LOCUS       NM_009167              11556 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus src homology 2 domain-containing transforming protein
            C3 (Shc3), mRNA.
ACCESSION   NM_009167
VERSION     NM_009167.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11556)
  AUTHORS   Montecchi,T., Shaba,E., De Tommaso,D., Di Giuseppe,F.,
            Angelucci,S., Bini,L., Landi,C., Baldari,C.T. and Ulivieri,C.
  TITLE     Differential Proteomic Analysis of Astrocytes and
            Astrocytes-Derived Extracellular Vesicles from Control and Rai
            Knockout Mice: Insights into the Mechanisms of Neuroprotection
  JOURNAL   Int J Mol Sci 22 (15), 7933 (2021)
   PUBMED   34360699
  REMARK    GeneRIF: Differential Proteomic Analysis of Astrocytes and
            Astrocytes-Derived Extracellular Vesicles from Control and Rai
            Knockout Mice: Insights into the Mechanisms of Neuroprotection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11556)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11556)
  AUTHORS   Criscuoli,M., Ulivieri,C., Filippi,I., Monaci,S., Guerrini,G.,
            Crifo,B., De Tommaso,D., Pelicci,G., Baldari,C.T., Taylor,C.T.,
            Carraro,F. and Naldini,A.
  TITLE     The Shc protein Rai enhances T-cell survival under hypoxia
  JOURNAL   J Cell Physiol 235 (11), 8058-8070 (2020)
   PUBMED   31944299
  REMARK    GeneRIF: The Shc protein Rai enhances T-cell survival under
            hypoxia.
REFERENCE   4  (bases 1 to 11556)
  AUTHORS   Ulivieri,C., De Tommaso,D., Finetti,F., Ortensi,B., Pelicci,G.,
            D'Elios,M.M., Ballerini,C. and Baldari,C.T.
  TITLE     A T Cell Suppressive Circuitry Mediated by CD39 and Regulated by
            ShcC/Rai Is Induced in Astrocytes by Encephalitogenic T Cells
  JOURNAL   Front Immunol 10, 1041 (2019)
   PUBMED   31134091
  REMARK    GeneRIF: Rai deficiency enhances the ability of astrocytes to
            upregulate the expression and activity of the ectonucleotidase
            CD39, which catalyzes the conversion of extracellular ATP to the
            immunosuppressive metabolite adenosine, through both
            contact-dependent and-independentmechanisms.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11556)
  AUTHORS   Heng,X., Guo,Q., Leung,A.W. and Li,J.Y.
  TITLE     Analogous mechanism regulating formation of neocortical basal
            radial glia and cerebellar Bergmann glia
  JOURNAL   Elife 6, e23253 (2017)
   PUBMED   28489004
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11556)
  AUTHORS   Sakai,R., Henderson,J.T., O'Bryan,J.P., Elia,A.J., Saxton,T.M. and
            Pawson,T.
  TITLE     The mammalian ShcB and ShcC phosphotyrosine docking proteins
            function in the maturation of sensory and sympathetic neurons
  JOURNAL   Neuron 28 (3), 819-833 (2000)
   PUBMED   11163269
REFERENCE   7  (bases 1 to 11556)
  AUTHORS   Luzi,L., Confalonieri,S., Di Fiore,P.P. and Pelicci,P.G.
  TITLE     Evolution of Shc functions from nematode to human
  JOURNAL   Curr Opin Genet Dev 10 (6), 668-674 (2000)
   PUBMED   11088019
  REMARK    Review article
REFERENCE   8  (bases 1 to 11556)
  AUTHORS   Pelicci,G., Dente,L., De Giuseppe,A., Verducci-Galletti,B.,
            Giuli,S., Mele,S., Vetriani,C., Giorgio,M., Pandolfi,P.P.,
            Cesareni,G. and Pelicci,P.G.
