LOCUS       NM_199022               4358 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus SHC (Src homology 2 domain containing) family, member
            4 (Shc4), mRNA.
ACCESSION   NM_199022 XM_197511
VERSION     NM_199022.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4358)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4358)
  AUTHORS   Ahmed,S.B.M., Amer,S., Emad,M., Rahmani,M. and Prigent,S.A.
  TITLE     Studying the ShcD and ERK interaction under acute oxidative stress
            conditions in melanoma cells
  JOURNAL   Int J Biochem Cell Biol 112, 123-133 (2019)
   PUBMED   31121283
  REMARK    GeneRIF: data also showed that the death signalling initiated by
            the ShcD/ERK interaction was accompanied by p21 phosphorylation. In
            summary, these data identified ShcD, via its interaction with ERK,
            as a proapoptotic protein under oxidative stress conditions.
REFERENCE   3  (bases 1 to 4358)
  AUTHORS   Turco,M.Y., Furia,L., Dietze,A., Fernandez Diaz,L., Ronzoni,S.,
            Sciullo,A., Simeone,A., Constam,D., Faretta,M. and Lanfrancone,L.
  TITLE     Cellular heterogeneity during embryonic stem cell differentiation
            to epiblast stem cells is revealed by the ShcD/RaLP adaptor protein
  JOURNAL   Stem Cells 30 (11), 2423-2436 (2012)
   PUBMED   22948967
  REMARK    GeneRIF: Shc4 is an important modulator in the switch of key
            pathway(s) involved in determining epiblast stem cell identity.
REFERENCE   4  (bases 1 to 4358)
  AUTHORS   Hawley,S.P., Wills,M.K., Rabalski,A.J., Bendall,A.J. and Jones,N.
  TITLE     Expression patterns of ShcD and Shc family adaptor proteins during
            mouse embryonic development
  JOURNAL   Dev Dyn 240 (1), 221-231 (2011)
   PUBMED   21117147
  REMARK    GeneRIF: The unique tissue distribution patterns of Shc proteins
            likely contribute to their complex tissue-specific signaling
            functions during embryogenesis.
REFERENCE   5  (bases 1 to 4358)
  AUTHORS   Jones,N., Hardy,W.R., Friese,M.B., Jorgensen,C., Smith,M.J.,
            Woody,N.M., Burden,S.J. and Pawson,T.
  TITLE     Analysis of a Shc family adaptor protein, ShcD/Shc4, that
            associates with muscle-specific kinase
  JOURNAL   Mol Cell Biol 27 (13), 4759-4773 (2007)
   PUBMED   17452444
  REMARK    GeneRIF: A new member of the Shc family of docking proteins is
            characterised, which may mediate a specific aspect of signaling
            downstream of the MuSK receptor.
REFERENCE   6  (bases 1 to 4358)
  AUTHORS   Fagiani,E., Giardina,G., Luzi,L., Cesaroni,M., Quarto,M., Capra,M.,
            Germano,G., Bono,M., Capillo,M., Pelicci,P. and Lanfrancone,L.
  TITLE     RaLP, a new member of the Src homology and collagen family,
            regulates cell migration and tumor growth of metastatic melanomas
  JOURNAL   Cancer Res 67 (7), 3064-3073 (2007)
   PUBMED   17409413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844580.13 and AL929166.7.
            
            On Nov 8, 2022 this sequence version replaced NM_199022.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY464564.1, SRR1660813.187635.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-894               AL844580.13        14315-15208         c
            895-965             AL929166.7         115156-115226       c
            966-1029            AL929166.7         100417-100480       c
            1030-1149           AL929166.7         99018-99137         c
            1150-1203           AL929166.7         90597-90650         c
            1204-1255           AL929166.7         86603-86654         c
            1256-1376           AL929166.7         77819-77939         c
            1377-1545           AL929166.7         75882-76050         c
            1546-1606           AL929166.7         72805-72865         c
            1607-1780           AL929166.7         69476-69649         c
            1781-2034           AL929166.7         59594-59847         c
            2035-4358           AL929166.7         47777-50100         c
FEATURES             Location/Qualifiers
     source          1..4358
