LOCUS       NM_172530               5751 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus src homology 2 domain-containing transforming protein
            E (She), transcript variant 1, mRNA.
ACCESSION   NM_172530
VERSION     NM_172530.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5751)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   2  (bases 1 to 5751)
  AUTHORS   Takase,H., Matsumoto,K., Yamadera,R., Kubota,Y., Otsu,A.,
            Suzuki,R., Ishitobi,H., Mochizuki,H., Kojima,T., Takano,S.,
            Uchida,K., Takahashi,S. and Ema,M.
  TITLE     Genome-wide identification of endothelial cell-enriched genes in
            the mouse embryo
  JOURNAL   Blood 120 (4), 914-923 (2012)
   PUBMED   22535667
REFERENCE   3  (bases 1 to 5751)
  AUTHORS   Oda,T., Kujovich,J., Reis,M., Newman,B. and Druker,B.J.
  TITLE     Identification and characterization of two novel SH2
            domain-containing proteins from a yeast two hybrid screen with the
            ABL tyrosine kinase
  JOURNAL   Oncogene 15 (11), 1255-1262 (1997)
   PUBMED   9315092
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102392.8.
            
            On Aug 24, 2022 this sequence version replaced NM_172530.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157580.1, AK034662.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-744               AC102392.8         92861-93604         c
            745-871             AC102392.8         90694-90820         c
            872-1177            AC102392.8         75291-75596         c
            1178-1319           AC102392.8         73214-73355         c
            1320-1439           AC102392.8         72478-72597         c
            1440-5751           AC102392.8         66122-70433         c
FEATURES             Location/Qualifiers
     source          1..5751
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.19 cM"
     gene            1..5751
                     /gene="She"
                     /gene_synonym="9430022A14"
                     /note="src homology 2 domain-containing transforming
                     protein E"
                     /db_xref="GeneID:214547"
                     /db_xref="MGI:MGI:1099462"
     exon            1..744
                     /gene="She"
                     /gene_synonym="9430022A14"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1623
                     /gene="She"
                     /gene_synonym="9430022A14"
                     /note="isoform 1 is encoded by transcript variant 1; Src
                     homology 2 domain containing E; SH2 domain-containing
                     adapter protein E"
                     /codon_start=1
                     /product="SH2 domain-containing adapter protein E isoform
                     1"
                     /protein_id="NP_766118.3"
                     /db_xref="CCDS:CCDS17518.1"
                     /db_xref="GeneID:214547"
                     /db_xref="MGI:MGI:1099462"
                     /translation="MRRPPAPGAPRCLSWASSLFCSAASTLPGPLMAAKWFKEFPLTL
                     KTASERARPGGAGGKPRKNSETGGAAPTPGKGRKNSAAELGASKASSGPPKDSRLSRD
                     SLQGLIQAAAGKGRKNSRVTATATEEEPHRGAVTKSAGCSTYISRLIKVDTQEKNGKS
                     AYPGGGSTSSSSSSSSSASSSPSSLGPELDKAKIMRQQDTVIILEDYADPYDAKRTKG
                     QRDAERVGENDGYMEPYDAQQMITEIRRRGSKDPLVKALQLLDGPSEPGETVKVEATA
                     KRRSSKDLLGKPPQLYDTPYEPSEGGQRVAEVKTRPADSRLPEEDDRPAAEYEQPWEW
                     KREQIARALSVQFEGSDRPPGREDAGRPHHWQKTLKPTLSDHGDGEKVDPGLALEKQP
                     WYHGSISRAEAESRLQPCKEAAYLVRNSESGNSKYSIALKTSQGCVHIIVAQTKDNKY
                     TLNQTSAVFDSIPEVVHYYSNAKLPFKGAEHMTLLHPVHKLH"
     exon            745..871
                     /gene="She"
                     /gene_synonym="9430022A14"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1177
                     /gene="She"
                     /gene_synonym="9430022A14"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1319
