LOCUS       NM_001033415            3754 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus shisa family member 3 (Shisa3), mRNA.
ACCESSION   NM_001033415 XM_485619 XM_924109
VERSION     NM_001033415.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3754)
  AUTHORS   Kim,H.T., Yin,W., Nakamichi,Y., Panza,P., Grohmann,B., Buettner,C.,
            Guenther,S., Ruppert,C., Kobayashi,Y., Guenther,A. and
            Stainier,D.Y.R.
  TITLE     WNT/RYK signaling restricts goblet cell differentiation during lung
            development and repair
  JOURNAL   Proc Natl Acad Sci U S A 116 (51), 25697-25706 (2019)
   PUBMED   31776260
REFERENCE   2  (bases 1 to 3754)
  AUTHORS   Murakami,K., Zhifeng,H., Suzuki,T., Kobayashi,Y. and Nakamura,Y.
  TITLE     The Shisa3 knockout mouse exhibits normal bone phenotype
  JOURNAL   J Bone Miner Metab 37 (6), 967-975 (2019)
   PUBMED   31222549
  REMARK    GeneRIF: here appears to be a redundancy in the function of Shisa3
            in bone development, likely with other Shisa family members.
REFERENCE   3  (bases 1 to 3754)
  AUTHORS   Noack,C., Iyer,L.M., Liaw,N.Y., Schoger,E., Khadjeh,S., Wagner,E.,
            Woelfer,M., Zafiriou,M.P., Milting,H., Sossalla,S.,
            Streckfuss-Boemeke,K., Hasenfuss,G., Zimmermann,W.H. and
            Zelarayan,L.C.
  TITLE     KLF15-Wnt-Dependent Cardiac Reprogramming Up-Regulates SHISA3 in
            the Mammalian Heart
  JOURNAL   J Am Coll Cardiol 74 (14), 1804-1819 (2019)
   PUBMED   31582141
  REMARK    GeneRIF: SHISA3 is normally expressed in the developing heart and
            is up-regulated in pathological remodeling.
REFERENCE   4  (bases 1 to 3754)
  AUTHORS   Phua,Y.L., Chen,K.H., Hemker,S.L., Marrone,A.K., Bodnar,A.J.,
            Liu,X., Clugston,A., Kostka,D., Butterworth,M.B. and Ho,J.
  TITLE     Loss of miR-17~92 results in dysregulation of Cftr in nephron
            progenitors
  JOURNAL   Am J Physiol Renal Physiol 316 (5), F993-F1005 (2019)
   PUBMED   30838872
REFERENCE   5  (bases 1 to 3754)
  AUTHORS   Ludtke,T.H., Rudat,C., Wojahn,I., Weiss,A.C., Kleppa,M.J., Kurz,J.,
            Farin,H.F., Moon,A., Christoffels,V.M. and Kispert,A.
  TITLE     Tbx2 and Tbx3 Act Downstream of Shh to Maintain Canonical Wnt
            Signaling during Branching Morphogenesis of the Murine Lung
  JOURNAL   Dev Cell 39 (2), 239-253 (2016)
   PUBMED   27720610
REFERENCE   6  (bases 1 to 3754)
  AUTHORS   Chen,C.C., Chen,H.Y., Su,K.Y., Hong,Q.S., Yan,B.S., Chen,C.H.,
            Pan,S.H., Chang,Y.L., Wang,C.J., Hung,P.F., Yuan,S., Chang,G.C.,
            Chen,J.J., Yang,P.C., Yang,Y.C. and Yu,S.L.
  TITLE     Shisa3 is associated with prolonged survival through promoting
            beta-catenin degradation in lung cancer
  JOURNAL   Am J Respir Crit Care Med 190 (4), 433-444 (2014)
   PUBMED   25036006
  REMARK    GeneRIF: Shisa3 acts as a tumor suppressor by acceleration of
            beta-catenin degradation.  Read More:
            http://www.atsjournals.org/doi/full/10.1164/rccm.201312-2256OC
REFERENCE   7  (bases 1 to 3754)
  AUTHORS   Furushima,K., Yamamoto,A., Nagano,T., Shibata,M., Miyachi,H.,
            Abe,T., Ohshima,N., Kiyonari,H. and Aizawa,S.
  TITLE     Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings
  JOURNAL   Dev Biol 306 (2), 480-492 (2007)
   PUBMED   17481602
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143290.1 and AC123662.13.