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 61.76 cM"
     gene            1..4358
                     /gene="Shc4"
                     /gene_synonym="6230417E10Rik; 9930029B02Rik; Gm685; RaLP"
                     /note="SHC (Src homology 2 domain containing) family,
                     member 4"
                     /db_xref="GeneID:271849"
                     /db_xref="MGI:MGI:2655364"
     exon            1..894
                     /gene="Shc4"
                     /gene_synonym="6230417E10Rik; 9930029B02Rik; Gm685; RaLP"
                     /inference="alignment:Splign:2.1.0"
     exon            895..965
                     /gene="Shc4"
                     /gene_synonym="6230417E10Rik; 9930029B02Rik; Gm685; RaLP"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1029
                     /gene="Shc4"
                     /gene_synonym="6230417E10Rik; 9930029B02Rik; Gm685; RaLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1149
                     /gene="Shc4"
                     /gene_synonym="6230417E10Rik; 9930029B02Rik; Gm685; RaLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1203
                     /gene="Shc4"
                     /gene_synonym="6230417E10Rik; 9930029B02Rik; Gm685; RaLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1255
                     /gene="Shc4"
                     /gene_synonym="6230417E10Rik; 9930029B02Rik; Gm685; RaLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1376
                     /gene="Shc4"
                     /gene_synonym="6230417E10Rik; 9930029B02Rik; Gm685; RaLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1545
                     /gene="Shc4"
                     /gene_synonym="6230417E10Rik; 9930029B02Rik; Gm685; RaLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1606
                     /gene="Shc4"
                     /gene_synonym="6230417E10Rik; 9930029B02Rik; Gm685; RaLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1780
                     /gene="Shc4"
                     /gene_synonym="6230417E10Rik; 9930029B02Rik; Gm685; RaLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..2034
                     /gene="Shc4"
                     /gene_synonym="6230417E10Rik; 9930029B02Rik; Gm685; RaLP"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..4358
                     /gene="Shc4"
                     /gene_synonym="6230417E10Rik; 9930029B02Rik; Gm685; RaLP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4339..4344
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Shc4"
                     /gene_synonym="6230417E10Rik; 9930029B02Rik; Gm685; RaLP"
                     /note="hexamer: AATAAA"
     polyA_site      4358
                     /gene="Shc4"
                     /gene_synonym="6230417E10Rik; 9930029B02Rik; Gm685; RaLP"
                     /note="major polyA site"
ORIGIN      
        1 gggtaaatat ttctgctaag actagaggcg tggtggcacc cgctgcccca gcctggggga
       61 cgggactccg gggcgaagac acccccgctc ccaccccacc ccaccccccg cgctccgggg
      121 gcctctgcca gggcctggaa gggccggcct gcaatcagag ctggggaggc gtcctccggg
      181 actgtcatcc ttgagcagtc tcggacccgg gctggtgacc gccagagcag gagaggtgac
      241 tgtggcgtgg gtctaccgga ctgcgaggca ctttaggctg cggtgcccag tctcagcact
      301 gctaaggcta tgcgagaacg cagccaggac agccaggcag gactcacgct gtatgtagga
      361 ctctttgggc acctggggat gcttcacagg accaagtaca gccgctttcg gaacgagtcc
      421 atcacgtctt tggacgaagg gagccccgga ggctccgttg gaaacaaggg ctcgtcgccg
      481 cctccctacc cagccctggc ccctcacctg ccgactgagg atgccactgt gtccagccag
      541 gagagcccca cggcgctgtg caccttgatt ccccgtatgg caagcatgaa gctggccaac
      601 cccatcactt ttctgggtct gaaaaccttc tgcttgggta cgaaacaggt gagccggttg
      661 aagctccaag agaaccagga tcagactcca agccgtccag cgtccccaga atccaatcta
      721 aacaggactg gacctgcacc tgcaccggat ccggaccagg tgggacgcag gcccacctct
      781 ttgcgtcctg atacttgccc actgcctggc cctggagaac caagccccag gagcaagcag
      841 gacgggcccc ctctgcagca cctgttgggg aacggtctga actactgtgt gcggtacatg
      901 ggctgcattg aagtgctgca atcaatgagg tcactggatt ttggaatgag aacccaagtt
      961 acaagggaag caataagtcg cctgtgtgaa gctgtccccg gggcccatgg agccattaaa
     1021 aaacgaaagg ctcccgttaa gttcctgaca acggttcttg gcaaaagcaa tcttcagttt
