LOCUS       NM_001410668            1482 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus src homology 2 domain-containing transforming protein
            D (Shd), transcript variant 6, mRNA.
ACCESSION   NM_001410668
VERSION     NM_001410668.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1482)
  AUTHORS   Chern,T., Achilleos,A., Tong,X., Hill,M.C., Saltzman,A.B.,
            Reineke,L.C., Chaudhury,A., Dasgupta,S.K., Redhead,Y., Watkins,D.,
            Neilson,J.R., Thiagarajan,P., Green,J.B.A., Malovannaya,A.,
            Martin,J.F., Rosenblatt,D.S. and Poche,R.A.
  TITLE     Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin
            metabolism and ribosomopathy
  JOURNAL   Nat Commun 13 (1), 134 (2022)
   PUBMED   35013307
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1482)
  AUTHORS   Ritter,N., Ali,T., Kopitchinski,N., Schuster,P., Beisaw,A.,
            Hendrix,D.A., Schulz,M.H., Muller-McNicoll,M., Dimmeler,S. and
            Grote,P.
  TITLE     The lncRNA Locus Handsdown Regulates Cardiac Gene Programs and Is
            Essential for Early Mouse Development
  JOURNAL   Dev Cell 50 (5), 644-657 (2019)
   PUBMED   31422919
REFERENCE   3  (bases 1 to 1482)
  AUTHORS   Oda,T., Kujovich,J., Reis,M., Newman,B. and Druker,B.J.
  TITLE     Identification and characterization of two novel SH2
            domain-containing proteins from a yeast two hybrid screen with the
            ABL tyrosine kinase
  JOURNAL   Oncogene 15 (11), 1255-1262 (1997)
   PUBMED   9315092
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154235.2 and CT009719.10.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3925277.1,
                                           SRR17784644.511812.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               AC154235.2         209966-210188
            224-513             AC154235.2         210860-211149
            514-619             AC154235.2         212277-212382
            620-796             AC154235.2         212466-212642
            797-905             AC154235.2         213377-213485
            906-1025            AC154235.2         213723-213842
            1026-1482           CT009719.10        20352-20808
FEATURES             Location/Qualifiers
     source          1..1482
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.09 cM"
     gene            1..1482
                     /gene="Shd"
                     /note="src homology 2 domain-containing transforming
                     protein D"
                     /db_xref="GeneID:20420"
                     /db_xref="MGI:MGI:1099461"
     exon            1..223
                     /gene="Shd"
                     /inference="alignment:Splign:2.1.0"
     exon            224..513
                     /gene="Shd"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..1266
                     /gene="Shd"
                     /note="isoform 5 is encoded by transcript variant 6; SH2
                     domain-containing adapter protein D"
                     /codon_start=1
                     /product="SH2 domain-containing adapter protein D isoform
                     5"
                     /protein_id="NP_001397597.1"
                     /db_xref="GeneID:20420"
                     /db_xref="MGI:MGI:1099461"
                     /translation="MAKWLRDYLNLGSRRPPPQPPTPDYTESDILRAYREQKDLDFED
                     PYEDSNGRAEPEVTGSGDPKYNSPRHRLIKPEAETEYSDPFDAQPQPPAPNSGYMEPY
                     DARSVSSEQPSRAVQLYDTPYEEQATKPEDGGSSGQSRRPLEDERPADEYDQPWEWKK
                     DHISRAFAVQFDGPDWERTPCSTKEPWRPQPAERVDTALALEKQPWFHGPLSRAEAEN
                     LLSLCKEGSYLVRLSETRAQDCILSLRSNQGSMHLKFARTRENQVVLGQHSGPFPSIP
                     ELVLHYSARPLPVQGAEHLALLYPVTSSQSSQGPCTLAAKPERGQGDP"
     exon            514..619
                     /gene="Shd"
                     /inference="alignment:Splign:2.1.0"
     exon            620..796
                     /gene="Shd"
                     /inference="alignment:Splign:2.1.0"
     exon            797..905
                     /gene="Shd"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1025
                     /gene="Shd"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1482
                     /gene="Shd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1455..1460
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shd"
                     /note="hexamer: AATAAA"
     regulatory      1464..1469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shd"
                     /note="hexamer: AATAAA"
     polyA_site      1475
                     /gene="Shd"
                     /note="major polyA site"
     polyA_site      1482
                     /gene="Shd"
                     /note="major polyA site"
ORIGIN      
        1 acaaagcgac ggacggacgc agcggtgacg gacgacgcct cccgccctgc gccacctcca
       61 gccgcgaccc tgcgcgatgc tcgggcctct cgcccaatcc ctgcccggcc ctggtcccaa
      121 gggcaactcg gtccccacgc cggtggtctc gtcctccggg atcctccagg gtccgagtcc
      181 tgctgtctcc accccggagc cacagaaggt ctgaggtctg cagccccagg acgagctgca
      241 gagctaggca tgaaggtcct tgtttgacac cagcatattt tgggggcacc aatggccaag
      301 tggctccgag actatctgaa cttgggcagc cggaggccgc ctccgcagcc gcccaccccc
      361 gactacaccg agagcgacat cctgcgggcc taccgcgaac agaaggacct ggacttcgag
      421 gacccctatg aggattccaa tggccgcgct gagccagagg tcaccgggtc cggtgacccc
      481 aagtacaact ctcctaggca ccggctgatc aagccggaag cagaaactga gtactcagac
      541 ccttttgatg cccagcctca gccaccagcc cccaacagtg ggtacatgga gccctatgat
      601 gcccggagcg tctccagtga acagccaagc agagctgtcc agctttacga tactccatat
      661 gaggagcagg ctacgaaacc agaagatgga gggtcttcgg gccagagccg gaggcccctg
      721 gaggatgaga ggccagcaga tgaatacgac cagccttggg agtggaagaa ggatcacatc
      781 tccagggctt tcgcagtgca atttgatggt cctgactggg aacggactcc atgctccacc
      841 aaggagccct ggagaccaca gcctgcggag cgtgtggata cagcccttgc cctggagaag
      901 cagccgtggt ttcacggccc cctgagccga gcagaggccg agaaccttct gtccctctgc
      961 aaggaaggca gctacctcgt tcggctcagc gagaccaggg ctcaggactg cattctgtct
     1021 ctcagaagca accagggttc catgcacctg aaattcgcaa ggacccggga gaaccaggtg
     1081 gtactgggac agcacagtgg gcccttcccc agcatacctg agctggtcct gcattacagt
     1141 gcccgcccac tgcccgtgca aggggcagag cacctggccc tgctctatcc tgtcaccagc
     1201 agccagagct ctcaaggacc ctgcacattg gctgctaagc cagagagggg acaaggggac
     1261 ccatgacgca cagacttcct ttaatgccct ctagtggggt gctccagatc atggcctgcg
     1321 ggcatgcttg acaggtgaag aaaggcggct gccgccaggc ctgctgggct caaccctggg
     1381 aatccacacg gtggcagccg agagctgcaa gtcgttctct gatttacaaa caagtcacac
     1441 accataaatt aataaataaa tgtaataaaa attaatctta aa
//
