LOCUS       NM_011369               2151 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus Shc SH2-domain binding protein 1 (Shcbp1), mRNA.
ACCESSION   NM_011369
VERSION     NM_011369.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2151)
  AUTHORS   Gu,Q., Ma,Z., Wang,Q., Dai,Y., Shi,W. and Jiao,Z.
  TITLE     Knockout of Shcbp1 sensitizes immunotherapy by regulating alpha-SMA
            positive cancer-associated fibroblasts
  JOURNAL   Mol Carcinog 63 (4), 601-616 (2024)
   PUBMED   38169303
  REMARK    GeneRIF: Knockout of Shcbp1 sensitizes immunotherapy by regulating
            alpha-SMA positive cancer-associated fibroblasts.
REFERENCE   2  (bases 1 to 2151)
  AUTHORS   Li,L., Zhao,H., Li,Z., Shi,W. and Jiao,Z.
  TITLE     SHCBP1 Overexpression Aggravates Pancreatitis by Triggering the
            Loss of Primary Cilia
  JOURNAL   DNA Cell Biol 43 (3), 141-151 (2024)
   PUBMED   38215233
  REMARK    GeneRIF: SHCBP1 Overexpression Aggravates Pancreatitis by
            Triggering the Loss of Primary Cilia.
REFERENCE   3  (bases 1 to 2151)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2151)
  AUTHORS   Naiman,N., Fujioka,K., Fujino,M., Valerius,M.T., Potter,S.S.,
            McMahon,A.P. and Kobayashi,A.
  TITLE     Repression of Interstitial Identity in Nephron Progenitor Cells by
            Pax2 Establishes the Nephron-Interstitium Boundary during Kidney
            Development
  JOURNAL   Dev Cell 41 (4), 349-365 (2017)
   PUBMED   28535371
REFERENCE   5  (bases 1 to 2151)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   6  (bases 1 to 2151)
  AUTHORS   Chen,J., Lai,F. and Niswander,L.
  TITLE     The ubiquitin ligase mLin41 temporally promotes neural progenitor
            cell maintenance through FGF signaling
  JOURNAL   Genes Dev 26 (8), 803-815 (2012)
   PUBMED   22508726
  REMARK    Erratum:[Genes Dev. 2012 Jun 15;26(12):1392]
REFERENCE   7  (bases 1 to 2151)
  AUTHORS   Shimogori,T., Lee,D.A., Miranda-Angulo,A., Yang,Y., Wang,H.,
            Jiang,L., Yoshida,A.C., Kataoka,A., Mashiko,H., Avetisyan,M.,
            Qi,L., Qian,J. and Blackshaw,S.
  TITLE     A genomic atlas of mouse hypothalamic development
  JOURNAL   Nat Neurosci 13 (6), 767-775 (2010)
   PUBMED   20436479
REFERENCE   8  (bases 1 to 2151)
  AUTHORS   Papin,J. and Subramaniam,S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
REFERENCE   9  (bases 1 to 2151)
  AUTHORS   Carlson,C.M., Dupuy,A.J., Fritz,S., Roberg-Perez,K.J.,
            Fletcher,C.F. and Largaespada,D.A.
  TITLE     Transposon mutagenesis of the mouse germline
  JOURNAL   Genetics 165 (1), 243-256 (2003)
   PUBMED   14504232
REFERENCE   10 (bases 1 to 2151)
  AUTHORS   Schmandt,R., Liu,S.K. and McGlade,C.J.
  TITLE     Cloning and characterization of mPAL, a novel Shc SH2
            domain-binding protein expressed in proliferating cells
  JOURNAL   Oncogene 18 (10), 1867-1879 (1999)
   PUBMED   10086341
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129942.7 and AC155814.6.
