /gene_synonym="ckamp39; Orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1792
                     /gene="Shisa8"
                     /gene_synonym="ckamp39; Orf26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1762..1767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shisa8"
                     /gene_synonym="ckamp39; Orf26"
                     /note="hexamer: AATAAA"
     polyA_site      1792
                     /gene="Shisa8"
                     /gene_synonym="ckamp39; Orf26"
                     /note="major polyA site"
ORIGIN      
        1 agagcgcggg caccgcggag cgggcggcgg gaagacagag gtgtccggcg acccgccgcc
       61 cggcgcagtc tccaaaagac ccaggccccg cacgccctcc cgggtcagag ggagctgggg
      121 actgtgcagg cgagcactcg ccgcccgcct ccaccgtgcg cagtccgagg tgagccccgg
      181 aggaaaacgc gcccaccgga gatccagccc cgcgtactct acaccgagct cacttgtgtc
      241 tggaaccgca gacgcaccag gaggcgtcgg cggggagact gcgcgggcag ctgggcgacc
      301 gagcgaccgg tcccggaggg ctgggggagc ctggcagagc ggccacgcgc cgagccatgc
      361 gccgggcgca atagcagaag gagcgggctg catggagcgc gctggggcgc ggggacagcg
      421 ctgtggccgg cgctcgcatg ggctcccgct cgcactccga ctggcgctgc tgctggcagg
      481 gtcgccgtcg ggccgcgcgg gggctcccga ggagcaggag atcgcagggt ccggtaccgt
      541 ggcaccggcg ggaggcgacc gctgccgcgg ctattacgac gtgatgggcc agtgggaccc
      601 gcccttcaac tgcagctcgg gcgtctacag cttctgctgc ggcacgtgcg gctaccgctt
      661 ctgttgccac gacggcccgc gccgcctgga ccagagccgc tgctccaact acgacacacc
      721 ggcctgggtg cagactggcc ggccgcccgc ccgcgcccgt gacaccgccg ccccgcgcga
      781 cccggcccgg gagcgcagcc acactgcggt ctacgcggtg tgcggtgtcg ccgctctact
      841 cgtgctggtc ggcatcgggg cgcgcctggg cctggagaga gcgcacagcc cccgcgctcg
      901 gcgcacggtg accaggacac tgacagaact tctcaagcag ccaggtcccc aagaaccact
      961 gcctccgcct ctgggtccac ccttgggtaa ctgcgtccag gtacaaatgg gtgacggtgt
     1021 tctccggggt tccccccaca acagcacaga caagaaacgc ctcaataatg cgcctctggg
     1081 gtccgccaca ccgggacccc cgcgcggccc gaggctgcag ggtggtggca gcctgacgtt
     1141 gcagcctgac tatgccaagt tcgctaccct caaagcagct gcgctcaagg ctacagaggt
     1201 tgcaccccag gacttctatc aacgttttcc ctctacggag acgggcccgc ggaccctccc
     1261 tgcgcgggtc ccgcggcctc cggaggactt gcctgcgttg ctcgacgcct gtccctgggc
     1321 ccctccgggt tacgtacctc cggccggtcc tgtctcgtcg gtcccttatg ccgcctggac
     1381 cgcgggccgc cccgcgaggc cgctcccccg tagccacttg gtggctcagg tctccccagc
     1441 tccccggcgg cccaaccacg cgccacggcg ccagttcagc gtggagaagc tgcccgaggc
     1501 cttcagcgcg cagcaggcga gcttttacag cagcgcgggc agaggacccc ggcacctgag
     1561 caccaacagc aaagccgagg tcacggtcta gaatggaacc attggagcct tctgcagggt
     1621 cctgggcccc aggtcgtgaa attgcactgc aggcttgaat ccaagcagga acaaggacat
     1681 tcagagcctg tggctaaagg gccaaaaggg tagggccagg tgttctgtcc ttgggaatgt
     1741 agggctatcc ttacctgtgt aaataaaccc tctaatgtgg ttcctgtccc aa
//
