LOCUS       NM_145463               3164 bp    mRNA    linear   ROD 17-JUL-2024
DEFINITION  Mus musculus shisa family member 2 (Shisa2), mRNA.
ACCESSION   NM_145463
VERSION     NM_145463.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3164)
  AUTHORS   Moreau,M.X., Saillour,Y., Elorriaga,V., Bouloudi,B., Delberghe,E.,
            Deutsch Guerrero,T., Ochandorena-Saa,A., Maeso-Alonso,L.,
            Marques,M.M., Marin,M.C., Spassky,N., Pierani,A. and Causeret,F.
  TITLE     Repurposing of the multiciliation gene regulatory network in fate
            specification of Cajal-Retzius neurons
  JOURNAL   Dev Cell 58 (15), 1365-1382 (2023)
   PUBMED   37321213
REFERENCE   2  (bases 1 to 3164)
  AUTHORS   Matern,M.S., Durruthy-Durruthy,R., Birol,O., Darmanis,S.,
            Scheibinger,M., Groves,A.K. and Heller,S.
  TITLE     Transcriptional dynamics of delaminating neuroblasts in the mouse
            otic vesicle
  JOURNAL   Cell Rep 42 (6), 112545 (2023)
   PUBMED   37227818
REFERENCE   3  (bases 1 to 3164)
  AUTHORS   Kurz,J., Weiss,A.C., Ludtke,T.H., Deuper,L., Trowe,M.O.,
            Thiesler,H., Hildebrandt,H., Heineke,J., Duncan,S.A. and Kispert,A.
  TITLE     GATA6 is a crucial factor for Myocd expression in the visceral
            smooth muscle cell differentiation program of the murine ureter
  JOURNAL   Development 149 (15) (2022)
   PUBMED   35905011
REFERENCE   4  (bases 1 to 3164)
  AUTHORS   Lee,D.R., Rhodes,C., Mitra,A., Zhang,Y., Maric,D., Dale,R.K. and
            Petros,T.J.
  TITLE     Transcriptional heterogeneity of ventricular zone cells in the
            ganglionic eminences of the mouse forebrain
  JOURNAL   Elife 11, e71864 (2022)
   PUBMED   35175194
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3164)
  AUTHORS   Kurz,J., Weiss,A.C., Thiesler,H., Qasrawi,F., Deuper,L., Kaur,J.,
            Rudat,C., Ludtke,T.H., Wojahn,I., Hildebrandt,H., Trowe,M.O. and
            Kispert,A.
  TITLE     Notch signaling is a novel regulator of visceral smooth muscle cell
            differentiation in the murine ureter
  JOURNAL   Development 149 (4) (2022)
   PUBMED   35103284
REFERENCE   6  (bases 1 to 3164)
  AUTHORS   Johansson,P.A., Irmler,M., Acampora,D., Beckers,J., Simeone,A. and
            Gotz,M.
  TITLE     The transcription factor Otx2 regulates choroid plexus development
            and function
  JOURNAL   Development 140 (5), 1055-1066 (2013)
   PUBMED   23364326
REFERENCE   7  (bases 1 to 3164)
  AUTHORS   Goncalves,L., Filipe,M., Marques,S., Salgueiro,A.M., Becker,J.D.
            and Belo,J.A.
  TITLE     Identification and functional analysis of novel genes expressed in
            the Anterior Visceral Endoderm
  JOURNAL   Int J Dev Biol 55 (3), 281-295 (2011)
   PUBMED   21553379
REFERENCE   8  (bases 1 to 3164)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   9  (bases 1 to 3164)
  AUTHORS   Furushima,K., Yamamoto,A., Nagano,T., Shibata,M., Miyachi,H.,
            Abe,T., Ohshima,N., Kiyonari,H. and Aizawa,S.
  TITLE     Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings
  JOURNAL   Dev Biol 306 (2), 480-492 (2007)
   PUBMED   17481602
  REMARK    GeneRIF: Shisa is antagonistic to Wnt and Fgf signalings
REFERENCE   10 (bases 1 to 3164)
  AUTHORS   Filipe,M., Goncalves,L., Bento,M., Silva,A.C. and Belo,J.A.
  TITLE     Comparative expression of mouse and chicken Shisa homologues during
            early development
  JOURNAL   Dev Dyn 235 (9), 2567-2573 (2006)
   PUBMED   16773659
  REMARK    GeneRIF: shisa is expressed throughout embryonic development,
            predominantly in the anterior visceral endoderm, headfolds,
            somites, forebrain, optic vesicle, and limb buds
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY147933.1, AK034905.1 and AA217921.1.