  TITLE     A family of Shc related proteins with conserved PTB, CH1 and SH2
            regions
  JOURNAL   Oncogene 13 (3), 633-641 (1996)
   PUBMED   8760305
REFERENCE   9  (bases 1 to 11556)
  AUTHORS   O'Bryan,J.P., Songyang,Z., Cantley,L., Der,C.J. and Pawson,T.
  TITLE     A mammalian adaptor protein with conserved Src homology 2 and
            phosphotyrosine-binding domains is related to Shc and is
            specifically expressed in the brain
  JOURNAL   Proc Natl Acad Sci U S A 93 (7), 2729-2734 (1996)
   PUBMED   8610109
REFERENCE   10 (bases 1 to 11556)
  AUTHORS   Pelicci,G., Lanfrancone,L., Grignani,F., McGlade,J., Cavallo,F.,
            Forni,G., Nicoletti,I., Grignani,F., Pawson,T. and Pelicci,P.G.
  TITLE     A novel transforming protein (SHC) with an SH2 domain is implicated
            in mitogenic signal transduction
  JOURNAL   Cell 70 (1), 93-104 (1992)
   PUBMED   1623525
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159104.2.
            
            On Apr 15, 2019 this sequence version replaced NM_009167.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14777534.882554.1,
                                           SRR14777530.661213.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2481              AC159104.2         779-3259
            2482-2552           AC159104.2         53635-53705
            2553-2616           AC159104.2         87285-87348
            2617-2736           AC159104.2         90012-90131
            2737-2790           AC159104.2         97374-97427
            2791-2842           AC159104.2         103665-103716
            2843-2969           AC159104.2         108786-108912
            2970-3120           AC159104.2         118590-118740
            3121-3208           AC159104.2         120916-121003
            3209-3367           AC159104.2         122182-122340
            3368-3663           AC159104.2         127245-127540
            3664-11556          AC159104.2         138949-146841
FEATURES             Location/Qualifiers
     source          1..11556
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 26.12 cM"
     gene            1..11556
                     /gene="Shc3"
                     /gene_synonym="N-Shc; Rai; ShcC"
                     /note="src homology 2 domain-containing transforming
                     protein C3"
                     /db_xref="GeneID:20418"
                     /db_xref="MGI:MGI:106179"
     exon            1..2481
                     /gene="Shc3"
                     /gene_synonym="N-Shc; Rai; ShcC"
                     /inference="alignment:Splign:2.1.0"
     CDS             2008..3792
                     /gene="Shc3"
                     /gene_synonym="N-Shc; Rai; ShcC"
                     /note="neuronal Shc; SH2 domain protein C3;
                     SHC-transforming protein C"
                     /codon_start=1