            
            On Jan 4, 2022 this sequence version replaced NM_011369.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070455.1, AF017152.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AC129942.7         121984-122112       c
            130-297             AC129942.7         110707-110874       c
            298-413             AC129942.7         110470-110585       c
            414-622             AC129942.7         107444-107652       c
            623-715             AC129942.7         96783-96875         c
            716-949             AC155814.6         190191-190424       c
            950-1118            AC155814.6         189931-190099       c
            1119-1239           AC155814.6         189344-189464       c
            1240-1371           AC155814.6         185086-185217       c
            1372-1490           AC155814.6         182487-182605       c
            1491-1577           AC155814.6         180234-180320       c
            1578-1719           AC155814.6         179764-179905       c
            1720-2151           AC155814.6         176615-177046       c
FEATURES             Location/Qualifiers
     source          1..2151
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 2.09 cM"
     gene            1..2151
                     /gene="Shcbp1"
                     /gene_synonym="mPAL"
                     /note="Shc SH2-domain binding protein 1"
                     /db_xref="GeneID:20419"
                     /db_xref="MGI:MGI:1338802"
     exon            1..129
                     /gene="Shcbp1"
                     /gene_synonym="mPAL"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..2033
                     /gene="Shcbp1"
                     /gene_synonym="mPAL"
                     /note="SHC-binding protein; protein expressed in activated
                     lymphocytes"
                     /codon_start=1
                     /product="SHC SH2 domain-binding protein 1"
                     /protein_id="NP_035499.1"
                     /db_xref="CCDS:CCDS22088.1"
                     /db_xref="GeneID:20419"
                     /db_xref="MGI:MGI:1338802"
                     /translation="MADDLRAGGVLEPIAMVPPRPDLAAEKEPASWKEGLFLDADPCS
                     DQGYHANPGATVKTLIPEGKTPFPRIIQTNELLFYERFRAYQDYILADCKASEVKEFT
                     VSFLEKVLEPSGWWAVWHTNVFEVLVEVTNVDFPSLKAVVRLAEPCIYESKLSTFTLA
                     NVKELLDLKEFHLPLQELWVVSDDSHEFHQMALAIEHVRFFYKHIWRSWDEEEEDEYD
                     YFVRCVEPRLRLYYDILEDRVPSGLIVDYHNLLSQCEESYRKFLNLRSSLSNCNSDSE
                     QENISMVEGLNLYSEIEQLKQKLKLIENPLLRYVFGYQKNSNIQGKGTRQNGQKVIHV
                     VSSTMKTGLLRSLFKDRFCEESCKEETEIKFHSDLLSGINACYDGDTVIICPGHYVVH
                     GTCSIADSIELEGYGLPDDIVIEKRGKGDTFVDCTGMDVKISGIKFIQHDSVEGILII
                     HHGKTTLENCVLQCETTGVTVRTSAELFMKNSDVYGAKGAGIEIYPGSKCTLTDNGIH
                     HCKEGILIKDFLDEHYDIPKISMINNVIHNNEGYGVVLVKPTIFCDLQENTQDEINDN
                     MVQKNKEADVTEGLDLEEMLQCVASKMEPYATADFNEQAKGNCEIINELLAISMQKGR
                     MKKRLSELGITQADDNIMSQEMFIEIMGNQFKWNGKGSFGTFLY"
     exon            130..297
                     /gene="Shcbp1"
                     /gene_synonym="mPAL"
                     /inference="alignment:Splign:2.1.0"
     exon            298..413
                     /gene="Shcbp1"
                     /gene_synonym="mPAL"
                     /inference="alignment:Splign:2.1.0"
     exon            414..622
                     /gene="Shcbp1"
                     /gene_synonym="mPAL"
                     /inference="alignment:Splign:2.1.0"
     exon            623..715
                     /gene="Shcbp1"
                     /gene_synonym="mPAL"
                     /inference="alignment:Splign:2.1.0"
     exon            716..949
                     /gene="Shcbp1"
                     /gene_synonym="mPAL"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1118
                     /gene="Shcbp1"
