LOCUS       NM_001410672            1678 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus src homology 2 domain-containing transforming protein
            D (Shd), transcript variant 10, mRNA.
ACCESSION   NM_001410672
VERSION     NM_001410672.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1678)
  AUTHORS   Chern,T., Achilleos,A., Tong,X., Hill,M.C., Saltzman,A.B.,
            Reineke,L.C., Chaudhury,A., Dasgupta,S.K., Redhead,Y., Watkins,D.,
            Neilson,J.R., Thiagarajan,P., Green,J.B.A., Malovannaya,A.,
            Martin,J.F., Rosenblatt,D.S. and Poche,R.A.
  TITLE     Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin
            metabolism and ribosomopathy
  JOURNAL   Nat Commun 13 (1), 134 (2022)
   PUBMED   35013307
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1678)
  AUTHORS   Ritter,N., Ali,T., Kopitchinski,N., Schuster,P., Beisaw,A.,
            Hendrix,D.A., Schulz,M.H., Muller-McNicoll,M., Dimmeler,S. and
            Grote,P.
  TITLE     The lncRNA Locus Handsdown Regulates Cardiac Gene Programs and Is
            Essential for Early Mouse Development
  JOURNAL   Dev Cell 50 (5), 644-657 (2019)
   PUBMED   31422919
REFERENCE   3  (bases 1 to 1678)
  AUTHORS   Oda,T., Kujovich,J., Reis,M., Newman,B. and Druker,B.J.
  TITLE     Identification and characterization of two novel SH2
            domain-containing proteins from a yeast two hybrid screen with the
            ABL tyrosine kinase
  JOURNAL   Oncogene 15 (11), 1255-1262 (1997)
   PUBMED   9315092
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154235.2 and CT009719.10.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784645.947878.1,
                                           ERR3363658.4308568.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               AC154235.2         209966-210188
            224-709             AC154235.2         210860-211345
            710-815             AC154235.2         212277-212382
            816-992             AC154235.2         212466-212642
            993-1101            AC154235.2         213377-213485
            1102-1221           AC154235.2         213723-213842
            1222-1678           CT009719.10        20352-20808
FEATURES             Location/Qualifiers
     source          1..1678
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.09 cM"
     gene            1..1678
                     /gene="Shd"
                     /note="src homology 2 domain-containing transforming
                     protein D"
                     /db_xref="GeneID:20420"
                     /db_xref="MGI:MGI:1099461"
     exon            1..223
                     /gene="Shd"
                     /inference="alignment:Splign:2.1.0"
     exon            224..709
                     /gene="Shd"
                     /inference="alignment:Splign:2.1.0"
     exon            710..815
                     /gene="Shd"
                     /inference="alignment:Splign:2.1.0"
     CDS             782..1462
                     /gene="Shd"
                     /note="isoform 6 is encoded by transcript variant 10; SH2
                     domain-containing adapter protein D"
                     /codon_start=1
                     /product="SH2 domain-containing adapter protein D isoform
                     6"
                     /protein_id="NP_001397601.1"
                     /db_xref="GeneID:20420"
                     /db_xref="MGI:MGI:1099461"
                     /translation="MEPYDARSVSSEQPSRAVQLYDTPYEEQATKPEDGGSSGQSRRP
                     LEDERPADEYDQPWEWKKDHISRAFAVQFDGPDWERTPCSTKEPWRPQPAERVDTALA
                     LEKQPWFHGPLSRAEAENLLSLCKEGSYLVRLSETRAQDCILSLRSNQGSMHLKFART
                     RENQVVLGQHSGPFPSIPELVLHYSARPLPVQGAEHLALLYPVTSSQSSQGPCTLAAK
                     PERGQGDP"
     exon            816..992
                     /gene="Shd"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1101
                     /gene="Shd"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1221
                     /gene="Shd"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1678
                     /gene="Shd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1651..1656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shd"
                     /note="hexamer: AATAAA"
     regulatory      1660..1665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shd"
                     /note="hexamer: AATAAA"
     polyA_site      1671
                     /gene="Shd"
                     /note="major polyA site"
     polyA_site      1678
                     /gene="Shd"
                     /note="major polyA site"
ORIGIN      
        1 acaaagcgac ggacggacgc agcggtgacg gacgacgcct cccgccctgc gccacctcca
       61 gccgcgaccc tgcgcgatgc tcgggcctct cgcccaatcc ctgcccggcc ctggtcccaa
      121 gggcaactcg gtccccacgc cggtggtctc gtcctccggg atcctccagg gtccgagtcc
      181 tgctgtctcc accccggagc cacagaaggt ctgaggtctg cagccccagg acgagctgca
      241 gagctaggca tgaaggtcct tgtttgacac cagcatattt tgggggcacc aatggccaag
      301 tggctccgag actatctgaa cttgggcagc cggaggccgc ctccgcagcc gcccaccccc
      361 gactacaccg agagcgacat cctgcgggcc taccgcgaac agaaggacct ggacttcgag
      421 gacccctatg aggattccaa tggccgcgct gagccagagg tcaccgggtc cggtgacccc
      481 aagtacaact ctcctaggca ccggctgatc aaggtggagg ctgcagacat ggccagagcc
      541 aaggctctgc tggggagccc gggggaagag gtgcgtggag gacctggacg ggtgttctgt
      601 ccctatcacc ctgggttccc cacctcatcc cccgccccct ggggagtcca agatcttctg
      661 ggctagccat tatccccctc ggcccattct cccttcaggg agacagaggc cggaagcaga
      721 aactgagtac tcagaccctt ttgatgccca gcctcagcca ccagccccca acagtgggta
      781 catggagccc tatgatgccc ggagcgtctc cagtgaacag ccaagcagag ctgtccagct
      841 ttacgatact ccatatgagg agcaggctac gaaaccagaa gatggagggt cttcgggcca
      901 gagccggagg cccctggagg atgagaggcc agcagatgaa tacgaccagc cttgggagtg
      961 gaagaaggat cacatctcca gggctttcgc agtgcaattt gatggtcctg actgggaacg
     1021 gactccatgc tccaccaagg agccctggag accacagcct gcggagcgtg tggatacagc
     1081 ccttgccctg gagaagcagc cgtggtttca cggccccctg agccgagcag aggccgagaa
     1141 ccttctgtcc ctctgcaagg aaggcagcta cctcgttcgg ctcagcgaga ccagggctca
     1201 ggactgcatt ctgtctctca gaagcaacca gggttccatg cacctgaaat tcgcaaggac
     1261 ccgggagaac caggtggtac tgggacagca cagtgggccc ttccccagca tacctgagct
     1321 ggtcctgcat tacagtgccc gcccactgcc cgtgcaaggg gcagagcacc tggccctgct
     1381 ctatcctgtc accagcagcc agagctctca aggaccctgc acattggctg ctaagccaga
     1441 gaggggacaa ggggacccat gacgcacaga cttcctttaa tgccctctag tggggtgctc
     1501 cagatcatgg cctgcgggca tgcttgacag gtgaagaaag gcggctgccg ccaggcctgc
     1561 tgggctcaac cctgggaatc cacacggtgg cagccgagag ctgcaagtcg ttctctgatt
     1621 tacaaacaag tcacacacca taaattaata aataaatgta ataaaaatta atcttaaa
//