                     /product="SHC-transforming protein 3"
                     /protein_id="NP_033193.3"
                     /db_xref="CCDS:CCDS49265.2"
                     /db_xref="GeneID:20418"
                     /db_xref="MGI:MGI:106179"
                     /translation="MLPRTKYNRFRNDSVTSVDDLLHSLSVSGSGGKVSAEPAASPYL
                     VSGEALRKAPDDGPGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSL
                     AAPDGGSATPGSRAPAASMSATRKSRAGDEPLPRPPRGAPHTSDQVLGPGVTYVVKYL
                     GCIEVLRSMRSLDFSTRTQVTREAISRVCEAVPGAKGALKKRKPPSKMLSSILGKSNL
                     QFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVN
                     RRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCPSKVPALQDRMQSLDEPWTEEEG
                     DGPDHPYYNSVPTKMPPPGGFLDARLKGRPHAPEAAQFAGKEQTYYQGRHLGDTFGED
                     WQRAPTRQGSLDIYSTAEGKTHMVPVGETPTYVNTQPVPPQVWPAATSSTESSPRKDL
                     FDMKPFEDALRNQPLGPMLSKAASVECISPVTPRAPDARMLEELNAEPWYQGEMSRKE
                     AEALLREDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIRTKDRVFDSISHL
                     INYHLESSLPIVSAGSELCLQQPVERKP"
     exon            2482..2552
                     /gene="Shc3"
                     /gene_synonym="N-Shc; Rai; ShcC"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2616
                     /gene="Shc3"
                     /gene_synonym="N-Shc; Rai; ShcC"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..2736
                     /gene="Shc3"
                     /gene_synonym="N-Shc; Rai; ShcC"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..2790
                     /gene="Shc3"
                     /gene_synonym="N-Shc; Rai; ShcC"
                     /inference="alignment:Splign:2.1.0"
     exon            2791..2842
                     /gene="Shc3"
                     /gene_synonym="N-Shc; Rai; ShcC"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..2969
                     /gene="Shc3"
                     /gene_synonym="N-Shc; Rai; ShcC"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3120
                     /gene="Shc3"
                     /gene_synonym="N-Shc; Rai; ShcC"
                     /inference="alignment:Splign:2.1.0"
     exon            3121..3208
                     /gene="Shc3"
                     /gene_synonym="N-Shc; Rai; ShcC"
                     /inference="alignment:Splign:2.1.0"
     exon            3209..3367
                     /gene="Shc3"
                     /gene_synonym="N-Shc; Rai; ShcC"
                     /inference="alignment:Splign:2.1.0"
     exon            3368..3663
                     /gene="Shc3"
                     /gene_synonym="N-Shc; Rai; ShcC"
                     /inference="alignment:Splign:2.1.0"
     exon            3664..11556
                     /gene="Shc3"
                     /gene_synonym="N-Shc; Rai; ShcC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attcacagaa acgctggctc gctcgccggc cctttcattc acacaaacag catctcattc