                     /gene_synonym="mPAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1239
                     /gene="Shcbp1"
                     /gene_synonym="mPAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1371
                     /gene="Shcbp1"
                     /gene_synonym="mPAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1490
                     /gene="Shcbp1"
                     /gene_synonym="mPAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1577
                     /gene="Shcbp1"
                     /gene_synonym="mPAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1719
                     /gene="Shcbp1"
                     /gene_synonym="mPAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..2151
                     /gene="Shcbp1"
                     /gene_synonym="mPAL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2132..2137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shcbp1"
                     /gene_synonym="mPAL"
                     /note="hexamer: TATAAA"
     polyA_site      2151
                     /gene="Shcbp1"
                     /gene_synonym="mPAL"
                     /note="major polyA site"
ORIGIN      
        1 gtgacagccg cccgcgtaaa tttgaaatgg ctgatgattt gcgggctggt ggagttctgg
       61 aacctatagc tatggttcca ccgagacctg acttggcggc ggagaaggaa ccggcgtcct
      121 ggaaggaagg tttattcttg gatgcagatc catgcagtga tcaaggctat catgctaatc
      181 caggtgctac tgtaaaaact ctcataccag aaggaaaaac tccttttcca cgaattatcc
      241 aaacaaatga acttctgttt tatgaacgat tcagagccta tcaagattac attttagctg
      301 actgtaaggc ctctgaggta aaggaattca cagtcagctt cttggaaaag gtccttgaac
      361 catctggatg gtgggcagtc tggcacacta atgtgtttga ggtgttggtt gaggttacaa
      421 atgtggactt tccatccctg aaggcggtcg taaggcttgc agagccatgc atctatgaat
      481 ctaaattgag cacgtttacc ttggccaatg tgaaggagct tttggacctg aaggagtttc
      541 atctgcctct gcaggagttg tgggtggtat cagatgactc acatgaattc caccagatgg
      601 cacttgcaat tgagcacgtc agatttttct acaaacacat ctggaggagt tgggatgagg
      661 aagaggagga tgagtatgac tattttgtca gatgtgttga acctcgactg agattgtatt
      721 atgacatact tgaagatcga gttccctcgg gacttattgt tgactaccac aatctgttgt
      781 ctcaatgtga agagagttac aggaaatttt taaatctgag aagcagtttg tccaattgta
      841 attctgattc tgagcaggaa aatatctcca tggtggaagg gttaaatttg tattcagaaa
      901 ttgaacagtt gaaacaaaag ctaaagctca ttgagaatcc tttgttaaga tatgtttttg
      961 gttatcagaa gaactctaat atccaaggaa agggtactcg tcaaaatggc cagaaggtca
     1021 tccatgtggt ttcctccacc atgaagacag gtctacttcg gtctctattc aaggacaggt
     1081 tttgtgagga gtcttgcaaa gaagaaacag aaattaagtt ccatagtgat ctgttgtctg
     1141 gtataaatgc ctgctatgat ggtgacactg tcattatttg tcctggccat tatgtagttc
     1201 atggcacctg ttccatagct gactccattg agttggaagg atatggccta ccagatgaca
     1261 ttgtcataga aaagaggggc aaaggagata cttttgtgga ttgcacgggt atggatgtta
     1321 aaatttcagg cataaaattt attcagcatg attctgtgga aggaatctta atcattcacc
     1381 atggcaagac cacactggaa aactgtgtac tacaatgtga aaccacagga gtcacagtgc
     1441 gcacatcagc agaacttttc atgaaaaact cagatgtata tggtgccaag ggtgctggta
     1501 tagaaatata tcctggaagt aaatgtaccc tgactgacaa tggaatccat cactgcaagg
     1561 aaggaattct cattaaggac ttccttgatg aacattatga tattcccaaa atatcgatga
     1621 taaataacgt catacacaat aatgaaggtt atggtgttgt tttggtgaag cctacaattt
     1681 tctgtgatct acaggaaaat acacaagatg aaattaatga caatatggtt cagaaaaata
     1741 aagaggcaga tgtcactgaa ggattagatc tggaagaaat gcttcagtgt gtggctagca
     1801 aaatggagcc ttatgccaca gctgacttta atgaacaagc taagggaaac tgtgaaatta
     1861 taaatgaact acttgctatt tccatgcaaa aaggccggat gaagaaaaga ctgagtgaac
     1921 ttgggattac acaagctgat gacaacataa tgtcacagga gatgtttatt gaaattatgg
     1981 ggaaccagtt taagtggaat ggcaaaggga gttttggcac atttctttac tagctacaat
     2041 aatatcaata ctcacaaaat actgtatttt gaacatgtct taagtatgct gcttatatac
     2101 tttgcttcat ttgcttcatg gctgtgtatt atataaagtg tacttgatta a
//