                     /gene="She"
                     /gene_synonym="9430022A14"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1439
                     /gene="She"
                     /gene_synonym="9430022A14"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..5751
                     /gene="She"
                     /gene_synonym="9430022A14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5728..5733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="She"
                     /gene_synonym="9430022A14"
                     /note="hexamer: AATAAA"
     polyA_site      5751
                     /gene="She"
                     /gene_synonym="9430022A14"
                     /note="major polyA site"
ORIGIN      
        1 agccccaagc ggtggagcgc agagaacacg gcggtccgat cactgcgccc gtctagcttc
       61 gggccgagcg ggtgccaccc tgccaggcgc gcgcgtctag cggcccggag cctcgcggcg
      121 gcctccagcg tccagccccg gggaatgcgg cggcccccgg cccctggcgc cccacggtgt
      181 ctcagctggg cctcctcact cttctgctcc gcggcctcga cgctcccggg ccccctgatg
      241 gcggcgaaat ggttcaagga gttcccgctt actctgaaga ccgcgtcgga gcgcgcccgg
      301 cccgggggcg ccggcggcaa gccgcgcaag aactcggaga ctggcggcgc ggcgcccacc
      361 ccgggcaagg gccggaagaa ctcagcggcc gagctggggg ccagcaaggc gagcagcgga
      421 cccccaaagg acagtcggct gtcccgggac agcctgcagg gtctgatcca ggccgctgct
      481 ggcaaaggcc gtaagaactc ccgggtcacc gccaccgcca ccgaggagga gccccaccgt
      541 ggcgcggtga ccaagagcgc gggctgcagc acctacatca gtaggctcat caaggtggac
      601 acgcaggaga agaatgggaa gagcgcctac ccgggcggtg gcagcaccag cagctccagc
      661 agctcctctt cctctgcgtc ctcttccccg tcctccctgg gccctgagct ggacaaggcc
      721 aagataatga gacagcaaga cacggtcatc attttagagg actacgctga cccgtatgat
      781 gccaaacgga cgaaaggtca aagggatgcg gagagagtgg gtgagaacga cggctacatg
      841 gaaccgtacg atgcacaaca gatgataaca gaaatcagac gccgtggttc caaagatccc
      901 ctggtgaagg ccctccagtt gcttgatggc ccgagtgaac caggggagac tgtgaaggtg
      961 gaggccacag ccaagagacg cagctccaag gacctgctgg ggaagccgcc acaactctat
     1021 gacaccccgt acgagccttc ggagggtggc caacgtgtgg cagaggtgaa gacgcggcca
     1081 gcagacagca ggctaccaga ggaggatgat cggcccgctg ctgagtatga acagccctgg
     1141 gagtggaaga gggagcagat cgcgagagcc ctgtcagtcc agtttgaggg atctgatcga
     1201 cctccgggca gagaggatgc agggagaccg caccactggc agaagacctt gaagccgacc
     1261 ctgtcagacc acggtgatgg ggagaaggtg gacccaggcc tggccctgga aaaacaacct
     1321 tggtatcacg gctccatcag ccgagctgag gccgagagcc gactacagcc ctgcaaagaa
     1381 gccgcttacc tggtccggaa cagtgagtca gggaacagca agtattccat tgcactgaag
     1441 acgagtcaag ggtgtgtcca catcatagtg gctcagacaa aagacaacaa atacacactg
     1501 aaccagacga gcgctgtgtt tgacagcatc cctgaagtgg tacactatta ctccaatgca
     1561 aagctgcctt tcaaaggagc agagcacatg acccttctcc atccagtgca caagctccac
     1621 taaagtcggc cagcaagagc ccgggcacct gtgaggcctt cagcacccaa caacatcatg
     1681 tggacaggac tcgctgctgc tgctgcagac caggagtcgg cgcctagaag tcaagcggtc
     1741 tgtggtctta aatccaggac acagtggttt ctgacctgtt ctttctctcc ctactacaag
     1801 aaagtattgc ttgcctgcca ccttctccct tgggctagga gttctgtttg gagtgtgagc
     1861 cttaggaagg ttagatccag agcccaggag cactgagctt agcccttggc tgttctctgg
     1921 catgcctggc ctctgcacaa cagagaaccc ctaggccttt atgagtgact gctaggctgg
     1981 aagatcctgc cagtgtgagc cctttgtgag gaagtggatg gacggtggga aacaggaacg
     2041 atgggcagga aagctgtctt tctccacgtc ctgatgcagc tgtggccttc acacagcatt
     2101 cacaacctga ggacttcaca agagtattat ttggttggct ctcctaagta cttgctttct
     2161 caatttctct ggacatctct atccttctgc agtaaatcag tgatatgagc agaaattgga
     2221 cggaggcccc cagatgaaag tgttaccagt gtaatcaaga ggtggcatcc tttctataac
     2281 tctgatcgtt attaagtgca ctccaaagat ttgatttctg atttaaaaaa aaaattctac
     2341 agagctcaac acctgttttg ttattggata attacatagc actcgagaca gcctttttct
     2401 ttgtggtttt tttgtttttg tttttttttg tttttttgca tgaaatcatc tttaagattc
     2461 ctttctgaaa ttagatttgc tttgtaattt ttggcaaaaa atttttacaa caaaattggg
     2521 atcccattgt atgaactgag tcgctggtct gaaaagattg cccctgatgt acagacagaa
