LOCUS       NM_009170               2727 bp    mRNA    linear   ROD 05-MAR-2024
DEFINITION  Mus musculus sonic hedgehog (Shh), mRNA.
ACCESSION   NM_009170
VERSION     NM_009170.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2727)
  AUTHORS   Li,M.Y., Yang,X.L., Chung,C.C., Lai,Y.J., Tsai,J.C., Kuo,Y.L.,
            Yu,J.Y. and Wang,T.W.
  TITLE     TRIP6 promotes neural stem cell maintenance through YAP-mediated
            Sonic Hedgehog activation
  JOURNAL   FASEB J 38 (5), e23501 (2024)
   PUBMED   38411462
  REMARK    GeneRIF: TRIP6 promotes neural stem cell maintenance through
            YAP-mediated Sonic Hedgehog activation.
REFERENCE   2  (bases 1 to 2727)
  AUTHORS   Hasselluhn,M.C., Decker-Farrell,A.R., Vlahos,L., Thomas,D.H.,
            Curiel-Garcia,A., Maurer,H.C., Wasko,U.N., Tomassoni,L.,
            Sastra,S.A., Palermo,C.F., Dalton,T.C., Ma,A., Li,F., Tolosa,E.J.,
            Hibshoosh,H., Fernandez-Zapico,M.E., Muir,A., Califano,A. and
            Olive,K.P.
  TITLE     Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF
            Signals Driving Pancreatic Cancer Angiosuppression
  JOURNAL   Cancer Discov 14 (2), 348-361 (2024)
   PUBMED   37966260
  REMARK    GeneRIF: Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT,
            and VEGF Signals Driving Pancreatic Cancer Angiosuppression.
REFERENCE   3  (bases 1 to 2727)
  AUTHORS   Lospinoso Severini,L., Loricchio,E., Navacci,S., Basili,I.,
            Alfonsi,R., Bernardi,F., Moretti,M., Conenna,M., Cucinotta,A.,
            Coni,S., Petroni,M., De Smaele,E., Giannini,G., Maroder,M.,
            Canettieri,G., Mastronuzzi,A., Guardavaccaro,D., Ayrault,O.,
            Infante,P., Bufalieri,F. and Di Marcotullio,L.
  TITLE     SALL4 is a CRL3REN/KCTD11 substrate that drives Sonic
            Hedgehog-dependent medulloblastoma
  JOURNAL   Cell Death Differ 31 (2), 170-187 (2024)
   PUBMED   38062245
  REMARK    GeneRIF: SALL4 is a CRL3[REN/KCTD11] substrate that drives Sonic
            Hedgehog-dependent medulloblastoma.
REFERENCE   4  (bases 1 to 2727)
  AUTHORS   Hall,E.T., Dillard,M.E., Cleverdon,E.R., Zhang,Y., Daly,C.A.,
            Ansari,S.S., Wakefield,R., Stewart,D.P., Pruett-Miller,S.M.,
            Lavado,A., Carisey,A.F., Johnson,A., Wang,Y.D., Selner,E.,
            Tanes,M., Ryu,Y.S., Robinson,C.G., Steinberg,J. and Ogden,S.K.
  TITLE     Cytoneme signaling provides essential contributions to mammalian
            tissue patterning
  JOURNAL   Cell 187 (2), 276-293 (2024)
   PUBMED   38171360
REFERENCE   5  (bases 1 to 2727)
  AUTHORS   Pei,F., Ma,L., Guo,T., Zhang,M., Jing,J., Wen,Q., Feng,J., Lei,J.,
            He,J., Janeckova,E., Ho,T.V., Chen,J.F. and Chai,Y.
  TITLE     Sensory nerve regulates progenitor cells via FGF-SHH axis in tooth
            root morphogenesis
  JOURNAL   Development 151 (2) (2024)
   PUBMED   38108472
  REMARK    GeneRIF: Sensory nerve regulates progenitor cells via FGF-SHH axis
            in tooth root morphogenesis.
REFERENCE   6  (bases 1 to 2727)
  AUTHORS   Cereghini,S., Ott,M.O., Power,S. and Maury,M.
  TITLE     Expression patterns of vHNF1 and HNF1 homeoproteins in early
            postimplantation embryos suggest distinct and sequential
            developmental roles
  JOURNAL   Development 116 (3), 783-797 (1992)
   PUBMED   1363228
REFERENCE   7  (bases 1 to 2727)
  AUTHORS   Martin,G.R., Richman,M., Reinsch,S., Nadeau,J.H. and Joyner,A.