            
            On Dec 22, 2011 this sequence version replaced NM_001033415.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143290.1, BC120536.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1711              AK143290.1         2-1712
            1712-3754           AC123662.13        53880-55922         c
FEATURES             Location/Qualifiers
     source          1..3754
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 36.15 cM"
     gene            1..3754
                     /gene="Shisa3"
                     /gene_synonym="D830007B15Rik"
                     /note="shisa family member 3"
                     /db_xref="GeneID:330096"
                     /db_xref="MGI:MGI:3041225"
     exon            1..802
                     /gene="Shisa3"
                     /gene_synonym="D830007B15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             526..1242
                     /gene="Shisa3"
                     /gene_synonym="D830007B15Rik"
                     /note="protein shisa-3 homolog; shisa homolog 3"
                     /codon_start=1
                     /product="protein shisa-3 homolog precursor"
                     /protein_id="NP_001028587.1"
                     /db_xref="CCDS:CCDS19318.1"
                     /db_xref="GeneID:330096"
                     /db_xref="MGI:MGI:3041225"
                     /translation="MGALLAFCLLVGLLRWGPAGAQQPGEYCHGWVDAQGNYHEGFQC
                     PEDFDTQDATICCGSCALRYCCAAADARLEQGGCTNDRGELEHPGITAQPVYVPFLIV
                     GSIFIAFIILGSLVAIYCCTCLRPKEPSQQPIRFSLRSYQTETLPMILTSTSLRAASR
                     QSSTATSSSSTGGSVRRFSFARAEPSCLVPSSPPPYTTGHTIHLTQPSGFLVSPQYFA
                     YPLQQEPPLPGKSCPDFSSS"
     exon            803..3754
                     /gene="Shisa3"
                     /gene_synonym="D830007B15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3727..3732
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shisa3"
                     /gene_synonym="D830007B15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3753
                     /gene="Shisa3"
                     /gene_synonym="D830007B15Rik"
                     /note="major polyA site"
ORIGIN      
        1 agccacccca ggccctctgc acttggccgc gactgggctg tctcccgcct gcgtgacagt
       61 caggggcggg agcggaatta gccgttggtc cccgagacct gcacgtggag agccaagctc
      121 agttcccggc tctgccgggt accgggcgac agcccacgat tgggacattg cccggccctg
      181 gagttggtcg ttcagggctc gacggcccgc aagaatagcg gcctggcccc gggtgctcct
      241 agcgcgatga gcctggctaa aggcggccgc tgcttcagtc gcagcctacg cggtggcctc
      301 ccgcgatccc tggtcccctc accctcgcgc accatgctgt cctccggcca gcggagcccg
      361 cagagcagcc cacgcctcct gcccagccgc tgctaaccca cgagaacgcg ttcttgaccg
      421 ggaggtcaac cggccgcgtg gtgcctcggg gaggcggaac cttggtcccc cggagctccg
      481 gctccgccct cggattctcc agctgccacc gggcgcgggg cggcgatggg ggcgctgctg
      541 gcgttctgtc tgctcgtggg cttgctacgt tggggcccgg cgggcgcgca gcagcctggg
      601 gaatactgcc acggctgggt ggacgcgcag ggcaactatc acgaggggtt ccagtgcccc
      661 gaggacttcg acacgcagga cgccaccatc tgctgcggct cgtgtgcgct gcgctactgc
      721 tgcgcggcag ccgacgccag gttggagcag gggggctgca ccaacgaccg cggagagctg
      781 gagcatcctg gcatcaccgc gcaacctgtc tatgtcccct tcctgatcgt cggctccatc
      841 ttcatcgcct tcatcatttt gggctcttta gtggctatct attgttgcac ctgtttgaga
      901 cccaaggagc cctctcagca gcccatccgc ttctcgctcc gaagctatca gacagagacc
      961 ttgcccatga tcctcacctc caccagcctc agagcagctt ccaggcagtc cagcaccgct
