LOCUS       NM_001374011            1928 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus Src homology 2 domain containing F (Shf), transcript
            variant 1, mRNA.
ACCESSION   NM_001374011 XM_006499876
VERSION     NM_001374011.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1928)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1928)
  AUTHORS   Yamaguchi-Kabata,Y., Morihara,T., Ohara,T., Ninomiya,T.,
            Takahashi,A., Akatsu,H., Hashizume,Y., Hayashi,N., Shigemizu,D.,
            Boroevich,K.A., Ikeda,M., Kubo,M., Takeda,M. and Tsunoda,T.
  TITLE     Integrated analysis of human genetic association study and mouse
            transcriptome suggests LBH and SHF genes as novel susceptible genes
            for amyloid-beta accumulation in Alzheimer's disease
  JOURNAL   Hum Genet 137 (6-7), 521-533 (2018)
   PUBMED   30006735
  REMARK    GeneRIF: These results, obtained from the integrative approach,
            suggest that LBH and SHF are associated with the Alzheimer's
            disease pathogenesis.
REFERENCE   3  (bases 1 to 1928)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844566.8.
            
            On Sep 6, 2019 this sequence version replaced XM_006499876.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4349890.1,
                                           ERR2680377.1262748.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-501               AL844566.8         114857-115357
            502-643             AL844566.8         124415-124556
            644-850             AL844566.8         126715-126921
            851-991             AL844566.8         128389-128529
            992-1160            AL844566.8         129807-129975
            1161-1280           AL844566.8         130120-130239
            1281-1928           AL844566.8         134465-135112
FEATURES             Location/Qualifiers
     source          1..1928
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.63 cM"
     gene            1..1928
                     /gene="Shf"
                     /note="Src homology 2 domain containing F"
                     /db_xref="GeneID:435684"
                     /db_xref="MGI:MGI:3613669"
     exon            1..501
                     /gene="Shf"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1467
                     /gene="Shf"
                     /note="isoform 1 is encoded by transcript variant 1; SH2
                     domain-containing adapter protein F"
                     /codon_start=1
                     /product="SH2 domain-containing adapter protein F isoform
                     1"
                     /protein_id="NP_001360940.1"
                     /db_xref="GeneID:435684"
                     /db_xref="MGI:MGI:3613669"
                     /translation="MLLSGAPPTGSGPGPRAQGSAGGGPGGSRRGAGGAGTGPGGGGS
                     GGVAKWLREHLGFRGGGGGGGAKPAPPEPDYRPPAPCPAAPPAPPPDILAAYRLQRDR
                     DFEDPYSGGPSASAALSTPAVPGPTPPPRHGSPPHRLIRVETPGPPAPPPDSGPPASS
                     DRLAILEDYADPFDVQETGEGSGGTSGAPGKVPENDGYMEPYEAQKMMAEIRGSKETA
                     AQPLPLYDTPYEPEDEGASPEGEGTPWPRESRLPEDDERPPEEYDQPWEWKKERISKA
                     FAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEGSENC
                     LSPGREEKGRLPPRLSAGNPKSAKPLGMEPSSPLGEWTDPALPLENQVWYHGAISRTD
                     AENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFS
                     SVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL"
     exon            502..643
                     /gene="Shf"
                     /inference="alignment:Splign:2.1.0"
     exon            644..850
                     /gene="Shf"
                     /inference="alignment:Splign:2.1.0"
     exon            851..991
                     /gene="Shf"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1160
                     /gene="Shf"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1280
                     /gene="Shf"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1928
                     /gene="Shf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1885..1890
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shf"
                     /note="hexamer: TATAAA"
     polyA_site      1928
                     /gene="Shf"
                     /note="major polyA site"
ORIGIN      
        1 agttgggagg gccccatgct actgagcgga gctcctccta cgggctccgg cccggggccg
       61 agggcgcagg gcagcgcggg gggcggccct gggggatccc gccgcggggc tgggggtgcg
      121 gggaccggcc cgggaggggg cggcagcggt ggagtcgcaa agtggctgcg ggagcacctg
      181 ggctttcgcg ggggcggcgg tggagggggc gccaaacccg cccccccaga gcccgactac
      241 cgccccccag ctccctgccc ggccgcgccc cctgcgccgc ccccggacat cctggccgcc
      301 taccggctgc agcgagaccg cgacttcgag gacccctact ccgggggccc gtccgcgtcc
      361 gccgcccttt ccacccctgc ggtccctggc cccactccgc ccccgcgcca cggctcaccc
      421 ccgcaccgcc tcattcgggt cgagaccccc ggccccccag caccccctcc ggactccgga
      481 ccccctgcca gcagcgacag gttggcaatc ctagaggact atgcggaccc atttgatgtt
      541 caggagactg gtgaaggctc aggagggact tcaggagccc cggggaaggt ccctgagaat
      601 gatggctaca tggagcccta cgaggcccaa aagatgatgg ctgagatccg gggttctaag
      661 gagactgcag ctcaacccct acctctctat gacacaccct atgagccaga agatgagggg
      721 gccagcccag aaggtgaggg gactccctgg cccagggagt cgcgcctgcc agaggatgac
      781 gagaggcctc cagaagagta tgaccagccc tgggagtgga agaaggaacg gatttccaaa
      841 gcctttgctg ttgacataaa ggtcatcaaa gacctacctt ggcctccgcc ggtgggacag
      901 ctggacagca gcccctccct gcctgacggg gacagggaca tctccggtcc agcttcaccc
      961 ctccctgagc ccagcctgga ggacagcagc gcccagtttg aaggatcgga gaactgcctg
     1021 tcacctggcc gggaggagaa ggggcggcta cctcccaggc tatctgctgg gaaccccaag
     1081 tcagccaagc ccctaggcat ggaacccagc agccccctgg gggagtggac agatccagca
     1141 ctgcctctgg aaaaccaggt ctggtaccac ggggccatca gccgaacaga tgccgagaac
     1201 ctgctcaggc tgtgcaaaga ggccagctac ctggtgcgca acagtgagac cagcaaaaat
     1261 gacttctctc tctccctcaa gagcagtcag ggcttcatgc acatgaagct gtcccggact
     1321 aaggaacaca agtatgtgtt gggccagaac agcccaccct tcagcagcgt ccctgaaatc
     1381 gtgcaccact atgccagccg caagctgccc attaagggag cggaacacat gtccctgctc
     1441 taccctgtgg ccatccggac tctgtagatg tgagaccagg gcactatgat agacctggac
     1501 ccagtccttg tcacctgcac gggggcagcg gttcttacca aggacatgat gtcagaaacc
     1561 tggcttcccc ttgtcctagg atctagcagg cgctgaagat tccttaattt attataaagg
     1621 ggagggaatc ctgggccttg gaataaaggg actgtgtgga gctgggcacc gaggagagcc
     1681 tgaggaggaa ggggtctccc cgccccagtc agacactagg gagggagtgg cgacctccct
     1741 cccgcaccac ccaccctccg catcctccct tctccccgtc cccagcgggc cgcccgggct
     1801 ccgggccaga ggctcggcca ggcagagctg cggctgccgg cgccgcccag gggctgccgg
     1861 gagggggcgg ggagcgagcc cgactataaa ttgaggctgg agccgacgcc ggccgcctgc
     1921 gaaaagca
//