  TITLE     Mapping of the two mouse engrailed-like genes: close linkage of
            En-1 to dominant hemimelia (Dh) on chromosome 1 and of En-2 to
            hemimelic extra-toes (Hx) on chromosome 5
  JOURNAL   Genomics 6 (2), 302-308 (1990)
   PUBMED   2307472
REFERENCE   8  (bases 1 to 2727)
  AUTHORS   Cheng,S.V., Martin,G.R., Nadeau,J.H., Haines,J.L., Bucan,M.,
            Kozak,C.A., MacDonald,M.E., Lockyer,J.L., Ledley,F.D., Woo,S.L. et
            al.
  TITLE     Synteny on mouse chromosome 5 of homologs for human DNA loci linked
            to the Huntington disease gene
  JOURNAL   Genomics 4 (3), 419-426 (1989)
   PUBMED   2523855
REFERENCE   9  (bases 1 to 2727)
  AUTHORS   Kozak,C.A., Gromet,N.J., Ikeda,H. and Buckler,C.E.
  TITLE     A unique sequence related to the ecotropic murine leukemia virus is
            associated with the Fv-4 resistance gene
  JOURNAL   Proc Natl Acad Sci U S A 81 (3), 834-837 (1984)
   PUBMED   6322171
REFERENCE   10 (bases 1 to 2727)
  AUTHORS   Kozak,C.A. and Rowe,W.P.
  TITLE     Genetic mapping of ecotropic murine leukemia virus-inducing loci in
            six inbred strains
  JOURNAL   J Exp Med 155 (2), 524-534 (1982)
   PUBMED   6276492
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK077688.1 and BC063087.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_009170.4.
            
            On Dec 1, 2007 this sequence version replaced NM_009170.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063087.1, AK077688.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849381, SAMN01164133
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2442              AK077688.1         2-2443
            2443-2727           BC063087.1         2432-2716
FEATURES             Location/Qualifiers
     source          1..2727
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 14.39 cM"
     gene            1..2727
                     /gene="Shh"
                     /gene_synonym="9530036O11Rik; Dsh; Hhg1; Hx; Hxl3;
                     M100081; ShhNC"
                     /note="sonic hedgehog"
                     /db_xref="GeneID:20423"
                     /db_xref="MGI:MGI:98297"
     exon            1..641
                     /gene="Shh"
                     /gene_synonym="9530036O11Rik; Dsh; Hhg1; Hx; Hxl3;
                     M100081; ShhNC"
                     /inference="alignment:Splign:2.1.0"
     CDS             339..1652
                     /gene="Shh"
                     /gene_synonym="9530036O11Rik; Dsh; Hhg1; Hx; Hxl3;
                     M100081; ShhNC"
                     /note="sonic hedgehog protein; HHG-1; hemimelic extra
                     toes; short digits; shh unprocessed N-terminal signaling
                     and C-terminal autoprocessing domains"
                     /codon_start=1
                     /product="sonic hedgehog protein precursor"
                     /protein_id="NP_033196.1"
                     /db_xref="CCDS:CCDS19146.1"
                     /db_xref="GeneID:20423"
                     /db_xref="MGI:MGI:98297"
                     /translation="MLLLLARCFLVILASSLLVCPGLACGPGRGFGKRRHPKKLTPLA
                     YKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQR
                     CKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYG
                     MLARLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKD
                     LRPGDRVLAADDQGRLLYSDFLTFLDRDEGAKKVFYVIETLEPRERLLLTAAHLLFVA
                     PHNDSGPTPGPSALFASRVRPGQRVYVVAERGGDRRLLPAAVHSVTLREEEAGAYAPL
                     TAHGTILINRVLASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDGGGGGSIPAA
                     QSATEARGAEPTAGIHWYSQLLYHIGTWLLDSETMHPLGMAVKSS"
     exon            642..903
                     /gene="Shh"
                     /gene_synonym="9530036O11Rik; Dsh; Hhg1; Hx; Hxl3;