     1081 tcaggaatga atataaaact gactgtttca acaagcagcc tcacactgat gaaccttgac
     1141 aaccaacaga ttattgcaaa tcaccaaatg caatcgattt catttgcctc tggaggggac
     1201 cctgatacca cagactatgt tgcctatgta gctaaagatc cagtcaacca acgagcgtgc
     1261 cacatactgg agtgtcgcag tggaatggcc caagacgtca taagcaccat agggcaggcc
     1321 tttgaactcc ggttcaaaca gtacttgaaa aatccttcct tgaacacttg ggaaagggag
     1381 gaggtacttg ttgatggtgc ccctgaagac agagaccatg actattacaa ctccatcccg
     1441 gggaagcagc cacctgaagg cggcatttca gatgtgcgca tccaggctca agctacagac
     1501 caaatggcat actgccctat ccggtgtgaa aagttgtgct atttgcctgg gaactccacg
     1561 tgcagcggtg tgtataagaa ctgtatggga cggagcaggc caataggtat cccgcacgag
     1621 agagcggggc agggtgacac accatcgctg aggcacttct ggagagtgga tctctttgac
     1681 gacccctgct atgtcaatac acaggctctt cagagtatgc acagctatgc tggaaatcaa
     1741 agctcagctc tgccacaggg gagcccctgg cacctcggaa aggcaccaga aactgtgcag
     1801 cctggagcca cggccaagcc tgggagcgca ctcgctttgc cacacattag gcagcagctg
     1861 tgggacgagg agtgcttcca tggcaagctg agcagagggg cagcggagaa acttttggtg
     1921 aaggatgggg actttttggt tcgagagagt gtgacatctc ccggccagtt tgtactgagt
     1981 ggactgcaag gtggccaggc caagcatctt ctcttggtgg atccagaagg caaggtgagg
     2041 accaaggacc atgtgtttga taatgttggc caccttatca aataccatat ggataataat
     2101 ttgccaatca tctcttctgg aagtgaagta cgccttaaac aaccaataag aaaatatgat
     2161 aacacaggac ttttgccccc caagaaatga tgactcccgg aactgtgtca gtgctatgag
     2221 aagcatattc ctttggtgcc aggaacagtg gccgctcaac ccttttcttc acacaaagta
     2281 gaacatagac tgtgaaacat gtctttctta gaccgccaca gaccaggtct tttataaaac
     2341 atagaagtaa caaactatct tctgagtatg aaaatcagag aataataatt ttggtccatt
     2401 tggaaatgcg atactcatct gcacggaggt cactttttaa aggtcacatt gcattggtga
     2461 aaagctaaaa gcacaacttc aatttcagat gctaaagaca acttgaactg ctcaggcagt
     2521 ggtacgtgcc tttaccttga taatccgggg acattttcct atgggggaga ttagttacac
     2581 gtgtcttcac gttctatagc tacagaacca gttgccaaaa aagttcttcc ttgctaaaaa
     2641 cagcaagaag cagcattttg actagtagtg ttgactttat tacattttgt ttagtagcac
     2701 tttttgctgc catgttaaca atgacactga catcaaattc agactgtgcc tgtgcttgtg
     2761 gaatgaaagc aaacaccgct gatggtttcc caattctgtc tcatttgctg attgagaggc
     2821 tggggctcaa attcactggc cagcgttcct cagtctttgc tacctgaact gtccgtaggc
     2881 agcatgggac acattcagga agccaaatct cttggttagt tctgatttgg agtatttggt
     2941 tataaaagac agcaaacaaa gccattgttc ttcatgctca gcccatactg gtgccattga
     3001 aaatgcatta aggcaatcta aagtatatga aaatctcctt gtgattggct gccactgcgc
     3061 cctggtgtca cctcggtatg tgtcttatca ccatctgtac gtgtgatcag acaaaatgca
     3121 gaagggctgg gaaaggtctg ctacacaccg gacaatggtt caaccagtgg tgagattaag
     3181 aattctcaga gaagcccaag gctcagacta ttcaccactg tgagtcttgg caggtcgcta
     3241 aacctgtctg gattccagtt ttcttgtcca taagatgagg gagcttgagg tgcactcaga
     3301 gggccgttgc tatcctaaca tagtagtttt tttctttgtt aaaagttaac actgataagc
     3361 agactgtgca gttgagggca aatatttagg atttttccct ttattctgtg tctatactct
     3421 acaggtaaca ggtttagcca aattacactc tcatagtctg accccaagtg tttcagcata
     3481 aatcaggtaa tgttggttta gtggatctgg ttgtctttag taatagcaga aatgcttcag
     3541 tcagtcctta cttgcctatg catataaaga tacagtcact acaggagaga gagagagaga
     3601 gagagagaga gagagagaga gagagagaga gagagagaga gagagagagg agagaggaga
     3661 gaggagagag gagagaggag agaggagaga gatcctaagc tttctggata gttatctcaa
     3721 caccacttca ttttggctaa gtagagacaa cttaaccttt gtgattatga tgtatttggt
     3781 aagttttaag tatagtatgg gatcgttcct atgggtagaa atcatcagaa atcaagtaca
     3841 ttgaagcctg gcatttttac ataacaactc accattttat ttctgtcgcc actggcttct
     3901 taggtaagtt tgtttccttt ccacagctag aaagtcgtgc atattccatt gcttttcctc
     3961 catctatctt aggtcttaat catttttctt cgtaagaggg atcagcatag tgatagggac
     4021 tcataggtaa cctgcagcag agacagggcg ggcctactgc ctccttccag ctggggaacg
     4081 cagactgggt ggccagcgga gttccagatg cagggggcac tgtggtgtga gccgcacgca
     4141 tgggcagtca acactggact ggtgctgttg tagcctggga ggcagatgct gcactttcag
     4201 atgccataga cactgttcac caaccctaaa agatgtaaga aatgtctgca tgcggtttta
     4261 atctcatagt ctcaacctct attttaaaat ggtggttcat ttgcctataa atatctgtaa
     4321 atgagttttc tttaaaaaaa taaatgatta ttgcttta
//