            
            On Aug 21, 2009 this sequence version replaced NM_145463.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034905.1, AK087512.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BY147933.1         1-27
            28-2600             AK034905.1         3-2575
            2601-2815           AK034905.1         2577-2791
            2816-2987           AA217921.1         156-327
            2988-3164           AK034905.1         2964-3140
FEATURES             Location/Qualifiers
     source          1..3164
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 31.49 cM"
     gene            1..3164
                     /gene="Shisa2"
                     /gene_synonym="9430059P22Rik; MAd2; mShisa; shisa; Tmem46"
                     /note="shisa family member 2"
                     /db_xref="GeneID:219134"
                     /db_xref="MGI:MGI:2444716"
     exon            1..1120
                     /gene="Shisa2"
                     /gene_synonym="9430059P22Rik; MAd2; mShisa; shisa; Tmem46"
                     /inference="alignment:Splign:2.1.0"
     CDS             787..1674
                     /gene="Shisa2"
                     /gene_synonym="9430059P22Rik; MAd2; mShisa; shisa; Tmem46"
                     /note="transmembrane protein 46; protein shisa-2 homolog;
                     shisa-like protein 2; shisa homolog 2"
                     /codon_start=1
                     /product="protein shisa-2 homolog precursor"
                     /protein_id="NP_663438.1"
                     /db_xref="CCDS:CCDS27173.1"
                     /db_xref="GeneID:219134"
                     /db_xref="MGI:MGI:2444716"
                     /translation="MWGGRCSPSTSSRHRASLLQLLLAALLAAGARASGEYCHGWLDA
                     QGVWRIGFQCPERFDGGDATICCGSCALRYCCSSAEARLDQGGCDNDRQQGVGEPGRT
                     DREGPDSSAVPIYVPFLIVGSVFVAFIILGSLVAACCCRCLRPKQDPQQSRAPGANRL
                     METIPMIPSASTSRGSSSRQSSTAASSSSSANSGARAPPTRSQTNCCLPEGTMNNVYV
                     NMPTNFSVLNCQQATQIVPHQGQYLHTPYVGYAVQHDSVPMTPVPPFMDGLQPGYRPV
                     QPPFAHTNSEQKMFPAVTV"
     exon            1121..3146
                     /gene="Shisa2"
                     /gene_synonym="9430059P22Rik; MAd2; mShisa; shisa; Tmem46"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3125..3130
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shisa2"
                     /gene_synonym="9430059P22Rik; MAd2; mShisa; shisa; Tmem46"
                     /note="hexamer: AATAAA"
     polyA_site      3146
                     /gene="Shisa2"
                     /gene_synonym="9430059P22Rik; MAd2; mShisa; shisa; Tmem46"
                     /note="major polyA site"
ORIGIN      
        1 tttaagtgag gagcgcggtg cgcagccggg cagtcggagc tggctcgcag ccttgccagg
       61 cgagcgtggg gtgtccgcgc gctcctctgc tcccatagcc cgagggactg aaacttccgt
      121 gggcggctcc caccggagcg cactgccggg ggcgcaccag cgacagggag aaaggagacc
      181 agacgcgggc tgcagtagga gccggggagg gcagcccgct ggcccggcgc ccaacagcag
      241 ccgcgcggcc gccgccagcc gggcgggctc cgggactgca ggggaggtgc gggcactcgc
      301 agcgtcccga gcggtggccg gagccatgag gaccgagcac agagtggcgg aggcagagcg
      361 cagccggccg ctgctgcact tgccgccggg agcactgcgc gcactgcccg cctccttcgc
      421 tgcttctcgc aggggaagtg aatagagggg gaaagcagcc accagctccg gactctgatg
      481 ctgaaacgct ccagccgcgg cctggctcct ggtcggcagc gaggcgtccc ctcgaggatg