                     M100081; ShhNC"
                     /inference="alignment:Splign:2.1.0"
     exon            904..2667
                     /gene="Shh"
                     /gene_synonym="9530036O11Rik; Dsh; Hhg1; Hx; Hxl3;
                     M100081; ShhNC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaagctctc cagccttgct accatttaaa atcaggctct ttttgtcttt taattgctgt
       61 ctcgagaccc aactccgatg tgttccgtta ccagcgaccg gcagcctgcc atcgcagccc
      121 cagtctgggt ggggatcgga gacaagtccc ctgcagcagc ggcaggcaag gttatatagg
      181 aagagaaaga gccaggcagc gccagaggga acgaacgagc cgagcgagga agggagagcc
      241 gagcgcaagg aggagcgcac acgcacacac ccgcgcgtac ccgctcgcgc acagacagcg
      301 cggggacagc tcacaagtcc tcaggttccg cggacgagat gctgctgctg ctggccagat
      361 gttttctggt gatccttgct tcctcgctgc tggtgtgccc cgggctggcc tgtgggcccg
      421 gcagggggtt tggaaagagg cggcacccca aaaagctgac ccctttagcc tacaagcagt
      481 ttattcccaa cgtagccgag aagaccctag gggccagcgg cagatatgaa gggaagatca
      541 caagaaactc cgaacgattt aaggaactca cccccaatta caaccccgac atcatattta
      601 aggatgagga aaacacggga gcagaccggc tgatgactca gaggtgcaaa gacaagttaa
      661 atgccttggc catctctgtg atgaaccagt ggcctggagt gaagctgcga gtgaccgagg
      721 gctgggatga ggacggccat cattcagagg agtctctaca ctatgagggt cgagcagtgg
      781 acatcaccac gtccgaccgg gaccgcagca agtacggcat gctggctcgc ctggctgtgg
      841 aagcaggttt cgactgggtc tactatgaat ccaaagctca catccactgt tctgtgaaag
      901 cagagaactc cgtggcggcc aaatccggcg gctgtttccc gggatccgcc accgtgcacc
      961 tggagcaggg cggcaccaag ctggtgaagg acttacgtcc cggagaccgc gtgctggcgg
     1021 ctgacgacca gggccggctg ctgtacagcg acttcctcac cttcctggac cgcgacgaag
     1081 gcgccaagaa ggtcttctac gtgatcgaga cgctggagcc gcgcgagcgc ctgctgctca
     1141 ccgccgcgca cctgctcttc gtggcgccgc acaacgactc ggggcccacg cccgggccaa
     1201 gcgcgctctt tgccagccgc gtgcgccccg ggcagcgcgt gtacgtggtg gctgaacgcg
     1261 gcggggaccg ccggctgctg cccgccgcgg tgcacagcgt gacgctgcga gaggaggagg
     1321 cgggcgcgta cgcgccgctc acggcgcacg gcaccattct catcaaccgg gtgctcgcct
     1381 cgtgctacgc tgtcatcgag gagcacagct gggcacaccg ggccttcgcg cctttccgcc
     1441 tggcgcacgc gctgctggcc gcgctggcac ccgcccgcac ggacggcggg ggcgggggca
     1501 gcatccctgc agcgcaatct gcaacggaag cgaggggcgc ggagccgact gcgggcatcc
     1561 actggtactc gcagctgctc taccacattg gcacctggct gttggacagc gagaccatgc
     1621 atcccttggg aatggcggtc aagtccagct gaagcccgac gggaccgggc aaggggcggg
     1681 cggggcgggg agcgactgcg aaataaggaa ctgatgggaa agcgcacgga aggagacttt
     1741 taattataag aataattcat aataataata ataatgataa taataataat aataagtagg
     1801 gcagtccaaa gtagactata aggaagcaaa aaccccgggg agttctgttg ttatgtttag
     1861 tttatatatt tttttgaaat ttttcgttat tgtcttatat gggttgtttt tctcctctcc
     1921 tggctattta tttgtttcgt atgaatagat gttttaaaaa tatgaacgga ccttcaagag
     1981 ccttaactag tttgtgtctt ggataattta ttattgtgtg aactgtactc acagtgaggg
     2041 aaagattatt ttgtgaggcc aagcaacctg ctgaaagtct atttttctac atgtcccttg
     2101 tcctgcgttt cagaaggcaa acctccgcat tcctctcctg ctatgctcct gctttcccgc
     2161 aagtgtaaac taaaacctgc tccatggggg tccacaaatt atatttttat acacagaatt
     2221 gtaaattaga tttttgagag atcaatacct aactgaatga catttcattt tttgaaagtg
     2281 taaaatatga aaatatatta ttttaattta actattttcc aatgtaatag ccgtcttctg
     2341 tactgccttc ttggtttgta tttgctttgt aaccgccact ttgtcatgtt cttggaaacc
     2401 aagactgtta acgcacacat atacactttt ttttttgaca gactggaaga actctgttat
     2461 ttttaacttc aaagaattta ttagaaaata atatttttta aaagtgcacc tagcagcgag
     2521 cccacgagga tggagcctgt agtttgtaca gagaaaaaca aggatgtttt tgcattaata
     2581 aactgagaag taactgctgt aaatttacta aaatgtattt ttgaatattt tgtaatagtt
     2641 ttatagaaat aaagcgtgcc acacacaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2701 aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