       61 acattcggtc tgtttttttt ttttttcctt tttctttttt tctttttgtc tgcttctaat
      121 gaagaagacc acggtttggg aatggtgggg ctgacttgct tcagattgga gggggactcc
      181 aatcaccatc gaaatcgtcc gtggggtgcg catctgctgt tgctatgcga gctagaggaa
      241 gggagaaaag agagtgcggg gtggctgttc agctagggct gccgcgcggt tggagagcgg
      301 tggggacgtg tttgctgcgc cagggcgggc ctggcggctc tgcgcttttt cgtcctctgg
      361 aaccggcctc acttgcacgg ccgccacggg tggctctccc taaactccct tcctggggct
      421 cccagaaagc ctgggaaccg cactgcctcc cgagatcagc cctgggcgtg agaagactca
      481 gggtgacctg ctagtgtgct agaaggcaaa tgcattcgct tgcacagaag ttaccaggaa
      541 actttgacag cgattgactt ctcggtggtg caggttatct gtcttaacac atgaggccac
      601 ctggtagagg ccaccgagga agggctcagt gggtctcaga atcttggtca gaccctcggg
      661 gaggctgtcg atgtcctatt ctcccaagcg tcaggaagaa ggcctgtgcg tgtcactgca
      721 agcctgggcc cgactcgcaa ggaagaggcc attcttgctg tggatttgat ggacagttag
      781 agcagccgca ttttttttcc tgcctgactg cagggctgca agcagcaact gaagggacat
      841 tgaaacggat tggtaatgct actaaggcat gcttccaggg ctgaaacaca ttcacttgga
      901 ataaaactca aaacgcggcc ctctttctct ctctctctct ttttttggca tggatttctg
      961 gagcctgttg ccgctcagca gagatgcagg tttttttttg aagtagattt ttcaactgaa
     1021 ccctagctga gtacggctgc tgactgctgt aaattattag ggaagacccc ctctgagctg
     1081 tactgagaag aaatttctgt gctgattttt tttttttttc gtgaattggt acaggaattg
     1141 caccgccaca gatacatggc tgctctgctg atctgaacaa gaaaagcaaa ccacaggaaa
     1201 ctgacaggtt tttttctttc tttcttaaat attcatctgc tggtgaaggg tcccccctct
     1261 tttttttttt cctacttaaa attcttgcta ctttccaaaa tcaggattca tcaggattcg
     1321 ccttgaagac ttctttaaaa gccttcgtca catttgaacg catccctgtc agacacttct
     1381 gggcttcatc cacatgagct gagcaaggga agagcaagcc attgcacgga ataatgggtt
     1441 gcggaaagtt caagagatca tttgacggga ctggatttac ctttggcaca gatgcgggat
     1501 ggggaggggg taggtgaaaa ggcaaagact ggaaggaaat atctgcgaag gtagaaaaag
     1561 gaaatttgag aactgattgg ctgtagttgc tgtcagcggg tggatgtcgt tttcttctct
     1621 ctctttttgc tacaggaagt gatttgcgga gctcaccgag cctttgttga gaagggtctc
     1681 ctcagagtga gtcacgcttt tgctgggagc agccccgtgc agctggccgc tcgctccatc
     1741 agccgcaact atgacttttg caaggcaagc gttccacccc aaccctcggt ctccagggcc
     1801 cgcgctgcgt ggctgctgct ctgctgcctt gtaacggtga aaagggctcg gtcgtcggcc
     1861 tcggctgtcc ctctccggaa aggctgtcct gggactcggg ctcctcgtcc cgctcggggg
     1921 accgcggctc gtgtgctatg cgcggcagtc cgcgccaggg ccggcagcag cagcgcccgg
     1981 gtggatgcgg cgagcccacg gaggggcatg cttccacgca ccaagtacaa ccgcttcagg
     2041 aatgactcgg tgacatcggt cgatgacctt ctccacagcc tgtcggtgag cggcagcggc
     2101 ggcaaggtct cggcggagcc cgcggcgagc ccctacctgg tgtcgggcga ggcgctgcgc
     2161 aaggcgccgg acgatgggcc cggcagcctg ggccacctgc tccacaaggt gtcccacttg
     2221 aaactctcca gctccggcct gcgtggcctg tcgtcggccg cccgggagcg ggcaggagcg
     2281 cggctctcgg gcagctgcag cgcgcccagc ctggcggccc cggacggcgg cagcgcgacc