      541 cccaaagaag gtcggatcac aagccaagct ttcagaaacg tttcttctgt gatgcccctg
      601 tgaaggccga acctagcagg gacgtggtca ctcgcaagga gggatgactt agaccctggc
      661 tctgcagcct gggcttcgcc tcagagggga gtgttcctca cggaaagccc cagggatcgc
      721 cgaaccataa cttcttgggg gagatctgtg acctctagag acatcaccgg tgcccagggc
      781 agtgccatgt ggggcggacg ctgctcacct tccacctctt ccaggcaccg cgcgtcgctg
      841 ctgcagctgc tgctggccgc gctgctggcg gcgggggcgc gggccagcgg cgagtactgc
      901 cacggctggc tggacgcgca gggcgtctgg cgcatcggct tccagtgccc cgagcgcttc
      961 gacggcggcg acgccaccat ctgctgcggc agctgcgcgc tgcgctactg ctgctccagc
     1021 gccgaggcgc gcctagacca gggcggctgc gacaacgacc gccagcaggg cgtaggggag
     1081 cctggccgga cagaccgaga aggcccagac agctcggcag tccccatcta cgtgccgttc
     1141 ctcatcgttg gctcagtgtt cgttgccttc atcatcctcg ggtctctcgt tgccgcatgc
     1201 tgttgccgat gtctacgtcc aaagcaggat ccccagcaga gcagagcccc aggggccaac
     1261 cgcctgatgg agaccatccc catgattccc agtgccagca cttccagggg ctcatcctct
     1321 cgtcagtcca gcaccgctgc cagctccagt tccagtgcga actcgggggc ccgggctccc
     1381 ccgacgagat cacagaccaa ttgctgcttg cccgagggaa ccatgaacaa tgtgtatgtc
     1441 aacatgccca caaatttctc agtactcaac tgtcagcagg ccacccagat cgtaccccac
     1501 caagggcagt acctgcatac tccatatgta ggctatgccg tacagcatga ctctgtgccc
     1561 atgacgccag tgcctccgtt catggatggc ctgcagcctg gctacagacc agtgcagccc
     1621 ccctttgctc acactaacag tgagcagaag atgttccctg cagtgactgt atagcctgca
     1681 cggcacagat tagactcctt tacgagactg aacaacatgg ggcctgattc ttgcaccaca
     1741 agtctgctca agttggtggt gtacccgccg atgcgcttcc ggatgacgtc attcacctct
     1801 aacctataag gggacatctc cacagcagcg tgtctgtgtg tgtctccaga tgcaaaattg
     1861 aaagccacag cccctggagt tgccacctgt gtcctcaagc gtgtgacaaa agcttgagcc
     1921 ccttaagtgc ccttgaggtg tggctgccag agtcaggggt tgaaggatgt ctttattcct
     1981 ttctgtttca gcggcgggca caggagaatg cccattaccg cccctttacc tgggcttttt
     2041 taaaatcagt gttcaaggct gaaaggagat gtaaattata taattattat gaaaagaagc
     2101 gatcttgaac tccgacccta gtcatgagcc tcaatcatca gaggcatgtc ttaatttcat
     2161 tgtaaaagat atagtctgtc tatttttatg cttttggggg aggggaggct attatgtgct
     2221 tttgttgata accatgtgta gagatcttaa gtgatttttc tacagtacag aaattgaaag
     2281 aaaatgtcca tttctaagga agacattcaa cattctgggg gtggagtggc attgaagcca
     2341 ttcctctcct tttgatggtg tctttttatt tcctggctct acagaagaag caattggatg
     2401 tggtttttgt tttgtttgtt tgtttgtttg ttttccattg aaaacatgag ctgtcatctg
     2461 ctgctctcca agttactttc aactttgcct catgatacag cctggtggtt catttgttct
     2521 gcccagtttt gggatcccct tgtctaaata gtcccaaggg caggaaatta tcaatgggcc
     2581 gatgaagatc agtaaaaaaa caactgtact gaggagatgc tcagataggt tgtccgctgt
     2641 cactgggaca tgaggtggca cttaaacctc aaacgtgaac cactttgcaa atcagaaggc
     2701 ttttttatgc tcttgttatc agatggttta tttttccagc agcaggagct atgaaatcca
     2761 gagaaaagct ccccagggag acatggcatc ccttttctcc tcagccttca acaagctctg
     2821 tgttcactgc caaggtttta atttatcaaa ttcaactgaa tttgtacatt ggttacttat
     2881 ggaaaaagtt taaatacatt gtaagtgaat tttcaactgc tagcaaagcc aaaatttgtt
     2941 aaataactgt gaagtttggt gttttatacc atcctaccca cagcgtcttc ttcttgcctt
     3001 ctgtcatctg tttctcatct catgatgaca gcgataatgt tacattatca atggcaattg
     3061 gtaccaacag ataagaatca aagattttaa taaccaaagc aggagaaaat cattttaaat
     3121 ttttaataaa tattttatgg tgtgaaaaaa aaaaaaaaaa aaaa
//