     2581 caagccaata tgtgccttac agaaacattt tgaacaatat tgtagtctga ggctgtctct
     2641 tctgctctct aggacactaa atcatcgcat gcttatccgt gatctgtgta ctgtagggaa
     2701 tcccacagga ggggcacgct gtgtgtaggt gctagtggga atgggctgga ccagaaccag
     2761 aggaacattt cgtgttcagg tttataaact ggatctcaag actgttccac cctcagtgga
     2821 aactgaaggt ttgtagcttc tcagatgcac aaaaaaatat taaccataaa ttgggtgtgg
     2881 tggcatacac ctttaatccc agcacccggc aaaggtaggt gggtctttgt gagtttaagg
     2941 tcagcctggt ctacagagtt gcaggacagc tagggctgca cagagaaacc ctgtcttgaa
     3001 aatctaaaac aacacaaaaa ccaccaccaa caaaacatct ggtcagatgt cttagggaag
     3061 catagcccca tcctcggctc cctcacccgg ccatcctgac tgaaatgtag gaagactttt
     3121 gctcctgtgt cagcggacct tagccaaagg gttgtgcgag attttgtttt aaaaggctga
     3181 aagggacttc tcctcagtgg agcacagtgg cctgcacgaa ggctgttctc acagcactga
     3241 caatcatttt ggcttctatg tgtagtgcag ggctctcggt ttaagttttc agtagccaca
     3301 attccgccca gcaaatgtca gtcatcatgt attaccttgt atctgtgcat tgttcactgt
     3361 gttgaaccta gtttagctca gcattctagc catgaagcct tatttttttg cttagccctc
     3421 cctattcagc aaatggagcc gttgtcttta atggtaagaa tatcataaaa tgtttctggg
     3481 tggggaagga tttgggcaca cgcctcatga ctctgatgaa caccggcctg gcaggtcggt
     3541 gtcacctggc ctctgccaca cgcctgagcg tgctccctcc atatttgctt tacatgagtg
     3601 aaagtggagg agacagagtt tatatatagt ccagtcttca tggtagggca tggggctata
     3661 aaaagcaaaa atactgtaga ctagtggaag gccagtgagg gagatgttaa agctgctatt
     3721 ttcttcttag gttgtgacac aagctgacag gagccagggg actcacagct gggtggtagc
     3781 ataaagtacc ctatcctacc gtgctaaaaa caattaagcg cagcagggtg tcctaaccac
     3841 tcactggtga gcctgccagc tggggcttgt cctccgagct ccaaaagatt gagctttttg
     3901 tccttttctt cctgataaag gtattttctt gttatcttta ttcctttgaa ttgattctgt
     3961 ctgggggggg ggtgtttctt ctggtgaacc ctcaagatgc tgtgaacatc tatagcatct
     4021 agagagctgt ccactttttc tcctttagca aaacttattt gtaaaaaaac tgctttcttt
     4081 gttccagagt atggacttag acagggaccc ctgagaacgg aaggcatctg taatccatcc
     4141 agctgtccag gaggtccaag agtccaaaac taaccttggc aatagagcaa gggtgtctcc
     4201 aaaaagaata caggaaggca aagggcattt ctacttcctg taatagcata gcagattctg
     4261 tccagatgta ttctaatcac tgtctgaggg ggcgctggcc agtaggatgt gctgaggagg
     4321 cagagacagg aggagttgaa ttagaggtta ctcttgggtt acaccttggg ccaaagaaat
     4381 ggctcagagg tggaaaatgc tgcacttgta gaagaccctg gttagttcca gtatccacat
     4441 gctgtccagg tctaggggat ctggcgccct cttctggctt ctgagggtac tgggcaggaa
     4501 catggtacac atacaagcaa aacattcatg cacataaact ttttaaaaac ctgaatgaag
     4561 gaatagaaac aatggaggaa gtctagtgag tatgcacaaa agcaagtggt ggtaaagaaa
     4621 caggtgtccc ttccggttac tgagaatgct ttaataggca tctgtaagaa cagcctgtat
     4681 tgttggccgt ttagagtctg cgtctgtggt gctggagttc agtcactggt ctctgccaca
     4741 ggaaggggag ctgggcagag aaccagtagg gaaagctggc tcttctcaac acaggtccta
     4801 ccttaatagt ccttgtttgg tgtttagatt atttaccagt gttgcccctg ttggataggt
     4861 cttaatgttt aattcaagaa caactgtaag tcattctttg cttactagat gagtctgtta
     4921 acattttcgt taggagctaa tgacttattt ttcctggcct cagtcaagaa gccagtgcat
     4981 ctagattcat gccccctgta catgcttctg aaacttagga tttcattgct cccttcctgg
     5041 gaccagacag ccattggtcg tctttctgtc ttctgtagcc agcacccatt taaccgtaaa
     5101 ctcccttggg atcaatcttt tgtcttctct ttgccaccta catcccacta acttggcctt
     5161 gaagaaactt gacctgtaag agccttccct gtaatttagc ttcccggctt catggaccct
     5221 atgcaatgaa agatggtgtt ctactgccat ctactgggac aagaaaaaaa ctgcagttga
     5281 gaaacaaggg tgcatttagg gtagtttgtc tcaaggattt ttgatacagt ccataaatca
     5341 aaataaacga tgacacagca gttgccatct tgaaatgtgc cctttactgt agaaagggtg
     5401 ttttgactcc tagtcttccc ctggacctag gctgggtcat gttgttcaca attttaattc
     5461 tatttttgaa gactgctctg tcaacagatc attgaggcag gaatcattct gttaagctct
     5521 tagctgttcc aaatgctgtc aggaggattt tacatttaaa atatcaactg atacgtcatt
     5581 ttaacttttt aaaatattta aaaggttgta atgcaggtgc cttggcaatt gttattataa
     5641 tggaatctta taaattgttg gctctcttca ccggtcagcg tagctgtgtg ccttccggaa
     5701 gatggtttac cctgaagtgt tactttcaat aaatgctttg ccaggaaaac a
//