     2341 cccgggtccc gcgccccggc cgccagcatg agtgccacca ggaagagccg ggccggcgac
     2401 gagccactgc ccaggccccc tcggggcgcg ccgcacacca gcgatcaggt gctggggccg
     2461 ggagtcacct atgtggtcaa gtacttgggc tgcatcgaag ttctgcgctc aatgaggtct
     2521 cttgacttca gtacaagaac tcaggttacc agggaagcca tcagccgtgt ctgcgaagct
     2581 gtgccaggtg ccaaaggagc cctcaagaag agaaagccgc cgagtaagat gctgtccagc
     2641 atcctgggga agagcaacct ccagttcgca gggatgagca tctccctgac catctccacc
     2701 gccagcctga atctgcgcac tcctgactcc aaacagatca tagcgaacca tcatatgcgg
     2761 tctatctctt ttgcctcagg gggagacccg gacacaacgg actatgttgc ctatgtcgct
     2821 aaggaccctg tcaatcgcag agcttgccac attctggaat gctgtgacgg gctagcccaa
     2881 gatgtcattg gctccatcgg acaagccttt gaactccggt tcaaacagta tttgcagtgc
     2941 ccttccaagg ttcctgccct ccaggaccga atgcagagtc tggatgagcc atggactgaa
     3001 gaagagggag atggccctga tcacccatac tacaacagcg ttcccaccaa gatgcctccc
     3061 ccaggggggt ttctggatgc tcgattgaaa ggcagacccc acgctcctga ggcagcccag
     3121 tttgcaggaa aagagcaaac ttattaccag ggaagacact taggagatac atttggtgaa
     3181 gactggcagc gagcacccac caggcaaggc tccttggaca tctatagcac agcagaaggg
     3241 aaaactcaca tggttcctgt aggagaaaca ccaacctatg tcaacaccca gccagtccca
     3301 ccacaggtgt ggccagcagc aaccagcagc actgagagca gcccacggaa ggacctcttt
     3361 gacatgaagc cctttgaaga tgccctgaga aaccagcccc tgggccccat gttgagcaaa
     3421 gccgcgtctg tggagtgcat cagcccggtc acacccagag ccccggatgc caggatgctg
     3481 gaggagctta acgctgagcc ctggtaccaa ggagagatga gcaggaagga ggcagaggcc
     3541 ctgctacggg aagatggaga cttcctagtg aggaagagta ccaccaaccc cggctccttt
     3601 gtcctcacag gcatgcacaa tgggcaggcc aagcacctgc tgctggtgga cccggaaggc
     3661 acgatccgga cgaaggacag ggtctttgac agcatcagcc acctcatcaa ttaccacctc
     3721 gagagcagcc tgcccattgt ctctgccggg agtgagcttt gtctccagca accagtggag
     3781 aggaaaccct gagcttgccc agcgccccag cccccatacc ttatgccagg tcaggaagac
     3841 ctgggctctg cggctctcag cctatggaaa tggggcaact gtctgtgggc ccatcaccat
     3901 taaaagcccc cccagggagg tttccttcaa gttcaaattt cataaatatg ttcacacgat
     3961 tcagacatgc ttattagaag tgtatatacc cacacatcct gtacaaatgg ccccgatatt
     4021 tatatttttt aagactaaga gagatgtgag acactagtgc tctatgctgt gtgtttttag
     4081 ggagaggcag gttcgactgt agttgttctg tgaaaaatat taactaacct gttctactgg
     4141 gaaattttgc taggaagtca ttcttatgta ctaagcacaa ttcaaggcga atgcaggtga
     4201 gctggcagct ccaggacaaa cagaattgtg agagaataca gtagcatgct gcccaaacat
     4261 ctgcccctgc tgatacagct ttgtgtgagt gctggttcca gactacagct tggctcatga
     4321 gtggtggtgt ttcctccggg atgatggtac cttctccagg atggtggtac ctcctccagt
     4381 catggcttgc tgggtgctgc ctcctatgcc ctgaattgac attgtgtgag tgggttttct
     4441 gccataggat aatccactga atccccactc caaagtagat ggtagtctgg cttgttcagg
     4501 tcgtgtttca gcatggggaa cctttgactt caattgtgtg tgtgtgtgtg tgtgtgtgtg
     4561 tgtgtgtgtg tgtgtgtgtg tgtgtgtgta tttgggagat tcatttgagg ccaaacatga