     1021 accagctcca gctccacggg aggatctgtg cggaggttct cctttgccag ggctgagcca
     1081 agctgcctgg tgccctcatc acccccacct tacaccactg gtcacaccat acacctaacc
     1141 caaccgtccg gtttcctggt atcaccccag tattttgcat accctctcca gcaggagccc
     1201 ccattacctg ggaagagctg tccagatttc agttccagtt gacggggcga tggctgtgaa
     1261 taggccacac agggaaacgg cagccagcca ggtggagtgc tgctgtctcg gccaagccac
     1321 gctcacttct gaagagatgt gtggtaaccc accatgctca tggaagaaag ggctggaaag
     1381 actcagcact ttctggtctt gagattcttg gctacaatga caggaggtct gacttagcaa
     1441 tcatggcgaa cgtgacaacc tagtcacctt ttgttaaaat agtcagcagc ttgatgttca
     1501 gtttgcaagt tgaaagaaaa tattttacca gacaattcat ctaccctttg tagaaaaaca
     1561 ccctgtgttc cttttcctga gttgaattgt agtacaaata tatacataaa taaggacata
     1621 cacttaactg taattataaa ggttcactta aaaattaact attaagtaaa ctcgaagggc
     1681 cagtgaacta cctatttata atttttggag caacctaact ataagcaata ttagtatgat
     1741 gagaacagtt acttcttaaa ttaataacaa actttgtttt aaaatatgag ttttcttttt
     1801 ccaaaataca aggtttcact aaccacctgg gaagcttaga gttttaaata taaactcaga
     1861 catgcgctgt aacccagatt aaagttttaa atatctactc agacatgcgt tgcaacccag
     1921 attctaggta aaaacacctc ccccgccaac ctgagggaat atttattgca gactttttgt
     1981 tcagcaatat tagtgtttaa atagaagttg gacaattggg tcttaaaaca tttatttgta
     2041 caaagaatta tatataaacg tgaagatttg taatttaatt tacttaccac attgacggta
     2101 ctaattattt agaagtcata ctgtaatttt gctcgaagtc aaagggaggg gagacattag
     2161 tgtaagcatt cagtattcca cattttatgt gccactgtgt ttgatgtctg gtgacgacac
     2221 ataaggacca ggctagaaaa taaataaata aatttatcca gtttcctgaa ctctatttgg
     2281 ggttttcaaa tcaggattct tgatttgaaa ttcatccagt catctatcac cttcagtatc
     2341 cctgtaccaa gtcaacagag gtagaggagg gttaattggc tcccttgttt tccagttgag
     2401 ggtcagagaa aaccagttcg aaggcattgc tccttagcca ggaagttaga gtggtgccaa
     2461 cttccagtcg cttctctctt ccacatgcaa atctggtctt tcttccaagt attcaagatt
     2521 atataaaaat caacttaaga gataattgga tgtaaagaac aaatgtctga gactgtgctc
     2581 aaacccacac aacgggatca ccatcctggt tgtagtagct cttctgtcct gtttcgttga
     2641 cagttttaag ttaacttccg ctgagttctc tgttctaaca caagtcaagt gcagtgctga
     2701 gcagttgtgt gttaacttat ccaatcctcc aaacaactca gaggtattgt aactaccatc
     2761 ttacaaaatt ggaaacggag gaaaagacta aagtgttcaa ctttctacag caagttaata
     2821 ctggagtcgg tgtgtagaga atgcctcaaa caccagattg gcacctgctt taaaatttat
     2881 ttagcttctt tttgagatag agtgtcccta catagcaagg ctgctctaga actcacgatc
     2941 ccgccgcctc agcacccctg tacccacata ctggggttat ggttgtgtga cgtcataccc
     3001 tgctttaatg tgctgattct tggtcctact aagtgtggtg aatgtttctt attttgtaat
     3061 ctcctttagt tgttgaaaaa atgaattaca ggcaatatac ctgtaattaa aataaaccca
     3121 ttcagtgtgc taatgagagg gagagagagc aagaacaaga gccagaggga gcagcaagag
     3181 tgagagagag tggaaggggg agagagagag agagagacag acagacagac agacagacac
     3241 acagagagag agagagagag agagagagag agagagagag aatcaaagct tcagtagact
     3301 ctgaaggact cacagagagg tgactgagct aatttcaccc tcccataccc agttccacag
     3361 tgcctgctag agtatggaaa tgccccctcc catgctaagc acgattctag tttgtcagtg
     3421 gctgtatttt ctgtttcctg ctgctttgga gaacagaatg cattctttag gcgcaccgat
     3481 gttgagtgac tcaccgagtg ctcacatcta tatttccctg ctgctgtggg attctccaac
     3541 caatcacctg gccatatagt atttaaaact aggatggtgt tgtctatgta atttattgta
     3601 acgtggcatt cagtgacatt gagtcaaatc atatactcat gtacttggcg acacaaaaat
     3661 gtatctttgt acaagccttc tctttggaag ctaagtggct gctaatacta tttatgatct
     3721 taacataata aagccatccc atggtaattt ttag
//