     4621 tactttgaat aagacttaag atgtctgatt ggcaaatgct tccttgtcag cgtactgatg
     4681 acgtgtatgt ctgaggaagt aggatatgcg tattcctggt ctgtaggtcc ttcaagccaa
     4741 tgtgaccatc atgggctttt tatggaaggt gccagtgaag tggcctccca cctacctctc
     4801 gtattcagta gaacaaaaaa ccatgtgtta gagcctcgca aggcctgtgc cagcttctgc
     4861 ccagaattga gctttggaga tacacacaca ctggctgttt ttcccaggtc cgtgtgtgct
     4921 cagctccacg ctccagtctt tgggagcagc tggagtgagg ggtggtgagc cttcttgtct
     4981 cccctccata ttttctcagt agccccatga aaaggaacca cgctcgtggc gctctgtctt
     5041 ctttctctgc catttcagaa gctgttgttt catggtgggt gataacctgt gtttcaaagc
     5101 tggctacgtc tatgacttcg gtgacttaac aaacatgagc agatggtgca cttagtggtt
     5161 ggtacttcag cataggactg tgacctgggt gttgctccct gtgagactcc atgtggtagc
     5221 acccctgact agtatagcag gactctacgt tttagggttg tgtgatgaaa aactggattt
     5281 ttttcttttt ctttttcttt ttttttggtt ttggtttttc aagacggggt ttctctgtat
     5341 cgccctgact gtcctggttg aactcagaaa tctgcctgcc tctgcctccc aagtgctggg
     5401 attaaaggca tgtgccacca ctgcctggct aaaactggat atttttaaga ggaaggaatt
     5461 aagtctctgt gtgtgtgttt gtgtgtgtgt gtattgtggg tagatggggt gggggtgggg
     5521 cgctcagtgg ttaagaatac tggctgcttt tccagaggac tcaagttcaa ttctctgagc
     5581 ctacatgaca gctcacagct gtctgtaact caagtcccag gaatcttgtg gcctccgtgg
     5641 acaccaagta ggcacataat gcacttacac acttgcaagc aaaacaccca tacatataaa
     5701 cataaataaa ttatattcta aagagtatag ttaaggggag actaaacgtt gggccaatca
     5761 gagttcggca tggctctaat tgtaagtgtg agccccgctt ttgctgccct gtagtcagtt
     5821 gggtgctaac aggagaggct gggaagggaa gatcttggag gctcagtagg agatctcttg
     5881 acagttttaa ccctttgagt gcccgctgga tccaagctgg cagcacagca gtcttctagc
     5941 atcaactttc aggatcctgc tgtttcctga gtggtgtcag ttgggacaaa tgctacatgg
     6001 atgaaatcac agagatgagc agatatgctg gtagccccta gttcaggctc ttgccttgtg
     6061 gccacataca taagcattga ggtaccccaa gagtcaccct gtcctctgtc ccccaagagg
     6121 ctgtgctctg tgcacacaca tacaggtcct gctgctcctg tgtgtgactg tattgtacat
     6181 agaaaaacat acaaaattat ccaatcttga attccccgct cacgcactgc tagaatgctt
     6241 ctgttcaagt cactagcaaa gtgttacaga ccatgagcgc ctcagcattc gcctgatttc
     6301 atttccctct ccagggaagt ttaaaaaaaa aaaaaaaaaa aaaggaatac tcagaaatga
     6361 attctctgaa gtcagtgttg agtttgaggg taataagatt tataggaatc aacatttctc
     6421 tttttaattt taattcaaaa catctaatta ttgttccaga ttagaggaca gatgttatag
     6481 ttagggaaat cttttagaca cagggcagac tgcagaggtt gttcttggca gccgtgttct
     6541 ggcctgcatt ccttttaaag catgtcagag ttcacagggg ttcgtcatgt cttgctacaa
     6601 acaccatgta tgtgatggga caactccctc aaacctcaca tacacccggg gaaactgagg
     6661 ctcacttcag gtcacatcgt cagctaacag aagagctgtt ctagtcactc agcattttct
     6721 gcgcacaggt gtggcctgcc tgtgttttga ggccagggtt tgggggcaga ccccaaagct
     6781 tctcctcctg tgcctacaca cctcttccat gggttcccag accatatctg cctgggtagg
     6841 gcagggcttc gggctatgaa ggagcaactc catactgtgc agaacagcac tctgctgtgc
     6901 attcaggggc ttcagctccc agggcacggt ggctgagtct acgccaggca tgagggtctg
     6961 gcgtgtgcct ggatcctgtg ctcctcctta taggcacccc accactccgt ccagaactct
     7021 gcatctattt tagtggtgcg tggtggggtt cagcagcctt aaaaacagcc cctgtctgct
     7081 cttgcacagt ggctctgaat cccctgccaa atccttccat cccttgctct cctgggagag
     7141 ttagctgttc ttcagatcac ctctgcacac tcttggggct gactgacctt ccatggggtt
     7201 gttcatcatg gtctaggttg gctctgattc tcaaatctcc ctccaccata aggtgggcag
     7261 tctgctaaca acacaggtca aatgactcaa tctttgacct atacttgtgt tatgaccatg
     7321 gtgtcccttt tgtattttaa agacaaagag cgggatacct gcttagcctg gataaacagc
     7381 tttctgtgac aggccaactc agatggtgga tagatgggcc aaataggaca catgaagcaa
     7441 ccgtgaggtt ctcttagcaa cagaggcagt tgtacgtaaa ggccgtgaga atccatgaat
     7501 ggagggtaaa gcttaggttg gaaggacagg gagaatgaat tccccaaagc ccatgggatt
     7561 caggtcacag ttgccatatg tccaggctcc actggtgtcc tgaagatgcc tctctttcga
     7621 agggaagatc tcccccatgg tgacattaga cacctgggag gcctccttat aggagtggct
     7681 atagagtgga cacctccatt ccacgttaga tccagtgcca cattctcttc ttgttgaagt
     7741 gagttgagtt gaaatccaac tcagtcccca agacagtgat gcagcagagg ccacccccat
     7801 gaagctcatc ctggtacaac ctgaacaata ggttctctga caccatgact tgtgcttcct
     7861 tcaaagagtg gtgtggatag agaaataaat atataaagtg acttcctggg actcttcact
     7921 gacagaacgt atctcactcc tcctccatgg gcccaaagtg gtaggccatc tataaacagc
     7981 ttttgtggat ggtgacagcc agattttaaa taggaggagg gtagtagaaa ggttgcaaat
     8041 gaaaccatgt gctcagaaac atatgtgtga tgctagttct tatggaaatt ttgaagtgtg
     8101 tgtgtgtgtt ttcaagaaag acaatgtaga taataaaccc cactcctgga acatattaca
     8161 aacctagaaa ttttgccctt ctgggataat gggcaggtgc tttcgagatg tttcagctga
     8221 aggggccctt gtatttcagc tgaaaaaatt ggatggcagt ggtcaatggc tagatctagg
     8281 aaagaatgca ggacttacta aggccttttg aggctcagac atgtagctca catggaagca
     8341 acatactcca ccttttgaag tacaggaagg actgagccat ttgcctgaga gagtcaggac
     8401 ctgtggttgg tgacttagct ggtattctac caaggggagc tgggggtggg ggtggggatg
     8461 gaggggggat ttgggtccat atagcttact ttggaaatga tcccagaagt caagaaggaa
     8521 gtagctgctg tggaatggtt gcattgtgga acacgagtcc acccaggata cattgtgggc
     8581 atctatttgc tgttaagccc caggaacaga actgaagaca cctgggttag ctagtgggtg
     8641 gggcatggag gagctccacc acagtcagca tggatggaag gctatctcca gagatttctg
     8701 cccagccttg tgcatacctg tgcacactct gtgaactggg acatcctggg gcagaggctg
     8761 gtatttataa aatatcagtc tcagagcaga aggcagacat cgaagaacca ggctgcctga
     8821 tccacacatg gatttcaggg ctctggccct tgggctcctg actcagcagg cctagtgtga
     8881 gggtagagca cttgcctttt cagtgtgagg acatgctaat gctaaggatc ttggctttga
     8941 tattgactgg tgagcctcca ccccttcctt gacgcttact ggtggactcc atctccatct
     9001 ccctcccacc cccaccaatt atgaagaaaa tttcacacca cttcacatca tatttcccag
     9061 gcccatgccg tgaatttgaa aatggggaat taataagtac ttataactcc ctgcaactgt
     9121 ggctggcaga taaaatgcca tctgccagac aggatttatt tataatgggg tttatacata
     9181 tttataagtt tgcaagcaac aaatgcacag ttttaaaact ggcacatttt atatcagcta
     9241 gaaaaaaatt gcaactttat actaaggctt tctgagtgtg aactgcatgt gtgtagtata
     9301 cacgtacacg agctttcttt agttcagatg gaatgcgcac cacagcatgt gtatgtccag
     9361 atgcagacca gctctgtgtt gggtctctct ctactgagcc tctggggttt cctgcattgg
     9421 atgacctgta tatgagaaat ggcaccaaga gcttggcggt tgatttgctc tcatttgcag
     9481 acctgtggag cagagttctg ggtgtcgtgg actctgagac catggtacaa aaagggaagt
     9541 agggctctca ctgcaggccg agagagaggg aaagcaagcc aggagtgtgg tgcatttctg
     9601 taatcccaga acttggatgg taaaggctag ctcagggtca acctgggcta aacgaggcca
     9661 tgtctcaaga gaactaaaca gaagggtagc cagcagaaga caaggaagag gcaggtgtta
     9721 gagaaaagga aaagggacat gcagatgaaa cacccacaga cccacatcct ttcttgaccc
     9781 agcctgactt accacaaccg gacttggctg gccagccctc ctggccacat ttatacctta
     9841 gatcctatgt agcaggtcct gcagggactt gtgggacaga gaagggaaca taaggtgaat
     9901 ctgttcctgt ttataatcta actggagccc ctcctccaac acacacatga agtgtgagag
     9961 tgttggagtg ggagtcgggg aggctttcag ggctggtgtg ctcacattca gtatggacca
    10021 aggatcaggc tcaggactga gctggaggcg ctgaaggctt ttaaacagca ggtggcgcag
    10081 ttgtaccctt gaggaagaaa agggtgcaaa agttcaagtt ggtgtccctc atggaatctg
    10141 ctgatgtcag taggatgccg gaggacaggt tgaaaagctt tcctttcctc tcgctgccct
    10201 ctcagatgcc ctgggggtaa gtgagtccct gagaccccca gacacaccta tgggtgaaag
    10261 agaaaccaca ggaaatggac agctttatgt acccactgta catagaggac agaacctatg
    10321 gggtgaatct gaaacccgag ctcctgagga catacaggtt cacactggag gaaattcctt
    10381 taccacaacc aaagtcactc acagcggagt caagcaacag ttcacaaggc agagacagta
    10441 gactaactag tctggggaca actagtttct tttcctcttc ttcttcttct ttgtttaaca
    10501 acactatgtg tgagttgcca attgaatgtt ctctgttcaa ctgacttttg gatataactt
    10561 gtttctgagt attgtgaaat ttatgtgaat ttctttgtgt tcagaatgag acatttgatg
    10621 ttcaaaagcc ccaggattag gggacagctc agtgtaaatg taatgtgtaa caaggtattg
    10681 aacagttttc caaaagcatt cgggtggcca attatacata ttgatatata catatttgaa
    10741 atttcttttt gtttctgtta accattgtga aacaccaaca gttactgtaa cagttactgc
    10801 ctgggagtgt ggccaaccgc cccttgccac tttgatactg gcctgggatt ggctccctaa
    10861 gtcacctgtt gaggagcaga aatacaaagt caactttaag ttttctaata tttttctttg
    10921 ataaaactta ggcgatttga cgaccatttg gcattcccaa gagataacag gtgaaggtga
    10981 tcaggcagct tggactccct cacctgcagg gactctttag agaaacggtg ttgctttcgg
    11041 tctcatgccc tccaccacgg tcctggcaca ccacagccga gcttctggga taaccacgag
    11101 gaggcagcat agaacatccc atcaccatgg ccgaggtatg gctggtggca ggctaaccct
    11161 agacaatgct gctcttcttg ttattattag gtactggaac atgtgccttt atcattggga
    11221 cggccaccca tgcacttcca atcccagagc tcagagctga ccctctgccc tctgacttag
    11281 acaactatgt gggtgatgag gtttttgttt ttttgtttgt ttgtttgttt tcattttttt
    11341 catttgtcac tagtctccaa agcatggaac tggcggcgat gtcattagac attttctata
    11401 aaatgcacct tgttatcttt ctgtgaccgg ctctttccca gcacacagaa taaccacggc
    11461 tcaaagattg agaggagtaa ccatttttaa atagttaatt gtttcagtga ctgtaagtgt
    11521 taagtctgtt gttggcaata aaggctactg tgaaaa
//
